Higher cell stiffness indicating lower metastatic potential in B16 melanoma cell variants and in (-)-epigallocatechin gallate-treated cells.

abstract：:Methods have been developed in an in vitro system (1) of assessing the number of disseminated tumor cells in peripheral blood and (2) of enriching tumor cells from peripheral blood samples for further characterization. Cells from three human carcinoma lines (E 14, ChaGo, and LEDWiDr) were mixed with leukocytes from no...

journal_title：Journal of cancer research and clinical oncology

authors： Schwartz R,Walk A,Toomes H,Schirrmacher V

更新日期：1985-01-01 00:00:00

abstract：:The arabinofuranosylcytosine (AraC) derivative N4-octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC) and its (5'-->5')-heterodinucleoside phosphate analog NOAC-AraC were compared with AraC for cytotoxicity, cell-cycle dependence, phosphorylation by deoxycytidine (dC) kinase and apoptosis induction in native, AraC- or ...

journal_title：Journal of cancer research and clinical oncology

authors： Horber DH,Cattaneo-Pangrazzi RM,von Ballmoos P,Schott H,Ludwig PS,Eriksson S,Fichtner I,Schwendener RA

更新日期：2000-06-01 00:00:00

abstract：:According to a "two-hit" model, dominantly inherited predisposition to cancer entails a germline mutation, while tumorigenesis requires a second, somatic, mutation. Non-hereditary cancer of the same type requires the same two hits, but both are somatic. The original tumor used in this model, retinoblastoma, involves m...

journal_title：Journal of cancer research and clinical oncology

authors： Knudson AG

更新日期：1996-01-01 00:00:00

abstract：:Sarcoma 180 tumor tissue from C57 mice was processed in a soft agar clonogenic assay immediately after removal from the animal and after various methods of storage. The sensitivity to the antineoplastic drug cis-platinum was not affected by different storage methods. The highest yield of colony forming cells per 100 m...

journal_title：Journal of cancer research and clinical oncology

authors： Krischke W,Hartmann R,Schneider M,Schönenberger H

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Uterine neoplasms comprise a broad spectrum of lesions, some of which may pose a diagnostic challenge even to experienced pathologists. Recently, genome-wide DNA methylation-based classification of central nervous system tumors has been shown to increase diagnostic precision in clinical practice when combined w...

journal_title：Journal of cancer research and clinical oncology

authors： Kommoss FKF,Stichel D,Schrimpf D,Kriegsmann M,Tessier-Cloutier B,Talhouk A,McAlpine JN,Chang KTE,Sturm D,Pfister SM,Romero-Pérez L,Kirchner T,Grünewald TGP,Buslei R,Sinn HP,Mechtersheimer G,Schirmacher P,Schmidt D,Leh

更新日期：2020-01-01 00:00:00

abstract：:Resistance to cytotoxic chemotherapy is a major problem in the management of patients with metastatic breast cancer. Various data suggest P-glycoprotein-associated multidrug resistance (MDR) to be a relevant resistance mechanism in this tumor. The purpose of this study was to evaluate feasibility and activity of combi...

journal_title：Journal of cancer research and clinical oncology

authors： Thürlimann B,Kröger N,Greiner J,Mross K,Schüller J,Schernhammer E,Schumacher K,Gastl G,Hartlapp J,Kupper H

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To evaluate the role of radioembolization and systemic chemotherapy as a combined modality therapy for unresectable colorectal liver metastases. PATIENTS AND METHODS:Prospective database of a major yttrium-90 microsphere radioembolization treatment center in Sydney, Australia, that included 140 patients with u...

journal_title：Journal of cancer research and clinical oncology

authors： Chua TC,Bester L,Saxena A,Morris DL

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:The benefit of adding docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy to chemoradiotherapy (CRT) in head and neck squamous cell carcinoma (HNSCC) remains uncertain. We aimed to investigate whether ICT is well tolerated when given with prophylactic treatment against predicted adverse effects...

journal_title：Journal of cancer research and clinical oncology

authors： Lowe NM,Bernstein JM,Mais K,Garcez K,Lee LW,Sykes A,Thomson DJ,Homer JJ,West CM,Slevin NJ

更新日期：2018-02-01 00:00:00

abstract：:159 "poor risk" patients with previously untreated small cell lung cancer were entered into a randomised study of intravenous bolus versus continuous infusion chemotherapy with doxorubicin on weeks 1, 3, 5 and ifosfamide with mesna on weeks 2, 4, 6. Oral etoposide was given on days 1-5, 15-19, and 29-33. There was no ...

journal_title：Journal of cancer research and clinical oncology

authors： Anderson H,Prendiville J,Thatcher N,Radford JA,Swindell R

更新日期：1991-01-01 00:00:00

abstract：:This study was undertaken in order to compare the usefulness of three indices of tumour proliferation in detecting primary hepatocellular carcinoma (HCC) and in differentiating this neoplasm from liver cirrhosis. In 10 patients with HCC and in 63 with liver cirrhosis serum alpha-fetoprotein (AFP), tissue polypeptide a...

journal_title：Journal of cancer research and clinical oncology

authors： Leandro G,Basso D,Fabris C,Zizzari S,Elba S,Del Favero G,Di Mario F,Meggiato T,Angonese C,Naccarato R

更新日期：1989-01-01 00:00:00

abstract：:The extent of ethylation of guanine in 7 N and O 6 position in rat liver DNA was studied after chronic feeding with unlabelled nitrosodiethylamine followed by a single application of the 14C labelled drug. Disulfiram inhibits the alkylation of rat liver DNA. It was also shown that a discontinuous dosage of disulfiram ...

journal_title：Journal of cancer research and clinical oncology

authors： Frank N,Hadjiolov D,Bertram B,Wiessler M

更新日期：1980-01-01 00:00:00

abstract：:This report describes two types of reticular epithelial cell in the thymic cortex of the BALB/c mouse, an immature and a mature form. During early stages of lymphoma development, i.e., 2-6 weeks postinfection (p.i.) with Moloney leukemia virus (M-MuLV), activation of the epithelial cells is observed. Although the perc...

journal_title：Journal of cancer research and clinical oncology

authors： Heine UI,Krueger GR,Karpinski A,Munoz E,Krueger MB

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Cancer is a serious public health problem worldwide, and difficulty in early diagnosis has been the chief obstacle to improve the prognosis of patients. Recently, microRNAs (miRNAs) were widely studied to be potential biomarkers for cancer detection. miR-16 is a prevalent but sophisticated one. In the curren...

journal_title：Journal of cancer research and clinical oncology

authors： Huang Z,Chen W,Du Y,Guo Q,Mao Y,Zhou X,Hua D

更新日期：2019-03-01 00:00:00

abstract：:The ileal sarcomas induced in rats given diet containing bracken fern were examined microscopically and electron microscopically. These ileal sarcomas, which were induced at high incidence (80%-44%), have previously been identified as spindle cell fibrosarcomas. However, studies showed that they should be diagnosed as...

journal_title：Journal of cancer research and clinical oncology

authors： Ogino H,Fujimoto M,Hirono I

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Molecules which are exclusively or preferentially expressed by malignant cells are potential targets for immunotherapeutic approaches to the treatment of cancer. METHODS:We therefore tested serum samples of 95 patients with aggressive B-cell lymphomas for antibodies against lymphoma-associated molecules using ...

journal_title：Journal of cancer research and clinical oncology

authors： Zwick C,Held G,Hammermeister V,Alahmad A,Kubuschok B,Bittenbring J,Ahlgrimm M,Neumann F,Preuss KD,Pfreundschuh M

更新日期：2009-09-01 00:00:00

abstract：:Circulating blood cell counts, serum cortisol, proteins, alkaline phosphatase, carcinoembryonic antigen and CA15.3 displayed significant circadian rhythms in a group of 13 women with metastatic breast cancer. Statistical significance (P < 0.05) was assessed with both analysis of variance and cosinor analysis. All pati...

journal_title：Journal of cancer research and clinical oncology

authors： Touitou Y,Lévi F,Bogdan A,Benavides M,Bailleul F,Misset JL

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:With the increasing interest in treatment decision-making based on risk prediction models, it is essential for clinicians to understand the steps in developing and interpreting such models. METHODS:A retrospective registry of 20 Dutch hospitals with data on patients treated for castration-resistant prostate ca...

journal_title：Journal of cancer research and clinical oncology

authors： Veen KM,de Angst IB,Mokhles MM,Westgeest HM,Kuppen M,Groot CAU,Gerritsen WR,Kil PJM,Takkenberg JJM

更新日期：2020-08-01 00:00:00

abstract：:Targeted therapy refers to anticancer treatment which specifically targets key molecules of cancer cells and/or neovascular cells, aiming to thus interfere with processes of tumorigenesis, cancer progression and metastasis. The epidermal growth factor receptor (EGFR) was the first receptor to be proposed for targeted ...

journal_title：Journal of cancer research and clinical oncology

authors： Zahorowska B,Crowe PJ,Yang JL

更新日期：2009-09-01 00:00:00

abstract：:A short-term organ culture of rat tracheal epithelium was used to detect the ability of 53 chemicals to induce UDS. In this system all direct-acting compounds (ultimate or proximate carcinogens) tested induced UDS. Of 24 compounds requiring metabolism (procarcinogens), nine induced UDS, viz., 4NQO, AF-2, BP, DMN, DEN,...

journal_title：Journal of cancer research and clinical oncology

authors： Ide F,Ishikawa T,Takayama S

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:PTEN is an essential tumour suppressor gene which encodes a phosphatase protein that antagonises the PI3K/Akt/mTOR antiapoptotic pathway. Impairment of this tumour suppressor pathway potentially becomes a causal factor for development of malignancies. This review aims to assess current understanding of mechanis...

journal_title：Journal of cancer research and clinical oncology

authors： Lim HJ,Crowe P,Yang JL

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of concurrent radiochemotherapy in patients with stage III non-small cell lung cancer (NSCLC), and to examine the effect of hemoglobin levels on survival of those patients. The negative impact of anemia on survival has been noticed for other cancer sites including the head and neck, and...

journal_title：Journal of cancer research and clinical oncology

authors： Pradier O,Lederer K,Hille A,Weiss E,Christiansen H,Schmidberger H,Hess CF

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:RhoA and RhoC are closely related, small GTPases that are clearly involved in breast cancer tumorigenesis. Nonetheless, their specific roles in the control of estrogen receptor alpha (ERα) activities have not been elucidated. METHODS:We used siRNA sequences to specifically down-regulate RhoA and RhoC expressio...

journal_title：Journal of cancer research and clinical oncology

authors： Malissein E,Meunier E,Lajoie-Mazenc I,Médale-Giamarchi C,Dalenc F,Doisneau-Sixou SF

更新日期：2013-12-01 00:00:00

abstract：:A total of 27 persons, working in cancer stations with exposure to cytostatics, and 40 healthy control persons were examined for DNA single-strand breaks in peripheral lymphocytes. Non-smoking personnel from cancer stations were found to have an increased rate of DNA single-strand breaks compared to the non-smoking co...

journal_title：Journal of cancer research and clinical oncology

authors： Reitz M,Afghanyar S,Gutjahr P

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:In selected patients with rectal cancer, laparoscopic surgery is as safe as open surgery, with similar resection margins and completeness of resection. In addition, recovery is faster after laparoscopic surgery. We analyzed long-term outcomes in a group of patients with locally advanced rectal cancer (LARC) ...

journal_title：Journal of cancer research and clinical oncology

authors： Calvo FA,Sole CV,Serrano J,Rodriguez M,Marcos F,Muñoz-Calero A,Zorrilla J,Lopez-Baena JA,Diaz-Zorita B,García-Sabrido JL,del Valle E

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:Achievement of deep molecular response with a tyrosine kinase inhibitor in patients with chronic myeloid leukemia (CML) is required to attempt discontinuation of therapy in these patients. The current subanalysis from the Evaluating Nilotinib Efficacy and Safety in Clinical Trials as First-Line Treatment (ENEST...

journal_title：Journal of cancer research and clinical oncology

authors： Giles FJ,Rea D,Rosti G,Cross NCP,Steegmann JL,Griskevicius L,le Coutre P,Coriu D,Petrov L,Ossenkoppele GJ,Mahon FX,Saussele S,Hellmann A,Koskenvesa P,Brümmendorf TH,Gastl G,Castagnetti F,Vincenzi B,Haenig J,Hochhaus

更新日期：2017-08-01 00:00:00

abstract：:The effect of beta-cyclodextrin-benzaldehyde (CDBA) on experimental pulmonary metastasis in C3H/He mice was examined. In an in vitro assay, the growth of RCT(+) cells was inhibited by 1200 micrograms/ml CDBA using unrenewed media, and by 600 micrograms/ml CDBA in that using daily renewed media. When mice were treated ...

journal_title：Journal of cancer research and clinical oncology

authors： Ochiai H,Niwayama S,Masuyama K

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to summarize the accuracy of preoperative vascular invasion with endoscopic ultrasound (EUS) and computed tomography (CT) test performance in pancreatic cancer with meta-analysis METHOD:Two reviewers searched MEDLINE database to identify relevant studies. The reference lists o...

journal_title：Journal of cancer research and clinical oncology

authors： Yang R,Lu M,Qian X,Chen J,Li L,Wang J,Zhang Y

更新日期：2014-12-01 00:00:00

abstract：:The standard definition of platinum-resistant ovarian cancer or primary peritoneal carcinoma commonly includes patients whose disease initially responded to a platinum-based combination regimen, but recurred less than 6 months after the completion of primary therapy. Recent experience with several patients with these ...

journal_title：Journal of cancer research and clinical oncology

authors： Markman M,Kennedy A,Webster K,Kulp B,Peterson G,Belinson J

更新日期：1998-01-01 00:00:00

abstract：:Ovarian cancer is a leading cause of death among gynecologic malignancies. This disappointing prognosis is closely related to intrinsic or acquired resistance to conventional platinum-based chemotherapy, which can affect a third of patients. As such, investigating relevant molecular targets is crucial in the fight aga...

journal_title：Journal of cancer research and clinical oncology

authors： Gasparri ML,Besharat ZM,Farooqi AA,Khalid S,Taghavi K,Besharat RA,Sabato C,Papadia A,Panici PB,Mueller MD,Ferretti E

更新日期：2018-12-01 00:00:00