Laboratory evaluation during high-dose vitamin A administration: a randomized study on lung cancer patients after surgical resection.


:The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300,000 IU daily for 12 months) or standard follow-up, and are now evaluable after a median observation period of 28 months. At regular intervals, all the patients underwent a physical examination, chest roentgenogram, blood chemistries, haematological assays, hepatic and renal function tests and determinations of serum triglycerides and cholesterol. Serum transaminase abnormalities were of similar magnitude in cases and controls, while gamma-glutamyltransferase levels were abnormally elevated in 69% of the treated patients compared to 39% of controls (mean values 149 vs 57 IU/l at 24 months, P less than 0.05). Serum triglyceride concentrations over 150 mg/dl were seen in 74% of treated patients compared to 43% of controls at 12 months, the average concentration was 283 mg/dl compared to 179 mg/dl (P less than 0.05). Cholesterol levels showed a modest, non-significant rise with time in both groups, and there was no other laboratory evidence of toxicity attributable to vitamin A. Serum retinol and retinol-binding protein, assessed on a limited sample of patients, were higher in the treatment arm (P less than 0.05) at 12 months. In our experience 300,000 IU/day of retinyl palmitate can be administered as a possible chemopreventive agent with reasonable safety for up to 2 years.


Infante M,Pastorino U,Chiesa G,Bera E,Pisani P,Valente M,Ravasi G




Has Abstract


1991-01-01 00:00:00












  • RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients.

    abstract:BACKGROUND:Several reports describe the importance of the chaperone HSP27 (HSPB1) in cancer progression, and the demand for drugs that modulate HSPB1-activity is increasing rapidly. We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in pancreatic cancer. METH...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,随机对照试验


    authors: Heinrich JC,Tuukkanen A,Schroeder M,Fahrig T,Fahrig R

    更新日期:2011-09-01 00:00:00

  • Distribution of fibronectin and laminin in human liver tumors.

    abstract::Two extracellular matrix and basement-membrane components, fibronectin (Fn) and laminin, were studied by the indirect immunoperoxidase technique in ten primary human liver cancers. Similar distributions of both Fn and laminin were detected in the well differentiated hepatocellular carcinomas with trabecular and tubula...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Szendröi M,Lapis K

    更新日期:1985-01-01 00:00:00

  • Age-, sex-, and strain-dependent differences in the induction of enzyme-altered islands in rat liver by diethylnitrosamine.

    abstract::The formation of foci with loss of ATPase and emergence of gamma-GTase was studied histochemically in livers of male and female Wistar and Sprague-Dawley rats of 3--4 and 6--7 weeks of age, respectively, after application of diethylnitrosamine. A single dose of 8 mg/kg body weight induced a considerable island formati...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Deml E,Oesterle D,Wolff T,Greim H

    更新日期:1981-01-01 00:00:00

  • A low dose of ionizing radiation increases luminal release of intestinal peptidases in rats.

    abstract:PURPOSE:Mucosal inflammation in the small intestine is a potentially hazardous side effect of abdominal irradiation. In an effort to develop a quantitative method of evaluating mucosal damage, the luminal release of brush border enzymes in response to ionizing radiation was examined using two investigational strategies...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Fittkau M,Grothey A,Gerlach R,Schmoll HJ

    更新日期:2001-02-01 00:00:00

  • Chemotherapeutic drugs change actin skeleton organization and the expression of beta-thymosins in human breast cancer cells.

    abstract:PURPOSE:Elevated expression of the beta-thymosin isotypes T beta(4), T beta(10), and T(15) appears to be involved in the manifestation of a malignant phenotype of human tumor cells, including those of mammary carcinomas. This has evoked an interest in these peptides as diagnostic/prognostic tumor markers. If increased ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Otto AM,Müller CS,Huff T,Hannappel E

    更新日期:2002-05-01 00:00:00

  • Are exon 19 deletions and L858R different in early stage lung adenocarcinoma?

    abstract:INTRODUCTION:Evidence shows that exon 19 deletions (19del) and exon 21 Leu858Arg point mutation (L858R) of EGFR are different in response to EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in advanced lung cancers. However, the impact of the two mutational types in the early stage lung adenocarcinoma is unknown. MET...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Zhang Y,Ma Y,Li Y,Shen X,Yu Y,Pan Y,Zhang Y,Yu S,Zheng D,Zhao Y,Hu H,Sun Y,Zhang Y,Xiang J,Chen H

    更新日期:2018-01-01 00:00:00

  • Prognostic implication of immunodetection of P glycoprotein in Ewing's sarcoma.

    abstract::Increased expression of P glycoprotein is associated with multidrug resistance in many cell lines. P glycoprotein has been detected in different human tumors. To assess the implication of multidrug resistance in the prognosis of Ewing's sarcoma the expression of P glycoprotein was studied immunohistochemically in pre-...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Roessner A,Ueda Y,Bockhorn-Dworniczak B,Blasius S,Peters A,Wuisman P,Ritter J,Paulussen M,Jürgens H,Böcker W

    更新日期:1993-01-01 00:00:00

  • Immunohistochemical demonstration of proliferating cell nuclear antigen in glioblastomas: pronounced heterogeneity and lack of prognostic significance.

    abstract::In order to evaluate a possible significance of the expression of proliferating cell nuclear antigen (PCNA) as clinically useful prognostic parameter, we retrospectively investigated a series of 40 glioblastomas by means of immunohistochemistry and compared the results to patient survival. All glioblastomas included i...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Figge C,Reifenberger G,Vogeley KT,Messing M,Roosen N,Wechsler W

    更新日期:1992-01-01 00:00:00

  • 5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil.

    abstract::The aim of the present studies was to elucidate the effects and optimal modulatory conditions of 5-ethyl-2'-deoxyuridine (EtdUrd) on the antitumour efficacy, pharmacokinetics and catabolism of 5-fluorouracil (5-FU) on Colon-26 and Colon-38 murine tumours. HPLC and GC-MS techniques were used to measure the concentratio...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Kralovánszky J,Katona C,Jeney A,Pandi E,Noordhuis P,Erdélyi-Tóth V,Otvös L,Kovács P,Van der Wilt CL,Peters GJ

    更新日期:1999-12-01 00:00:00

  • Effects of irradiation and cisplatin on human glioma spheroids: inhibition of cell proliferation and cell migration.

    abstract:PURPOSE:Investigation of cell migration and proliferation of human glioma cell line spheroids (CLS) and evaluation of morphology, apoptosis, and immunohistochemical expression of MIB-1, p53, and p21 of organotypic muticellular spheroids (OMS) following cisplatin (CDDP) and irradiation (RT). MATERIAL AND METHODS:Sphero...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Fehlauer F,Muench M,Rades D,Stalpers LJ,Leenstra S,van der Valk P,Slotman B,Smid EJ,Sminia P

    更新日期:2005-11-01 00:00:00

  • Substantially reduced expression of PIAS1 is associated with colon cancer development.

    abstract:PURPOSE:Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-gamma) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expre...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Coppola D,Parikh V,Boulware D,Blanck G

    更新日期:2009-09-01 00:00:00

  • Efficacy of beta-diketonato complexes of titanium, zirconium, and hafnium against chemically induced autochthonous colonic tumors in rats.

    abstract::Bis-beta-diketonato complexes of titanium, zirconium, and hafnium were tested against autochthonous colorectal tumors in rats. The model was found to reflect the clinical situation most closely. Of the compounds tested, budotitane was the most effective in terms of decrease in tumor weight and number and in increasing...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Bischoff H,Berger MR,Keppler BK,Schmähl D

    更新日期:1987-01-01 00:00:00

  • Increased gene copy number of HER2 and concordant protein overexpression found in a subset of eyelid sebaceous gland carcinoma indicate HER2 as a potential therapeutic target.

    abstract:PURPOSE:To identify crucial molecular alterations of receptor tyrosine kinases that can be used as potential therapeutic targets for eyelid sebaceous gland carcinoma (SbGC). METHODS:The expression levels of HER2, EGFR, C-MET, and FGFR1 were determined by immunohistochemistry (IHC). The copy numbers of the HER2, EGFR, ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Lee MJ,Kim N,Choung HK,Choe JY,Khwarg SI,Kim JE

    更新日期:2016-01-01 00:00:00

  • Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer.

    abstract:PURPOSE:The polymorphisms in microRNA (miRNA) machinery genes and miRNA-containing genomic regions may play an important role in cancer development and prognosis. Accordingly, the present study analyzed the single nucleotide polymorphisms (SNPs) of miRNA-related genes and their impact on the prognosis for patients with...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Lee HC,Kim JG,Chae YS,Sohn SK,Kang BW,Moon JH,Jeon SW,Lee MH,Lim KH,Park JY,Choi GS,Jun SH

    更新日期:2010-07-01 00:00:00

  • Different autochthonous models of colorectal cancer in the rat.

    abstract::Chemically induced (autochthonous) tumors in the rodent are thought to be the best models at hand to obtain results transferable to the clinical situation. Four different autochthonous tumor models: 1,2-dimethylhydrazine, N-methylnitrosourea (MNU), N-methyl-N-nitro-nitrosoguanidine (MNNG), and N-nitroso-acetoxymethyl-...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Amberger H

    更新日期:1986-01-01 00:00:00

  • Comparative study of autophagy inhibition by 3MA and CQ on Cytarabine‑induced death of leukaemia cells.

    abstract:BACKGROUND:As the molecular mechanisms of Cytarabine,one of the most important drugs used in the leukaemia’s treatment, are only partially understood and the role of autophagy on leukaemia development and treatment is only recently being investigated, in this study, by using Chloroquine (CQ) and 3-methyladenine (3MA) a...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Palmeira dos Santos C,Pereira GJ,Barbosa CM,Jurkiewicz A,Smaili SS,Bincoletto C

    更新日期:2014-06-01 00:00:00

  • Transarterial chemoembolisation (TACE) combined with endovascular implantation of an iodine-125 seed strand for the treatment of hepatocellular carcinoma with portal vein tumour thrombosis versus TACE alone: a two-arm, randomised clinical trial.

    abstract:PURPOSE:There was no standard treatment for hepatocellular carcinoma with portal vein tumour thrombosis (PVTT). This prospective, randomised, two-arm clinical trial aims to investigate the feasibility, safety and effectiveness of transarterial chemoembolisation (TACE) combined with the endovascular implantation of an i...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,随机对照试验


    authors: Yang M,Fang Z,Yan Z,Luo J,Liu L,Zhang W,Wu L,Ma J,Yang Q,Liu Q

    更新日期:2014-02-01 00:00:00

  • The role of p53 as a surrogate marker for chemotherapeutical responsiveness in ovarian cancer.

    abstract:INTRODUCTION:In advanced ovarian cancers (OCs), p53 mutations are frequently observed. The objective of this study was to explore the value of the p53 mutational status, using four different techniques, in advanced OC patients as a predictive marker for responsiveness to platinum-based chemotherapy. METHODS:One hundre...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Bauerschlag DO,Schem C,Weigel MT,Von Kaisenberg C,Strauss A,Bauknecht T,Maass N,Meinhold-Heerlein I

    更新日期:2010-01-01 00:00:00

  • Scaling adult dose and schedule of anticancer agents to children.

    abstract:PURPOSE:Objective of this work was to extend pharmacokinetic scaling theory of the writer for bolus dosing to include the case of constant-rate i.v. dosing over fixed interval so as to allow projection of adult dose and schedule of typically administered anticancer agents to children. METHODS:The basis for the scaling...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Dawson TH

    更新日期:2013-12-01 00:00:00

  • Ultrasound-mediated nanobubble destruction (UMND) facilitates the delivery of VEGFR2-targeted CD-TK-loaded cationic nanobubbles in the treatment of bladder cancer.

    abstract:BACKGROUND:The CD-TK double suicide gene has become an effective therapy for bladder cancer. A novel molecular-targeted ultrasound (US) method has been developed to precisely guide nanobubbles loaded with this gene to regions within bladder tumor cells and is widely used due to its efficiency in delivering drugs to the...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Hu C,Jiang D,Wu M,Wang J,Zhang R

    更新日期:2020-06-01 00:00:00

  • Nilotinib first-line therapy in patients with Philadelphia chromosome-negative/BCR-ABL-positive chronic myeloid leukemia in chronic phase: ENEST1st sub-analysis.

    abstract:PURPOSE:The ENEST1st sub-analysis presents data based on Philadelphia chromosome (Ph) status, i.e., Ph+ and Ph-/BCR-ABL1 + chronic myeloid leukemia. METHODS:Patients received nilotinib 300 mg twice daily, up to 24 months. RESULTS:At screening, 983 patients were identified as Ph+ and 30 patients as Ph-/BCR-ABL + based...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,多中心研究


    authors: Hochhaus A,Mahon FX,le Coutre P,Petrov L,Janssen JJWM,Cross NCP,Rea D,Castagnetti F,Hellmann A,Rosti G,Gattermann N,Coronel MLP,Gutierrez MAE,Garcia-Gutierrez V,Vincenzi B,Dezzani L,Giles FJ

    更新日期:2017-07-01 00:00:00

  • A simple method of delayed processing of tumor tissue in a soft agar clonogenic assay.

    abstract::Sarcoma 180 tumor tissue from C57 mice was processed in a soft agar clonogenic assay immediately after removal from the animal and after various methods of storage. The sensitivity to the antineoplastic drug cis-platinum was not affected by different storage methods. The highest yield of colony forming cells per 100 m...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Krischke W,Hartmann R,Schneider M,Schönenberger H

    更新日期:1988-01-01 00:00:00

  • Inhibition of protein-kinase-C--dependent cell proliferation of human lung cancer cell lines by the dihydropyridine dexniguldipine.

    abstract::The dihydropyridine, dexniguldipine hydrochloride (B859-35), has shown therapeutic activity in experimentally induced neuroendocrine hamster lung tumors and demonstrated antiproliferative effects in a mammary cancer cell line via inhibition of Ca2+ calmodulin. Studies in NIH 3T3 fibroblasts have provided evidence that...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Schuller HM,Orloff M,Reznik GK

    更新日期:1994-01-01 00:00:00

  • Tricistronic expression of MOAP-1, Bax and RASSF1A in cancer cells enhances chemo-sensitization that requires BH3L domain of MOAP-1.

    abstract:PURPOSE:Although important for apoptosis, the signaling pathway involving MOAP-1(Modulator of Apoptosis 1), RASSF1A (RAS association domain family 1A), and Bax (Bcl-2 associated X protein) is likely to be dysfunctional in many types of human cancers due to mechanisms associated with gene mutation and DNA hyper-methylat...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Lee YH,Pang SW,Revai Lechtich E,Shah K,Simon SE,Ponnusamy S,Narayanan R,Poh CL,Tan KO

    更新日期:2020-07-01 00:00:00

  • Dept. of Microbiology, School of Medicine, East Carolina University, Greenville, NC.

    abstract::The responsiveness of spleen cells from C57BL/6J mice to various immunogenic stimuli was examined during the progressive growth of a poorly immunogenic fibrosarcoma T241. A strong correlation was observed between the progressive tumor growth and the depression of response to Concanavalin A, lipopolysaccharide, sheep r...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Gautam SC,Gautam S,Deodhar SD

    更新日期:1981-01-01 00:00:00

  • Antitumor activity of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea (MeCCNU) on Yoshida sarcoma ascites cells implanted into the colon wall of rats.

    abstract::Three thousand Yoshida sarcoma cells were inoculated into the wall of the descending colon of each of 120 male Sprague-Dawley rats. On day 8 after the tumor implantation, the animals were at random divided into four groups of 30 rats each. The effect of cyclophosphamide (70 mg/kg), BCNU (25 mg/kg), and methyl-CCNU (45...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Bhide S,Habs M,Reinbold H,Schmähl D

    更新日期:1979-05-14 00:00:00

  • A high serum-free fatty acid level is associated with cancer.

    abstract:PURPOSE:The objectives of this work were to investigate whether the serum-free fatty acid (FFA) level is meaningful in cancer patients and its role in cancer diagnosis. METHODS:A total of 2206 patients were divided into a cancer group (n = 1019) and a noncancer group (n = 1187). Age, sex, body mass index (BMI), and se...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Zhang L,Han L,He J,Lv J,Pan R,Lv T

    更新日期:2020-03-01 00:00:00

  • Dendritic cell-based tumor vaccine for cervical cancer I: in vitro stimulation with recombinant protein-pulsed dendritic cells induces specific T cells to HPV16 E7 or HPV18 E7.

    abstract:PURPOSE:Human papillomavirus (HPV) type 16 and 18 are the most prevalent genotypes in cervical cancers. The viral oncoproteins E6 and E7 are considered to be tumor-specific targets for immunotherapy. HPV E7 antigen-loaded dendritic cells (DC) were evaluated as cellular tumor vaccine. METHODS:Autologous monocyte-derive...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章


    authors: Nonn M,Schinz M,Zumbach K,Pawlita M,Schneider A,Dürst M,Kaufmann AM

    更新日期:2003-09-01 00:00:00

  • Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?

    abstract:PURPOSE:Ribonucleotide reductase (RR) enzymes (RR1 and RR2) play an important role in the reduction of ribonucleotides to deoxyribonucleotides which is involved in DNA replication and repair. Augmented RR activity has been ascribed to uncontrolled cell growth and tumorigenic transformation. METHODS:This review mainly ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,评审


    authors: Mannargudi MB,Deb S

    更新日期:2017-08-01 00:00:00

  • DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics.

    abstract:PURPOSE:Uterine neoplasms comprise a broad spectrum of lesions, some of which may pose a diagnostic challenge even to experienced pathologists. Recently, genome-wide DNA methylation-based classification of central nervous system tumors has been shown to increase diagnostic precision in clinical practice when combined w...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,多中心研究


    authors: Kommoss FKF,Stichel D,Schrimpf D,Kriegsmann M,Tessier-Cloutier B,Talhouk A,McAlpine JN,Chang KTE,Sturm D,Pfister SM,Romero-Pérez L,Kirchner T,Grünewald TGP,Buslei R,Sinn HP,Mechtersheimer G,Schirmacher P,Schmidt D,Leh

    更新日期:2020-01-01 00:00:00