The analysis of lymphoid subpopulations in normal and malignant tissues by immunofluorescence techniques.

abstract：:In 361 Sprague-Dawley rats autochthonous colorectal carcinomas were induced by intrarectal application of the carcinogen AMMN. Tumor-bearing animals were treated with a synthetic thioether-lysophospholipid (TLP) derivative and in combination chemotherapy with 5-fluorouracil (5-FU) and carmustine (BCNU). There was no d...

journal_title：Journal of cancer research and clinical oncology

authors： Heim ME,Swoboda M,Pahlke W,Edler L,Bicker U

更新日期：1984-01-01 00:00:00

abstract：:Bromelain, a pineapple-derived plant product, added to C57Bl/6 mice laboratory chow decreased lung metastasis of Lewis lung cancer cells implanted s.c. This antimetastatic potential was demonstrated by both the active and inactive bromelain with or without proteolytic, anticoagulant properties. ...

journal_title：Journal of cancer research and clinical oncology

authors： Batkin S,Taussig SJ,Szekerezes J

更新日期：1988-01-01 00:00:00

abstract：:A previous cohort-study in a cardboard factory demonstrated that high and prolonged occupational exposure to trichloroethene (C2HCl3) is associated with an increased incidence of renal cell cancer. The present hospital-based case/control study investigates occupational exposure in 58 patients with renal cell cancer wi...

journal_title：Journal of cancer research and clinical oncology

authors： Vamvakas S,Brüning T,Thomasson B,Lammert M,Baumüller A,Bolt HM,Dekant W,Birner G,Henschler D,Ulm K

更新日期：1998-01-01 00:00:00

abstract：:Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer pa...

journal_title：Journal of cancer research and clinical oncology

authors： Kynast B,Binder L,Marx D,Zoll B,Schmoll HJ,Oellerich M,Schauer A

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Tumor suppressor gene therapy and cytokine gene therapy have limited antitumor effects when used alone. Thus, in the present study, we investigated the antitumor potentials of the combined transfer of the p16 tumor suppressor gene and the murine granulocyte-macrophage colony-stimulating factor (GM-CSF) gene. M...

journal_title：Journal of cancer research and clinical oncology

authors： Wang LH,Ju DW,Sun Y,Tao Q,Qian S,Mi J,Hamada H,Cao X

更新日期：2001-02-01 00:00:00

abstract：:The cytostatic drugs Chlorambucil and Bleomycin were labeled with 131I and with 57Co, respectively: Ruthenocenealdehyde-(N-methyl-N-beta-chlorethyl)-hydrazone and Ruthenocene-3-phenyl-prop.1-en-3-one were labeled with the gamma emitter 103Ru. In tumor-bearing mice the elimination and organ distribution of these radioa...

journal_title：Journal of cancer research and clinical oncology

authors： Wenzel M,Schneider M,Bier J,Benders P,Schachschneider G

更新日期：1979-10-01 00:00:00

abstract：PURPOSE:Castration-resistant prostate cancer (CRPC) refers to prostate cancer that has progressed after initial androgen deprivation therapy (ADT). Over the years, treatment strategies for metastatic CRPC (mCRPC) have undergone considerable changes. We performed a network meta-analysis to assess the effectiveness and t...

journal_title：Journal of cancer research and clinical oncology

authors： Wang Y,Zhang H,Shen W,He P,Zhou Z

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Recently, it was reported that expression of transglutaminase 2 plays an important role in doxorubicin/cisplatin resistance in breast and ovarian cancer. The aims of this study were to verify the role of transglutaminase 2 in cisplatin response in non-small cell lung cancer (NSCLC) and to study if transglutamin...

journal_title：Journal of cancer research and clinical oncology

authors： Park KS,Kim HK,Lee JH,Choi YB,Park SY,Yang SH,Kim SY,Hong KM

更新日期：2010-04-01 00:00:00

abstract：:The responsiveness of spleen cells from C57BL/6J mice to various immunogenic stimuli was examined during the progressive growth of a poorly immunogenic fibrosarcoma T241. A strong correlation was observed between the progressive tumor growth and the depression of response to Concanavalin A, lipopolysaccharide, sheep r...

journal_title：Journal of cancer research and clinical oncology

authors： Gautam SC,Gautam S,Deodhar SD

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen. SLCO4A1 is highly expressed in several cancers and a gender bias has been observed in colorectal cancer ...

journal_title：Journal of cancer research and clinical oncology

authors： Ban MJ,Ji SH,Lee CK,Bae SB,Kim HJ,Ahn TS,Lee MS,Baek MJ,Jeong D

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:RhoA and RhoC are closely related, small GTPases that are clearly involved in breast cancer tumorigenesis. Nonetheless, their specific roles in the control of estrogen receptor alpha (ERα) activities have not been elucidated. METHODS:We used siRNA sequences to specifically down-regulate RhoA and RhoC expressio...

journal_title：Journal of cancer research and clinical oncology

authors： Malissein E,Meunier E,Lajoie-Mazenc I,Médale-Giamarchi C,Dalenc F,Doisneau-Sixou SF

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors' biology and explore t...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang F,Cai Z,Lv H,Li W,Liang M,Wei X,Zhou F

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Based on the poor prognosis of drug resistance in pediatric acute lymphoblastic leukemia (ALL) and adverse effects of chemotherapy, this study was aimed to evaluate the effect of several herbal extracts on leukemic cells. METHODS:Two subtypes of T- and B-ALL cell lines, followed by ALL primary cells were treat...

journal_title：Journal of cancer research and clinical oncology

authors： Rahimi Babasheikhali S,Rahgozar S,Mohammadi M

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:This study aimed to determine the dose effect of smoking on the mutational frequency and spectrum of epidermal growth factor receptor (EGFR) gene in Korean non-small cell lung cancer (NSCLC). METHODS:Detailed smoking histories were obtained from 324 consecutively enrolled Korean NSCLC patients. Mutational stat...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YJ,Shim HS,Kang YA,Hong SJ,Kim HK,Kim H,Kim SK,Choi SH,Kim JH,Cho BC

更新日期：2010-12-01 00:00:00

abstract：:The association of Epstein-Barr virus (EBV) with gastric medullary carcinoma with lymphoid infiltration (GMCL) was investigated. The presence of GMCL exhibited a 2/1 male-to-female ratio and a 1/2 early-to-advanced cancer ratio, predominantly located in the cardia and corpus of the stomach (90%). The presence of EBV D...

journal_title：Journal of cancer research and clinical oncology

authors： Takano Y,Kato Y,Sugano H

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to characterize changes in the expression of copper-zinc superoxide dismutase (Cu/Zn-SOD) and manganese SOD (Mn-SOD) in oral squamous-cell carcinoma (OSCC). METHODS:Real-time quantitative reverse transcriptase-polymerase chain reaction analysis of Cu/Zn-SOD and Mn-SOD mRNA express...

journal_title：Journal of cancer research and clinical oncology

authors： Yokoe H,Nomura H,Yamano Y,Fushimi K,Sakamoto Y,Ogawara K,Shiiba M,Bukawa H,Uzawa K,Takiguchi Y,Tanzawa H

更新日期：2009-11-01 00:00:00

abstract：:Among several nucleosides, adenosine is the only one to induce typical apoptotic cell death in human promyelocytic leukemia HL-60 cells. Intracellularly transported adenosine seemed to be required for the induction of apoptosis, since dipyridamole, which inhibits the transport of adenosine, strongly suppressed apoptos...

journal_title：Journal of cancer research and clinical oncology

authors： Kim KT,Yeo EJ,Choi H,Park SC

更新日期：1998-01-01 00:00:00

abstract：AIM:In men with adverse pathology after radical prostatectomy, the most appropriate timing to administer radiotherapy (RT) remains a topic of debate. We analyzed in terms of efficacy, prognostic factors and toxicity the two therapeutic strategies: immediate postoperative radiotherapy (PORT) and salvage radiotherapy (SA...

journal_title：Journal of cancer research and clinical oncology

authors： Detti B,Scoccianti S,Cassani S,Cipressi S,Villari D,Lapini A,Saieva C,Cai T,Pertici M,Giacomelli I,Livi L,Ceroti M,Nicita G,Carini M,Biti G

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:Isocitrate dehydrogenase (IDH)-wildtype glioblastomas are the most malignant glial tumours. Median survival is only 14-16 months after diagnosis, with patients aged ≥ 65 years reportedly showing worse outcome. This study aimed to further evaluate the prognostic role of age in a homogenously treated patient co...

journal_title：Journal of cancer research and clinical oncology

authors： Berger K,Turowski B,Felsberg J,Malzkorn B,Reifenberger G,Steiger HJ,Budach W,Haussmann J,Knipps J,Rapp M,Hänggi D,Sabel M,Mijderwijk HJ,Kamp MA

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Mutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and prognostic effects of TP53 mutations in certain cancers. METHODS:Over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer (IARC) TP...

journal_title：Journal of cancer research and clinical oncology

authors： Li VD,Li KH,Li JT

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Constructed from a theoretical framework, the coordinated undermining of survival paths in glioblastoma (GBM) is a combination of nine drugs approved for non-oncological indications (CUSP9; aprepitant, auranofin, captopril, celecoxib, disulfiram, itraconazole, minocycline, quetiapine, and sertraline) combined w...

journal_title：Journal of cancer research and clinical oncology

authors： Skaga E,Skaga IØ,Grieg Z,Sandberg CJ,Langmoen IA,Vik-Mo EO

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:B-cell translocation gene 3 (BTG3) has been identified as a candidate driver gene for various cancers, but its specific role in colorectal cancer (CRC) is poorly understood. We aimed to investigate the relationship between expression of BTG3 and clinicopathological features and prognosis, as well as to explore ...

journal_title：Journal of cancer research and clinical oncology

authors： Lv C,Wang H,Tong Y,Yin H,Wang D,Yan Z,Liang Y,Wu D,Su Q

更新日期：2018-02-01 00:00:00

abstract：:The aim of the present studies was to elucidate the effects and optimal modulatory conditions of 5-ethyl-2'-deoxyuridine (EtdUrd) on the antitumour efficacy, pharmacokinetics and catabolism of 5-fluorouracil (5-FU) on Colon-26 and Colon-38 murine tumours. HPLC and GC-MS techniques were used to measure the concentratio...

journal_title：Journal of cancer research and clinical oncology

authors： Kralovánszky J,Katona C,Jeney A,Pandi E,Noordhuis P,Erdélyi-Tóth V,Otvös L,Kovács P,Van der Wilt CL,Peters GJ

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:To evaluate through retrospective analysis the efficacy and toxicity of combination chemotherapy with etoposide, vincristine, doxorubin and dexamethasone (EVAD) as second-line therapy in patients with advanced AIDS-related Kaposi's sarcoma (AIDS-KS) after failure of first-line chemotherapy. METHODS:Eighty-ei...

journal_title：Journal of cancer research and clinical oncology

authors： Zhong DT,Shi CM,Chen Q,Huang JZ,Liang JG,Lin D

更新日期：2012-03-01 00:00:00

abstract：:Induction of gene transcription in response to extracellular stimuli constitutes an essential aspect of host defense mechanisms. Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating the mechanism of t...

journal_title：Journal of cancer research and clinical oncology

authors： Taniguchi T,Harada H,Lamphier M

更新日期：1995-01-01 00:00:00

abstract：:Gastric and intestinal phenotypic cell markers are widely expressed in gastric carcinomas, irrespective of their histological type. In the present study, the relations between the phenotypic marker expression of the tumour, histological findings, expression of cell adhesion molecules, and the chromosomal changes in ga...

journal_title：Journal of cancer research and clinical oncology

authors： Morohara K,Tajima Y,Nakao K,Nishino N,Aoki S,Kato M,Sakamoto M,Yamazaki K,Kaetsu T,Suzuki S,Tsunoda A,Tachikawa T,Kusano M

更新日期：2006-06-01 00:00:00

abstract：:Solitary fibrous tumors (SFT) of extremities, especially the thighs are very rare. Despite SFTs are generally benign, well-circumscribed soft tissue tumors new cases should be presented and followed up carefully to monitor their biological behavior. In general for tumor classification a biopsy is state of the art. His...

journal_title：Journal of cancer research and clinical oncology

authors： Anders JO,Aurich M,Lang T,Wagner A

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Insulin-like growth factor 1 (IGF-1) stimulates mitosis and inhibits apoptosis. High circulating IGF-1 levels are linked with an increased risk of colorectal and breast cancer. Recently, IGF-1 single nucleotide polymorphisms (SNPs), especially variant rs2946834, have been associated with poor clinical outcome i...

journal_title：Journal of cancer research and clinical oncology

authors： Muendlein A,Lang AH,Geller-Rhomberg S,Winder T,Gasser K,Drexel H,Decker T,Mueller-Holzner E,Chamson M,Marth C,Hubalek M

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:The purpose of this study is to elucidate the expression of angiogenin and its previously undemonstrated clinical significance in gastric cancer (GC). METHODS:Angiogenin expression was examined immunohistochemically in 21 GC tissues and 21 corresponding normal gastric tissues. The serum concentration was deter...

journal_title：Journal of cancer research and clinical oncology

authors： Shimoyama S,Kaminishi M

更新日期：2000-08-01 00:00:00