当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha.

Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha.

Abstract：

:The expression of mRNAs for epidermal growth factor (EGF), transforming growth factor alpha(TGF alpha), EGFR, platelet-derived growth factor (PDGF) A and B chain, PDGF receptor (PDGFR), transforming growth factor beta (TGF beta), erbB-2 and estrogen receptor (ER) genes was first examined in 6 human esophageal carcinoma cell lines, 6 xenoplanted and 15 surgically resected esophageal carcinomas. Secondly, the effect of EGF and TGF alpha on the expression of these genes by the TE-1 esophageal carcinoma cell line was investigated. The expression of EGF mRNA was detected in 8 (29.6%) of 27 tumors including the cell lines, whereas the TGF alpha and EGFR genes were expressed in 21 (77.8%) and 24 (88.9%) tumors respectively. PDGF B chain and PDGFR were detected in 18 (66.7%) and 20 (74.1%), respectively, and ER mRNA was observed in 16 (59.3%) tumors. Genes for PDGF A chain and TGF beta and the erbB-2 gene were commonly expressed. On the other hand, exogenous EGF and TGF alpha stimulated the expressions of fos and myc genes by TE-1 cells. The expression of mRNAs for TGF alpha, PDGF A and B chain and the erbB-2 genes was also increased after treatment with EGF. TGF alpha increased the accumulation of mRNAs for EGF, TGF alpha, EGFR, PDGF A and B chain and the erbB-2 gene. Moreover, the expression of mRNAs for interstitial collagenase, stromelysin and type IV collagenase was increased after EGF or TGF alpha treatment. These results indicate that EGF and TGF alpha may regulate the multi-growth-factor receptor expression and may play a central role for tumor invasion and metastasis as autocrine modulators for human esophageal carcinoma.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Yoshida K,Kuniyasu H,Yasui W,Kitadai Y,Toge T,Tahara E

doi

10.1007/BF01218421

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

401-7

issue

7

eissn

0171-5216

issn

1432-1335

journal_volume

119

pub_type

杂志文章

相关文献

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY文献大全
  • Prognostic significance of serum lactate dehydrogenase level in osteosarcoma: a meta-analysis.

    abstract：BACKGROUND:A number of studies have investigated the role of serum lactate dehydrogenase (LDH) level in patients with osteosarcoma but have yielded inconsistent and inconclusive results. Thus, we conducted a meta-analysis to assess its prognostic value more precisely. METHODS:Systematic computerized searches of PubMed...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00432-014-1644-0

    authors： Chen J,Sun MX,Hua YQ,Cai ZD

    更新日期：2014-07-01 00:00:00

  • Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer.

    abstract：PURPOSE:Multidrug resistance (MDR) has been linked to sphingolipid metabolism and preclinical data ascribe glucosylceramide synthase (GCS) a major role for MDR especially in breast cancer cells but no profound data are available on the expression of this potential therapeutic target in clinical breast cancer specimens....

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-008-0436-9

    authors： Ruckhäberle E,Karn T,Hanker L,Gätje R,Metzler D,Holtrich U,Kaufmann M,Rody A

    更新日期：2009-01-01 00:00:00

  • Glutathione S-transferase expression in malignant mesothelioma and non-neoplastic mesothelium: an immunohistochemical study.

    abstract：:Expression of the glutathione S-transferase (GST) subclasses alpha, mu and pi was investigated immunohistochemically in 20 normal or hyperplastic mesothelium and in 57 malignant mesothelioma cases. These results were correlated with survival and also with P-170 glycoprotein expression. Nearly all the non-neoplastic me...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01221194

    authors： Segers K,Kumar-Singh S,Weyler J,Bogers J,Ramael M,Van Meerbeeck J,Van Marck E

    更新日期：1996-01-01 00:00:00

  • RhoA and RhoC differentially modulate estrogen receptor α recruitment, transcriptional activities, and expression in breast cancer cells (MCF-7).

    abstract：PURPOSE:RhoA and RhoC are closely related, small GTPases that are clearly involved in breast cancer tumorigenesis. Nonetheless, their specific roles in the control of estrogen receptor alpha (ERα) activities have not been elucidated. METHODS:We used siRNA sequences to specifically down-regulate RhoA and RhoC expressio...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-013-1533-y

    authors： Malissein E,Meunier E,Lajoie-Mazenc I,Médale-Giamarchi C,Dalenc F,Doisneau-Sixou SF

    更新日期：2013-12-01 00:00:00

  • Clinical characteristics and comparison of the outcome in young versus older patients with upper gastrointestinal carcinoma.

    abstract：BACKGROUND:The clinical behaviour and outcome of young patients with gastroesophageal tumours (GET) is surmised to differ from older patients, yet data on the comparison of these two patient subgroups is scarce. This study focuses on the investigation of the clinical characteristics and survival outcome of younger-age ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-020-03302-x

    authors： Puhr HC,Karner A,Taghizadeh H,Jomrich G,Schoppmann SF,Preusser M,Ilhan-Mutlu A

    更新日期：2020-12-01 00:00:00

  • Effect of glutathione-modulating compounds on hydrogen-peroxide-induced cytotoxicity in human glioblastoma and glioma cell lines.

    abstract：:The relation between the intracellular glutathione (GSH) concentration and hydrogen-peroxide(H2O2)-induced cytotoxicity was investigated. The intracellular GSH concentration in human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines was one or two orders of magnitude higher than that in a human myelogenous leuke...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320050115

    authors： Iida M,Sunaga S,Hirota N,Kuribayashi N,Sakagami H,Takeda M,Matsumoto K

    更新日期：1997-01-01 00:00:00

  • t (11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in buccal mucosa.

    abstract：PURPOSE:The t(11;18)(q21;q21) chromosome translocation is frequent in gastric MALT lymphoma, but the t(11;18)(q21;q21) chromosome translocation is very rare in other sites of MALT lymphomas. We investigated the possibility that MALT lymphoma occurred in the right buccal mucosa of a 66-year-old Japanese woman who had th...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 信件

    doi：10.1007/s00432-010-0939-z

    authors： Tanaka T,Iino M

    更新日期：2010-11-01 00:00:00

  • Cooperative evaluation of human tumor chemosensitivity in the soft-agar assay and its clinical correlations.

    abstract：:In supporting the human-tumor cloning effort of the Southwest Oncology Group, we conducted an independent retrospective study to evaluate the clinical correlations of the soft-agar colony-forming assay developed by Hamburger and Salmon (1977). This study was made with the cooperation of 76 clinicians and 11 hospitals ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF01884250

    authors： Fan D,Morgan LR,Schneider C,Blank H,Fan S

    更新日期：1985-01-01 00:00:00

  • The effect of post-irradiation tumor oxygenation status on recovery from radiation-induced damage in vivo: with reference to that in quiescent cell populations.

    abstract：PURPOSE:To elucidate the effect of tumor oxygenation status on recovery from damage following gamma-ray or accelerated carbon ion irradiation in vivo, including in quiescent (Q) cells. METHODS:SCC VII tumor-bearing mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. They r...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-009-0552-1

    authors： Masunaga S,Hirayama R,Uzawa A,Kashino G,Suzuki M,Kinashi Y,Liu Y,Koike S,Ando K,Ono K

    更新日期：2009-08-01 00:00:00

  • Lack of correlation between deoxyribonucleotide pool sizes, spontaneous mutation rates and malignant potential in Chinese hamster ovary cells.

    abstract：:To examine the relationship between altered spontaneous mutation rates and malignant characteristics of cells, two hydroxyurea-resistant Chinese hamster ovary cell lines, with alterations in ribonucleotide reductase, were examined for their rates of spontaneous mutation to 6-thioguanine and ouabain resistance, tumor g...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00393331

    authors： Tagger AY,Damen JE,Greenberg AH,Wright JA

    更新日期：1989-01-01 00:00:00

  • Additive effect of concomitant multiple low-dose doxorubicin and thoracic irradiation on ex vivo cardiac performance of the rat heart.

    abstract：:The effects of doxorubicin alone or combined with local heart irradiation on ex vivo cardiac performance were studied in Sprague-Dawley rats. Rats were treated with doxorubicin either administered as a single bolus injection or administered weekly during a period of 10 weeks. In "combined" experiments, local heart irr...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320050148

    authors： Wondergem J,Franken NA,Chin A,van Ravels FJ,Leer JW

    更新日期：1998-01-01 00:00:00

  • Gastric and intestinal phenotypic cell marker expressions in gastric differentiated-type carcinomas: association with E-cadherin expression and chromosomal changes.

    abstract：:Gastric and intestinal phenotypic cell markers are widely expressed in gastric carcinomas, irrespective of their histological type. In the present study, the relations between the phenotypic marker expression of the tumour, histological findings, expression of cell adhesion molecules, and the chromosomal changes in ga...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-005-0062-8

    authors： Morohara K,Tajima Y,Nakao K,Nishino N,Aoki S,Kato M,Sakamoto M,Yamazaki K,Kaetsu T,Suzuki S,Tsunoda A,Tachikawa T,Kusano M

    更新日期：2006-06-01 00:00:00

  • Possible implications from results of animal studies in human risk estimations for benzene: nonlinear dose-response relationship due to saturation of metabolism.

    abstract：:To date, all risk assessment studies on benzene have been based almost exclusively on epidemiological data. We have attempted a more integrated and quantitative evaluation of carcinogenic risk for humans, trying to utilize, in addition to the epidemiological data, all data available, specifically data on metabolism, g...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00397718

    authors： Grilli S,Lutz WK,Parodi S

    更新日期：1987-01-01 00:00:00

  • Salvage intraperitoneal therapy of small-volume residual ovarian cancer: impact of pretreatment finding of peritoneal carcinomatosis on the surgical complete response rate.

    abstract：:Second-line intraperitoneal (i.p.) therapy has been demonstrated to result in surgically defined complete responses (S-CR) in 25%-40% of patients with small-volume residual ovarian cancer (microscopic disease or largest tumor mass less than 1 cm in diameter). To evaluate the influence of the surgical finding of diffus...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01410140

    authors： Markman M,Reichman B,Hakes T,Barakat R,Curtin J,Rubin S,Jones W,Lewis JL Jr,Almadrones L,Hoskins W

    更新日期：1992-01-01 00:00:00

  • T-cell receptor-α CDR3 domain chemical features correlate with survival rates in bladder cancer.

    abstract：PURPOSE:In certain cancer settings, a T-cell response to cancer represents a relatively favorable outcome. Thus, the near-future challenges include a better understanding of exactly which T-cell features contribute to a response to which cancer antigen-groups, to maximize the opportunities for tumor-infiltrating lympho...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-018-2815-1

    authors： Chobrutskiy BI,Zaman S,Diviney A,Mihyu MM,Blanck G

    更新日期：2019-03-01 00:00:00

  • Phase II evaluation of fractionated low and single high dose cisplatin in various tumors.

    abstract：:Seventy-three evaluable patients with advanced measurable solid tumors were given cisdichlorodiammineplatinum (II) (DDP) at a dose of 20 mg/M2 IV for 1-5 days every 3 weeks, and 19 patients who failed on this low dose DDP protocol received a single high dose of 100 mg/M2 IV once every 3 weeks. Forty-six patients had r...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00395492

    authors： Schilcher RB,Wessels M,Niederle N,Seeber S,Schmidt CG

    更新日期：1984-01-01 00:00:00

  • External validity of the Tokuhashi score in patients with vertebral metastasis.

    abstract：PURPOSE:To calculate the accuracy of the Tokuhashi score (TS) in recent patients with vertebral metastasis (VM), candidates or not to surgical treatment, and thus to assess the external validity of TS. METHODS:Retrospective analysis of prospectively collected data from 90 patients (55 men, 35 women) with VM between 20...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-012-1222-2

    authors： Hernandez-Fernandez A,Vélez R,Lersundi-Artamendi A,Pellisé F

    更新日期：2012-09-01 00:00:00

  • Antitumor activity of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea (MeCCNU) on Yoshida sarcoma ascites cells implanted into the colon wall of rats.

    abstract：:Three thousand Yoshida sarcoma cells were inoculated into the wall of the descending colon of each of 120 male Sprague-Dawley rats. On day 8 after the tumor implantation, the animals were at random divided into four groups of 30 rats each. The effect of cyclophosphamide (70 mg/kg), BCNU (25 mg/kg), and methyl-CCNU (45...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00405350

    authors： Bhide S,Habs M,Reinbold H,Schmähl D

    更新日期：1979-05-14 00:00:00

  • The effect of antibody against vascular endothelial growth factor on tumor growth and metastasis.

    abstract：:Vascular endothelial growth factor (VEGF), a very important in the process of tumor angiogenesis, was chosen as a target in a study to determine whether manipulation of angiogenesis with antibody against VEGF may interrupt tumor growth and metastasis. Anti-VEGF antibody was obtained from immunized rabbits, purified on...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320050223

    authors： Wang G,Dong Z,Xu G,Yang Z,Shou C,Wang N,Liu T

    更新日期：1998-01-01 00:00:00

  • Kaposi's sarcoma after liver transplantation.

    abstract：INTRODUCTION:Kaposi's Sarcoma (KS) is a malignant neoplasm arising from endothelial cells. HHV8-infection represents a key pathogenic determinant for the development of KS. There are no standard criteria to treat KS in immunosuppressed-individuals. Six cases (2.1%) of KS occurred in our Center among 285-recipients who ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-007-0329-3

    authors： Di Benedetto F,Di Sandro S,De Ruvo N,Berretta M,Masetti M,Montalti R,Ballarin R,Cocchi S,Potenza L,Luppi M,Gerunda GE

    更新日期：2008-06-01 00:00:00

  • Analysis of molecular cytogenetic alterations in uterine leiomyosarcoma by array-based comparative genomic hybridization.

    abstract：OBJECTIVE:The aim of this study was to identify novel genes following genomic DNA copy number changes using a genome-wide array-based comparative genomic hybridization (array-CGH) analysis in uterine leiomyosarcoma (ULMS). METHODS:Genomic DNA copy number changes were analyzed in 15 cases of ULMS from St Mary's Hospita...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-012-1182-6

    authors： Raish M,Khurshid M,Ansari MA,Chaturvedi PK,Bae SM,Kim JH,Park EK,Park DC,Ahn WS

    更新日期：2012-07-01 00:00:00

  • The important prognostic value of Ki-67 expression as determined by image analysis in breast cancer.

    abstract：:A series of 191 female breast carcinomas (with long-term follow-up) were analysed immunohistochemically (with a monoclonal MIB1 antibody) for Ki-67 (a proliferation marker) expression with special reference to well-established prognostic factors and patient survival. Expression of Ki-67 was directly related to the S-p...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01209033

    authors： Pietiläinen T,Lipponen P,Aaltomaa S,Eskelinen M,Kosma VM,Syrjänen K

    更新日期：1996-01-01 00:00:00

  • Determination of growth kinetics in a renal sarcoma of the rat by double labeling with 14C- and 3H-thymidine.

    abstract：:An in vitro double-labeling technique for determination of kinetic growth parameters was tested; 13 renal sarcomas of rats were incubated after excision under standardized conditions with 14C- and 3H-thymidine successively. Another ten tumors were evaluated after in vivo double injection of 14C and 3H-thymidine into s...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00391832

    authors： Lang W,Kienzle S,Georgii A

    更新日期：1983-01-01 00:00:00

  • KDR expression is associated with the stage and cigarette smoking of the patients with lung cancer.

    abstract：PURPOSE:Kinase insert domain-containing receptor (KDR) is one of the molecular targets used in cancer therapy. We studied the KDR expression characteristics and the relationship with the clinical parameters of the patients with lung cancer, to give the basic evidence and clue for tailoring therapy. METHODS:Reverse tra...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-007-0214-0

    authors： An SJ,Nie Q,Chen ZH,Lin QX,Wang Z,Xie Z,Chen SL,Huang Y,Zhang AY,Yan JF,Wu HS,Lin JY,Li R,Zhang XC,Guo AL,Mok TS,Wu YL

    更新日期：2007-09-01 00:00:00

  • Induced pluripotent cancer cells: progress and application.

    abstract：:Induced pluripotent stem (iPS) cells are a group of pluripotent stem cells artificially derived from non-pluripotent cells typically by a forced expression of specific transcription factors. Generation of cancer-specific iPS cells, also called induced pluripotent cancer (iPC) cells, provides valuable experimental plat...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s00432-010-0955-z

    authors： Sun C,Liu YK

    更新日期：2011-01-01 00:00:00

  • Differentiation of the rat myelomonocytic leukemia cell line c-WRT-7 by in vitro culture with the rat bone marrow preadipocyte cell line REC A16.

    abstract：:Differentiation of the rat myelomonocytic leukemia cell line (c-WRT-7) was investigated, by co-culture with a rat embryonic bone marrow preadipose cell line (REC A16). Co-cultivation with REC A16, or with conditioned medium from REC A16 cultures (REC-CM), induced differentiation of c-WRT-7 cells to macrophages. A solu...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01208841

    authors： Tanaka T,Okamura S,Yasumoto S,Takeichi N,Kobayashi H,Niho Y

    更新日期：1993-01-01 00:00:00

  • Polyploidization of G2M phase cells separated from aerobically and anaerobically grown Ehrlich ascites tumor cells.

    abstract：:G2-enriched fractions of Ehrlich ascites tumor cells (up to 80%-85% G2 cells) separated from anaerobically and aerobically cultured asynchronous populations by centrifugal elutriation revealed the same growth characteristics after recultivation under standard conditions: a significant proportion of cells with increase...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00396389

    authors： Kroll C,Schneider F

    更新日期：1987-01-01 00:00:00

  • Clinical characteristics and outcomes of SDHB-related pheochromocytoma and paraganglioma in children and adolescents.

    abstract：PURPOSE:Pheochromocytomas/paragangliomas (PHEOs/PGLs) are rare in children with only a few SDHB mutation-related cases. Previous studies on children were conducted in small cohorts. This large set of pediatric patients provides robust data in the evaluation of clinical outcomes. METHODS:Sixty-four pediatric PHEO/PGL p...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-020-03138-5

    authors： Jochmanova I,Abcede AMT,Guerrero RJS,Malong CLP,Wesley R,Huynh T,Gonzales MK,Wolf KI,Jha A,Knue M,Prodanov T,Nilubol N,Mercado-Asis LB,Stratakis CA,Pacak K

    更新日期：2020-04-01 00:00:00

  • Ambulatory high-dose 5-day continuous-infusion ifosfamide combination chemotherapy in advanced solid tumors: a feasibility study.

    abstract：:The oxazaphosphorine analog ifosfamide (IFO) has demonstrated an increased therapeutic index in a variety of solid tumors and hematologic malignancies compared with its parent compound cyclophosphamide. A fractionated dose schedule over 5 days as continuous infusion in combination with the uroprotective agent sodium-2...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01613216

    authors： Loeffler TM,Weber FW,Hausamen TU

    更新日期：1991-01-01 00:00:00

  • Re: Results of a randomized trial of treatment modalities in patients with low or early‑intermediate risk prostate cancer (PREFERE trial).

    abstract：:The authors of this "Letter to the Editors" express their major concern about selective and biased reporting in this paper. ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 信件

    doi：10.1007/s00432-020-03499-x

    authors： Boehle A,Kahmann F,Henkel TO,Zimmermann J,Machtens S

    更新日期：2021-01-28 00:00:00