当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Phase II trial of aclacinomycin A in acute leukemia and various solid tumors.

Phase II trial of aclacinomycin A in acute leukemia and various solid tumors.

Abstract：

:Aclacinomycin A (ACM) is a new anthracycline antibiotic with a reduced cardiac toxicity in animal models. A phase II study was performed in a total of 25 patients, 23 of whom are evaluable for response. All suffered from recurrent and advanced tumors. Pretreatment consisted of at least four different chemotherapeutic agents (range: 4-9). Lung cancer patients (3/9) were irradiated to the mediastinum. Eighteen patients were pretreated with doxo- or daunomycin. The dose for solid tumors was 2-3 mg/kg given on 3 consecutive days every 3 weeks. Leukemia patients received a daily dose of 20 mg/m2, and standard response criteria were used. Marked reductions of leukocyte counts were achieved in leukemia patients. The overall response rate was about 15% in solid tumors, but major objective responses (CR + PR) have not been observed. Myelosuppression was commonly moderate in solid tumor patients, nausea and vomiting were rare, and alopecia was not induced. Cumulative cardiotoxicity was not evaluated in this trial. Treatment with ACM requires further investigation in acute leukemias and solid tumors, not pretreated with anthracycline antibiotics.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Schütte J,Niederle N,Seeber S

doi

10.1007/BF00406927

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

162-5

issue

2

eissn

0171-5216

issn

1432-1335

journal_volume

105

pub_type

杂志文章

相关文献

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY文献大全
  • The ambiguous role of microRNA-205 and its clinical potential in pancreatic ductal adenocarcinoma.

    abstract：PURPOSE:Early treatment of pancreatic ductal adenocarcinoma (PDAC) is significantly delayed due to the lack of liquid biopsy markers for early diagnosis at surgically resectable tumor stages. Recent studies suggest that microRNA-205 (miR-205) is involved in PDAC progression by post-transcriptional regulation of epithel...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-018-2755-9

    authors： Michael Traeger M,Rehkaemper J,Ullerich H,Steinestel K,Wardelmann E,Senninger N,Abdallah Dhayat S

    更新日期：2018-12-01 00:00:00

  • Characterization of three B-cell lymphoma cell lines from chemotherapy resistant patients with respect to in vitro sensitivity to 21 antitumor agents, ABC-transporter expression and cellular redox status.

    abstract：PURPOSE:The aim of this study was to characterize three new, recently established non-Hodgkin lymphoma cell lines (GUMBUS, DOGUM, and DOGKIT), isolated from patients developing high-clinical resistance to cytotoxic therapy, with respect to sensitivity toward 21 antitumor drugs from different classes of action, expressi...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-007-0241-x

    authors： Bracht K,Kiefer T,Dölken G,Bednarski PJ

    更新日期：2007-12-01 00:00:00

  • NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma.

    abstract：PURPOSE:In our previous global gene expression analysis, we identified NIPA-like domain containing 1 (NIPAL1), which encodes a magnesium transporter, as one of the most overexpressed genes in recurrent oral squamous cell carcinoma (OSCC). Although has been NIPAL1 linked with gout pathogenesis, little is known about its...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-018-2612-x

    authors： Sasahira T,Nishiguchi Y,Kurihara-Shimomura M,Nakashima C,Kuniyasu H,Kirita T

    更新日期：2018-05-01 00:00:00

  • Acute leukemias in adults: an overview of recent strategies.

    abstract：:In 1989, 65%-75% of previously untreated adults with ALL or AML may be expected to enter complete remission. Approximately 40% of these completely responding patients, whether they are treated with intensive chemotherapy, intensive chemotherapy followed by autologous bone marrow transplantation, or allogeneic bone mar...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01612646

    authors： Mayer RJ

    更新日期：1990-01-01 00:00:00

  • Effect of cisplatin in advanced colorectal cancer resistant to 5-fluorouracil plus (S)-leucovorin.

    abstract：:Modulation of 5-fluorouracil (5-FU) is currently being investigated in advanced colorectal cancer. In an attempt to improve the results obtainable for the association of 5-FU and leucovorin, we decided to add cisplatin to 5-FU and (6S)-leucovorin (S-LV) after disease progression. The hypothesis was that a pharmacologi...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF01218364

    authors： Cassano A,Pozzo C,Corsi DC,Fontana T,Noviello MR,Astone A,Barone C

    更新日期：1995-01-01 00:00:00

  • Incidence and risk factors for hepatocellular carcinoma in 967 patients with cirrhosis.

    abstract：PURPOSE:To determine the incidence of hepatocellular carcinoma in cirrhosis and to examine the influence of age and sex, and the contribution of etiological factors. METHODS:967 patients with liver cirrhosis and free of hepatocellular carcinoma were enrolled in this longitudinal, retrospective and observational study....

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320050215

    authors： del Olmo JA,Serra MA,Rodríguez F,Escudero A,Gilabert S,Rodrigo JM

    更新日期：1998-01-01 00:00:00

  • Immunohistochemical analysis of p53 protein in transplant recipients with Kaposi's sarcoma.

    abstract：PURPOSE:Kaposi's sarcoma (KS) is a proliferative process of suspected viral aetiology associated with immune deficiency. In transplanted patients, lesions regress on discontinuation of immunosuppressive therapy. The purpose of this work was to analyse the expression of the p53 oncosuppressor gene product, a proliferati...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01240324

    authors： Flamini G,Magalini S,Curigliano G,Nanni G,Boninsegna A,Agnes S,Faticato D,Castagneto M,Cittadini A

    更新日期：1997-01-01 00:00:00

  • Growth, ribonucleotide reductase and metals in murine leukemic lymphocytes.

    abstract：:Trace metals are essential for the growth and several other properties of human lymphocytes. We studied the effects of media with variable concentrations of three metals (Fe2+, Cu2+, Zn2+), a metal chelator (deferoxamine, DFX) and a cell-growth inhibitor (hydroxyurea) on the growth, intracellular metal concentration a...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01612765

    authors： Oblender M,Carpentieri U

    更新日期：1991-01-01 00:00:00

  • Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines.

    abstract：OBJECTIVES:The present study was designed to investigate the possible protective effects of berberine against cyclophosphamide (CP)-induced hepatotoxicity in rats. METHODS:The experimental rats were treated with berberine orally at a dose of 50 mg/kg for 11 consecutive days after the administration of a single intrape...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1665-8

    authors： Germoush MO,Mahmoud AM

    更新日期：2014-07-01 00:00:00

  • On the pathogenesis of preleukemic myelodysplastic syndromes: development of a dysplastic hemopoietic proliferation in the rat after a single pulse dose of dimethylbenz(a)anthracene (DMBA).

    abstract：:After a single pulse dose of DMBA, rats develop bone-marrow hypoplasia, which is almost compensated for by regeneration after 16 weeks. Subsequently, dysplastic signs of hemopoiesis appear in all experimental animals as massive extrusion of normoblasts into the peripheral blood, red-cell aniso- and poikilocytosis, nuc...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00406245

    authors： Fohlmeister I,Schaefer HE,Fischer R

    更新日期：1982-01-01 00:00:00

  • Characterization of deoxyguanosine-resistant hypoxanthine-guanine phosphoribosyltransferase(-)metastatic variants altered in soybean-agglutinin-binding properties and cell-surface glycoproteins.

    abstract：:The isolation of deoxyguanosine-resistant 10T1/2 mouse cell lines following stepwise selection in the presence of increasing concentrations of drug led to the identification of a highly metastatic line, as measured by the ability to form secondary tumors in syngenic mice after intravenous injection. This metastatic de...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01630712

    authors： Damen JE,Spearman MA,Greenberg AH,Wright JA

    更新日期：1991-01-01 00:00:00

  • Expression of nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) inversely correlates with tumor progression in gastric adenomas and carcinomas.

    abstract：PURPOSE:The expression of nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1), one of TGF-beta superfamily gene, is reported to be responsible for NSAID-induced apoptosis. We analyzed NAG-1 expression in gastric cancer and adenoma to find out its clinical implication. METHODS:Immunostaining was performed usin...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-008-0362-x

    authors： Park JY,Park KH,Bang S,Kim MH,Koh SS,Song SY

    更新日期：2008-09-01 00:00:00

  • Induced pluripotent cancer cells: progress and application.

    abstract：:Induced pluripotent stem (iPS) cells are a group of pluripotent stem cells artificially derived from non-pluripotent cells typically by a forced expression of specific transcription factors. Generation of cancer-specific iPS cells, also called induced pluripotent cancer (iPC) cells, provides valuable experimental plat...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s00432-010-0955-z

    authors： Sun C,Liu YK

    更新日期：2011-01-01 00:00:00

  • p53 Gene status in relation to ex vivo chemosensitivity of non-small cell lung cancer.

    abstract：PURPOSE:About 40% of non-small cell lung cancer (NSCLC) patients are candidates for systemic chemotherapy, despite the fact that at diagnosis most NSCLC are usually chemoresistant both in vivo and ex vivo. It is important to develop sufficient methods of prediction of the response to chemotherapy and to find molecular ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-001-0305-2

    authors： Vogt U,Zaczek A,Klinke F,Granetzny A,Bielawski K,Falkiewicz B

    更新日期：2002-03-01 00:00:00

  • [Comparative investigations on the organotropic carcinogenic effect of different N-nitroso compounds with rat after single and chronic treatment (author's transl)].

    abstract：:After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carcinomas in female rats (SIV 50). This change of the organ-specific carcinogenic effect is not observed in exper...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00401006

    authors： Schweinsberg F,Kouros M,Manncke K

    更新日期：1979-10-01 00:00:00

  • Age-, sex-, and strain-dependent differences in the induction of enzyme-altered islands in rat liver by diethylnitrosamine.

    abstract：:The formation of foci with loss of ATPase and emergence of gamma-GTase was studied histochemically in livers of male and female Wistar and Sprague-Dawley rats of 3--4 and 6--7 weeks of age, respectively, after application of diethylnitrosamine. A single dose of 8 mg/kg body weight induced a considerable island formati...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00403362

    authors： Deml E,Oesterle D,Wolff T,Greim H

    更新日期：1981-01-01 00:00:00

  • Genetic polymorphisms of phase I and phase II metabolic enzymes as modulators of lung cancer susceptibility.

    abstract：OBJECTIVES:Tobacco exposure remains the main etiologic factor for lung cancer (LC). Interactions between environment and individual genetic profile are particularly important for this disease. The aim of this study was to evaluate the contribution of CYP1A1*2A, CYP1A1*2C, CYP2D6*4, GSTP1, GSTM1, GSTT1 and NAT2 polymorp...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1868-z

    authors： Mota P,Silva HC,Soares MJ,Pego A,Loureiro M,Cordeiro CR,Regateiro FJ

    更新日期：2015-05-01 00:00:00

  • A multi-institutional study of clinicopathological features and molecular epidemiology of epidermal growth factor receptor mutations in lung cancer patients living with human immunodeficiency virus infection.

    abstract：PURPOSE:Lung cancer has become a crucial problem among individuals living with the human immunodeficiency virus (HIV) and causes high mortality in Western countries. Japan has an increasing number of newly infected HIV patients, and lung cancer is becoming a theme in this population. However, clinical factors of this p...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00432-015-1956-8

    authors： Okuma Y,Tanuma J,Kamiryo H,Kojima Y,Yotsumoto M,Ajisawa A,Uehira T,Nagai H,Takeda Y,Setoguchi Y,Okada S

    更新日期：2015-09-01 00:00:00

  • DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.

    abstract：PURPOSE:Uterine neoplasms comprise a broad spectrum of lesions, some of which may pose a diagnostic challenge even to experienced pathologists. Recently, genome-wide DNA methylation-based classification of central nervous system tumors has been shown to increase diagnostic precision in clinical practice when combined w...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00432-019-03093-w

    authors： Kommoss FKF,Stichel D,Schrimpf D,Kriegsmann M,Tessier-Cloutier B,Talhouk A,McAlpine JN,Chang KTE,Sturm D,Pfister SM,Romero-Pérez L,Kirchner T,Grünewald TGP,Buslei R,Sinn HP,Mechtersheimer G,Schirmacher P,Schmidt D,Leh

    更新日期：2020-01-01 00:00:00

  • KRAS allel-specific activity of sunitinib in an isogenic disease model of colorectal cancer.

    abstract：PURPOSE:To investigate the impact of different KRAS mutations on treatment with the tyrosine kinase inhibitor sunitinib in SW48 colorectal cancer cell line variants. MATERIALS AND METHODS:Isogenic SW48 KRAS wt, G12A, G12C, G12D, G12R, G12S, G12 V, and G13D cells were evaluated for ERK phosphorylation with and without ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-013-1401-9

    authors： Modest DP,Camaj P,Heinemann V,Schwarz B,Jung A,Laubender RP,Gamba S,Haertl C,Stintzing S,Primo S,Bruns CJ

    更新日期：2013-06-01 00:00:00

  • The important prognostic value of Ki-67 expression as determined by image analysis in breast cancer.

    abstract：:A series of 191 female breast carcinomas (with long-term follow-up) were analysed immunohistochemically (with a monoclonal MIB1 antibody) for Ki-67 (a proliferation marker) expression with special reference to well-established prognostic factors and patient survival. Expression of Ki-67 was directly related to the S-p...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01209033

    authors： Pietiläinen T,Lipponen P,Aaltomaa S,Eskelinen M,Kosma VM,Syrjänen K

    更新日期：1996-01-01 00:00:00

  • Discontinuation and non-adherence to endocrine therapy in breast cancer patients: is lack of communication the decisive factor?

    abstract：INTRODUCTION:Non-adherence to anti-hormonal therapy is a major problem in gynecologic oncology. Reasons reported are side effects and lack of support. The aim of our study was an analysis of influence of experiences of patients with endocrine therapy and communication and information on this topic and their influence o...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1779-z

    authors： Wuensch P,Hahne A,Haidinger R,Meißler K,Tenter B,Stoll C,Senf B,Huebner J

    更新日期：2015-01-01 00:00:00

  • Over-expression of beta-1,4-galactosyltransferase I, II, and V in human astrocytoma.

    abstract：PURPOSE:beta-1,4-Galactosyltransferase (beta-1,4-GalT) I, II, and V are the enzymes responsible for the biosynthesis of N-acetyllactosamine on N-glycans by transferring UDP-galactose to the terminal N-acetylglucosamine (N-GlcNAc) residues with the formation of a beta-1,4-linkage. Neoplasms undergo various changes in th...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320100246

    authors： Xu S,Zhu X,Zhang S,Yin S,Zhou L,Chen C,Gu J

    更新日期：2001-08-01 00:00:00

  • Characterization of steroid hormone sensitivity in human breast cancers maintained ex vivo under organotypical culture conditions.

    abstract：PURPOSE:The methodology we propose combines the immunohistochemical determination of the oestrogen and progesterone receptors (ER and PgR) with the characterization of the oestradiol- and progesterone-induced influence on cell proliferation in breast cancers in order to characterize their steroid hormone sensitivity at...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320050340

    authors： Darro F,Schwarz G Jr,Pétein M,Schwarz S,Chaboteaux C,Nogaret JM,Decaestecker C,Salmon I,Kiss R

    更新日期：2000-05-01 00:00:00

  • Immunocytochemical detection of P-glycoprotein in the management of malignant effusions.

    abstract：:P-glycoprotein (P-gp), a cell membrane protein, has been found in multidrug-resistant cancer cells. A total of 104 smears from patients with breast-cancer-associated pleural effusions and ovarian-cancer-related peritoneal effusions were studied for P-gp with the antibody C-219 and the avidin-biotin-immunoperoxidase me...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01372551

    authors： Athanassiadou P,Athanassiades P,Petrakakou E,Zerva C,Mavrikakis M

    更新日期：1997-01-01 00:00:00

  • Surgical outcomes of second primary lung cancer after the extrapulmonary malignancy.

    abstract：OBJECTIVE:To study the surgical outcomes of patients with a second primary lung cancer after the extrapulmonary malignancy. MATERIALS AND METHODS:Patients who underwent surgical resection for lung cancers between January 2005 and December 2014 were reviewed. Clinical data, imaging characteristics of tumors, surgical a...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-020-03310-x

    authors： Ko KH,Huang HK,Chen YI,Chang H,Tsai WC,Huang TW

    更新日期：2020-12-01 00:00:00

  • Expression of a novel lacrimal gland gene lacritin in human breast tissues.

    abstract：PURPOSE:The purpose of this study was to examine breast tumors and normal breast tissues for the expression of the glycoprotein lacritin. The mRNA and protein expression of lacritin has been reported to be restricted to the lacrimal gland. METHODS:We investigated 37 human primary invasive breast tumors, seven breast c...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-003-0514-y

    authors： Weigelt B,Bosma AJ,van 't Veer LJ

    更新日期：2003-12-01 00:00:00

  • Alzheimer disease and cancer risk: a meta-analysis.

    abstract：PURPOSE:Alzheimer disease (AD) and cancer are seemingly two opposite ends of one spectrum. Studies have suggested that patients with AD showed a reduced risk of cancer and vice versa. However, available evidences are not conclusive. So we conducted a meta-analysis using published literatures to systematically examine c...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00432-014-1773-5

    authors： Shi HB,Tang B,Liu YW,Wang XF,Chen GJ

    更新日期：2015-03-01 00:00:00

  • TPP1 OB-fold domain protein suppresses cell proliferation and induces cell apoptosis by inhibiting telomerase recruitment to telomeres in human lung cancer cells.

    abstract：PURPOSE:Maintaining telomeres by recruiting telomerase-to-chromosome ends is essential for cancer cell survival. Inhibiting telomerase recruitment to telomeres represents a novel strategy for telomere-based lung cancer therapy. However, approaches for interrupting telomerase recruitment for cancer therapy still need to...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-019-02921-3

    authors： Zhu J,Liu W,Chen C,Zhang H,Yue D,Li C,Zhang L,Gao L,Huo Y,Liu C,Giaccone G,Zhang B,Wang C

    更新日期：2019-06-01 00:00:00

  • Expression and clinical significance of EGFL7 in malignant glioma.

    abstract：PURPOSE:Tumor angiogenesis is an important factor for the continuous growth of human malignancies and can be used to predict the prognosis for patients. In the current study, we examined the expression of EGF-like domain 7 (EGFL7), an endothelial cell-derived secreted factor, in malignant gliomas and explored its clini...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-010-0832-9

    authors： Huang CH,Li XJ,Zhou YZ,Luo Y,Li C,Yuan XR

    更新日期：2010-11-01 00:00:00