Ambulatory high-dose 5-day continuous-infusion ifosfamide combination chemotherapy in advanced solid tumors: a feasibility study.

abstract：:The two hormone analogues octreotide and goserelin have been shown to decelerate growth of human pancreatic cancer in vitro and in vivo. The objective of this pilot study was to investigate the efficacy and toxicity of the combination of these two agents in patients with advanced pancreatic cancer. Octreotide was inje...

journal_title：Journal of cancer research and clinical oncology

authors： Fazeny B,Baur M,Prohaska M,Hudec M,Kremnitzer M,Meryn S,Huber H,Grunt T,Tuchmann A,Dittrich C

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Results from in vitro chemosensitivity testing recommend treosulfan/gemcitabine chemotherapy for the treatment of stage IV uveal melanoma. METHODS:Twenty patients received treosulfan 3,500 mg/m2 followed by gemcitabine 1,000 mg/m2 on day 1 and day 8 repeated on day 29. In cases of prior chemotherapy only 75% o...

journal_title：Journal of cancer research and clinical oncology

authors： Terheyden P,Bröcker EB,Becker JC

更新日期：2004-07-01 00:00:00

abstract：:According to a "two-hit" model, dominantly inherited predisposition to cancer entails a germline mutation, while tumorigenesis requires a second, somatic, mutation. Non-hereditary cancer of the same type requires the same two hits, but both are somatic. The original tumor used in this model, retinoblastoma, involves m...

journal_title：Journal of cancer research and clinical oncology

authors： Knudson AG

更新日期：1996-01-01 00:00:00

abstract：:E-cadherin mainly mediated the epithelial cell-cell adhesion, and integrin signaling can modulate the signaling pathway of E-cadherin in the different levels. Up to now, however, it is still unclear that whether E-cadherin could interfere with cell-matrix interaction, a typical adhesion through integrins. In this stud...

journal_title：Journal of cancer research and clinical oncology

authors： Wu H,Liang YL,Li Z,Jin J,Zhang W,Duan L,Zha X

更新日期：2006-12-01 00:00:00

abstract：:We describe a slide assay that allows the demonstration of antigens localized in the nucleus from isolated white blood cells as well as from single tumor cells derived from malignant effusions. With the antibodies Ki-67 and anti-p-145 an increased rate of nuclear and nucleolar staining resulted in cells from highly ma...

journal_title：Journal of cancer research and clinical oncology

authors： Hirsch FW,Deibert P,Busch H,Löhr GW,Bross KJ

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To establish a hepatocellular carcinoma (HCC) cell line from lung metastatic lesions of human HCC in nude mice so as to provide a suitable model for the study of lung-metastasis-related molecular mechanisms. METHODS:HCC clone cells MHCC97-H were inoculated into BALB/c nude mice, and the pulmonary metastatic le...

journal_title：Journal of cancer research and clinical oncology

authors： Li Y,Tang Y,Ye L,Liu B,Liu K,Chen J,Xue Q

更新日期：2003-01-01 00:00:00

abstract：:Ftorafur (FT), a 2-tetrahydrofuryl derivative of 5-fluorouracil (5-FU) was introduced into cancer chemotherapy with the hope to obtain a therapeutic effect comparable to 5-FU with a smaller dose and less side effects. A comparison of the effect of FT and 5-FU on the proliferation of L 1210 ascites tumor cells in the p...

journal_title：Journal of cancer research and clinical oncology

authors： Schultze B,Jellinghaus W,Weis G,Müller V,Maurer W

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Patterns of locoregional rectal cancer recurrences following total mesorectal excision (TME) were analyzed to define the irradiation volume, especially the lateral pelvic lymph node (LPLN). MATERIALS AND METHODS:Of 1243 patients who underwent TME without pelvic radiotherapy between 2005 and 2012, the data of 8...

journal_title：Journal of cancer research and clinical oncology

authors： Choi SH,Chang JS,Yoon HI,Jang DS,Kim NK,Lim JS,Min BS,Huh H,Shin SJ,Ahn JB,Koom WS

更新日期：2018-06-01 00:00:00

abstract：:Bone metastatic prostate cancer is one of the most common malignancies in developed countries and the second leading cause of cancer-related death in men. There remains no effective treatment for metastatic prostate cancer. We investigate here the anticancer effects of botanical component p-hydroxycinnamic acid (HCA) ...

journal_title：Journal of cancer research and clinical oncology

authors： Yamaguchi M,Murata T,Ramos JW

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:The majority of patients with germ cell tumors are cured by multimodality therapy that consists of cisplatin-based chemotherapy and/or surgical resection. Serum tumor markers and conventional radiographs are utilized to stratify patients into treatment categories. Efforts to individualize chemotherapy or minimi...

journal_title：Journal of cancer research and clinical oncology

authors： Amato R,Kim EE,Prow D,Andreopoulos D,Kasi LP

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To understand how nanomechanical stiffness affects metastatic potential, we studied the relationship between cell migration, a characteristic of metastasis, and cell stiffness using atomic force microscopy (AFM), which can measure stiffness (elasticity) of individual living cells. METHODS:Migration and cell st...

journal_title：Journal of cancer research and clinical oncology

authors： Watanabe T,Kuramochi H,Takahashi A,Imai K,Katsuta N,Nakayama T,Fujiki H,Suganuma M

更新日期：2012-05-01 00:00:00

abstract：:The standard definition of platinum-resistant ovarian cancer or primary peritoneal carcinoma commonly includes patients whose disease initially responded to a platinum-based combination regimen, but recurred less than 6 months after the completion of primary therapy. Recent experience with several patients with these ...

journal_title：Journal of cancer research and clinical oncology

authors： Markman M,Kennedy A,Webster K,Kulp B,Peterson G,Belinson J

更新日期：1998-01-01 00:00:00

abstract：:Ovarian cancer is a leading cause of death among gynecologic malignancies. This disappointing prognosis is closely related to intrinsic or acquired resistance to conventional platinum-based chemotherapy, which can affect a third of patients. As such, investigating relevant molecular targets is crucial in the fight aga...

journal_title：Journal of cancer research and clinical oncology

authors： Gasparri ML,Besharat ZM,Farooqi AA,Khalid S,Taghavi K,Besharat RA,Sabato C,Papadia A,Panici PB,Mueller MD,Ferretti E

更新日期：2018-12-01 00:00:00

abstract：:Breast cancer tissue was examined for overexpression of HER-2/neu and p53 oncogene proteins. Samples from 105 breast cancer patients were investigated by Western-blot analysis and their relationship to other established markers and clinical outcome was examined. In 21.0% of the cases HER-2/neu was overexpressed, and i...

journal_title：Journal of cancer research and clinical oncology

authors： Wiltschke C,Kindas-Muegge I,Steininger A,Reiner A,Reiner G,Preis PN

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Previous studies showed poorer survival in T4 disease with residual lesion. To evaluate the efficacy and toxicity of a boost dose for T4 nasopharyngeal carcinoma (NPC), patients with a residual primary lesion after intensity-modulated radiotherapy (IMRT). METHODS:398 T4 NPC patients with residual primary le...

journal_title：Journal of cancer research and clinical oncology

authors： Fei Z,Xu T,Qiu X,Li M,Chen T,Li L,Huang C,Chen C

更新日期：2021-01-03 00:00:00

abstract：PURPOSE:The polymorphisms in microRNA (miRNA) machinery genes and miRNA-containing genomic regions may play an important role in cancer development and prognosis. Accordingly, the present study analyzed the single nucleotide polymorphisms (SNPs) of miRNA-related genes and their impact on the prognosis for patients with...

journal_title：Journal of cancer research and clinical oncology

authors： Lee HC,Kim JG,Chae YS,Sohn SK,Kang BW,Moon JH,Jeon SW,Lee MH,Lim KH,Park JY,Choi GS,Jun SH

更新日期：2010-07-01 00:00:00

abstract：:The concentration of estrogen receptor protein (ER) in 113 primary or metastatic breast cancers was studied. ER was found to be correlated with the age of the patient. The ER values were generally lower in premenopausal patients (5.6 fmol/mg cytosol protein) than in postmenopausal patients (32.8 fmol/mg cytosol protei...

journal_title：Journal of cancer research and clinical oncology

authors： Johansson R,Vanharanta R,Söderholm J

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Hypersensitivity reactions (HSRs) to chemotherapy is an ongoing issue in cancer treatments. Strategies to induce tolerance and maximize chemotherapy efficacy include desensitization protocols. The precise impact of these protocols, however, in the long-term treatments remains unclear. We aim to compare overall ...

journal_title：Journal of cancer research and clinical oncology

authors： Altwerger G,Florsheim EB,Menderes G,Black J,Schwab C,Gressel GM,Nelson WK,Carusillo N,Passante T,Huang G,Litkouhi B,Azodi M,Silasi DA,Santin A,Schwartz PE,Ratner ES

更新日期：2018-12-01 00:00:00

abstract：:Chinese hamster ovary cells were heated for 20 min at 45.5 degrees C in different conditions, and quantitative determinations of cellular membrane blebbing were performed for cells maintained at 25 degrees C and 37 degrees C after hyperthermia. The percentage of cells with blebs following heating was dependent upon th...

journal_title：Journal of cancer research and clinical oncology

authors： Kapiszewska M,Hopwood LE

更新日期：1988-01-01 00:00:00

abstract：:Peptide growth factors involved in the regulation of haematopoiesis (HPGF), for example granulocyte-colony-stimulating factor (G-CSF) and granulocyte/macrophage-colony-stimulating factor (GM-CSF), are of clinical importance in the treatment of testicular germ cell tumour (GCT) patients with modern chemotherapy regimen...

journal_title：Journal of cancer research and clinical oncology

authors： Dunn TA,Schmoll HJ,Rie C,Hartmann K,Casper J

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:Triple (ER-, PR-, HER2-) negative breast carcinoma lack targeted therapies, making this group of tumors difficult to treat. By definition, the lack of HER2 expression means a case scoring 0 or 1+ after immunophenotypical analysis and makes the patients avoiding therapeutical chances with anti-HER2 inhibitors. W...

journal_title：Journal of cancer research and clinical oncology

authors： Brunello E,Bogina G,Bria E,Vergine M,Zamboni G,Pedron S,Daniele I,Furlanetto J,Carbognin L,Marconi M,Manfrin E,Ibrahim M,Miller K,Tortora G,Molino A,Jasani B,Beccari S,Bonetti F,Chilosi M,Martignoni G,Brunelli M

更新日期：2013-09-01 00:00:00

abstract：:We measured an estrogen-receptor-associated protein (ER-D5), estrogen and progesterone receptors (ER; PgR) in samples obtained from 28 female patients with primary breast carcinoma. A correlation of r = 0.79 was found between ER-D5 and ER values and between ER-D5 and PgR values in premenopausal woman. In postmenopausa...

journal_title：Journal of cancer research and clinical oncology

authors： Navarro MA,Guardia M,Arranz B,Bonnin MR,Rosel P

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Tumor grade is one of the more controversial factors with limited prognostic information in squamous cell carcinomas (SCC) of the uterine cervix. METHODS:Histologic slides of 233 surgically treated cervical SCC (FIGO IB1) were re-examined regarding the prognostic impact of the WHO-based grading system, using t...

journal_title：Journal of cancer research and clinical oncology

authors： Horn LC,Höhn AK,Hentschel B,Fischer U,Bilek K,Brambs CE

更新日期：2019-02-01 00:00:00

abstract：:Human ovarian cancer cells from ten patients were cultured in the agar double layer assay as described by Hamburger and Salmon and in a methylcellulose monolayer system. The assays were compared under the same experimental conditions. The rate of positives (defined as greater than 30 colonies/dish) was 75% in the meth...

journal_title：Journal of cancer research and clinical oncology

authors： Runge HM,Neumann HA,Bücke W,Pfleiderer A

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly remain unknown. This study was aimed to investigate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of p...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang ZM,Wang Y,Huang R,Liu YP,Li X,Hu FL,Zhu L,Wang F,Cui BB,Dong XS,Zhao YS

更新日期：2014-12-01 00:00:00

abstract：:The genetically engineered chimeric cB72.3m4 and cB72.3m12 antibodies recognize the same tumor-associated TAG72 antigen. The high-affinity cB72.3m4 antibody had an approximately 18-fold higher affinity constant for the TAG72 antigen than the low-affinity cB72.3m12 antibody. The relationship between antibody affinity a...

journal_title：Journal of cancer research and clinical oncology

authors： Qi Y,Matte G,Wilkinson A,Jim X

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:The spread of malignant lymph nodes due to malignancies of the head and neck is systematically observed. However, sentinel lymph nodes in the cervical region, such as in the axillary or supraclavicular regions, are not described. Therefore, precise preoperative lymph node screening of all neck compartments is r...

journal_title：Journal of cancer research and clinical oncology

authors： Hohlweg-Majert B,Metzger MC,Voss PJ,Hölzle F,Wolff KD,Schulze D

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:In 2008, we reported that 10 Japanese-size cups of green tea daily, supplemented with tablets of green tea extract (GTE), reduced the recurrence of colorectal adenoma by 51.6% in patients after polypectomy. Based on these results, we paid special attention to Japanese cancer patients, who consume green tea ever...

journal_title：Journal of cancer research and clinical oncology

authors： Fujiki H,Sueoka E,Watanabe T,Suganuma M

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To evaluate prognostic factors in estrogen receptor (ER)-positive, operable breast cancer focusing on the progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). PATIENTS AND METHODS:A total of 819 patients with ER-positive, operable breast cancer were enrolled. All patients received up...

journal_title：Journal of cancer research and clinical oncology

authors： Moon YW,Park S,Sohn JH,Kang DR,Koo JS,Park HS,Chung HC,Park BW

更新日期：2011-07-01 00:00:00

abstract：:The increase of plasma cortisol in patients with tumors of five different sites compared with a control group of patients with benign surgical diseases amounted to: +39% (breast), +34% (stomach), +86% (intestine), +60% (skin) and +194% (gall bladder). The first detectable increase of cortisol occurred in patients with...

journal_title：Journal of cancer research and clinical oncology

authors： Schaur RJ,Semmelrock HJ,Schauenstein E,Kronberger L

更新日期：1979-04-12 00:00:00