当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells.

Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells.

Abstract：

PURPOSE:To discover new molecular targets for cancer therapy and diagnosis, we surveyed signal transducers and activators of transcription 3 (Stat3)-regulated genes, because constitutive activation of Stat3 is associated with a wide variety of human malignancies. METHODS:We investigated the Stat3-regulated genes in 293 cells with cDNA microarray analysis and found that Nicotinamide N-methyltransferase (NNMT) was induced on stimulation of the cells with leukemia inhibitory factor. We examined the expression of NNMT in several types of cancer cells by real-time quantitative RT-PCR. To examine the role of Stat3, Hep-G2 hepatocellular carcinoma cells were transfected with NNMT promoter-luciferase reporter construct together with conditionally active Stat3 (Stat3ER) or dominant-negative Stat3 expression vector and NNMT promoter activity was determined. The expression of NNMT and activated Stat3 in 88 colon cancer tissues and 17 normal colon tissues was examined with immunohistochemical analysis. RESULTS:In Hep-G2 cells and SW480 colon cancer cells, NNMT expression increased on stimulation of the cells with interleukin 6. NNMT promoter activity in Hep-G2 cells was dependent on the activation of Stat3. MDA-MB-468 breast cancer cells and HT29 colon cancer cells expressed constitutively a high level of NNMT. Treatment of these cells with Stat3 siRNA or curcumin, which inhibited Stat3 phosphorylation, resulted in reduction of the NNMT level. We found a correlation between the expression of NNMT and activated Stat3 (P<0.001) in the colon cancer tissues. CONCLUSION:NNMT is a novel Stat3-regulated gene. Its expression is enhanced with the activation of Stat3 in colon cancer tissues. NNMT may be a potential candidate for a tumor marker of various kinds of cancers.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Tomida M,Ohtake H,Yokota T,Kobayashi Y,Kurosumi M

doi

10.1007/s00432-007-0318-6

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

551-9

issue

5

eissn

0171-5216

issn

1432-1335

journal_volume

134

pub_type

杂志文章

相关文献

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY文献大全
  • Inhibition of experimental pulmonary metastasis in mice by beta-cyclodextrin-benzaldehyde.

    abstract：:The effect of beta-cyclodextrin-benzaldehyde (CDBA) on experimental pulmonary metastasis in C3H/He mice was examined. In an in vitro assay, the growth of RCT(+) cells was inhibited by 1200 micrograms/ml CDBA using unrenewed media, and by 600 micrograms/ml CDBA in that using daily renewed media. When mice were treated ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00395915

    authors： Ochiai H,Niwayama S,Masuyama K

    更新日期：1986-01-01 00:00:00

  • Folinic acid effect on 5-fluorouracil kinetics in vivo.

    abstract：:Synergy of folinic acid and FU has been shown in several experimental systems. In the present study we examined the kinetics of concurrent administration of folinic acid on the kinetics of FU in an in vivo model. Folinic acid significantly increased the amount of FU bound to the TS complex. In the sequential combinati...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00390490

    authors： Herrmann R,Reuter J,Port R,Osswald H

    更新日期：1988-01-01 00:00:00

  • Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and recurrent glioblastoma multiforme.

    abstract：PURPOSE:To investigate the pattern and level of cyclooxygenase-2 (COX-2) expression in a series of high grade primary and recurrent glioblastoma multiforme (GBM) and correlation with time to recurrence and patients' survival following therapy. The relationship between COX-2 and epidermal growth factor receptor (EGFR) i...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-005-0020-5

    authors： Sminia P,Stoter TR,van der Valk P,Elkhuizen PH,Tadema TM,Kuipers GK,Vandertop WP,Lafleur MV,Slotman BJ

    更新日期：2005-10-01 00:00:00

  • Carcinogenicity studies of masheri: pyrolysed tobacco product, in vitamin-A-deficient Sprague Dawley rats.

    abstract：:The carcinogenicity of long-term feeding of masheri extract to animals in a vitamin-A-sufficient (SLO+) and deficient (SLO-) state was studied in Sprague Dawley rats by feeding daily dose of 3 mg extract over a period of 21 months. The phase I activating enzymes, the glutathione (GSH)/glutathione S-transferase (GST) d...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01613196

    authors： Ammigan N,Nair UJ,Lalitha VS,Bhide SV

    更新日期：1991-01-01 00:00:00

  • Increased susceptibility to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in transgenic mice overexpressing c-myc and epidermal growth factor in alveolar type II cells.

    abstract：PURPOSE:As previously described, SPC/myc transgenic mice developed bronchioloalveolar adenocarcinomas derived from alveolar type II (AT II) cells within 10-14 months, whereas SPC/IgEGF transgenic mice developed hyperplasias. Our purpose was to determine the potential interplay of environmental and genetic factors in lu...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-002-0400-z

    authors： Ehrhardt A,Bartels T,Klocke R,Paul D,Halter R

    更新日期：2003-02-01 00:00:00

  • Kaposi's sarcoma after liver transplantation.

    abstract：INTRODUCTION:Kaposi's Sarcoma (KS) is a malignant neoplasm arising from endothelial cells. HHV8-infection represents a key pathogenic determinant for the development of KS. There are no standard criteria to treat KS in immunosuppressed-individuals. Six cases (2.1%) of KS occurred in our Center among 285-recipients who ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-007-0329-3

    authors： Di Benedetto F,Di Sandro S,De Ruvo N,Berretta M,Masetti M,Montalti R,Ballarin R,Cocchi S,Potenza L,Luppi M,Gerunda GE

    更新日期：2008-06-01 00:00:00

  • The PI3K pathway impacts stem gene expression in a set of glioblastoma cell lines.

    abstract：BACKGROUND:The PI3K pathway controls diverse cellular processes including growth, survival, metabolism, and apoptosis. Nuclear FOXO factors were observed in cancers that harbor constitutively active PI3K pathway output and stem signatures. FOXO1 and FOXO3 were previously published to induce stem genes such as OCT4 in e...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-020-03133-w

    authors： Martinez E,Vazquez N,Lopez A,Fanniel V,Sanchez L,Marks R,Hinojosa L,Cuello V,Cuevas M,Rodriguez A,Tomson C,Salinas A,Abad M,Holguin M,Garza N,Arenas A,Abraham K,Maldonado L,Rojas V,Basdeo A,Schuenzel E,Persans M

    更新日期：2020-03-01 00:00:00

  • Chemotherapeutic drugs change actin skeleton organization and the expression of beta-thymosins in human breast cancer cells.

    abstract：PURPOSE:Elevated expression of the beta-thymosin isotypes T beta(4), T beta(10), and T(15) appears to be involved in the manifestation of a malignant phenotype of human tumor cells, including those of mammary carcinomas. This has evoked an interest in these peptides as diagnostic/prognostic tumor markers. If increased ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-002-0332-7

    authors： Otto AM,Müller CS,Huff T,Hannappel E

    更新日期：2002-05-01 00:00:00

  • Integrative metabolome and transcriptome profiling reveals discordant glycolysis process between osteosarcoma and normal osteoblastic cells.

    abstract：BACKGROUND:Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and adolescents. However, few biomarkers of diagnostic significance have been established. In recent years, high-throughput transcriptomic and metabolomic approaches make it possible for studying the levels of thousands of bioma...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1719-y

    authors： Chen K,Zhu C,Cai M,Fu D,Cheng B,Cai Z,Li G,Liu J

    更新日期：2014-10-01 00:00:00

  • Carcinogenicity of vinylethylnitrosamine in Syrian golden hamsters.

    abstract：:Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00411342

    authors： Green U,Althoff J

    更新日期：1982-01-01 00:00:00

  • Alkylphosphocholine-induced production of nitric oxide and tumor necrosis factor alpha by U 937 cells.

    abstract：:The human histiocytic cell line U 937, which expresses a number of monocyte markers and properties, was investigated with regard to its ability to be activated for NO and tumor necrosis factor (TNF) release after treatment with alkylphosphocholines (APC) and APC liposomes. Using APC multilamellar vesicles (MLV) a clea...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01225687

    authors： Eue I,Zeisig R,Arndt D

    更新日期：1995-01-01 00:00:00

  • Feasibility of induced metabolic bioluminescence imaging in advanced ovarian cancer patients: first results of a pilot study.

    abstract：PURPOSE:The precise determination of energy metabolites is challenged by the heterogeneity of their distribution, their rapid changes after surgical resection and the architectural complexity of malignancies. Induced metabolic bioluminescence imaging (imBI) allows to determine energy metabolites in tissue sections and ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-016-2200-x

    authors： Battista MJ,Goetze K,Schmidt M,Cotarelo C,Weyer-Elberich V,Hasenburg A,Mueller-Klieser W,Walenta S

    更新日期：2016-09-01 00:00:00

  • Effects of von Hippel-Lindau gene mutation and methylation status on expression of transmembrane carbonic anhydrases in renal cell carcinoma.

    abstract：PURPOSE:Our primary goal was to determine whether increased expression of the transmembrane carbonic anhydrase (CA) isozymes in renal cell carcinoma (RCC) is regulated by the von Hippel-Lindau (VHL) gene. METHODS:We studied mRNA expression of all three transmembrane CAs - CA IX, XII, and XIV - in 17 RCC cell lines, tr...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-002-0374-x

    authors： Ashida S,Nishimori I,Tanimura M,Onishi S,Shuin T

    更新日期：2002-10-01 00:00:00

  • DNA repair at the level of the gene: molecular and clinical considerations.

    abstract：:DNA repair is an important process. It is as essential for the cell as is transcription and replication. There is evidence that deficient DNA repair processes lead to human disease including cancer, and recent progress in the field of DNA repair is likely to expand our knowledge about these relationships considerably....

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01612922

    authors： Bohr VA

    更新日期：1990-01-01 00:00:00

  • PIK3CA mutation is associated with poor survival among patients with metastatic colorectal cancer following anti-EGFR monoclonal antibody therapy: a meta-analysis.

    abstract：PURPOSE:PIK3CA mutation appears to predict a lack of response to anti-EGFR monoclonal antibody (mAb) treatment in patients with metastatic colorectal cancer (mCRC). However, the predictive value of PIK3CA mutations for survival remains inconclusive. Here, we pooled the data from published studies to estimate the associ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00432-013-1400-x

    authors： Wu S,Gan Y,Wang X,Liu J,Li M,Tang Y

    更新日期：2013-05-01 00:00:00

  • Substantially reduced expression of PIAS1 is associated with colon cancer development.

    abstract：PURPOSE:Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-gamma) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expre...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-009-0570-z

    authors： Coppola D,Parikh V,Boulware D,Blanck G

    更新日期：2009-09-01 00:00:00

  • Prognostic implication of immunodetection of P glycoprotein in Ewing's sarcoma.

    abstract：:Increased expression of P glycoprotein is associated with multidrug resistance in many cell lines. P glycoprotein has been detected in different human tumors. To assess the implication of multidrug resistance in the prognosis of Ewing's sarcoma the expression of P glycoprotein was studied immunohistochemically in pre-...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01624429

    authors： Roessner A,Ueda Y,Bockhorn-Dworniczak B,Blasius S,Peters A,Wuisman P,Ritter J,Paulussen M,Jürgens H,Böcker W

    更新日期：1993-01-01 00:00:00

  • Multidisciplinary therapy for patients with locally oligo-recurrent pelvic malignancies.

    abstract：PURPOSE:To analyze prognostic factors and long-term outcomes in patients with locally recurrent pelvic cancer (LRPC) treated with a multidisciplinary approach. METHODS AND MATERIALS:From January 1995 to December 2011, 81 patients [rectal (47 %); gynecologic (39 %); retroperitoneal sarcoma (14 %)] underwent extended su...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1667-6

    authors： Sole CV,Calvo FA,de Sierra PA,Herranz R,Gonzalez-Bayon L,García-Sabrido JL

    更新日期：2014-07-01 00:00:00

  • DNA adducts in experimental cancer research.

    abstract：:The role of DNA adducts in the initiation of cancer is scrutinized in this presentation. Work on the activation of oncogenes, particularly on ras, has provided new evidence to link DNA adducts and tumour formation. Polycyclic hydrocarbons and nitroso compounds can cause activation of ras oncogenes through a defined po...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/BF00395910

    authors： Hemminki K,Försti A,Mustonen R,Savela K

    更新日期：1986-01-01 00:00:00

  • Expression of stathmin/op18 as a significant prognostic factor for cervical carcinoma patients.

    abstract：PURPOSE:Stathmin (Oncoprotein18), a ubiquitous and highly conserved 19-kDa cytosolic phosphoprotein, has been reported to play a critical role in mitosis and possibly other cellular processes, which is associated with tumor carcinogenesis and development. The purpose of this study was to examine the involvement of stat...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-008-0520-1

    authors： Xi W,Rui W,Fang L,Ke D,Ping G,Hui-Zhong Z

    更新日期：2009-06-01 00:00:00

  • TFAP2E hypermethylation was associated with survival advantage in patients with colorectal cancer.

    abstract：PURPOSE:Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly remain unknown. This study was aimed to investigate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of p...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1766-4

    authors： Zhang ZM,Wang Y,Huang R,Liu YP,Li X,Hu FL,Zhu L,Wang F,Cui BB,Dong XS,Zhao YS

    更新日期：2014-12-01 00:00:00

  • The effect of COX-2 inhibitor on capecitabine-induced hand-foot syndrome in patients with stage II/III colorectal cancer: a phase II randomized prospective study.

    abstract：PURPOSE:Hand-foot syndrome (HFS) is a common adverse event that can be induced by capecitabine. It is hypothesized that capecitabine (Hoffmann-La Roche Inc.) based chemotherapy can cause overexpression of COX-2 in tumor and healthy tissue, which finally induced HFS in hands and feet. Based on this, we believed that a s...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00432-010-0958-9

    authors： Zhang RX,Wu XJ,Lu SX,Pan ZZ,Wan DS,Chen G

    更新日期：2011-06-01 00:00:00

  • Alpha-fetoprotein, tissue polypeptide antigen and ferritin in diagnosing primary hepatocellular carcinoma in patients with liver cirrhosis.

    abstract：:This study was undertaken in order to compare the usefulness of three indices of tumour proliferation in detecting primary hepatocellular carcinoma (HCC) and in differentiating this neoplasm from liver cirrhosis. In 10 patients with HCC and in 63 with liver cirrhosis serum alpha-fetoprotein (AFP), tissue polypeptide a...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00391702

    authors： Leandro G,Basso D,Fabris C,Zizzari S,Elba S,Del Favero G,Di Mario F,Meggiato T,Angonese C,Naccarato R

    更新日期：1989-01-01 00:00:00

  • Differential expression of cancer-related genes by single and permanent exposure to bone morphogenetic protein 2.

    abstract：PURPOSE:Bone morphogenetic proteins (BMPs) are multifunctional regulators of various cell functions. The BMP-signalling network plays a pivotal role during embryogenesis and tumorigenesis. BMPs, e.g. BMP-2 exert their biological function in a time and concentration-dependent manner but also modulated by the context of ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-008-0396-0

    authors： Steinert S,Kroll TC,Taubert I,Pusch L,Hortschansky P,Höffken K,Wölfl S,Clement JH

    更新日期：2008-11-01 00:00:00

  • Laboratory evaluation during high-dose vitamin A administration: a randomized study on lung cancer patients after surgical resection.

    abstract：:The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300,000 IU daily for 12 months) or standard follow-up, and are now evaluable after a median observation ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF01613140

    authors： Infante M,Pastorino U,Chiesa G,Bera E,Pisani P,Valente M,Ravasi G

    更新日期：1991-01-01 00:00:00

  • Cancer of the ovary, fallopian tube, and peritoneum: a population-based comparison of the prognostic factors and outcomes.

    abstract：PURPOSE:The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. METHODS:We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of th...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-017-2422-6

    authors： Rottmann M,Burges A,Mahner S,Anthuber C,Beck T,Grab D,Schnelzer A,Kiechle M,Mayr D,Pölcher M,Schubert-Fritschle G,Engel J

    更新日期：2017-09-01 00:00:00

  • Attitudes of members of the German Society for Palliative Medicine toward complementary and alternative medicine for cancer patients.

    abstract：BACKGROUND:A high proportion of cancer patients use complementary and alternative medicine (CAM). In oncology, risks of CAM are side effects and interactions. OBJECTIVE:Our aim was to conduct a survey on professionals in palliative care regarding attitudes toward CAM. DESIGN AND SUBJECTS:An internet-based survey with...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1656-9

    authors： Conrad AC,Muenstedt K,Micke O,Prott FJ,Muecke R,Huebner J

    更新日期：2014-07-01 00:00:00

  • Distinct functional domains of PNMA5 mediate protein-protein interaction, nuclear localization, and apoptosis signaling in human cancer cells.

    abstract：PURPOSE:Members of paraneoplastic Ma (PNMA) family have been identified as onconeuronal antigens, which aberrant expressions in cancer cells of patients with paraneoplastic disorder (PND) are closely linked to manifestation of auto-immunity, neuro-degeneration, and cancer. The purpose of present study was to determine ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-016-2205-5

    authors： Lee YH,Pang SW,Poh CL,Tan KO

    更新日期：2016-09-01 00:00:00

  • Influence of recombinant tumour necrosis factor alpha on blood flow and antibody localisation in human tumour xenografts in nude mice.

    abstract：:Mice with s.c. grafts of gastric carcinoma MKN45 or osteosarcoma 788T were injected i.v. with recombinant tumour necrosis factor alpha (rTNF alpha) and tumour blood flow rates were determined 4 h later as a fraction of the cardiac output g tissue-1. With MKN45, the tumour blood flow rate was significantly reduced from...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01613286

    authors： Pimm MV,Gribben SJ,Morris TM

    更新日期：1991-01-01 00:00:00

  • Survivin gene-expression and splicing isoforms in oral squamous cell carcinoma.

    abstract：PURPOSE:Survivin, an inhibitor of apoptosis protein and a cell cycle regulator, has been detected in the majority of human cancers. Five splice variants (survivin, survivin-2alpha, survivin-2B, survivin-3B, and survivin-DeltaEx3) have been identified; their expressions have been investigated here. METHODS:By means of ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-008-0433-z

    authors： De Maria S,Pannone G,Bufo P,Santoro A,Serpico R,Metafora S,Rubini C,Pasquali D,Papagerakis SM,Staibano S,De Rosa G,Farina E,Emanuelli M,Santarelli A,Mariggiò MA,Lo Russo L,Lo Muzio L

    更新日期：2009-01-01 00:00:00