Re: Results of a randomized trial of treatment modalities in patients with low or early‑intermediate risk prostate cancer (PREFERE trial).

abstract：PURPOSE:Lung cancer has become a crucial problem among individuals living with the human immunodeficiency virus (HIV) and causes high mortality in Western countries. Japan has an increasing number of newly infected HIV patients, and lung cancer is becoming a theme in this population. However, clinical factors of this p...

journal_title：Journal of cancer research and clinical oncology

authors： Okuma Y,Tanuma J,Kamiryo H,Kojima Y,Yotsumoto M,Ajisawa A,Uehira T,Nagai H,Takeda Y,Setoguchi Y,Okada S

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:Solitary plasmacytoma (SP) is characterized by a single mass of clonal plasma cells. Definitive RT can result in long-term local control of the SP. Due to the small number of patients and narrow range of doses, phase III randomized trials are lacking. The aim of this study is to further support the potential...

journal_title：Journal of cancer research and clinical oncology

authors： Alghisi A,Borghetti P,Maddalo M,Roccaro AM,Tucci A,Mazzola R,Magrini SM,Lo Casto A,Bonù ML,Tomasini D,Pasinetti N,Peretto G,Bertagna F,Tomasi C,Buglione M,Triggiani L

更新日期：2020-11-17 00:00:00

abstract：PURPOSE:Gastrokine 1 (GKN1) plays an important role in the gastric mucosal defense mechanism and also acts as a functional gastric tumor suppressor. The specific aim of this study was to determine the molecular mechanisms underlying GKN1 tumor suppressor activity in the progression of gastric cancers. METHODS:We exami...

journal_title：Journal of cancer research and clinical oncology

authors： Yoon JH,Kang YH,Choi YJ,Park IS,Nam SW,Lee JY,Lee YS,Park WS

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:Genomic stability is maintained by error-free DNA replication, repair, and recombination. To determine if repair genes contribute to genomic instability, we used a newly established cell line RCC-AJR (from clear-cell renal cell carcinoma) to examine hMSH2 (a mismatch-repair gene) and the gene encoding DNA beta ...

journal_title：Journal of cancer research and clinical oncology

authors： Chen HC,Bhattacharyya N,Wang L,Recupero AJ,Klein EA,Harter ML,Banerjee S

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:Natural killer (NK) cells can kill transformed cells and represent anti-tumor activities for improving the immunotherapy of cancer. In previous works, we established human interleukin-15 (hIL-15) gene-modified NKL cells (NKL-IL15) and demonstrated their efficiency against human hepatocarcinoma cells (HCCs) in v...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang W,Zhang C,Tian Z,Zhang J

更新日期：2018-07-01 00:00:00

abstract：:Butylnitrosourea (BNU) was used to induce thymic lymphomas in BDF1 mice. During and after the 12-week BNU exposure the spontaneous NK cell activity against YAC-1 cells and that arising 4 days after stimulation with Corynebacterium parvum (CP) were measured, as were the mitogen responses of splenic T and B cells. In ad...

journal_title：Journal of cancer research and clinical oncology

authors： Seidel HJ,Stolz W

更新日期：1984-01-01 00:00:00

abstract：:The dihydropyridine, dexniguldipine hydrochloride (B859-35), has shown therapeutic activity in experimentally induced neuroendocrine hamster lung tumors and demonstrated antiproliferative effects in a mammary cancer cell line via inhibition of Ca2+ calmodulin. Studies in NIH 3T3 fibroblasts have provided evidence that...

journal_title：Journal of cancer research and clinical oncology

authors： Schuller HM,Orloff M,Reznik GK

更新日期：1994-01-01 00:00:00

abstract：:Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of this study was to compare and to characterize the tumour vascula...

journal_title：Journal of cancer research and clinical oncology

authors： Pautu V,Mellinger A,Resnier P,Lepeltier E,Martin L,Boussemart L,Letournel F,Passirani C,Clere N

更新日期：2019-03-01 00:00:00

abstract：:In a wider sense iatrogenic carcinogenesis means the induction of cancer by medical treatment. Some drugs have been now identified to be carcinogenic not only in experimental animals but also in man. For example, chlornaphazine used in the treatment of polycythemia has been proved to induce bladder cancer in 30% of th...

journal_title：Journal of cancer research and clinical oncology

authors： Schmähl D

更新日期：1981-01-01 00:00:00

abstract：:Two cell clones of a methylnitrosourea-induced rat mammary carcinoma, a hyperdiploid (44 chromosomes, clone A) and a hypertetraploid clone (88 chromosomes, clone B) were cultured and transplanted subcutaneously into three groups of eight rats. Group 1 was treated with 62.6 mg cyclophosphamide/kg, group 2 with 41.8 mg/...

journal_title：Journal of cancer research and clinical oncology

authors： Angres G,Scherf HR

更新日期：1989-01-01 00:00:00

abstract：:The DMBA-TPA-mediated two-stage skin carcinogenesis experiment was modified in that pregnant mice were systemically treated once during pregnancy with the carcinogen. Intragastric application times were fetal days 6, 8, and 10-20. A control group of pregnant mice received repeated doses (from days 8-20) of sesame oil,...

journal_title：Journal of cancer research and clinical oncology

authors： Goerttler K,Loehrke H,Schweizer J,Hesse B

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:The blockade of the renin-angiotensin-aldosterone system (RAAS) by angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) is one of the most common treatments for hypertension, heart failure and renal diseases. However, concerns have been raised about a possible link between RA...

journal_title：Journal of cancer research and clinical oncology

authors： Rachow T,Schiffl H,Lang SM

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:It is estimated that about half of cancer patients use at least one form of complementary and alternative medicines (CAM) in their life but there is a strong reticence of patients in talking about CAM with their oncologist. Primary aim of this study was to inform patients about CAM, focusing on their suppose...

journal_title：Journal of cancer research and clinical oncology

authors： Bozza C,Gerratana L,Basile D,Vitale MG,Bartoletti M,Agostinetto E,Russo S,Follador A,De Carlo E,Pella N,Sottile R,Fasola G,Puglisi F

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Death-associated protein kinase (DAPK) and adenomatous polyposis coli gene (APC) have been recently shown to be associated with outcome in patients with esophageal carcinoma, especially adenocarcinoma. We wanted to validate the correlation of these two markers with outcome by detecting methylated DNA sequenc...

journal_title：Journal of cancer research and clinical oncology

authors： Hoffmann AC,Vallböhmer D,Prenzel K,Metzger R,Heitmann M,Neiss S,Ling F,Hölscher AH,Schneider PM,Brabender J

更新日期：2009-09-01 00:00:00

abstract：:Phenotypically altered, preneoplastic cell populations were detected by micromorphological and cytochemical methods in a number of tissues treated with various chemical carcinogens. Further cellular analysis of carcinogenesis has shown that different cellular phenotypes follow each other during tumor development. Thus...

journal_title：Journal of cancer research and clinical oncology

authors： Bannasch P

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and has been shown to induce extrinsic pathway of apoptosis in many types of cancer cells. AT-101, an (-)-enantiomer of gossypol, is a potent anticancer agent that is shown to be an inhibitor of Bcl-2/Bcl-XL. In t...

journal_title：Journal of cancer research and clinical oncology

authors： Kisim A,Atmaca H,Cakar B,Karabulut B,Sezgin C,Uzunoglu S,Uslu R,Karaca B

更新日期：2012-07-01 00:00:00

abstract：:In the original publication, the 6th author's first name and the last name was inverted and incorrectly published. The correct author name is Letizia Ferella. ...

journal_title：Journal of cancer research and clinical oncology

authors： Marampon F,Leoni F,Mancini A,Pietrantoni I,Codenotti S,Ferella L,Megiorni F,Porro G,Galbiati E,Pozzi P,Mascagni P,Budillon A,Maggio R,Tombolini V,Fanzani A,Gravina GL,Festuccia C

更新日期：2019-09-01 00:00:00

abstract：:We performed intraoperative peritoneal cytology in 171 gastric cancer patients undergoing curative surgery. Intraperitoneal free cancer cells were demonstrated in almost all patients in whom the area of serosal cancer invasion exceeded 15-20 cm2. In patients with both serosal cancer invasion and free cancer cells the ...

journal_title：Journal of cancer research and clinical oncology

authors： Koga S,Kaibara N,Iitsuka Y,Kudo H,Kimura A,Hiraoka H

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The spread of malignant lymph nodes due to malignancies of the head and neck is systematically observed. However, sentinel lymph nodes in the cervical region, such as in the axillary or supraclavicular regions, are not described. Therefore, precise preoperative lymph node screening of all neck compartments is r...

journal_title：Journal of cancer research and clinical oncology

authors： Hohlweg-Majert B,Metzger MC,Voss PJ,Hölzle F,Wolff KD,Schulze D

更新日期：2009-06-01 00:00:00

abstract：:Using batroxobin, a thrombin-like enzyme found in snake venom, the effects of defibrinogenation on artificial lung metastasis in mice were studied. The role of natural killer (NK) cells in the inhibitory effects of defibrinogenation on metastasis was also investigated. Artificial lung metastasis experiments were perfo...

journal_title：Journal of cancer research and clinical oncology

authors： Shibuya M,Niitani H,Aoyama A,Kawachi S,Nukariya N,Baba M,Iizuka K,Sakai S,Ohtsuka M

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Lung cancer is the commonest cause of cancer deaths worldwide, and its mortality can be reduced significantly by performing early diagnosis and screening. Since the 1960s, driven by the pressing needs to accurately and effectively interpret the massive volume of chest images generated daily, computer-assisted d...

journal_title：Journal of cancer research and clinical oncology

authors： Liu B,Chi W,Li X,Li P,Liang W,Liu H,Wang W,He J

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:In certain cancer settings, a T-cell response to cancer represents a relatively favorable outcome. Thus, the near-future challenges include a better understanding of exactly which T-cell features contribute to a response to which cancer antigen-groups, to maximize the opportunities for tumor-infiltrating lympho...

journal_title：Journal of cancer research and clinical oncology

authors： Chobrutskiy BI,Zaman S,Diviney A,Mihyu MM,Blanck G

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Metastatic renal cell carcinoma (mRCC) sometimes presents with an indolent course without any significant symptoms. Here, the potential impact of active surveillance (AS) on clinical outcomes in asymptomatic or minimally symptomatic mRCC patients was retrospectively evaluated. METHODS:mRCC patients who were fo...

journal_title：Journal of cancer research and clinical oncology

authors： Park I,Lee JL,Ahn JH,Lee DH,Lee KH,Jeong IG,Song C,Hong B,Hong JH,Ahn H

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:Tumor detection and visualization plays a key role in the clinical workflow of a patient with suspected cancer, both in the diagnosis and treatment. Several optical imaging techniques have been evaluated for guidance during oncological interventions. Optical coherence tomography (OCT) is a technique which ...

journal_title：Journal of cancer research and clinical oncology

authors： van Manen L,Dijkstra J,Boccara C,Benoit E,Vahrmeijer AL,Gora MJ,Mieog JSD

更新日期：2018-10-01 00:00:00

abstract：:Aclacinomycin A (ACM) is a new anthracycline antibiotic with a reduced cardiac toxicity in animal models. A phase II study was performed in a total of 25 patients, 23 of whom are evaluable for response. All suffered from recurrent and advanced tumors. Pretreatment consisted of at least four different chemotherapeutic ...

journal_title：Journal of cancer research and clinical oncology

authors： Schütte J,Niederle N,Seeber S

更新日期：1983-01-01 00:00:00

abstract：:Some unsolved problems in DNA alkylation by N-nitroso compounds are discussed in this overview. Does O6 alkylation of guanine represent the initiating event exclusively or are O4 alkylation of thymidine and phosphate triester formation also involved in the initiating process? Does the formation of rearranged DNA alkyl...

journal_title：Journal of cancer research and clinical oncology

authors： Wiessler M

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Patterns of locoregional rectal cancer recurrences following total mesorectal excision (TME) were analyzed to define the irradiation volume, especially the lateral pelvic lymph node (LPLN). MATERIALS AND METHODS:Of 1243 patients who underwent TME without pelvic radiotherapy between 2005 and 2012, the data of 8...

journal_title：Journal of cancer research and clinical oncology

authors： Choi SH,Chang JS,Yoon HI,Jang DS,Kim NK,Lim JS,Min BS,Huh H,Shin SJ,Ahn JB,Koom WS

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Elevated expression of the beta-thymosin isotypes T beta(4), T beta(10), and T(15) appears to be involved in the manifestation of a malignant phenotype of human tumor cells, including those of mammary carcinomas. This has evoked an interest in these peptides as diagnostic/prognostic tumor markers. If increased ...

journal_title：Journal of cancer research and clinical oncology

authors： Otto AM,Müller CS,Huff T,Hannappel E

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:In the present study an antigen-mimetic peptide of the anti-JL1 leukemia-specific monoclonal antibody (mAb) was identified and characterized. METHODS:From combinatorial peptide phage display libraries displaying the random linear heptapeptides and dodecapeptides, we selected clones with affinity to anti-JL1 mA...

journal_title：Journal of cancer research and clinical oncology

authors： Chung J,Park S,Kim D,Rhim J,Kim I,Choi I,Yi K,Ryu S,Suh P,Chung D,Bae Y,Shin Y,Park S

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:The activity of dihydropyrimidine dehydrogenase (DPD) - the rate-limiting enzyme in fluorouracil (5-FU) catabolism - has been reported to vary according to the time of day. On the basis of this data, so-called chronomodulated chemotherapy regimens with variable-rate infusions of 5-FU have been investigated in t...

journal_title：Journal of cancer research and clinical oncology

authors： Raida M,Kliche KO,Schwabe W,Häusler P,Clement JH,Behnke D,Höffken K

更新日期：2002-02-01 00:00:00