当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Spontaneous uterine adenocarcinomas in aged rats and their relation to endocrine imbalance.

Spontaneous uterine adenocarcinomas in aged rats and their relation to endocrine imbalance.

Abstract：

:In addition to spontaneous uterine endometrial adenocarcinomas at a high incidence (35.1%), development of endometrial hyperplasia/adenoma was also frequently detected in rats of the Donryu strain. The total yield of all observed proliferative endometrial lesions was very high (60.6%). The tumors arose commonly in the uterine horn of aged rats. Histologically, most demonstrated glandular structures, consisting of cuboidal or columnar cells with weak eosinophilic or basophilic cytoplasm and large nuclei. In about half of the animals with adenocarcinomas, metastasis to remote organs such as the lung was observed. Histological examination of the ovary and vaginal epithelium revealed ovarian cysts, atrophy of the ovary and cornification of the vaginal epithelium more frequently in rats with endometrial carcinomas than in animals without tumors. These findings indicate that adenocarcinoma development in Donryu rats is associated with endocrine imbalance [increased serum estrogen: progesterone (E2:P)ratios]. By comparative investigation of strain differences, it was confirmed that irregular estrous cycles began earlier with higher incidence in Donryu rats than in F344 rats, a low-incidence strain. Histological findings of the ovary and vaginal epithelium also suggested relatively increased estrogen levels in Donryu rats compared to F344 rats. Estimated plasma values of gonad steroids showed that the E2:P ratio in Donryu rats at 12 months of age was about five times that in F344 rats. These results therefore indicate that hormone imbalance, particularly an increased E2:P ratio, may play an important role in the spontaneous occurrence of endometrial adenocarcinoma in Donryu rats.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Nagaoka T,Onodera H,Matsushima Y,Todate A,Shibutani M,Ogasawara H,Maekawa A

doi

10.1007/BF01637084

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

623-8

issue

6

eissn

0171-5216

issn

1432-1335

journal_volume

116

pub_type

杂志文章

相关文献

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY文献大全
  • A clinician's guide for developing a prediction model: a case study using real-world data of patients with castration-resistant prostate cancer.

    abstract：PURPOSE:With the increasing interest in treatment decision-making based on risk prediction models, it is essential for clinicians to understand the steps in developing and interpreting such models. METHODS:A retrospective registry of 20 Dutch hospitals with data on patients treated for castration-resistant prostate ca...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s00432-020-03286-8

    authors： Veen KM,de Angst IB,Mokhles MM,Westgeest HM,Kuppen M,Groot CAU,Gerritsen WR,Kil PJM,Takkenberg JJM

    更新日期：2020-08-01 00:00:00

  • Androgen receptor (AR) expression is an independent unfavorable prognostic factor in gastric cancer.

    abstract：PURPOSE:To investigate the expression of sex steroid receptors in gastric cancer and to correlate their tumor expression profile with the clinicopathological parameters and overall survival of the patients. METHODS:Immunohistochemical methodology was employed in formalin-fixed paraffin-embedded sections from 86 patien...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-003-0531-x

    authors： Kominea A,Konstantinopoulos PA,Kapranos N,Vandoros G,Gkermpesi M,Andricopoulos P,Artelaris S,Savva S,Varakis I,Sotiropoulou-Bonikou G,Papavassiliou AG

    更新日期：2004-05-01 00:00:00

  • hIL-15-gene modified human natural killer cells (NKL-IL15) exhibit anti-human leukemia functions.

    abstract：PURPOSE:Natural killer (NK) cells can kill transformed cells and represent anti-tumor activities for improving the immunotherapy of cancer. In previous works, we established human interleukin-15 (hIL-15) gene-modified NKL cells (NKL-IL15) and demonstrated their efficiency against human hepatocarcinoma cells (HCCs) in v...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-018-2654-0

    authors： Jiang W,Zhang C,Tian Z,Zhang J

    更新日期：2018-07-01 00:00:00

  • Incidence and risk factors for morbidity and mortality in elderly head and neck cancer patients undergoing major oncological surgery.

    abstract：PURPOSE:Cancer incidence in the elderly population has been continuously rising, and their treatment is an increasing concern among oncologists. This study aimed to evaluate the incidence and risk factors for morbidity and mortality after major oncological surgery in elderly patients with head and neck squamous cell ca...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-016-2141-4

    authors： Yoo SH,Roh JL,Choi SH,Nam SY,Kim SY

    更新日期：2016-06-01 00:00:00

  • [Permeability of N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into tumor cells (author's transl)].

    abstract：:The uptake of tritiated N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into Ehrlich-Ascites-Tumor cells of mice was studied by means of the siliconoil-filtration technique. At 10 mM concentration no permeation of the metabolite into the tumor cells could be found within 5 min at 1 degrees C, while its congenors cyclop...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00406573

    authors： Lenssen U,Hohorst HJ

    更新日期：1979-02-19 00:00:00

  • Trofosfamide in the treatment of elderly or frail patients with diffuse large B-cell lymphoma.

    abstract：PURPOSE:The introduction of immunochemotherapy has led to a significant improvement in treatment results and prognosis of diffuse large B-cell non-Hodgkins lymphoma (DLBCL) both at initial diagnosis and in relapse. Trofosfamide, an oxazaphosphorine derivative, has been utilized as alternative treatment option for patie...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-018-2772-8

    authors： Witte HM,Riecke A,Mayer T,Bartscht T,Rades D,Lehnert H,Merz H,Fetscher S,Biersack H,Gebauer N

    更新日期：2019-01-01 00:00:00

  • Chemotherapeutic drugs change actin skeleton organization and the expression of beta-thymosins in human breast cancer cells.

    abstract：PURPOSE:Elevated expression of the beta-thymosin isotypes T beta(4), T beta(10), and T(15) appears to be involved in the manifestation of a malignant phenotype of human tumor cells, including those of mammary carcinomas. This has evoked an interest in these peptides as diagnostic/prognostic tumor markers. If increased ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-002-0332-7

    authors： Otto AM,Müller CS,Huff T,Hannappel E

    更新日期：2002-05-01 00:00:00

  • Prognostic impact of pretherapeutic laboratory values in head and neck cancer patients.

    abstract：PURPOSE:The high comorbidity in patients with head and neck cancer (HNC) is mainly caused by the high incidence of tobacco and alcohol abuse and has direct impact on overall survival. We investigated whether HNC and its comorbidity also influence routine laboratory values and whether these values have influence on over...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-012-1320-1

    authors： Peter F,Wittekindt C,Finkensieper M,Kiehntopf M,Guntinas-Lichius O

    更新日期：2013-01-01 00:00:00

  • Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer.

    abstract：PURPOSE:Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen. SLCO4A1 is highly expressed in several cancers and a gender bias has been observed in colorectal cancer ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-017-2393-7

    authors： Ban MJ,Ji SH,Lee CK,Bae SB,Kim HJ,Ahn TS,Lee MS,Baek MJ,Jeong D

    更新日期：2017-08-01 00:00:00

  • Immunohistochemical versus biochemical estrogen-receptor and progesterone-receptor analysis: correlation with histological parameters.

    abstract：:Human breast carcinomas were evaluated for estrogen and progesterone receptors by immunohistochemistry using monoclonal anti-receptor antibodies (n = 267) and by cytosol steroid-binding assays (n = 212). The estrogen and progesterone receptor contents of the tumors correlated with histological features of differentiat...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00400963

    authors： Helle M,Helin M,Isola J,Helin H

    更新日期：1989-01-01 00:00:00

  • Intra-hepatic cholangiocarcinoma--frequency and demographic patterns: thirty-year data from the M.D. Anderson Cancer Center.

    abstract：PURPOSE:Recent reports have shown an increase in frequency of intra-hepatic cholangiocarcinoma (IHC) with a stable or decreased frequency of extra-hepatic cholangiocarcinoma (EHC). However, data on the demographic patterns associated with this change are limited. We analyzed cases of cholangiocarcinoma (CC) with aim to...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-010-0971-z

    authors： Singal AK,Vauthey JN,Grady JJ,Stroehlein JR

    更新日期：2011-07-01 00:00:00

  • Renal cell cancer correlated with occupational exposure to trichloroethene.

    abstract：:A previous cohort-study in a cardboard factory demonstrated that high and prolonged occupational exposure to trichloroethene (C2HCl3) is associated with an increased incidence of renal cell cancer. The present hospital-based case/control study investigates occupational exposure in 58 patients with renal cell cancer wi...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320050186

    authors： Vamvakas S,Brüning T,Thomasson B,Lammert M,Baumüller A,Bolt HM,Dekant W,Birner G,Henschler D,Ulm K

    更新日期：1998-01-01 00:00:00

  • Inhibition of protein-kinase-C--dependent cell proliferation of human lung cancer cell lines by the dihydropyridine dexniguldipine.

    abstract：:The dihydropyridine, dexniguldipine hydrochloride (B859-35), has shown therapeutic activity in experimentally induced neuroendocrine hamster lung tumors and demonstrated antiproliferative effects in a mammary cancer cell line via inhibition of Ca2+ calmodulin. Studies in NIH 3T3 fibroblasts have provided evidence that...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01247460

    authors： Schuller HM,Orloff M,Reznik GK

    更新日期：1994-01-01 00:00:00

  • Demonstration of estrogen and progesterone receptors as well as Ki-67 and p-145 antigens in single tumor cells from blood and pleural effusions using a slide assay.

    abstract：:We describe a slide assay that allows the demonstration of antigens localized in the nucleus from isolated white blood cells as well as from single tumor cells derived from malignant effusions. With the antibodies Ki-67 and anti-p-145 an increased rate of nuclear and nucleolar staining resulted in cells from highly ma...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01625427

    authors： Hirsch FW,Deibert P,Busch H,Löhr GW,Bross KJ

    更新日期：1991-01-01 00:00:00

  • Patient-reported outcomes in the phase 3 BFORE trial of bosutinib versus imatinib for newly diagnosed chronic phase chronic myeloid leukemia.

    abstract：BACKGROUND:In the phase 3 BFORE trial (NCT02130557), treatment with bosutinib resulted in a significantly higher major molecular response rate at 12 months versus imatinib in the modified intent-to-treat (mITT) population of patients with newly diagnosed chronic phase chronic myeloid leukemia (CP CML). Assessment of pa...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00432-019-02894-3

    authors： Cortes JE,Gambacorti-Passerini C,Deininger MW,Mauro MJ,Chuah C,Kim DW,Milojkovic D,le Coutre P,Garcia-Gutierrez V,Crescenzo R,Mamolo C,Reisman A,Hochhaus A,Brümmendorf TH,BFORE Study Investigators.

    更新日期：2019-06-01 00:00:00

  • The age-adjusted Charlson comorbidity index as a predictor of overall survival of surgically treated non-metastatic clear cell renal cell carcinoma.

    abstract：PURPOSE:No study has evaluated the prognostic impact of the age-adjusted Charlson comorbidity index (AACI) in those with renal cell carcinoma (RCC). This study aimed to evaluate the utility of the AACI for predicting long-term survival in patients with surgically treated non-metastatic clear cell RCC (ccRCC). METHODS:...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00432-019-03042-7

    authors： Kang HW,Kim SM,Kim WT,Yun SJ,Lee SC,Kim WJ,Hwang EC,Kang SH,Hong SH,Chung J,Kwon TG,Kim HH,Kwak C,Byun SS,Kim YJ,KORCC (KOrean Renal Cell Carcinoma) Group.

    更新日期：2020-01-01 00:00:00

  • Challenging the effectiveness of green tea in primary and tertiary cancer prevention.

    abstract：PURPOSE:Drinking green tea daily is part of Japanese culture, and various studies have revealed that green tea is a cancer preventive. We here review our progress in cancer prevention with green tea on 12 main topics, from basic to clinical level. TOPICS AND METHODS: Biochemical and biological studies of green tea cate...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s00432-012-1250-y

    authors： Fujiki H,Imai K,Nakachi K,Shimizu M,Moriwaki H,Suganuma M

    更新日期：2012-08-01 00:00:00

  • Allelic loss on chromosome 5q34 is associated with poor prognosis in hepatocellular carcinoma.

    abstract：PURPOSE:To identify and characterize novel genetic alterations in hepatocellular carcinoma (HCC). METHODS:DNA was extracted from 29 HCC and corresponding normal tissues and amplified with 59 different 10-base arbitrary primers. A 550 bp DNA fragment amplified using primer Q-9 and which was present in 19 of 29 cases (6...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-008-0379-1

    authors： Saelee P,Wongkham S,Bhudhisawasdi V,Sripa B,Chariyalertsak S,Petmitr S

    更新日期：2008-10-01 00:00:00

  • MicroRNA-155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1.

    abstract：PURPOSE:MicroRNAs (miRs) have been frequently reported dysregulating in tumors and playing a crucial role in tumor development and progression. However, the expression of miR-155 and its role in gastric cancer (GC) are still obscure. METHODS:qRT-PCR was applied to detect miR-155 expression in 60 matched GC samples and...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-016-2139-y

    authors： Ma Z,Ma Y,Xia Q,Li Y,Li R,Chang W,Chen J,Leng Z,Tao K

    更新日期：2016-06-01 00:00:00

  • Effect of tobacco smoking on various histological types of lung cancer.

    abstract：:In a population-based case/control study the differential lung cancer risk patterns due to tobacco smoking habits of various histological types have been investigated. The cases were 1432 deaths from lung cancer in the years 1980-1987, of which the histological type was known for 627 individuals. There was 54% squamou...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01208616

    authors： Jedrychowski W,Becher H,Wahrendorf J,Basa-Cierpialek Z,Gomola K

    更新日期：1992-01-01 00:00:00

  • Augmented antitumour effects of combination therapy with TNP-470 and chemoimmunotherapy in mice.

    abstract：PURPOSE:To investigate antitumour efficacy of the combination of the antiangiogenic agent TNP-470 combined with chemoimmunotherapy in different tumour models in mice MATERIALS:B6D2F1 mice and BALB/c mice were inoculated in the footpad of the right hind limb with B16F10 melanoma cells or colon adenocarcinoma cells C-26...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-002-0356-z

    authors： Dabrowska-Iwanicka A,Olszewska D,Jalili A,Makowski M,Grzela T,Marczak M,Hoser G,Giermasz A,Golab J,Jakóbisiak M

    更新日期：2002-08-01 00:00:00

  • A phase III, open label, randomized multicenter controlled trial of oral versus intravenous treosulfan in heavily pretreated recurrent ovarian cancer: a study of the North-Eastern German Society of Gynecological Oncology (NOGGO).

    abstract：OBJECTIVE:In recurrent ovarian cancer (ROC), there is a high demand on effective therapies with a mild toxicity profile. Treosulfan is an alkylating agent approved as oral (p.o.) and intravenous (i.v.) formulation for the treatment of recurrent ovarian cancer. Data on safety and efficacy for either formulation are rare...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00432-016-2307-0

    authors： Sehouli J,Tomè O,Dimitrova D,Camara O,Runnebaum IB,Tessen HW,Rautenberg B,Chekerov R,Muallem MZ,Lux MP,Trarbach T,Gitsch G

    更新日期：2017-03-01 00:00:00

  • Establishment and characterization of a new cell line (VHB-1) derived from a primary breast carcinoma.

    abstract：:A continuous line of human breast carcinoma cells, VHB-1, was established in culture following collagenase treatment of an infiltrating duct cell carcinoma. The cells displayed an epithelial pattern and multiplied rapidly. Maintained in monolayer culture, the VHB-1 cells exhibited a 30-h doubling time and a plating ef...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00390864

    authors： Vandewalle B,Collyn d'Hooghe M,Savary JB,Vilain MO,Peyrat JP,Deminatti M,Delobelle-Deroide A,Lefebvre J

    更新日期：1987-01-01 00:00:00

  • Gastric and intestinal phenotypic cell marker expressions in gastric differentiated-type carcinomas: association with E-cadherin expression and chromosomal changes.

    abstract：:Gastric and intestinal phenotypic cell markers are widely expressed in gastric carcinomas, irrespective of their histological type. In the present study, the relations between the phenotypic marker expression of the tumour, histological findings, expression of cell adhesion molecules, and the chromosomal changes in ga...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-005-0062-8

    authors： Morohara K,Tajima Y,Nakao K,Nishino N,Aoki S,Kato M,Sakamoto M,Yamazaki K,Kaetsu T,Suzuki S,Tsunoda A,Tachikawa T,Kusano M

    更新日期：2006-06-01 00:00:00

  • Alterations in cyclin D1 expression in esophageal squamous cell carcinoma in the Indian population.

    abstract：PURPOSE:The p16/cyclin D1/pRb pathway plays a critical role in tumourigenesis. We recently reported alterations in expression of tumour suppressor gene products, p16 and pRb in esophageal cancer. Knowledge of alterations in cyclin D1, a vital component of this pathway in esophageal carcinomas from the Indian subcontine...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320000185

    authors： Mathew R,Arora S,Khanna R,Shukla NK,Mathur M,Ralhan R

    更新日期：2001-04-01 00:00:00

  • Discrepancies between radiological and histological findings in preoperative core needle (CNB) and vacuum-assisted (VAB) breast biopsies.

    abstract：BACKGROUND:Ultrasound (US)-guided breast biopsy is a routine diagnostic method used to correlate imaging finding to a histological diagnosis which is still the gold standard in preoperative diagnostics. The accuracy of US-guided breast biopsies relies on a precise radiologic-histopathologic correlation, which is discus...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-020-03481-7

    authors： Jörg I,Wieler J,Elfgen C,Bolten K,Hutzli C,Talimi J,Vorburger D,Choschzick M,Moskovszky L,Dedes K,Varga Z

    更新日期：2020-12-07 00:00:00

  • A low dose of ionizing radiation increases luminal release of intestinal peptidases in rats.

    abstract：PURPOSE:Mucosal inflammation in the small intestine is a potentially hazardous side effect of abdominal irradiation. In an effort to develop a quantitative method of evaluating mucosal damage, the luminal release of brush border enzymes in response to ionizing radiation was examined using two investigational strategies...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320000174

    authors： Fittkau M,Grothey A,Gerlach R,Schmoll HJ

    更新日期：2001-02-01 00:00:00

  • Antisense Tcf inhibits the neoplastic growth of liver cancer cells.

    abstract：PURPOSE:T cell transcription factors are nuclear effectors of the Wnt signaling transduction pathway and play crucial roles in embryonic and malignant development. Our previous study showed increased expression level of Tcf mRNA in liver cancer. In the present paper, antisense Tcf RNA was used to explore the possible t...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-004-0580-9

    authors： Jiang Y,Zhou XD,Liu YK,Huang XW,Zhao Y,Xue Q,Sun RX,Chen J,Wu X

    更新日期：2004-11-01 00:00:00

  • Determination of a fragment of the c-erbB-2 translational product p185 in serum of breast cancer patients.

    abstract：:Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer pa...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01212719

    authors： Kynast B,Binder L,Marx D,Zoll B,Schmoll HJ,Oellerich M,Schauer A

    更新日期：1993-01-01 00:00:00

  • Association between polymorphisms in genes related to DNA base-excision repair with risk and prognosis of oropharyngeal squamous cell carcinoma.

    abstract：PURPOSE:We examined the influence of OGG1 c.977C>G (rs1052133), APEX1 c.444T>G (rs1130409), XRCC1 c.-77T>C (rs3213245), c.580C>T (rs1799782), c.839G>A (rs25489) and c.1196G>A (rs25487) single-nucleotide polymorphisms (SNPs), involved in base-excision repair (BER) pathway, on oropharyngeal squamous cell carcinoma (OPSCC...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-016-2202-8

    authors： Costa EF,Santos ES,Liutti VT,Leal F,Santos VC,Rinck-Junior JA,Mariano FV,Coutinho-Camillo CM,Altemani A,Lima CS,Lourenço GJ

    更新日期：2016-09-01 00:00:00