Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer.

abstract：:Some ellipticine derivative salts, including 9-chloro-2-methylellipticinium (CME), have been found to have a marked selectivity against all eight brain tumor cell lines of the U.S. National Cancer Institute's disease-oriented in vitro screen. We initiated in vivo antitumor studies to explore the feasibility for furthe...

journal_title：Journal of cancer research and clinical oncology

authors： Arguello F,Alexander MA,Greene JF Jr,Stinson SF,Jorden JL,Smith EM,Kalavar NT,Alvord WG,Klabansky RL,Sausville EA

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-gamma) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expre...

journal_title：Journal of cancer research and clinical oncology

authors： Coppola D,Parikh V,Boulware D,Blanck G

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Patients with metastatic nonseminomatous germ cell tumors (mNSGCT) and a high tumor burden or a poor performance status at initial diagnosis are at risk from potentially life-threatening early complications during or after the first chemotherapy cycle. The outcomes with dose-reduced first cycle of chemotherapy ...

journal_title：Journal of cancer research and clinical oncology

authors： Tryakin A,Fedyanin M,Bulanov A,Kashia S,Kurmukov I,Matveev V,Fainstein I,Gordeeva O,Zakharova T,Tjulandin S

更新日期：2018-09-01 00:00:00

abstract：:A short-term organ culture of rat tracheal epithelium was used to detect the ability of 53 chemicals to induce UDS. In this system all direct-acting compounds (ultimate or proximate carcinogens) tested induced UDS. Of 24 compounds requiring metabolism (procarcinogens), nine induced UDS, viz., 4NQO, AF-2, BP, DMN, DEN,...

journal_title：Journal of cancer research and clinical oncology

authors： Ide F,Ishikawa T,Takayama S

更新日期：1981-01-01 00:00:00

abstract：:To study whether fluorescent lighting at work might increase carcinogenesis, hairless mice were exposed to a bank of six 36 W standard fluorescent lamps (neutral-white) every workday for 8 h at an illuminance level of 1,000 lx. For comparison, other mice were exposed to UVB radiation or to simulated solar radiation. I...

journal_title：Journal of cancer research and clinical oncology

authors： Wiskemann A,Sturm E,Klehr NW

更新日期：1986-01-01 00:00:00

abstract：:A previous cohort-study in a cardboard factory demonstrated that high and prolonged occupational exposure to trichloroethene (C2HCl3) is associated with an increased incidence of renal cell cancer. The present hospital-based case/control study investigates occupational exposure in 58 patients with renal cell cancer wi...

journal_title：Journal of cancer research and clinical oncology

authors： Vamvakas S,Brüning T,Thomasson B,Lammert M,Baumüller A,Bolt HM,Dekant W,Birner G,Henschler D,Ulm K

更新日期：1998-01-01 00:00:00

abstract：:Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract...

journal_title：Journal of cancer research and clinical oncology

authors： Green U,Althoff J

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Piperlongumine (PL) has been shown to selectively induce apoptotic cell death in cancer cells via reactive oxygen species (ROS) accumulation. In this study, we characterized a molecular mechanism for PL-induced cell death. METHODS:Cell viability and cell death were assessed by MTT assay and Annexin V-FITC/PI s...

journal_title：Journal of cancer research and clinical oncology

authors： Jin HO,Lee YH,Park JA,Lee HN,Kim JH,Kim JY,Kim B,Hong SE,Kim HA,Kim EK,Noh WC,Kim JI,Chang YH,Hong SI,Hong YJ,Park IC,Lee JK

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The antimalarial agent, artemisinin, also confers cancer-specific cytotoxic effects by reacting with ferrous iron atoms to form free radicals. Here, we investigated the radiosensitizing effects of dihydroartemisinin on glioma cells and assessed some possible mechanisms for these effects. MATERIALS AND METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Kim SJ,Kim MS,Lee JW,Lee CH,Yoo H,Shin SH,Park MJ,Lee SH

更新日期：2006-02-01 00:00:00

abstract：:Seventy-three evaluable patients with advanced measurable solid tumors were given cisdichlorodiammineplatinum (II) (DDP) at a dose of 20 mg/M2 IV for 1-5 days every 3 weeks, and 19 patients who failed on this low dose DDP protocol received a single high dose of 100 mg/M2 IV once every 3 weeks. Forty-six patients had r...

journal_title：Journal of cancer research and clinical oncology

authors： Schilcher RB,Wessels M,Niederle N,Seeber S,Schmidt CG

更新日期：1984-01-01 00:00:00

abstract：:After a single pulse dose of DMBA, rats develop bone-marrow hypoplasia, which is almost compensated for by regeneration after 16 weeks. Subsequently, dysplastic signs of hemopoiesis appear in all experimental animals as massive extrusion of normoblasts into the peripheral blood, red-cell aniso- and poikilocytosis, nuc...

journal_title：Journal of cancer research and clinical oncology

authors： Fohlmeister I,Schaefer HE,Fischer R

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:This study aimed to determine the dose effect of smoking on the mutational frequency and spectrum of epidermal growth factor receptor (EGFR) gene in Korean non-small cell lung cancer (NSCLC). METHODS:Detailed smoking histories were obtained from 324 consecutively enrolled Korean NSCLC patients. Mutational stat...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YJ,Shim HS,Kang YA,Hong SJ,Kim HK,Kim H,Kim SK,Choi SH,Kim JH,Cho BC

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Drinking green tea daily is part of Japanese culture, and various studies have revealed that green tea is a cancer preventive. We here review our progress in cancer prevention with green tea on 12 main topics, from basic to clinical level. TOPICS AND METHODS: Biochemical and biological studies of green tea cate...

journal_title：Journal of cancer research and clinical oncology

authors： Fujiki H,Imai K,Nakachi K,Shimizu M,Moriwaki H,Suganuma M

更新日期：2012-08-01 00:00:00

abstract：:In 361 Sprague-Dawley rats autochthonous colorectal carcinomas were induced by intrarectal application of the carcinogen AMMN. Tumor-bearing animals were treated with a synthetic thioether-lysophospholipid (TLP) derivative and in combination chemotherapy with 5-fluorouracil (5-FU) and carmustine (BCNU). There was no d...

journal_title：Journal of cancer research and clinical oncology

authors： Heim ME,Swoboda M,Pahlke W,Edler L,Bicker U

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Mevalonate pathway inhibitors are potentially useful chemotherapeutic agents showing growth inhibition and pro-apoptotic effects in cancer cells. The effects of statins and bisphosphonates on cancer growth are attributed to a reduction in protein isoprenylation. Post-translational modification and activation of...

journal_title：Journal of cancer research and clinical oncology

authors： Garnett DJ

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Despite great progress in the diagnosis and treatment of localized prostate cancer (PCa), there remains a need for new diagnostic markers that can accurately distinguish indolent and aggressive variants. One promising approach is the antibody-based targeting of prostate stem cell antigen (PSCA), which is freque...

journal_title：Journal of cancer research and clinical oncology

authors： Kessler C,Pardo A,Tur MK,Gattenlöhner S,Fischer R,Kolberg K,Barth S

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Aim of the present study was to identify the genetic heterogeneity, prevalence and frequency of germline mutations of BRCA2 gene in Hereditary Breast/Ovarian cancer patients from Kerala, South India. METHODS:We analyzed 102 Breast/Ovarian cancer patients from 96 breast and/ovarian cancer families for BRCA2 gen...

journal_title：Journal of cancer research and clinical oncology

authors： Syamala V,Sreeja L,Syamala VS,Vinodkumar B,Raveendran PB,Sreedharan H,Kuttappan R,Balakrishnan L,Ankathil R

更新日期：2007-11-01 00:00:00

abstract：:A brain metastasis of bronchial squamous cell carcinoma in a patient was cultivated. The cells with epithelium-like characteristics were selected from the primary culture, and were subcultured to establish a cell line. The cultured cells were identified to be neoplastic by means of heterologous transplantation to nude...

journal_title：Journal of cancer research and clinical oncology

authors： Takaki T

更新日期：1980-01-01 00:00:00

abstract：:This report describes two types of reticular epithelial cell in the thymic cortex of the BALB/c mouse, an immature and a mature form. During early stages of lymphoma development, i.e., 2-6 weeks postinfection (p.i.) with Moloney leukemia virus (M-MuLV), activation of the epithelial cells is observed. Although the perc...

journal_title：Journal of cancer research and clinical oncology

authors： Heine UI,Krueger GR,Karpinski A,Munoz E,Krueger MB

更新日期：1983-01-01 00:00:00

abstract：:The proliferative activity in 70 cases of soft-tissue tumours was estimated immunohistochemically using the monoclonal antibody PC-10, which recognizes proliferating-cell nuclear antigen (PCNA) in paraffin sections. The PCNA index (i.e. the percentage of positive neoplastic nuclei) and to a lesser degree the PCNA coun...

journal_title：Journal of cancer research and clinical oncology

authors： Korkolopoulou P,Christodoulou P,Papanikolaou A,Tsenga A,Thomas-Tsagli E

更新日期：1994-01-01 00:00:00

abstract：:Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer pa...

journal_title：Journal of cancer research and clinical oncology

authors： Kynast B,Binder L,Marx D,Zoll B,Schmoll HJ,Oellerich M,Schauer A

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Approximately 5% of patients with cutaneous squamous cell carcinoma (CSCC) may develop recurrent or metastatic disease. The management of such cases is challenging and requires multi-disciplinary care. Immunotherapy using PD-1 inhibition was approved to treat unresectable or metastatic CSCC in 2018. Given limit...

journal_title：Journal of cancer research and clinical oncology

authors： In GK,Vaidya P,Filkins A,Hermel DJ,King KG,Ragab O,Tseng WW,Swanson M,Kokot N,Lang JE,Menendez L,DeClerck B,Kim G,Hu JC,Terando A,Jadvar H,Ricker C,Miller KA,Peng DH,Wysong A

更新日期：2020-11-18 00:00:00

abstract：PURPOSE:E- and P-selectins, expressed on vascular endothelium, and their sialyl-Lewis(x )(sLe(x))- and/or sialyl-Lewis(a) (sLe(a))-containing ligands have a crucial role in extravasation and metastasis of circulating cells. We wanted to analyse the role of selectins and their ligands in head and neck tumours. METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Renkonen J,Mäkitie A,Paavonen T,Renkonen R

更新日期：1999-10-01 00:00:00

abstract：:In 1989, 65%-75% of previously untreated adults with ALL or AML may be expected to enter complete remission. Approximately 40% of these completely responding patients, whether they are treated with intensive chemotherapy, intensive chemotherapy followed by autologous bone marrow transplantation, or allogeneic bone mar...

journal_title：Journal of cancer research and clinical oncology

authors： Mayer RJ

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Promising new therapies for neoplasia include tyrosine kinase receptor antagonists. Tyrosine kinase oncogenes present an appealing anti-tumor drug target since they play an integral role in a variety of cellular responses including cell proliferation and differentiation. We previously demonstrated a high rate o...

journal_title：Journal of cancer research and clinical oncology

authors： Henley JD,Cummings OW,Loehrer PJ Sr

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:In certain cancer settings, a T-cell response to cancer represents a relatively favorable outcome. Thus, the near-future challenges include a better understanding of exactly which T-cell features contribute to a response to which cancer antigen-groups, to maximize the opportunities for tumor-infiltrating lympho...

journal_title：Journal of cancer research and clinical oncology

authors： Chobrutskiy BI,Zaman S,Diviney A,Mihyu MM,Blanck G

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:The epithelial cell adhesion molecule (Ep-CAM) is a clinically validated target for antibody-based therapy of cancer. The aim of this work was to evaluate the specific cytotoxic activity of a novel fully human Ep-CAM-specific IgG1 antibody, called MT201, against primary ovarian tumor cells and an ovarian tumor ...

journal_title：Journal of cancer research and clinical oncology

authors： Xiang W,Wimberger P,Dreier T,Diebold J,Mayr D,Baeuerle PA,Kimmig R

更新日期：2003-06-01 00:00:00

abstract：:General principles for anticancer drug development include traditional drug-screening methods in biological test systems. Today, testing of a drug in a panel of selected human tumor xenografts in mice is assumed to have the best predictive value for clinical efficacy. Chemical modification of well-known antitumor drug...

journal_title：Journal of cancer research and clinical oncology

authors： Unger C

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Cancer incidence in the elderly population has been continuously rising, and their treatment is an increasing concern among oncologists. This study aimed to evaluate the incidence and risk factors for morbidity and mortality after major oncological surgery in elderly patients with head and neck squamous cell ca...

journal_title：Journal of cancer research and clinical oncology

authors： Yoo SH,Roh JL,Choi SH,Nam SY,Kim SY

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Pancreatic adenocarcinoma (PAAD) is among the deadliest forms of cancer globally. Carbonic anhydrase 12 (CA12) is known to play central roles in regulating many cancers, but its function in the context of PAAD is rarely discussed. This study was, therefore, designed to assess the expression of CA12 in PAAD...

journal_title：Journal of cancer research and clinical oncology

authors： Du Y,Xin Z,Liu T,Xu P,Mao F,Yao J

更新日期：2021-01-02 00:00:00