Age-, sex-, and strain-dependent differences in the induction of enzyme-altered islands in rat liver by diethylnitrosamine.

abstract：:The regulatory influence of medroxyprogesterone acetate (MPA) on estrogen and androgen receptors of the human breast cancer cell lines MCF-7 and EFM-19 was explored in conjunction with the growth-promoting properties of these steroids. In the absence of steroidal stimulation, up to 1 microM MPA had no effect on the pr...

journal_title：Journal of cancer research and clinical oncology

authors： Hackenberg R,Hofmann J,Wolff G,Hölzel F,Schulz KD

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Although important for apoptosis, the signaling pathway involving MOAP-1(Modulator of Apoptosis 1), RASSF1A (RAS association domain family 1A), and Bax (Bcl-2 associated X protein) is likely to be dysfunctional in many types of human cancers due to mechanisms associated with gene mutation and DNA hyper-methylat...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YH,Pang SW,Revai Lechtich E,Shah K,Simon SE,Ponnusamy S,Narayanan R,Poh CL,Tan KO

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To understand how nanomechanical stiffness affects metastatic potential, we studied the relationship between cell migration, a characteristic of metastasis, and cell stiffness using atomic force microscopy (AFM), which can measure stiffness (elasticity) of individual living cells. METHODS:Migration and cell st...

journal_title：Journal of cancer research and clinical oncology

authors： Watanabe T,Kuramochi H,Takahashi A,Imai K,Katsuta N,Nakayama T,Fujiki H,Suganuma M

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The receptor for the cytokine TWEAK (TweakR) is a cell surface member of the tumor necrosis factor receptor superfamily with diverse biological roles. TNFRSF family members are appealing therapeutic targets in oncology due to their aberrant expression and function in tumor cells. The goal of the current stud...

journal_title：Journal of cancer research and clinical oncology

authors： Chao DT,Su M,Tanlimco S,Sho M,Choi D,Fox M,Ye S,Hsi ED,Durkin L,Yin J,Zhang Y,Kim H,Starling GC,Culp PA

更新日期：2013-02-01 00:00:00

abstract：:This study was undertaken in order to compare the usefulness of three indices of tumour proliferation in detecting primary hepatocellular carcinoma (HCC) and in differentiating this neoplasm from liver cirrhosis. In 10 patients with HCC and in 63 with liver cirrhosis serum alpha-fetoprotein (AFP), tissue polypeptide a...

journal_title：Journal of cancer research and clinical oncology

authors： Leandro G,Basso D,Fabris C,Zizzari S,Elba S,Del Favero G,Di Mario F,Meggiato T,Angonese C,Naccarato R

更新日期：1989-01-01 00:00:00

abstract：:In a population-based case/control study the differential lung cancer risk patterns due to tobacco smoking habits of various histological types have been investigated. The cases were 1432 deaths from lung cancer in the years 1980-1987, of which the histological type was known for 627 individuals. There was 54% squamou...

journal_title：Journal of cancer research and clinical oncology

authors： Jedrychowski W,Becher H,Wahrendorf J,Basa-Cierpialek Z,Gomola K

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Our primary goal was to determine whether increased expression of the transmembrane carbonic anhydrase (CA) isozymes in renal cell carcinoma (RCC) is regulated by the von Hippel-Lindau (VHL) gene. METHODS:We studied mRNA expression of all three transmembrane CAs - CA IX, XII, and XIV - in 17 RCC cell lines, tr...

journal_title：Journal of cancer research and clinical oncology

authors： Ashida S,Nishimori I,Tanimura M,Onishi S,Shuin T

更新日期：2002-10-01 00:00:00

abstract：:The arabinofuranosylcytosine (AraC) derivative N4-octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC) and its (5'-->5')-heterodinucleoside phosphate analog NOAC-AraC were compared with AraC for cytotoxicity, cell-cycle dependence, phosphorylation by deoxycytidine (dC) kinase and apoptosis induction in native, AraC- or ...

journal_title：Journal of cancer research and clinical oncology

authors： Horber DH,Cattaneo-Pangrazzi RM,von Ballmoos P,Schott H,Ludwig PS,Eriksson S,Fichtner I,Schwendener RA

更新日期：2000-06-01 00:00:00

abstract：:The clinical course--and hence the prognosis--of patients suffering from malignant tumors are essentially determined by the capability of tumor cells to metastasize. During the past decade knowledge about genetic aberrations, as well as molecular and cell biological mechanisms which are involved in the regulation of t...

journal_title：Journal of cancer research and clinical oncology

authors： Engers R,Gabbert HE

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Death-associated protein kinase (DAPK) and adenomatous polyposis coli gene (APC) have been recently shown to be associated with outcome in patients with esophageal carcinoma, especially adenocarcinoma. We wanted to validate the correlation of these two markers with outcome by detecting methylated DNA sequenc...

journal_title：Journal of cancer research and clinical oncology

authors： Hoffmann AC,Vallböhmer D,Prenzel K,Metzger R,Heitmann M,Neiss S,Ling F,Hölscher AH,Schneider PM,Brabender J

更新日期：2009-09-01 00:00:00

abstract：:Two human melanoma xenografts were compared with respect to their in vivo growth and metastatic potentials as well as glycosaminoglycan patterns. The less differentiated HT 168 tumor showed faster growth at primary sites and a more pronounced capacity for metastasis into the liver. Although chondroitin sulfate was the...

journal_title：Journal of cancer research and clinical oncology

authors： Timár J,Kovalszky I,Paku S,Lapis K,Kopper L

更新日期：1989-01-01 00:00:00

abstract：:Tissue sections of frozen biopsy specimens obtained from normal and hyperplastic human lymphoid tissues as well as 40 cases of non-Hodgkin's lymphomas were analysed in immunofluorescence tests (using red TRITC and green FITC double-labeling). A panel of antisera including well-characterized conventional reagents to im...

journal_title：Journal of cancer research and clinical oncology

authors： Janossy G,Thomas JA,Pizzolo G

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:The blockade of the renin-angiotensin-aldosterone system (RAAS) by angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) is one of the most common treatments for hypertension, heart failure and renal diseases. However, concerns have been raised about a possible link between RA...

journal_title：Journal of cancer research and clinical oncology

authors： Rachow T,Schiffl H,Lang SM

更新日期：2021-01-01 00:00:00

abstract：:A continuous line of human breast carcinoma cells, VHB-1, was established in culture following collagenase treatment of an infiltrating duct cell carcinoma. The cells displayed an epithelial pattern and multiplied rapidly. Maintained in monolayer culture, the VHB-1 cells exhibited a 30-h doubling time and a plating ef...

journal_title：Journal of cancer research and clinical oncology

authors： Vandewalle B,Collyn d'Hooghe M,Savary JB,Vilain MO,Peyrat JP,Deminatti M,Delobelle-Deroide A,Lefebvre J

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Isocitrate dehydrogenase (IDH)-wildtype glioblastomas are the most malignant glial tumours. Median survival is only 14-16 months after diagnosis, with patients aged ≥ 65 years reportedly showing worse outcome. This study aimed to further evaluate the prognostic role of age in a homogenously treated patient co...

journal_title：Journal of cancer research and clinical oncology

authors： Berger K,Turowski B,Felsberg J,Malzkorn B,Reifenberger G,Steiger HJ,Budach W,Haussmann J,Knipps J,Rapp M,Hänggi D,Sabel M,Mijderwijk HJ,Kamp MA

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Little data exist on characteristics, treatment, and outcome of patients with bone metastases from germ cell cancer. METHODS:A total of 434 patients with poor prognosis germ cell cancer, who underwent primary high-dose chemotherapy (HD-CTX) within two phase II trials, were retrospectively analyzed. RESULTS:40...

journal_title：Journal of cancer research and clinical oncology

authors： Oechsle K,Bokemeyer C,Kollmannsberger C,Mayer F,Berger LA,Oing C,Honecker F

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:To evaluate the role of radioembolization and systemic chemotherapy as a combined modality therapy for unresectable colorectal liver metastases. PATIENTS AND METHODS:Prospective database of a major yttrium-90 microsphere radioembolization treatment center in Sydney, Australia, that included 140 patients with u...

journal_title：Journal of cancer research and clinical oncology

authors： Chua TC,Bester L,Saxena A,Morris DL

更新日期：2011-05-01 00:00:00

abstract：:Gastric and intestinal phenotypic cell markers are widely expressed in gastric carcinomas, irrespective of their histological type. In the present study, the relations between the phenotypic marker expression of the tumour, histological findings, expression of cell adhesion molecules, and the chromosomal changes in ga...

journal_title：Journal of cancer research and clinical oncology

authors： Morohara K,Tajima Y,Nakao K,Nishino N,Aoki S,Kato M,Sakamoto M,Yamazaki K,Kaetsu T,Suzuki S,Tsunoda A,Tachikawa T,Kusano M

更新日期：2006-06-01 00:00:00

abstract：:The distribution, size, and configuration of intercellular junctions in the sebaceous tumor of mice were examined using the freeze-fracture technique. Three types of junctions were observed: desmosomes, gap, and tight junctions. Tight junctions in general consisted of short linear unbranched fibrils, and macular or co...

journal_title：Journal of cancer research and clinical oncology

authors： Robenek H,Schöpper C,Fasske E,Fetting R,Themann H

更新日期：1982-01-01 00:00:00

abstract：:The role of L-tyrosine, L-phenylalanine, L-dihydroxyphenylalanine (dopa) and L-tryptophan in melanin biosynthesis in melanotic hamster melanoma IC-Sofia was investigated with the aid of 14C-aminoacids. Tyrosine and phenylalanine were found to be the main melanin precursors: about 64.5% of total melanin labeling was du...

journal_title：Journal of cancer research and clinical oncology

authors： Blagoeva PM

更新日期：1984-01-01 00:00:00

abstract：:The increase of plasma cortisol in patients with tumors of five different sites compared with a control group of patients with benign surgical diseases amounted to: +39% (breast), +34% (stomach), +86% (intestine), +60% (skin) and +194% (gall bladder). The first detectable increase of cortisol occurred in patients with...

journal_title：Journal of cancer research and clinical oncology

authors： Schaur RJ,Semmelrock HJ,Schauenstein E,Kronberger L

更新日期：1979-04-12 00:00:00

abstract：PURPOSE:beta-1,4-Galactosyltransferase (beta-1,4-GalT) I, II, and V are the enzymes responsible for the biosynthesis of N-acetyllactosamine on N-glycans by transferring UDP-galactose to the terminal N-acetylglucosamine (N-GlcNAc) residues with the formation of a beta-1,4-linkage. Neoplasms undergo various changes in th...

journal_title：Journal of cancer research and clinical oncology

authors： Xu S,Zhu X,Zhang S,Yin S,Zhou L,Chen C,Gu J

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:Lung cancer is the commonest cause of cancer deaths worldwide, and its mortality can be reduced significantly by performing early diagnosis and screening. Since the 1960s, driven by the pressing needs to accurately and effectively interpret the massive volume of chest images generated daily, computer-assisted d...

journal_title：Journal of cancer research and clinical oncology

authors： Liu B,Chi W,Li X,Li P,Liang W,Liu H,Wang W,He J

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:The orphan, membrane-bound estrogen receptor (GPER) is expressed at high levels in a large fraction of breast cancer patients, and its expression is favorable for patients' survival. We investigated the role of GPER as a potential tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells. METHODS:The effect of...

journal_title：Journal of cancer research and clinical oncology

authors： Weißenborn C,Ignatov T,Poehlmann A,Wege AK,Costa SD,Zenclussen AC,Ignatov A

更新日期：2014-04-01 00:00:00

abstract：:The subsets and functions of lymphocytes were investigated in patients with nasopharyngeal carcinoma (NPC). The patients were divided into two groups comprising tumor-bearing patients and those in remission. There was no difference in the proportion of T cells among tumor-bearing, remission and healthy control groups....

journal_title：Journal of cancer research and clinical oncology

authors： Tsukuda M,Sawaki S,Yanoma S

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:The aim of our study was to identify factors which influence survival in patients with disseminated seminoma in the good prognostic group according to IGCCCG, as well as to evaluate the impact of treatment intensification in patients with negative prognostic factors. METHODS:We analyzed the database of the pat...

journal_title：Journal of cancer research and clinical oncology

authors： Fedyanin M,Tryakin A,Bulanov A,Vybarava A,Tjulandina A,Chekini D,Sekhina O,Figurin K,Garin A,Tjulandin S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:We have demonstrated that overexpression of osteopontin (OPN) could contribute to metastasis in hepatocellular carcinoma (HCC), and that OPN-positive cancer cells are often localized in the periphery of cancer nodules adjacent to stromal cells. This study was to identify the difference of intratumor genomic abe...

journal_title：Journal of cancer research and clinical oncology

authors： Wu JC,Sun BS,Ren N,Ye QH,Qin LX

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Previous studies showed poorer survival in T4 disease with residual lesion. To evaluate the efficacy and toxicity of a boost dose for T4 nasopharyngeal carcinoma (NPC), patients with a residual primary lesion after intensity-modulated radiotherapy (IMRT). METHODS:398 T4 NPC patients with residual primary le...

journal_title：Journal of cancer research and clinical oncology

authors： Fei Z,Xu T,Qiu X,Li M,Chen T,Li L,Huang C,Chen C

更新日期：2021-01-03 00:00:00

abstract：:The precise place of local estrogen production in mammary cancer is still controversial. In this investigation localization of aromatase (the key enzyme of estrogen biosynthesis) was studied in breast cancer tissue by immunohistochemical method using polyclonal rabbit antibodies. The cytoplasmic staining was found in ...

journal_title：Journal of cancer research and clinical oncology

authors： Berstein LM,Larionov AA,Kyshtoobaeva ASh,Pozharisski KM,Semiglazov VF,Ivanova OA

更新日期：1996-01-01 00:00:00

abstract：:Sequential studies were made on the histopathologic changes in the glandular stomach of rats induced by a weak carcinogen. N-propyl-N'-nitro-N-nitrosoguanidine (PNNG). Fiftyfour rats were given 100 micrograms/ml of PNNG in their drinking water for 44 weeks, and then normal tap water until the end of the experiment. Ra...

journal_title：Journal of cancer research and clinical oncology

authors： Matsukura N,Itabashi M,Kawachi T,Hirota T,Sugimura T

更新日期：1980-01-01 00:00:00