Induction of tumors of the esophagus in rats by nitrosomethylalkylamines.

abstract：PURPOSE:Long interspersed nuclear element 1 (LINE-1 or L1) is a dominant non-long terminal repeat (non-LTR) retrotransposon in the human genome that has been implicated in the overexpression of MET. Both the canonical MET and L1-MET transcripts are considered to play a role in hepatocellular carcinoma (HCC) development...

journal_title：Journal of cancer research and clinical oncology

authors： Rashed WM,Kandeil MA,Mahmoud MO,Maher D,Ezzat S,Abdel-Rahman MH

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Mevalonate pathway inhibitors are potentially useful chemotherapeutic agents showing growth inhibition and pro-apoptotic effects in cancer cells. The effects of statins and bisphosphonates on cancer growth are attributed to a reduction in protein isoprenylation. Post-translational modification and activation of...

journal_title：Journal of cancer research and clinical oncology

authors： Garnett DJ

更新日期：2016-03-01 00:00:00

abstract：:The purpose of this study was to examine the structure/activity relationships of a series of substituted benzamides as poly(ADP-ribose) polymerase inhibitors. The experimental approach has involved the use of in vitro and in vivo assays in order to gather information either on the intrinsic activity of the benzamides ...

journal_title：Journal of cancer research and clinical oncology

authors： Sestili P,Spadoni G,Balsamini C,Scovassi I,Cattabeni F,Duranti E,Cantoni O,Higgins D,Thomson C

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Tumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation. METHODS:TNBC patients (n = 179) with complete clinical data and up to 18-year follow-up...

journal_title：Journal of cancer research and clinical oncology

authors： Vihervuori H,Autere TA,Repo H,Kurki S,Kallio L,Lintunen MM,Talvinen K,Kronqvist P

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Results from in vitro chemosensitivity testing recommend treosulfan/gemcitabine chemotherapy for the treatment of stage IV uveal melanoma. METHODS:Twenty patients received treosulfan 3,500 mg/m2 followed by gemcitabine 1,000 mg/m2 on day 1 and day 8 repeated on day 29. In cases of prior chemotherapy only 75% o...

journal_title：Journal of cancer research and clinical oncology

authors： Terheyden P,Bröcker EB,Becker JC

更新日期：2004-07-01 00:00:00

abstract：:The uptake of tritiated N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into Ehrlich-Ascites-Tumor cells of mice was studied by means of the siliconoil-filtration technique. At 10 mM concentration no permeation of the metabolite into the tumor cells could be found within 5 min at 1 degrees C, while its congenors cyclop...

journal_title：Journal of cancer research and clinical oncology

authors： Lenssen U,Hohorst HJ

更新日期：1979-02-19 00:00:00

abstract：:DNA repair is an important process. It is as essential for the cell as is transcription and replication. There is evidence that deficient DNA repair processes lead to human disease including cancer, and recent progress in the field of DNA repair is likely to expand our knowledge about these relationships considerably....

journal_title：Journal of cancer research and clinical oncology

authors： Bohr VA

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Pancreatic adenocarcinoma (PAAD) is among the deadliest forms of cancer globally. Carbonic anhydrase 12 (CA12) is known to play central roles in regulating many cancers, but its function in the context of PAAD is rarely discussed. This study was, therefore, designed to assess the expression of CA12 in PAAD...

journal_title：Journal of cancer research and clinical oncology

authors： Du Y,Xin Z,Liu T,Xu P,Mao F,Yao J

更新日期：2021-01-02 00:00:00

abstract：:The effect of a single blood transfusion on the formation and outgrowth of experimental lung metastases was assessed in two tumor models in rats. The transfusions were given either 1 week before (day -7) or 1 week after (day +7) tumor cell inoculation. The first approach was performed to investigate the effect of tran...

journal_title：Journal of cancer research and clinical oncology

authors： Marquet RL,de Bruin RW,Dallinga RJ,Singh SK,Jeekel J

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor that usually occurs in infants. It is commonly associated with Kasabach-Merritt phenomenon which is directly responsible for the significant morbidity and mortality, including hemodynamic instability, local invasion, and compression...

journal_title：Journal of cancer research and clinical oncology

authors： Kai L,Wang Z,Yao W,Dong K,Xiao X

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:To study the interplay of drugs and energy metabolism of tumor cells, metabolic changes induced by chloroacetaldehyde and cytochalasin B were analyzed in colon carcinoma cells LS174T. METHODS:O(2)-consumption and extracellular acidification were recorded using a bioelectronic sensor-chip system, which monitors...

journal_title：Journal of cancer research and clinical oncology

authors： Motrescu ER,Otto AM,Brischwein M,Zahler S,Wolf B

更新日期：2005-10-01 00:00:00

abstract：:In this study, lipid peroxide and total sulfhydryl contents and activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were investigated in the plasma of patients with benign prostatic hyperplasia (BPH) and prostate cancer. No significant change was found in lipid peroxidation or an...

journal_title：Journal of cancer research and clinical oncology

authors： Doğru-Abbasoğlu S,Aykaç-Toker G,Koçak T,Unlüer E,Uysal M

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Lysine-specific demethylase 1 (LSD1) was highly expressed in several malignancies and had been implicated in pathological processes of cancer cells. However, the role of LSD1 in colorectal cancer (CRC) carcinogenesis, prognosis and treatment remains uncharacterized. METHODS:In this study, we examined LSD1 expr...

journal_title：Journal of cancer research and clinical oncology

authors： Hsu HC,Liu YS,Tseng KC,Yang TS,Yeh CY,You JF,Hung HY,Chen SJ,Chen HC

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Serum low molecular weight protein biomarkers might be important in relation to portal vein tumor thrombi (PVTT) in hepatocellular carcinoma (HCC). This study aimed to screen and to detect these biomarkers. METHODS:We selected sera of 3 groups from 12 healthy volunteers, 12 HCC patients without PVTT and 12 HCC...

journal_title：Journal of cancer research and clinical oncology

authors： Qiu JG,Fan J,Liu YK,Zhou J,Dai Z,Huang C,Tang ZY

更新日期：2008-03-01 00:00:00

abstract：:Ascites tumor cells (2 X 10(6] of a DMBA-induced rat mammary adenocarcinoma (HH9-cl 14) were injected s.c. into tumor-free syngeneic female rats and produced a continuously growing solid tumor in all animals of this group. Inoculation of 2 X 10(7) cells induced a first brief period of tumor growth, followed by complet...

journal_title：Journal of cancer research and clinical oncology

authors： Vollmer E,Shimamoto F,Krieg V,Grundmann E

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Her-2/neu and the insulin-like growth factor-1 receptor (IGF-1R) share common postreceptor-signaling pathways, and pre-clinical models have implicated IGF-1R-signaling in resistance to treatment with the anti-Her-2/neu antibody trastuzumab. The present analysis was performed to evaluate the clinical relevance o...

journal_title：Journal of cancer research and clinical oncology

authors： Köstler WJ,Hudelist G,Rabitsch W,Czerwenka K,Müller R,Singer CF,Zielinski CC

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:E- and P-selectins, expressed on vascular endothelium, and their sialyl-Lewis(x )(sLe(x))- and/or sialyl-Lewis(a) (sLe(a))-containing ligands have a crucial role in extravasation and metastasis of circulating cells. We wanted to analyse the role of selectins and their ligands in head and neck tumours. METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Renkonen J,Mäkitie A,Paavonen T,Renkonen R

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:To evaluate through retrospective analysis the efficacy and toxicity of combination chemotherapy with etoposide, vincristine, doxorubin and dexamethasone (EVAD) as second-line therapy in patients with advanced AIDS-related Kaposi's sarcoma (AIDS-KS) after failure of first-line chemotherapy. METHODS:Eighty-ei...

journal_title：Journal of cancer research and clinical oncology

authors： Zhong DT,Shi CM,Chen Q,Huang JZ,Liang JG,Lin D

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:The clinical behaviour and outcome of young patients with gastroesophageal tumours (GET) is surmised to differ from older patients, yet data on the comparison of these two patient subgroups is scarce. This study focuses on the investigation of the clinical characteristics and survival outcome of younger-age ...

journal_title：Journal of cancer research and clinical oncology

authors： Puhr HC,Karner A,Taghizadeh H,Jomrich G,Schoppmann SF,Preusser M,Ilhan-Mutlu A

更新日期：2020-12-01 00:00:00

abstract：:The relation between the intracellular glutathione (GSH) concentration and hydrogen-peroxide(H2O2)-induced cytotoxicity was investigated. The intracellular GSH concentration in human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines was one or two orders of magnitude higher than that in a human myelogenous leuke...

journal_title：Journal of cancer research and clinical oncology

authors： Iida M,Sunaga S,Hirota N,Kuribayashi N,Sakagami H,Takeda M,Matsumoto K

更新日期：1997-01-01 00:00:00

abstract：:Bleomycin was injected i.p. in rats, and the amount of expired ethane which indicates lipid peroxidation was followed up for 78 h. Compared to controls neither 1 x 30 mg/kg and 2 x 30 mg/kg nor 1 x 70 mg/kg bleomycin led to increased ethane expiration, although body weight loss indicated toxicity. That pulmonary toxic...

journal_title：Journal of cancer research and clinical oncology

authors： Muliawan H,Burkhardt A,Scheulen ME,Kappus H

更新日期：1982-01-01 00:00:00

abstract：:Treatment of cultured mammalian cells with hydrogen peroxide results in the production of extensive DNA damage. Strand breakage was produced at the level of either nascent or mature DNA and the former target appeared slightly more resistant than the latter. Although inhibitors of the enzyme poly(ADP-ribose) polymerase...

journal_title：Journal of cancer research and clinical oncology

authors： Cantoni O,Fiorani M,Mugnaini M,Cattabeni F

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To discover new molecular targets for cancer therapy and diagnosis, we surveyed signal transducers and activators of transcription 3 (Stat3)-regulated genes, because constitutive activation of Stat3 is associated with a wide variety of human malignancies. METHODS:We investigated the Stat3-regulated genes in 29...

journal_title：Journal of cancer research and clinical oncology

authors： Tomida M,Ohtake H,Yokota T,Kobayashi Y,Kurosumi M

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:Evidence from multiple clinical trials showed that local consolidative therapy (LCT) improved survival in oligometastatic non-small cell lung cancer (NSCLC) patients. In the present study, we aim to explore the potential role of microwave ablation (MWA) as LCT for epidermal growth factor receptor (EGFR)-muta...

journal_title：Journal of cancer research and clinical oncology

authors： Ni Y,Ye X,Yang X,Huang G,Li W,Wang J,Han X,Wei Z,Meng M

更新日期：2020-01-01 00:00:00

abstract：:Two extracellular matrix and basement-membrane components, fibronectin (Fn) and laminin, were studied by the indirect immunoperoxidase technique in ten primary human liver cancers. Similar distributions of both Fn and laminin were detected in the well differentiated hepatocellular carcinomas with trabecular and tubula...

journal_title：Journal of cancer research and clinical oncology

authors： Szendröi M,Lapis K

更新日期：1985-01-01 00:00:00

abstract：:Second-line intraperitoneal (i.p.) therapy has been demonstrated to result in surgically defined complete responses (S-CR) in 25%-40% of patients with small-volume residual ovarian cancer (microscopic disease or largest tumor mass less than 1 cm in diameter). To evaluate the influence of the surgical finding of diffus...

journal_title：Journal of cancer research and clinical oncology

authors： Markman M,Reichman B,Hakes T,Barakat R,Curtin J,Rubin S,Jones W,Lewis JL Jr,Almadrones L,Hoskins W

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Mucosal inflammation in the small intestine is a potentially hazardous side effect of abdominal irradiation. In an effort to develop a quantitative method of evaluating mucosal damage, the luminal release of brush border enzymes in response to ionizing radiation was examined using two investigational strategies...

journal_title：Journal of cancer research and clinical oncology

authors： Fittkau M,Grothey A,Gerlach R,Schmoll HJ

更新日期：2001-02-01 00:00:00

abstract：:Osteosarcoma cells derived from patients have been isolated and subsequently cultured for the past 35 years. To date though, there have been no major breakthroughs in the development of a model for osteosarcoma that uses orthotopic implantation of human osteosarcoma cells and that closely emulates the clinical progres...

journal_title：Journal of cancer research and clinical oncology

authors： Dass CR,Ek ET,Choong PF

更新日期：2007-03-01 00:00:00

abstract：:According to a "two-hit" model, dominantly inherited predisposition to cancer entails a germline mutation, while tumorigenesis requires a second, somatic, mutation. Non-hereditary cancer of the same type requires the same two hits, but both are somatic. The original tumor used in this model, retinoblastoma, involves m...

journal_title：Journal of cancer research and clinical oncology

authors： Knudson AG

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00