Minor role of lipid peroxidation in acute bleomycin toxicity in rats.

abstract：PURPOSE:In 2008, we reported that 10 Japanese-size cups of green tea daily, supplemented with tablets of green tea extract (GTE), reduced the recurrence of colorectal adenoma by 51.6% in patients after polypectomy. Based on these results, we paid special attention to Japanese cancer patients, who consume green tea ever...

journal_title：Journal of cancer research and clinical oncology

authors： Fujiki H,Sueoka E,Watanabe T,Suganuma M

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:The N-myc downstream regulated gene 1 (NDRG1)/Cap43 is overexpressed in multiple cancer types, including lung cancer. In this study, we investigated the expression of NDRG1/Cap43 in lung cancer tissues and in serum from 90 lung cancer patients and 60 healthy controls. MATERIALS AND METHODS:Ninety patients with...

journal_title：Journal of cancer research and clinical oncology

authors： Wang D,Tian X,Jiang Y

更新日期：2012-11-01 00:00:00

abstract：:The chemotherapeutic action of tegafur (FT) against adenocarcinoma 755 in mice was markedly potentiated by oral administration of L-cysteine and L-cystine without increasing its toxicity. In particular, the combination of FT at 200 mg/kg per day (maximum dose) and 1000 mg/kg per day of L-cystine markedly inhibited tum...

journal_title：Journal of cancer research and clinical oncology

authors： Iigo M,Hoshi A,Kitagawa H

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To investigate the effect of a monoclonal antibody (CH12), targeted against epidermal growth factor receptor type III variant (EGFRvIII), on human ovarian cancer cells when administered in combination with cisplatin chemotherapy. METHODS:Western blot and reverse transcription polymerase chain reaction (RT-PCR)...

journal_title：Journal of cancer research and clinical oncology

authors： Li N,Chu Y,Yao L,Ying X,Jiang H,Zhou M,Xu C

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Stathmin (Oncoprotein18), a ubiquitous and highly conserved 19-kDa cytosolic phosphoprotein, has been reported to play a critical role in mitosis and possibly other cellular processes, which is associated with tumor carcinogenesis and development. The purpose of this study was to examine the involvement of stat...

journal_title：Journal of cancer research and clinical oncology

authors： Xi W,Rui W,Fang L,Ke D,Ping G,Hui-Zhong Z

更新日期：2009-06-01 00:00:00

abstract：:Second-line intraperitoneal (i.p.) therapy has been demonstrated to result in surgically defined complete responses (S-CR) in 25%-40% of patients with small-volume residual ovarian cancer (microscopic disease or largest tumor mass less than 1 cm in diameter). To evaluate the influence of the surgical finding of diffus...

journal_title：Journal of cancer research and clinical oncology

authors： Markman M,Reichman B,Hakes T,Barakat R,Curtin J,Rubin S,Jones W,Lewis JL Jr,Almadrones L,Hoskins W

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:In stomach adenocarcinoma, the role of the hormonal receptor, estrogen receptor (ER), has been controversial. Recently, a new estrogen receptor, called estrogen receptor beta (ER beta), was found to be expressed in various tissues including normal gastrointestinal tract. In this paper, the expression of ER beta...

journal_title：Journal of cancer research and clinical oncology

authors： Matsuyama S,Ohkura Y,Eguchi H,Kobayashi Y,Akagi K,Uchida K,Nakachi K,Gustafsson JA,Hayashi S

更新日期：2002-06-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF alpha) exerts cytotoxic and antiproliferative effects on neoplastic cells. It has been used as a therapeutic agent for solid tumours and haematological malignancies. We report on the ex vivo determination of the effect of recombinant human rhuTNF alpha on bone marrow aspirates by a br...

journal_title：Journal of cancer research and clinical oncology

authors： Kleine HD,Wagner U,Poliwoda H,Freund M

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:The incidence and mortality of gastric and colorectal cancers are among the highest malignant tumors in China. The aim of this study is to investigate whether variations of the human oxoguanine glycosylase 1 (hOGG1) gene are related to the risk of gastric and colorectal cancers in the Chinese population. METHO...

journal_title：Journal of cancer research and clinical oncology

authors： Liu X,Xiao N,Guo W,Wu Y,Cai Z,He Q,Zhang L,Chen X,Sun C,Wang J,Zhu C,Jin H,Wang Y

更新日期：2011-10-01 00:00:00

abstract：:In order to evaluate the preventive efficacy, safety and usefulness of mesna (Sodium 2-mercaptoethane sulfonate) against ifosfamide-induced urinary disorders, a placebo-controlled double-blind comparative study was performed. Ifosfamide was administered by intravenous drip infusion at a daily dose of 2 g/m2 for 5 cons...

journal_title：Journal of cancer research and clinical oncology

authors： Fukuoka M,Negoro S,Masuda N,Furuse K,Kawahara M,Kodama N,Ikegami H,Nakamura S,Nishio H,Ohnoshi T

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To elucidate the effect of tumor oxygenation status on recovery from damage following gamma-ray or accelerated carbon ion irradiation in vivo, including in quiescent (Q) cells. METHODS:SCC VII tumor-bearing mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. They r...

journal_title：Journal of cancer research and clinical oncology

authors： Masunaga S,Hirayama R,Uzawa A,Kashino G,Suzuki M,Kinashi Y,Liu Y,Koike S,Ando K,Ono K

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To study pre-treatment serum VEGF of patients with invasive cervical cancer and its possible role as prognostic indicator. METHODS:VEGF was measured using ELISA in the largest patient group (n = 167) to date. RESULTS:Serum VEGF was significantly higher in advanced tumor stage (P = 0.01), large tumor size (tum...

journal_title：Journal of cancer research and clinical oncology

authors： Zusterzeel PL,Span PN,Dijksterhuis MG,Thomas CM,Sweep FC,Massuger LF

更新日期：2009-02-01 00:00:00

abstract：:Two human melanoma xenografts were compared with respect to their in vivo growth and metastatic potentials as well as glycosaminoglycan patterns. The less differentiated HT 168 tumor showed faster growth at primary sites and a more pronounced capacity for metastasis into the liver. Although chondroitin sulfate was the...

journal_title：Journal of cancer research and clinical oncology

authors： Timár J,Kovalszky I,Paku S,Lapis K,Kopper L

更新日期：1989-01-01 00:00:00

abstract：:Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer pa...

journal_title：Journal of cancer research and clinical oncology

authors： Kynast B,Binder L,Marx D,Zoll B,Schmoll HJ,Oellerich M,Schauer A

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to explore the demographics, multimodality therapeutic outcomes*** and prognostic factors in sinonasal rhabdomyosarcoma (SNRMS). METHODS:We conducted a retrospective analysis of 40 patients who underwent treatment of SNRMS from March 2007 to March 2018. The Kaplan-Meier method ...

journal_title：Journal of cancer research and clinical oncology

authors： Li W,Lu H,Wang D

更新日期：2019-11-01 00:00:00

abstract：INTRODUCTION:Pancreatic adenocarcinoma (PAAD) is among the deadliest forms of cancer globally. Carbonic anhydrase 12 (CA12) is known to play central roles in regulating many cancers, but its function in the context of PAAD is rarely discussed. This study was, therefore, designed to assess the expression of CA12 in PAAD...

journal_title：Journal of cancer research and clinical oncology

authors： Du Y,Xin Z,Liu T,Xu P,Mao F,Yao J

更新日期：2021-01-02 00:00:00

abstract：INTRODUCTION:Tumor detection and visualization plays a key role in the clinical workflow of a patient with suspected cancer, both in the diagnosis and treatment. Several optical imaging techniques have been evaluated for guidance during oncological interventions. Optical coherence tomography (OCT) is a technique which ...

journal_title：Journal of cancer research and clinical oncology

authors： van Manen L,Dijkstra J,Boccara C,Benoit E,Vahrmeijer AL,Gora MJ,Mieog JSD

更新日期：2018-10-01 00:00:00

abstract：:The primary objective of this study was to determine the response rate of patients with metastatic colorectal cancer to combined therapy with 5-fluorouracil (5-FU), leucovorin, and intravenous azidothymidine (AZT), a thymidine nucleoside analog. By itself, AZT has limited antineoplastic efficacy. However, experimental...

journal_title：Journal of cancer research and clinical oncology

authors： Clark J,Sikov W,Cummings F,Browne M,Akerley W,Wanebo H,Weitberg A,Kennedy T,Cole B,Bigley J,Beitz J,Darnowski J

更新日期：1996-01-01 00:00:00

abstract：:The epoxide hydratase inhibitor, 1,1,1-trichloro-2,3-propene oxide (TCPO) in combination with benzo[a]pyrene (B[a]P) was injected s.c. in ddN mice. The formation of fibrosarcoma by B[a]P was slightly accelerated at low dose of TCPO, and remarkably inhibited at high dose of TCPO. The correlation of carcinogenesis with ...

journal_title：Journal of cancer research and clinical oncology

authors： Kodama M,Ioki Y,Nagata C

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the frequency of second primary non-breast cancer after breast cancer diagnosis and treatment, and its correlation with clinicopathological features. METHODS:Data from 21,527 patients with primary breast cancer were collected retrospectively in a single cancer centre; 4.1% o...

journal_title：Journal of cancer research and clinical oncology

authors： Corso G,Veronesi P,Santomauro GI,Maisonneuve P,Morigi C,Peruzzotti G,Intra M,Sacchini V,Galimberti V

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:The detection of disseminated tumor cells in the bone marrow (DTC-BM) of breast cancer patients is an independent prognostic factor. In recent years, the focus of research was on finding methods for the detection of circulating tumor cells (CTC) in peripheral blood (PB). In this study, we investigated the prese...

journal_title：Journal of cancer research and clinical oncology

authors： Schindlbeck C,Andergassen U,Hofmann S,Jückstock J,Jeschke U,Sommer H,Friese K,Janni W,Rack B

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:Solitary plasmacytoma (SP) is characterized by a single mass of clonal plasma cells. Definitive RT can result in long-term local control of the SP. Due to the small number of patients and narrow range of doses, phase III randomized trials are lacking. The aim of this study is to further support the potential...

journal_title：Journal of cancer research and clinical oncology

authors： Alghisi A,Borghetti P,Maddalo M,Roccaro AM,Tucci A,Mazzola R,Magrini SM,Lo Casto A,Bonù ML,Tomasini D,Pasinetti N,Peretto G,Bertagna F,Tomasi C,Buglione M,Triggiani L

更新日期：2020-11-17 00:00:00

abstract：:In the human gastric adenocarcinoma cell line AGS the effects of the protein-kinase-C-activating phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), the protein kinase C inhibitor staurosporine, the adenylate-cyclase activating agent forskolin, and the permeable dibutyryl-adenosine 3',5'-monophosphate (Bt2cAMP) ...

journal_title：Journal of cancer research and clinical oncology

authors： Piontek M,Hengels KJ,Porschen R,Strohmeyer G

更新日期：1993-01-01 00:00:00

abstract：:In 361 Sprague-Dawley rats autochthonous colorectal carcinomas were induced by intrarectal application of the carcinogen AMMN. Tumor-bearing animals were treated with a synthetic thioether-lysophospholipid (TLP) derivative and in combination chemotherapy with 5-fluorouracil (5-FU) and carmustine (BCNU). There was no d...

journal_title：Journal of cancer research and clinical oncology

authors： Heim ME,Swoboda M,Pahlke W,Edler L,Bicker U

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:To investigate antitumour efficacy of the combination of the antiangiogenic agent TNP-470 combined with chemoimmunotherapy in different tumour models in mice MATERIALS:B6D2F1 mice and BALB/c mice were inoculated in the footpad of the right hind limb with B16F10 melanoma cells or colon adenocarcinoma cells C-26...

journal_title：Journal of cancer research and clinical oncology

authors： Dabrowska-Iwanicka A,Olszewska D,Jalili A,Makowski M,Grzela T,Marczak M,Hoser G,Giermasz A,Golab J,Jakóbisiak M

更新日期：2002-08-01 00:00:00

abstract：:Circulating blood cell counts, serum cortisol, proteins, alkaline phosphatase, carcinoembryonic antigen and CA15.3 displayed significant circadian rhythms in a group of 13 women with metastatic breast cancer. Statistical significance (P < 0.05) was assessed with both analysis of variance and cosinor analysis. All pati...

journal_title：Journal of cancer research and clinical oncology

authors： Touitou Y,Lévi F,Bogdan A,Benavides M,Bailleul F,Misset JL

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:In this study we investigated the effect of Taxol, radiation, or Taxol plus radiation on highly proliferative normal tissue--the intestinal crypt cells of Swiss albino mice. MATERIALS AND METHODS:Swiss-albino mice, 3-4 months old, were used in this study. Taxol was administered by bolus intravenously through t...

journal_title：Journal of cancer research and clinical oncology

authors： Ozkan L,Ozuysal S,Egeli U,Adim SB,Tunca B,Aydemir N,Ceçener G,Ergül E,Akpinar G,Cimen C,Engin K,Ahmed MM

更新日期：2001-07-01 00:00:00

abstract：:The carcinogenic effectiveness of nitrosomethyl-n-butylamine,-n-hexylamine and -n-heptylamine was compared by administration to F344 rats at various concentrations in drinking water and by gavage in oil. Nitrosomethylbutylamine induced only tumors of the upper gastrointestinal tract, and was very toxic. Nitrosomethylh...

journal_title：Journal of cancer research and clinical oncology

authors： Lijinsky W,Reuber MD,Singer GM

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Several reports describe the importance of the chaperone HSP27 (HSPB1) in cancer progression, and the demand for drugs that modulate HSPB1-activity is increasing rapidly. We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in pancreatic cancer. METH...

journal_title：Journal of cancer research and clinical oncology

authors： Heinrich JC,Tuukkanen A,Schroeder M,Fahrig T,Fahrig R

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:To determine the potential involvement of ANXA1 in oral squamous-cell carcinoma (OSCC), we evaluated the ANXA1 protein expression in oral premalignant lesions (OPLs) and OSCCs and correlated the results with clinicopathologic variables. METHODS:Matched normal and tumour specimens of 44 primary OSCCs and 28 OPL...

journal_title：Journal of cancer research and clinical oncology

authors： Nomura H,Uzawa K,Yamano Y,Fushimi K,Nakashima D,Kouzu Y,Kasamatsu A,Ogawara K,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

更新日期：2009-07-01 00:00:00