A case-control study of pancreatic carcinoma.

Abstract:

:The hospital records of 60 female and 56 male pancreatic cancer patients and 232 age-, race-, sex-, and hospital-matched controls were reviewed for evidence of prior thyroid disease, cholecystectomy, appendectomy, alcohol consumption and among females, for diseases for the endometrium and ovary. No statistically significant differences were detected between case and control groups. It may be of interest, however, that there were four patients with a history of thyrotoxicosis among the pancreatic cancer patients and only one in the control group. In females, a history of thyroidectomy was somewhat more common among the patients than the controls.

authors

Haines AP,Moss AR,Whittemore A,Quivey J

doi

10.1007/BF00410309

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

93-7

issue

1

eissn

0171-5216

issn

1432-1335

journal_volume

103

pub_type

杂志文章
  • Combined therapies for cancer: a review of EGFR-targeted monotherapy and combination treatment with other drugs.

    abstract::Targeted therapy refers to anticancer treatment which specifically targets key molecules of cancer cells and/or neovascular cells, aiming to thus interfere with processes of tumorigenesis, cancer progression and metastasis. The epidermal growth factor receptor (EGFR) was the first receptor to be proposed for targeted ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s00432-009-0622-4

    authors: Zahorowska B,Crowe PJ,Yang JL

    更新日期:2009-09-01 00:00:00

  • Contamination of autologous peripheral blood progenitor cell grafts predicts overall survival after high-dose chemotherapy in multiple myeloma.

    abstract:BACKGROUND:Despite of the introduction of novel treatment modalities for multiple myeloma, high-dose chemotherapy with hematopoietic stem-cell rescue is still considered the standard of care for eligible patients <65 years of age. As we have previously reported, stem-cell grafts regularly contain quantities of plasma c...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-008-0499-7

    authors: Kopp HG,Yildirim S,Weisel KC,Kanz L,Vogel W

    更新日期:2009-04-01 00:00:00

  • DNA adducts by N-nitroso compounds.

    abstract::Some unsolved problems in DNA alkylation by N-nitroso compounds are discussed in this overview. Does O6 alkylation of guanine represent the initiating event exclusively or are O4 alkylation of thymidine and phosphate triester formation also involved in the initiating process? Does the formation of rearranged DNA alkyl...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00404386

    authors: Wiessler M

    更新日期:1986-01-01 00:00:00

  • Malignant fibrous histiocytoma of the renal capsule.

    abstract::We report about an extremely rare case of malignant fibrous histiocytoma (MFH) of the renal capsule. The tumor is composed of fibroblast-like cells arranged in a storiform pattern and histiocyte-like cells with multinucleated giant cells, both showing no iron reaction. Characteristic of the histiocytic quality of the ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF00410689

    authors: Gabbert H,Wagner R,Becht E

    更新日期:1981-01-01 00:00:00

  • Regulation of the interferon system and cell growth by the IRF transcription factors.

    abstract::Induction of gene transcription in response to extracellular stimuli constitutes an essential aspect of host defense mechanisms. Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating the mechanism of t...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/BF01197763

    authors: Taniguchi T,Harada H,Lamphier M

    更新日期:1995-01-01 00:00:00

  • Carcinogenicity of vinylethylnitrosamine in Syrian golden hamsters.

    abstract::Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF00411342

    authors: Green U,Althoff J

    更新日期:1982-01-01 00:00:00

  • Surgically treated oropharyngeal cancer: risk factors and tumor characteristics.

    abstract:PURPOSE:To assess risk factors of patients with oropharyngeal squamous cell carcinoma in the Munich area of Southern Germany in relation to human papillomavirus (HPV) association of the tumors. To demonstrate differences in tumor characteristics and their impact on adjuvant treatment. METHODS:Between November 2010 and...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-014-1631-5

    authors: Baumeister P,Reiter M,Welz C,Becker S,Betz C,Harréus U

    更新日期:2014-06-01 00:00:00

  • Reversal of multidrug resistance by novel cyclosporin A analogues and the cyclopeptolide SDZ 214-103 biosynthesized in vitro.

    abstract::It was shown that cyclopeptolide SDZ 214-103 (10 microM) is more active in rhodamine-123 accumulation in actinomycin-D-resistant human lymphoma cells CCRF/ACTD400 than cyclosporin A (10 microM), but equipotent in the doxorubicin-resistant Friend erythroleukemia cell line F4-6/ADR. In F4-6/ADR cells, the 3-(4,5-dimethy...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF01212947

    authors: Schwabe K,Steinheider G,Lawen A,Traber R,Hildebrandt A

    更新日期:1995-01-01 00:00:00

  • Evolving the pulmonary nodules diagnosis from classical approaches to deep learning-aided decision support: three decades' development course and future prospect.

    abstract:PURPOSE:Lung cancer is the commonest cause of cancer deaths worldwide, and its mortality can be reduced significantly by performing early diagnosis and screening. Since the 1960s, driven by the pressing needs to accurately and effectively interpret the massive volume of chest images generated daily, computer-assisted d...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s00432-019-03098-5

    authors: Liu B,Chi W,Li X,Li P,Liang W,Liu H,Wang W,He J

    更新日期:2020-01-01 00:00:00

  • Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer.

    abstract:PURPOSE:Multidrug resistance (MDR) has been linked to sphingolipid metabolism and preclinical data ascribe glucosylceramide synthase (GCS) a major role for MDR especially in breast cancer cells but no profound data are available on the expression of this potential therapeutic target in clinical breast cancer specimens....

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-008-0436-9

    authors: Ruckhäberle E,Karn T,Hanker L,Gätje R,Metzler D,Holtrich U,Kaufmann M,Rody A

    更新日期:2009-01-01 00:00:00

  • Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb.

    abstract:BACKGROUND:The receptor for the cytokine TWEAK (TweakR) is a cell surface member of the tumor necrosis factor receptor superfamily with diverse biological roles. TNFRSF family members are appealing therapeutic targets in oncology due to their aberrant expression and function in tumor cells. The goal of the current stud...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-012-1332-x

    authors: Chao DT,Su M,Tanlimco S,Sho M,Choi D,Fox M,Ye S,Hsi ED,Durkin L,Yin J,Zhang Y,Kim H,Starling GC,Culp PA

    更新日期:2013-02-01 00:00:00

  • Circulating miR-125b is a novel biomarker for screening non-small-cell lung cancer and predicts poor prognosis.

    abstract:PURPOSE:MicroRNAs are small, non-coding RNAs that are critical regulators of various diseases including cancer, and may represent a novel class of cancer biomarkers. Recent reports have highlighted the oncogenic aspects of miR-125b. However, the level and clinical relevance of circulating miR-125b transcripts in human ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-012-1285-0

    authors: Yuxia M,Zhennan T,Wei Z

    更新日期:2012-12-01 00:00:00

  • Nationwide analysis on surgical procedures for patients with endometrial cancer in Germany: results of the AGO pattern of care studies from the years 2013, 2009, and 2006.

    abstract:PURPOSE:In 2013, 2009, and 2006, the Arbeitsgemeinschaft Gynäkologische Onkologie evaluated the therapeutic approaches and the adherence to their guidelines for endometrial carcinoma (EC) in Germany. Here, we present the results concerning the surgical procedures. METHODS:A questionnaire was developed and sent to 682 ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-014-1755-7

    authors: Battista MJ,Schmidt M,Rieks N,Steetskamp J,Sicking I,Lebrecht A,Koelbl H,Mallmann P,Hoffmann G,Steiner E

    更新日期:2014-12-01 00:00:00

  • Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels.

    abstract:PURPOSE:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and has been shown to induce extrinsic pathway of apoptosis in many types of cancer cells. AT-101, an (-)-enantiomer of gossypol, is a potent anticancer agent that is shown to be an inhibitor of Bcl-2/Bcl-XL. In t...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-012-1187-1

    authors: Kisim A,Atmaca H,Cakar B,Karabulut B,Sezgin C,Uzunoglu S,Uslu R,Karaca B

    更新日期:2012-07-01 00:00:00

  • Serum matrix metalloproteinase-2 in patients with malignant melanoma.

    abstract:PURPOSE:Matrix metalloproteinases (MMPs) are a family of structurally related zinc-dependent endopeptidases that are able to degrade extracellular matrix components. MMPs play a role in tumor invasion and tumor metastasis. MMP-2 (also known as gelatinase A) is expressed in human melanoma cells. METHODS:In this study, ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s004320100257

    authors: Wollina U,Hipler UC,Knöll B,Graefe T,Kaatz M,Kirsch K

    更新日期:2001-10-01 00:00:00

  • KDR expression is associated with the stage and cigarette smoking of the patients with lung cancer.

    abstract:PURPOSE:Kinase insert domain-containing receptor (KDR) is one of the molecular targets used in cancer therapy. We studied the KDR expression characteristics and the relationship with the clinical parameters of the patients with lung cancer, to give the basic evidence and clue for tailoring therapy. METHODS:Reverse tra...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-007-0214-0

    authors: An SJ,Nie Q,Chen ZH,Lin QX,Wang Z,Xie Z,Chen SL,Huang Y,Zhang AY,Yan JF,Wu HS,Lin JY,Li R,Zhang XC,Guo AL,Mok TS,Wu YL

    更新日期:2007-09-01 00:00:00

  • Positive expression of E-cadherin suppresses cell adhesion to fibronectin via reduction of alpha5beta1 integrin in human breast carcinoma cells.

    abstract::E-cadherin mainly mediated the epithelial cell-cell adhesion, and integrin signaling can modulate the signaling pathway of E-cadherin in the different levels. Up to now, however, it is still unclear that whether E-cadherin could interfere with cell-matrix interaction, a typical adhesion through integrins. In this stud...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-006-0128-2

    authors: Wu H,Liang YL,Li Z,Jin J,Zhang W,Duan L,Zha X

    更新日期:2006-12-01 00:00:00

  • 6-Methylguanine and 6-methylguanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line but not in other xeroderma pigmentosum and normal human fibroblast strains after treatment with 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyeth

    abstract::The XP cell strain XP29MA, its malignant counterpart XP29MAmal and a normal human fibroblast strain were tested for colony-forming ability after treatment with HECNU in the presence of m6G, m6Gua, and he7G. In XP29MAmal, inhibition of post-HECNU colony-forming ability was 35% when 0.25 mM of either m6G or m6Gua were p...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF00389969

    authors: Thielmann HW,Edler L,Müller N,Eisenbrand G

    更新日期:1987-01-01 00:00:00

  • Endometrial sampling devices for early diagnosis of endometrial lesions.

    abstract:PURPOSE:Endometrial carcinoma is the most common gynecologic malignancy in both developed and some developing countries. Unlike cervical cancer, for which there is routine screening, only patients symptomatic for endometrial carcinoma typically seek medical help for its diagnosis and treatment. Dilatation and curettage...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s00432-016-2215-3

    authors: Du J,Li Y,Lv S,Wang Q,Sun C,Dong X,He M,Ulain Q,Yuan Y,Tuo X,Batchu N,Song Q,Li Q

    更新日期:2016-12-01 00:00:00

  • Survivin gene-expression and splicing isoforms in oral squamous cell carcinoma.

    abstract:PURPOSE:Survivin, an inhibitor of apoptosis protein and a cell cycle regulator, has been detected in the majority of human cancers. Five splice variants (survivin, survivin-2alpha, survivin-2B, survivin-3B, and survivin-DeltaEx3) have been identified; their expressions have been investigated here. METHODS:By means of ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-008-0433-z

    authors: De Maria S,Pannone G,Bufo P,Santoro A,Serpico R,Metafora S,Rubini C,Pasquali D,Papagerakis SM,Staibano S,De Rosa G,Farina E,Emanuelli M,Santarelli A,Mariggiò MA,Lo Russo L,Lo Muzio L

    更新日期:2009-01-01 00:00:00

  • Elevated absolute NK cell counts in peripheral blood predict good prognosis in chronic lymphocytic leukemia.

    abstract:PURPOSE:The aim of this study was to investigate the prognostic significance of the absolute natural killer (NK) cell counts in peripheral blood in patients with chronic lymphocytic leukemia (CLL). METHODS:A total of 273 previously untreated patients with CLL from April 2004 and October 2015 were enrolled into this re...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-017-2568-2

    authors: Wang WT,Zhu HY,Wu YJ,Xia Y,Wu JZ,Wu W,Liang JH,Wang L,Fan L,Li JY,Xu W

    更新日期:2018-03-01 00:00:00

  • Distinct functional domains of PNMA5 mediate protein-protein interaction, nuclear localization, and apoptosis signaling in human cancer cells.

    abstract:PURPOSE:Members of paraneoplastic Ma (PNMA) family have been identified as onconeuronal antigens, which aberrant expressions in cancer cells of patients with paraneoplastic disorder (PND) are closely linked to manifestation of auto-immunity, neuro-degeneration, and cancer. The purpose of present study was to determine ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-016-2205-5

    authors: Lee YH,Pang SW,Poh CL,Tan KO

    更新日期:2016-09-01 00:00:00

  • The identification of a small but significant subset of patients still targetable with anti-HER2 inhibitors when affected by triple negative breast carcinoma.

    abstract:PURPOSE:Triple (ER-, PR-, HER2-) negative breast carcinoma lack targeted therapies, making this group of tumors difficult to treat. By definition, the lack of HER2 expression means a case scoring 0 or 1+ after immunophenotypical analysis and makes the patients avoiding therapeutical chances with anti-HER2 inhibitors. W...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-013-1479-0

    authors: Brunello E,Bogina G,Bria E,Vergine M,Zamboni G,Pedron S,Daniele I,Furlanetto J,Carbognin L,Marconi M,Manfrin E,Ibrahim M,Miller K,Tortora G,Molino A,Jasani B,Beccari S,Bonetti F,Chilosi M,Martignoni G,Brunelli M

    更新日期:2013-09-01 00:00:00

  • DNA adducts in experimental cancer research.

    abstract::The role of DNA adducts in the initiation of cancer is scrutinized in this presentation. Work on the activation of oncogenes, particularly on ras, has provided new evidence to link DNA adducts and tumour formation. Polycyclic hydrocarbons and nitroso compounds can cause activation of ras oncogenes through a defined po...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00395910

    authors: Hemminki K,Försti A,Mustonen R,Savela K

    更新日期:1986-01-01 00:00:00

  • Metabolic activation of aromatic amines and dialkylnitrosamines.

    abstract::Metabolic activation steps involved in carcinogenesis by several aromatic amines, their N-acetylated derivatives, and dialkylnitrosamines are reviewed. N-Hydroxylation is the first activation step in the carcinogenesis by 2-acetylaminofluorene (AAF), other aromatic amides and amines. The cytochrome P-450 enzyme system...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF00412448

    authors: Lotlikar PD

    更新日期:1981-01-01 00:00:00

  • Challenging the effectiveness of green tea in primary and tertiary cancer prevention.

    abstract:PURPOSE:Drinking green tea daily is part of Japanese culture, and various studies have revealed that green tea is a cancer preventive. We here review our progress in cancer prevention with green tea on 12 main topics, from basic to clinical level. TOPICS AND METHODS: Biochemical and biological studies of green tea cate...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s00432-012-1250-y

    authors: Fujiki H,Imai K,Nakachi K,Shimizu M,Moriwaki H,Suganuma M

    更新日期:2012-08-01 00:00:00

  • Liver metastases from colorectal cancer: propensity score-based comparison of stereotactic body radiation therapy vs. microwave ablation.

    abstract:PURPOSE:The study aim was to compare the disease control in two groups of patients affected by liver metastases from CRC treated with microwave ablation (MWA) or stereotactic body radiation therapy (SBRT). METHODS:We extracted data of patients treated between 2009 and 2016. Inclusion criteria were: (1) maximum diamete...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-018-2692-7

    authors: Franzese C,Comito T,Clerici E,Di Brina L,Tomatis S,Navarria P,Reggiori G,Viganò L,Poretti D,Pedicini V,Torzilli G,Solbiati L,Scorsetti M

    更新日期:2018-09-01 00:00:00

  • DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer.

    abstract:PURPOSE:Metastasis is a primary cause of colorectal cancer (CRC)-related death, and cancer stem cells (CSCs) are thought to be majorly responsible for initiating metastatic behaviors. Doublecortin-like kinase 1 (DCLK1) was recently discovered to be a marker for gastrointestinal CSCs. Here, we aimed to explore whether D...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-016-2218-0

    authors: Gao T,Wang M,Xu L,Wen T,Liu J,An G

    更新日期:2016-10-01 00:00:00

  • Spontaneous uterine adenocarcinomas in aged rats and their relation to endocrine imbalance.

    abstract::In addition to spontaneous uterine endometrial adenocarcinomas at a high incidence (35.1%), development of endometrial hyperplasia/adenoma was also frequently detected in rats of the Donryu strain. The total yield of all observed proliferative endometrial lesions was very high (60.6%). The tumors arose commonly in the...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF01637084

    authors: Nagaoka T,Onodera H,Matsushima Y,Todate A,Shibutani M,Ogasawara H,Maekawa A

    更新日期:1990-01-01 00:00:00

  • Re: Results of a randomized trial of treatment modalities in patients with low or early‑intermediate risk prostate cancer (PREFERE trial).

    abstract::The authors of this "Letter to the Editors" express their major concern about selective and biased reporting in this paper. ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 信件

    doi:10.1007/s00432-020-03499-x

    authors: Boehle A,Kahmann F,Henkel TO,Zimmermann J,Machtens S

    更新日期:2021-01-28 00:00:00