当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Comparing cell kinetic studies of the effect of ftorafur and 5-fluorouracil on the L 1210 ascites tumor.

Comparing cell kinetic studies of the effect of ftorafur and 5-fluorouracil on the L 1210 ascites tumor.

Abstract：

:Ftorafur (FT), a 2-tetrahydrofuryl derivative of 5-fluorouracil (5-FU) was introduced into cancer chemotherapy with the hope to obtain a therapeutic effect comparable to 5-FU with a smaller dose and less side effects. A comparison of the effect of FT and 5-FU on the proliferation of L 1210 ascites tumor cells in the present work has shown that both drugs result in an inhibition of DNA synthesis due to an inhibition of thymidylate synthetase. However, the extent of the effect of FT is reduced, i.e., to achieve a cell kinetic effect comparable to that of 5-FU, 60 times the equimolecular FT dose has to be applied. Thus, there is no dose-saving effect of FT compared to 5-FU. A depot-like 5-FU effect of FT due to a slow release of 5-FU from FT as described in the literature could not be confirmed in the present study either. The effect of FT on the proliferation of L 1210 ascites tumor cells did not last longer than that of 5-FU. In contrast to 5-FU a severe side effect, viz., a drastic decrease of the body temperature from 39.1 degrees to 31.6 degrees C, was observed. That means that FT cannot only be effective by a release of 5-FU. This toxic side effect must be due to a different mechanism of action of FT. A significant increase in the median life span could only be achieved by the application of 5-FU (180 microgram/g). An equimolecular FT-dose did not result in an increase of the median life span. Based on the present study, the advantages of FT compared to 5-FU described in the literature cannot be confirmed. The present work shows that cell kinetic studies in animals are a useful tool to test the effect of new drugs in chemotherapy.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Schultze B,Jellinghaus W,Weis G,Müller V,Maurer W

doi

10.1007/BF00405899

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

25-40

issue

1

eissn

0171-5216

issn

1432-1335

journal_volume

100

pub_type

杂志文章

相关文献

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY文献大全
  • Kaposiform hemangioendothelioma without cutaneous involvement.

    abstract：PURPOSE:We sought to characterize the clinical features and management of patients diagnosed as Kaposiform hemangioendothelioma (KHE) without cutaneous involvement. METHODS:The electronic patient chats at six Triple A hospitals in China were searched to find all patient diagnoses with KHE without cutaneous involvement...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-018-2759-5

    authors： Ji Y,Chen S,Li L,Yang K,Xia C,Li L,Yang G,Kong F,Lu G,Liu X

    更新日期：2018-12-01 00:00:00

  • Contamination of autologous peripheral blood progenitor cell grafts predicts overall survival after high-dose chemotherapy in multiple myeloma.

    abstract：BACKGROUND:Despite of the introduction of novel treatment modalities for multiple myeloma, high-dose chemotherapy with hematopoietic stem-cell rescue is still considered the standard of care for eligible patients <65 years of age. As we have previously reported, stem-cell grafts regularly contain quantities of plasma c...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-008-0499-7

    authors： Kopp HG,Yildirim S,Weisel KC,Kanz L,Vogel W

    更新日期：2009-04-01 00:00:00

  • Radioimmunodetection of residual, recurrent or metastatic germ cell tumors using technetium-99 anti-(alpha-fetoprotein) Fab' fragment.

    abstract：PURPOSE:The majority of patients with germ cell tumors are cured by multimodality therapy that consists of cisplatin-based chemotherapy and/or surgical resection. Serum tumor markers and conventional radiographs are utilized to stratify patients into treatment categories. Efforts to individualize chemotherapy or minimi...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320050026

    authors： Amato R,Kim EE,Prow D,Andreopoulos D,Kasi LP

    更新日期：2000-03-01 00:00:00

  • Multiple functions of HuR in urinary tumors.

    abstract：PURPOSE:Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors' biology and explore t...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s00432-018-2778-2

    authors： Zhang F,Cai Z,Lv H,Li W,Liang M,Wei X,Zhou F

    更新日期：2019-01-01 00:00:00

  • Higher cell stiffness indicating lower metastatic potential in B16 melanoma cell variants and in (-)-epigallocatechin gallate-treated cells.

    abstract：PURPOSE:To understand how nanomechanical stiffness affects metastatic potential, we studied the relationship between cell migration, a characteristic of metastasis, and cell stiffness using atomic force microscopy (AFM), which can measure stiffness (elasticity) of individual living cells. METHODS:Migration and cell st...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-012-1159-5

    authors： Watanabe T,Kuramochi H,Takahashi A,Imai K,Katsuta N,Nakayama T,Fujiki H,Suganuma M

    更新日期：2012-05-01 00:00:00

  • Dialysis-requiring acute kidney injury increases risk of long-term malignancy: a population-based study.

    abstract：BACKGROUND:Acute kidney injury (AKI) is gaining worldwide attention recently, emerging as a major public health threat. However, the association between the development of AKI and subsequent malignancy has not been studied before. METHODS:We conducted a population study based on the Taiwan National Health Insurance da...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1600-z

    authors： Chao CT,Wang CY,Lai CF,Huang TM,Chen YY,Kao TW,Chu TS,Chang CH,Wu VC,Ko WJ,Chen L,Wu KD,National Taiwan University Study Group on Acute Renal Failure.

    更新日期：2014-04-01 00:00:00

  • Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells.

    abstract：PURPOSE:TNF-related apoptosis-inducing ligand (TRAIL) is a potential cancer therapeutic agent that preferentially induces apoptosis in cancer cells. However, breast cancer cells are generally resistant to TRAIL. Bufalin is a major active ingredient of the traditional Chinese medicine ChanSu. The present study aimed to ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-012-1204-4

    authors： Yan S,Qu X,Xu C,Zhu Z,Zhang L,Xu L,Song N,Teng Y,Liu Y

    更新日期：2012-08-01 00:00:00

  • Allelic loss on chromosome 5q34 is associated with poor prognosis in hepatocellular carcinoma.

    abstract：PURPOSE:To identify and characterize novel genetic alterations in hepatocellular carcinoma (HCC). METHODS:DNA was extracted from 29 HCC and corresponding normal tissues and amplified with 59 different 10-base arbitrary primers. A 550 bp DNA fragment amplified using primer Q-9 and which was present in 19 of 29 cases (6...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-008-0379-1

    authors： Saelee P,Wongkham S,Bhudhisawasdi V,Sripa B,Chariyalertsak S,Petmitr S

    更新日期：2008-10-01 00:00:00

  • Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features.

    abstract：BACKGROUND:The role of somatic BRCA1/2 gene mutations in breast cancer is getting increasing attention in view of hereditary disease. The medullary phenotype and triple negative intrinsic subtypes are often, but not exclusively encountered in BRCA1 germline mutated breast cancer, whilst for BRCA2, no association to spe...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-018-2609-5

    authors： Rechsteiner M,Dedes K,Fink D,Pestalozzi B,Sobottka B,Moch H,Wild P,Varga Z

    更新日期：2018-05-01 00:00:00

  • Impact of age on efficacy and toxicity of nilotinib in patients with chronic myeloid leukemia in chronic phase: ENEST1st subanalysis.

    abstract：PURPOSE:Achievement of deep molecular response with a tyrosine kinase inhibitor in patients with chronic myeloid leukemia (CML) is required to attempt discontinuation of therapy in these patients. The current subanalysis from the Evaluating Nilotinib Efficacy and Safety in Clinical Trials as First-Line Treatment (ENEST...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00432-017-2402-x

    authors： Giles FJ,Rea D,Rosti G,Cross NCP,Steegmann JL,Griskevicius L,le Coutre P,Coriu D,Petrov L,Ossenkoppele GJ,Mahon FX,Saussele S,Hellmann A,Koskenvesa P,Brümmendorf TH,Gastl G,Castagnetti F,Vincenzi B,Haenig J,Hochhaus

    更新日期：2017-08-01 00:00:00

  • Increase of hepcidin plasma and urine levels is associated with acute proctitis and changes in hemoglobin levels in primary radiotherapy for prostate cancer.

    abstract：PURPOSE:To analyse hepcidin serum and urine levels during radiotherapy for prostate cancer. METHODS:In 18 patients undergoing radiotherapy for prostate cancer, blood, plasma, and urine samples were taken before and during radiotherapy. Complete blood cell count, pro-hepcidin-, ferritin-, transferrin-, IL-1beta-, IL-6-...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-006-0170-0

    authors： Christiansen H,Saile B,Hermann RM,Rave-Fränk M,Hille A,Schmidberger H,Hess CF,Ramadori G

    更新日期：2007-05-01 00:00:00

  • GDF3 inhibits the growth of breast cancer cells and promotes the apoptosis induced by Taxol.

    abstract：PURPOSE:The aim of this study is to investigate whether GDF3 is related to the progression of human breast cancer and the effects of GDF3 on breast cancer cells. METHODS:The expression of GDF3 in 24 breast cancer specimens paired with corresponding neighboring nontumorous tissue was studied by Western blot. Breast can...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-012-1213-3

    authors： Li Q,Ling Y,Yu L

    更新日期：2012-06-01 00:00:00

  • Designing of chimeric DNA/RNA hammerhead ribozymes to be targeted against AML1/MTG8 mRNA.

    abstract：:For therapeutic purposes, two chimeric DNA/RNA hammerhead ribozymes were synthesized to cleave AML1/MTG8, the t(8;21)-associated fusion mRNA of acute myeloid leukemia. One ribozyme, A/MRZ-1, recognizes the area adjacent to the fusion point between AML1 and MTG8, and cleaves six bases downstream from this point. The ot...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01209655

    authors： Kozu T,Sueoka E,Okabe S,Sueoka N,Komori A,Fujiki H

    更新日期：1996-01-01 00:00:00

  • Expression and clinical significance of EGFL7 in malignant glioma.

    abstract：PURPOSE:Tumor angiogenesis is an important factor for the continuous growth of human malignancies and can be used to predict the prognosis for patients. In the current study, we examined the expression of EGF-like domain 7 (EGFL7), an endothelial cell-derived secreted factor, in malignant gliomas and explored its clini...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-010-0832-9

    authors： Huang CH,Li XJ,Zhou YZ,Luo Y,Li C,Yuan XR

    更新日期：2010-11-01 00:00:00

  • Effects of Taxol plus radiation on the apoptotic and mitotic indices of mouse intestinal crypt cells.

    abstract：PURPOSE:In this study we investigated the effect of Taxol, radiation, or Taxol plus radiation on highly proliferative normal tissue--the intestinal crypt cells of Swiss albino mice. MATERIALS AND METHODS:Swiss-albino mice, 3-4 months old, were used in this study. Taxol was administered by bolus intravenously through t...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320100240

    authors： Ozkan L,Ozuysal S,Egeli U,Adim SB,Tunca B,Aydemir N,Ceçener G,Ergül E,Akpinar G,Cimen C,Engin K,Ahmed MM

    更新日期：2001-07-01 00:00:00

  • A systematic review of head-to-head trials of approved monoclonal antibodies used in cancer: an overview of the clinical trials agenda.

    abstract：BACKGROUND:Since 1997, several monoclonal antibodies (mAbs) targeting the same receptor or its ligand have been approved for use in oncology. However, no studies have summarized head-to-head trials of these mAbs. METHODS:Systematic search of the biomedical literature and ClinicalTrials.gov for randomized studies compa...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-019-02984-2

    authors： Luo J,Nishikawa G,Prasad V

    更新日期：2019-09-01 00:00:00

  • Aminoacids--precursors of melanin synthesis in hamster melanoma.

    abstract：:The role of L-tyrosine, L-phenylalanine, L-dihydroxyphenylalanine (dopa) and L-tryptophan in melanin biosynthesis in melanotic hamster melanoma IC-Sofia was investigated with the aid of 14C-aminoacids. Tyrosine and phenylalanine were found to be the main melanin precursors: about 64.5% of total melanin labeling was du...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00390476

    authors： Blagoeva PM

    更新日期：1984-01-01 00:00:00

  • Alpha-fetoprotein, tissue polypeptide antigen and ferritin in diagnosing primary hepatocellular carcinoma in patients with liver cirrhosis.

    abstract：:This study was undertaken in order to compare the usefulness of three indices of tumour proliferation in detecting primary hepatocellular carcinoma (HCC) and in differentiating this neoplasm from liver cirrhosis. In 10 patients with HCC and in 63 with liver cirrhosis serum alpha-fetoprotein (AFP), tissue polypeptide a...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00391702

    authors： Leandro G,Basso D,Fabris C,Zizzari S,Elba S,Del Favero G,Di Mario F,Meggiato T,Angonese C,Naccarato R

    更新日期：1989-01-01 00:00:00

  • Association between survivin -31G>C polymorphism and cancer risk: meta-analysis of 29 studies.

    abstract：PURPOSE:A growing body of evidence has shown the possible relevance of survivin -31G>C (rs9904341) promoter polymorphism to the genetic susceptibility of cancer. Because of the lack of available conclusive data, we performed a meta-analysis of all relevant available studies to derive a more precise estimation of the re...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s00432-013-1524-z

    authors： Qin Q,Zhang C,Zhu H,Yang X,Xu L,Liu J,Lu J,Zhan L,Cheng H,Sun X

    更新日期：2014-02-01 00:00:00

  • Iatrogenic carcinogenesis.

    abstract：:In a wider sense iatrogenic carcinogenesis means the induction of cancer by medical treatment. Some drugs have been now identified to be carcinogenic not only in experimental animals but also in man. For example, chlornaphazine used in the treatment of polycythemia has been proved to induce bladder cancer in 30% of th...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00412444

    authors： Schmähl D

    更新日期：1981-01-01 00:00:00

  • Quantitative analysis of the early changes of hepatocyte nuclei after treating Syrian golden hamsters with di(2-ethylhexyl)phthalate.

    abstract：:Although the biological action of phthalates has been widely discussed there is little information on early cellular changes indicative for toxic or carcinogenic effects. To study subtle alterations in the cell morphology, we have by means of image processing evaluated the nuclei of hamster hepatocytes after treatment...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00400745

    authors： Komitowski D,Schmezer P,Schmitt B,Ehemann V,Muto S

    更新日期：1986-01-01 00:00:00

  • Cytotoxic activity of novel human monoclonal antibody MT201 against primary ovarian tumor cells.

    abstract：PURPOSE:The epithelial cell adhesion molecule (Ep-CAM) is a clinically validated target for antibody-based therapy of cancer. The aim of this work was to evaluate the specific cytotoxic activity of a novel fully human Ep-CAM-specific IgG1 antibody, called MT201, against primary ovarian tumor cells and an ovarian tumor ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-003-0438-6

    authors： Xiang W,Wimberger P,Dreier T,Diebold J,Mayr D,Baeuerle PA,Kimmig R

    更新日期：2003-06-01 00:00:00

  • Salvage intraperitoneal therapy of small-volume residual ovarian cancer: impact of pretreatment finding of peritoneal carcinomatosis on the surgical complete response rate.

    abstract：:Second-line intraperitoneal (i.p.) therapy has been demonstrated to result in surgically defined complete responses (S-CR) in 25%-40% of patients with small-volume residual ovarian cancer (microscopic disease or largest tumor mass less than 1 cm in diameter). To evaluate the influence of the surgical finding of diffus...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01410140

    authors： Markman M,Reichman B,Hakes T,Barakat R,Curtin J,Rubin S,Jones W,Lewis JL Jr,Almadrones L,Hoskins W

    更新日期：1992-01-01 00:00:00

  • Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma.

    abstract：PURPOSE:Normalization of the tumor vasculature and microenvironment by several angiogenesis inhibitors has been reported. Given that recombinant human endostatin (rh-endostatin) is also an endogenous angiogenesis inhibitor, a comprehensive evaluation of the effects of rh-endostatin on tumor vasculature and microenviron...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-010-0770-6

    authors： Huang G,Chen L

    更新日期：2010-08-01 00:00:00

  • Risk stratification of postoperative recurrence in hypopharyngeal squamous-cell carcinoma patients with nodal metastasis.

    abstract：PURPOSE:To explore lymph node-related risk factors and investigate the benefit of different adjuvant therapy strategies in hypopharyngeal squamous-cell carcinoma (HPSCC) patients with nodal metastasis (N +). METHODS:We conducted a retrospective review covering 266 HPSCC patients with nodal metastasis. Kaplan-Meier cur...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-020-03337-0

    authors： Lin H,Wang T,Heng Y,Zhu X,Zhou L,Zhang M,Shi Y,Cao P,Tao L

    更新日期：2020-07-29 00:00:00

  • Increased expression of cellular retinol-binding protein 1 in laryngeal squamous cell carcinoma.

    abstract：PURPOSE:To investigate the genomic alterations in larynx carcinomas (LaCa) tissues and its prognostics values in predicting survival. METHODS:To analyse the aberrations in the genome of LaCa patients, we used array comparative genomic hybridization in 19 human laryngeal tumour samples. DNA samples were also subjected ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-009-0735-9

    authors： Peralta R,Baudis M,Vazquez G,Juárez S,Ortiz R,Decanini H,Hernandez D,Gallegos F,Valdivia A,Piña P,Salcedo M

    更新日期：2010-06-01 00:00:00

  • Expression and prognostic relevance of CD44v6 in stage I non-small cell lung carcinoma.

    abstract：PURPOSE:Expression of CD44 and its variants has been shown to be relevant to tumor progression in various human malignancies. We evaluated the expression of CD44v6 in the primary lesions of stage I non-small cell lung cancer (NSCLC) and correlated the expression level to its prognosis. METHODS:The expression of CD44v6...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-010-0771-5

    authors： Situ D,Long H,Lin P,Zhu Z,Wang J,Zhang X,Xie Z,Rong T

    更新日期：2010-08-01 00:00:00

  • A case-control study of pancreatic carcinoma.

    abstract：:The hospital records of 60 female and 56 male pancreatic cancer patients and 232 age-, race-, sex-, and hospital-matched controls were reviewed for evidence of prior thyroid disease, cholecystectomy, appendectomy, alcohol consumption and among females, for diseases for the endometrium and ovary. No statistically signi...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00410309

    authors： Haines AP,Moss AR,Whittemore A,Quivey J

    更新日期：1982-01-01 00:00:00

  • DNA repair at the level of the gene: molecular and clinical considerations.

    abstract：:DNA repair is an important process. It is as essential for the cell as is transcription and replication. There is evidence that deficient DNA repair processes lead to human disease including cancer, and recent progress in the field of DNA repair is likely to expand our knowledge about these relationships considerably....

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01612922

    authors： Bohr VA

    更新日期：1990-01-01 00:00:00

  • Descriptive epidemiology of gall-bladder cancer in Europe.

    abstract：:Trends in mortality from cancer of the gall-bladder and bile ducts over the period 1965-1989 were analysed for 25 European countries on the basis of official death certifications from the World Health Organization databank. A high-mortality area--i.e. with overall death certification rates, world standard, around or o...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01229532

    authors： Zatonskí W,La Vecchia C,Levi F,Negri E,Lucchini F

    更新日期：1993-01-01 00:00:00