Substantially reduced expression of PIAS1 is associated with colon cancer development.

abstract：PURPOSE:T cell transcription factors are nuclear effectors of the Wnt signaling transduction pathway and play crucial roles in embryonic and malignant development. Our previous study showed increased expression level of Tcf mRNA in liver cancer. In the present paper, antisense Tcf RNA was used to explore the possible t...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang Y,Zhou XD,Liu YK,Huang XW,Zhao Y,Xue Q,Sun RX,Chen J,Wu X

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:Achievement of deep molecular response with a tyrosine kinase inhibitor in patients with chronic myeloid leukemia (CML) is required to attempt discontinuation of therapy in these patients. The current subanalysis from the Evaluating Nilotinib Efficacy and Safety in Clinical Trials as First-Line Treatment (ENEST...

journal_title：Journal of cancer research and clinical oncology

authors： Giles FJ,Rea D,Rosti G,Cross NCP,Steegmann JL,Griskevicius L,le Coutre P,Coriu D,Petrov L,Ossenkoppele GJ,Mahon FX,Saussele S,Hellmann A,Koskenvesa P,Brümmendorf TH,Gastl G,Castagnetti F,Vincenzi B,Haenig J,Hochhaus

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:The orphan, membrane-bound estrogen receptor (GPER) is expressed at high levels in a large fraction of breast cancer patients, and its expression is favorable for patients' survival. We investigated the role of GPER as a potential tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells. METHODS:The effect of...

journal_title：Journal of cancer research and clinical oncology

authors： Weißenborn C,Ignatov T,Poehlmann A,Wege AK,Costa SD,Zenclussen AC,Ignatov A

更新日期：2014-04-01 00:00:00

abstract：:159 "poor risk" patients with previously untreated small cell lung cancer were entered into a randomised study of intravenous bolus versus continuous infusion chemotherapy with doxorubicin on weeks 1, 3, 5 and ifosfamide with mesna on weeks 2, 4, 6. Oral etoposide was given on days 1-5, 15-19, and 29-33. There was no ...

journal_title：Journal of cancer research and clinical oncology

authors： Anderson H,Prendiville J,Thatcher N,Radford JA,Swindell R

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Ultrasound (US)-guided breast biopsy is a routine diagnostic method used to correlate imaging finding to a histological diagnosis which is still the gold standard in preoperative diagnostics. The accuracy of US-guided breast biopsies relies on a precise radiologic-histopathologic correlation, which is discus...

journal_title：Journal of cancer research and clinical oncology

authors： Jörg I,Wieler J,Elfgen C,Bolten K,Hutzli C,Talimi J,Vorburger D,Choschzick M,Moskovszky L,Dedes K,Varga Z

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:A number of studies have investigated the role of serum lactate dehydrogenase (LDH) level in patients with osteosarcoma but have yielded inconsistent and inconclusive results. Thus, we conducted a meta-analysis to assess its prognostic value more precisely. METHODS:Systematic computerized searches of PubMed...

journal_title：Journal of cancer research and clinical oncology

authors： Chen J,Sun MX,Hua YQ,Cai ZD

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:The expression of nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1), one of TGF-beta superfamily gene, is reported to be responsible for NSAID-induced apoptosis. We analyzed NAG-1 expression in gastric cancer and adenoma to find out its clinical implication. METHODS:Immunostaining was performed usin...

journal_title：Journal of cancer research and clinical oncology

authors： Park JY,Park KH,Bang S,Kim MH,Koh SS,Song SY

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:Pancreatic cancer is commonly detected at advanced stages when the tumor is no longer amenable to surgical resection. Therefore, finding biomarkers for early stage disease is urgent. Here, we show that high-definition mass spectrometry (HDMS(E)) can be used to identify serum protein alterations associated with ...

journal_title：Journal of cancer research and clinical oncology

authors： Ansari D,Andersson R,Bauden MP,Andersson B,Connolly JB,Welinder C,Sasor A,Marko-Varga G

更新日期：2015-02-01 00:00:00

abstract：:The arabinofuranosylcytosine (AraC) derivative N4-octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC) and its (5'-->5')-heterodinucleoside phosphate analog NOAC-AraC were compared with AraC for cytotoxicity, cell-cycle dependence, phosphorylation by deoxycytidine (dC) kinase and apoptosis induction in native, AraC- or ...

journal_title：Journal of cancer research and clinical oncology

authors： Horber DH,Cattaneo-Pangrazzi RM,von Ballmoos P,Schott H,Ludwig PS,Eriksson S,Fichtner I,Schwendener RA

更新日期：2000-06-01 00:00:00

abstract：:Increased expression of P glycoprotein is associated with multidrug resistance in many cell lines. P glycoprotein has been detected in different human tumors. To assess the implication of multidrug resistance in the prognosis of Ewing's sarcoma the expression of P glycoprotein was studied immunohistochemically in pre-...

journal_title：Journal of cancer research and clinical oncology

authors： Roessner A,Ueda Y,Bockhorn-Dworniczak B,Blasius S,Peters A,Wuisman P,Ritter J,Paulussen M,Jürgens H,Böcker W

更新日期：1993-01-01 00:00:00

abstract：:The oxazaphosphorine analog ifosfamide (IFO) has demonstrated an increased therapeutic index in a variety of solid tumors and hematologic malignancies compared with its parent compound cyclophosphamide. A fractionated dose schedule over 5 days as continuous infusion in combination with the uroprotective agent sodium-2...

journal_title：Journal of cancer research and clinical oncology

authors： Loeffler TM,Weber FW,Hausamen TU

更新日期：1991-01-01 00:00:00

abstract：:P-glycoprotein (P-gp), a cell membrane protein, has been found in multidrug-resistant cancer cells. A total of 104 smears from patients with breast-cancer-associated pleural effusions and ovarian-cancer-related peritoneal effusions were studied for P-gp with the antibody C-219 and the avidin-biotin-immunoperoxidase me...

journal_title：Journal of cancer research and clinical oncology

authors： Athanassiadou P,Athanassiades P,Petrakakou E,Zerva C,Mavrikakis M

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Objective of this work was to extend pharmacokinetic scaling theory of the writer for bolus dosing to include the case of constant-rate i.v. dosing over fixed interval so as to allow projection of adult dose and schedule of typically administered anticancer agents to children. METHODS:The basis for the scaling...

journal_title：Journal of cancer research and clinical oncology

authors： Dawson TH

更新日期：2013-12-01 00:00:00

abstract：:Point mutations occurring at codon 201 of the gene coding for the alpha subunit of the stimulatory G protein impair intrinsic GTPase activity and lead to a constitutive activation of adenylate cyclase. We have examined thyroid follicular and papillary carcinomas and follicular adenomas and found samples that bear this...

journal_title：Journal of cancer research and clinical oncology

authors： Gorelov VN,Dumon K,Barteneva NS,Palm D,Röher HD,Goretzki PE

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To investigate the impact of different KRAS mutations on treatment with the tyrosine kinase inhibitor sunitinib in SW48 colorectal cancer cell line variants. MATERIALS AND METHODS:Isogenic SW48 KRAS wt, G12A, G12C, G12D, G12R, G12S, G12 V, and G13D cells were evaluated for ERK phosphorylation with and without ...

journal_title：Journal of cancer research and clinical oncology

authors： Modest DP,Camaj P,Heinemann V,Schwarz B,Jung A,Laubender RP,Gamba S,Haertl C,Stintzing S,Primo S,Bruns CJ

更新日期：2013-06-01 00:00:00

abstract：:Primary CNS lymphomas (PCNSL), until recently representing about 1% of all brain tumors, show dramatically increased incidence both in high-risk groups (immunocompromised, AIDS) and in the general population. They are extranodal diffuse non-Hodgkin's lymphomas, the morphology and classification of which are identical ...

journal_title：Journal of cancer research and clinical oncology

authors： Jellinger KA,Paulus W

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:HepaCAM, an N-linked glycoprotein that encodes a member of the immunoglobulin superfamily, has been reported to be a tumor suppressor gene that mediates diverse cellular bio-functions. Recent studies have shown that the FoxO transcription factors play a pivotal role during cancer progression. Here, we explored ...

journal_title：Journal of cancer research and clinical oncology

authors： Tang M,Zhao Y,Liu N,Chen E,Quan Z,Wu X,Luo C

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Cholangiocarcinoma is defined as a chronic liver disease with altered estrogen metabolism and could result in estrogen retention. Estrogenic response was known as a promoting factor in progression of some cancer. In this study, we determined the significant increase of estrogen level in cholangiocarcinoma patie...

journal_title：Journal of cancer research and clinical oncology

authors： Hunsawong T,Singsuksawat E,In-chon N,Chawengrattanachot W,Thuwajit C,Sripa B,Paupairoj A,Chau-in S,Thuwajit P

更新日期：2012-08-01 00:00:00

abstract：AIMS:With three consecutive tetratricopeptide repeat (TPR) motifs at its C-terminus essential for neuronal migration, and a p23 domain at its N-terminus, DYX1C1 was the first gene proposed to have a role in developmental dyslexia. In this study, we attempted to identify the potential interaction of DYX1C1 and heat shoc...

journal_title：Journal of cancer research and clinical oncology

authors： Chen Y,Zhao M,Wang S,Chen J,Wang Y,Cao Q,Zhou W,Liu J,Xu Z,Tong G,Li J

更新日期：2009-09-01 00:00:00

abstract：:Protein extracted from conventional formalin-fixed and paraffin-embedded tissue sections of human gliomas was examined for immunoblot analysis using antibody against the placental form of glutathione S-transferase (GST-pi). Four benign astrocytomas, five anaplastic astrocytomas and four glioblastomas were used in this...

journal_title：Journal of cancer research and clinical oncology

authors： Hara A,Sakai N,Yamada H,Yoshimi N,Tanaka T,Mori H

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:In our previous publication, we have shown that dihydroartemisinin could significantly inhibit the growth of CML K562 cells by its anti-proliferative and inducing apoptotic effects. Given the pivotal effect of Bcr/Abl tyrosine kinase and its downstream signal factors on CML cell proliferation and survival, we e...

journal_title：Journal of cancer research and clinical oncology

authors： Lee J,Zhang G,Wu X,Xu F,Zhou J,Zhang X

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVES:Tobacco exposure remains the main etiologic factor for lung cancer (LC). Interactions between environment and individual genetic profile are particularly important for this disease. The aim of this study was to evaluate the contribution of CYP1A1*2A, CYP1A1*2C, CYP2D6*4, GSTP1, GSTM1, GSTT1 and NAT2 polymorp...

journal_title：Journal of cancer research and clinical oncology

authors： Mota P,Silva HC,Soares MJ,Pego A,Loureiro M,Cordeiro CR,Regateiro FJ

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and has been shown to induce extrinsic pathway of apoptosis in many types of cancer cells. AT-101, an (-)-enantiomer of gossypol, is a potent anticancer agent that is shown to be an inhibitor of Bcl-2/Bcl-XL. In t...

journal_title：Journal of cancer research and clinical oncology

authors： Kisim A,Atmaca H,Cakar B,Karabulut B,Sezgin C,Uzunoglu S,Uslu R,Karaca B

更新日期：2012-07-01 00:00:00

abstract：:Three oxygenated propylnitrosomethylamines were administered to female Syrian hamsters at doses similar to those which had induced high incidences of esophageal neoplasms in rats. Nitrosomethyl-2-oxopropylamine (NMOP) given at the rate of 2 mg/animal/week, whether as one application of 2 mg or two applications of 1 mg...

journal_title：Journal of cancer research and clinical oncology

authors： Lijinsky W,Kovatch RM,Knutsen GL

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Cancer-associated fibroblasts (CAFs) contribute to tumor progression through multiple pathways. However, the effect of CAFs on gene expression in lung cancer has been largely unknown. Here we systematically compared the gene expression changes in lung cancer cells induced by normal fibroblasts and CAFs. METHOD...

journal_title：Journal of cancer research and clinical oncology

authors： An J,Enomoto A,Weng L,Kato T,Iwakoshi A,Ushida K,Maeda K,Ishida-Takagishi M,Ishii G,Ming S,Sun T,Takahashi M

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:A high proportion of cancer patients use complementary and alternative medicine (CAM). In oncology, risks of CAM are side effects and interactions. OBJECTIVE:Our aim was to conduct a survey on professionals in palliative care regarding attitudes toward CAM. DESIGN AND SUBJECTS:An internet-based survey with...

journal_title：Journal of cancer research and clinical oncology

authors： Conrad AC,Muenstedt K,Micke O,Prott FJ,Muecke R,Huebner J

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:In 2008, we reported that 10 Japanese-size cups of green tea daily, supplemented with tablets of green tea extract (GTE), reduced the recurrence of colorectal adenoma by 51.6% in patients after polypectomy. Based on these results, we paid special attention to Japanese cancer patients, who consume green tea ever...

journal_title：Journal of cancer research and clinical oncology

authors： Fujiki H,Sueoka E,Watanabe T,Suganuma M

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:We have demonstrated that overexpression of osteopontin (OPN) could contribute to metastasis in hepatocellular carcinoma (HCC), and that OPN-positive cancer cells are often localized in the periphery of cancer nodules adjacent to stromal cells. This study was to identify the difference of intratumor genomic abe...

journal_title：Journal of cancer research and clinical oncology

authors： Wu JC,Sun BS,Ren N,Ye QH,Qin LX

更新日期：2010-04-01 00:00:00

abstract：:A series of 191 female breast carcinomas (with long-term follow-up) were analysed immunohistochemically (with a monoclonal MIB1 antibody) for Ki-67 (a proliferation marker) expression with special reference to well-established prognostic factors and patient survival. Expression of Ki-67 was directly related to the S-p...

journal_title：Journal of cancer research and clinical oncology

authors： Pietiläinen T,Lipponen P,Aaltomaa S,Eskelinen M,Kosma VM,Syrjänen K

更新日期：1996-01-01 00:00:00

abstract：CONTEXT:Parathyroid carcinoma (PC) is a rare endocrine malignancy with no approved systemic therapies for unresectable locally invasive or distant metastatic disease. Understanding the molecular changes in advanced PC can provide better understanding of this disease and potentially help directing targeted therapy. OBJ...

journal_title：Journal of cancer research and clinical oncology

authors： Kutahyalioglu M,Nguyen HT,Kwatampora L,Clarke C,Silva A,Ibrahim E,Waguespack SG,Cabanillas ME,Jimenez C,Hu MI,Sherman SI,Kopetz S,Broaddus R,Dadu R,Wanland K,Williams M,Zafereo M,Perrier N,Busaidy NL

更新日期：2019-08-01 00:00:00