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Immunocytochemical detection of P-glycoprotein in the management of malignant effusions.

Abstract：

:P-glycoprotein (P-gp), a cell membrane protein, has been found in multidrug-resistant cancer cells. A total of 104 smears from patients with breast-cancer-associated pleural effusions and ovarian-cancer-related peritoneal effusions were studied for P-gp with the antibody C-219 and the avidin-biotin-immunoperoxidase method. Samples were taken before and 3 and 7 days after intracavitary bleomycin therapy and reaccumulation of effusion was assessed at 30 days. Smears that were P-gp-negative by the 7th day were associated with a good 30-day response to bleomycin in the majority of cases, while P-gp-positive smears were associated with a significant reaccumulation of fluid at 30 days. P-gp status is a valuable prognostic indicator of response to intracavitary bleomycin treatment in effusions from breast or ovarian cancer.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Athanassiadou P,Athanassiades P,Petrakakou E,Zerva C,Mavrikakis M

doi

10.1007/BF01372551

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

456-60

issue

8

eissn

0171-5216

issn

1432-1335

journal_volume

123

pub_type

杂志文章

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