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A low dose of ionizing radiation increases luminal release of intestinal peptidases in rats.

Abstract：

PURPOSE:Mucosal inflammation in the small intestine is a potentially hazardous side effect of abdominal irradiation. In an effort to develop a quantitative method of evaluating mucosal damage, the luminal release of brush border enzymes in response to ionizing radiation was examined using two investigational strategies. METHODS:First, a 20 cm segment of the proximal jejunum was perfused in situ and enzymatic activities within the perfusates were evaluated. In a second approach, enzymatic activities were directly evaluated in isolated brush border membranes from the jejunal mucosa. RESULTS:Most of the peptidase activities measured were increased in the perfusates 1 day after irradiation and had returned to control levels at 4 days. In the brush border membranes, some enzyme activities decreased at 1 day and were, with the exception of leucineaminopeptidase (LAP), similar to control levels at 4 days. CONCLUSIONS:LAP is more strongly affected by radiation than the transmembranously bounded enzymes.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Fittkau M,Grothey A,Gerlach R,Schmoll HJ

doi

10.1007/s004320000174

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

96-100

issue

2

eissn

0171-5216

issn

1432-1335

journal_volume

127

pub_type

杂志文章

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