DNA adducts in experimental cancer research.

abstract：PURPOSE:The purpose of this study was to examine breast tumors and normal breast tissues for the expression of the glycoprotein lacritin. The mRNA and protein expression of lacritin has been reported to be restricted to the lacrimal gland. METHODS:We investigated 37 human primary invasive breast tumors, seven breast c...

journal_title：Journal of cancer research and clinical oncology

authors： Weigelt B,Bosma AJ,van 't Veer LJ

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:Ribonucleotide reductase (RR) enzymes (RR1 and RR2) play an important role in the reduction of ribonucleotides to deoxyribonucleotides which is involved in DNA replication and repair. Augmented RR activity has been ascribed to uncontrolled cell growth and tumorigenic transformation. METHODS:This review mainly ...

journal_title：Journal of cancer research and clinical oncology

authors： Mannargudi MB,Deb S

更新日期：2017-08-01 00:00:00

abstract：:A new experimental method to test the effect of drugs on tumor-induced osteolysis using a bladder tumor in mice has been designed. The method consisted of inoculating MBT-2 tumor cells s.c. over the calvaria in mice, resulting in a local tumor causing fragmentation of the bone. This was accompanied by adjacent osteopl...

journal_title：Journal of cancer research and clinical oncology

authors： Nemoto R,Uchida K,Tsutsumi M,Koiso K,Satou S,Satou T

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Proton therapy could minimize the risk of side effects and, therefore, reduce the possible detrimental effect on health-related quality of life (HRQOL) of re-irradiation. The aim of this study was to determine the effect of re-irradiation with active scanning proton therapy on recurrent glioblastoma (GBM) in te...

journal_title：Journal of cancer research and clinical oncology

authors： Scartoni D,Amelio D,Palumbo P,Giacomelli I,Amichetti M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor that usually occurs in infants. It is commonly associated with Kasabach-Merritt phenomenon which is directly responsible for the significant morbidity and mortality, including hemodynamic instability, local invasion, and compression...

journal_title：Journal of cancer research and clinical oncology

authors： Kai L,Wang Z,Yao W,Dong K,Xiao X

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:To establish a hepatocellular carcinoma (HCC) cell line from lung metastatic lesions of human HCC in nude mice so as to provide a suitable model for the study of lung-metastasis-related molecular mechanisms. METHODS:HCC clone cells MHCC97-H were inoculated into BALB/c nude mice, and the pulmonary metastatic le...

journal_title：Journal of cancer research and clinical oncology

authors： Li Y,Tang Y,Ye L,Liu B,Liu K,Chen J,Xue Q

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Clinical trials have reported conflicting results as to whether taxane-based doublet improves outcome over single-agent taxane in patients with advanced breast cancer. METHODS:We performed a meta-analysis comparing primary and secondary end points of taxane-based doublet with single-agent taxane chemotherapy i...

journal_title：Journal of cancer research and clinical oncology

authors： Xu HB,Xu Q,Li L

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in gastric cancer patients. METHODS:A systematic literature search was conducted to identify eligible studies in PubMed and Embase. The pooled hazard ratios (HRs) or odds ratios (ORs) with their correspond...

journal_title：Journal of cancer research and clinical oncology

authors： Wei K,Jiang L,Wei Y,Wang Y,Qian X,Dai Q,Guan Q

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Only few immunohistochemical markers besides c-kit exist for gastrointestinal stromal tumors (GISTs). Thy-1, a cell-surface glycoprotein, is a marker for several types of stem cells and particularly for neuronal precursor cells. The aim of this study was to determine Thy-1 expression in GISTs. MATERIALS AND ME...

journal_title：Journal of cancer research and clinical oncology

authors： Oikonomou D,Hassan K,Kaifi JT,Fiegel HC,Schurr PG,Reichelt U,Aridome K,Yekebas EF,Mann O,Kluth D,Strate T,Izbicki JR

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:Little data exist on characteristics, treatment, and outcome of patients with bone metastases from germ cell cancer. METHODS:A total of 434 patients with poor prognosis germ cell cancer, who underwent primary high-dose chemotherapy (HD-CTX) within two phase II trials, were retrospectively analyzed. RESULTS:40...

journal_title：Journal of cancer research and clinical oncology

authors： Oechsle K,Bokemeyer C,Kollmannsberger C,Mayer F,Berger LA,Oing C,Honecker F

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:Recently, it was reported that expression of transglutaminase 2 plays an important role in doxorubicin/cisplatin resistance in breast and ovarian cancer. The aims of this study were to verify the role of transglutaminase 2 in cisplatin response in non-small cell lung cancer (NSCLC) and to study if transglutamin...

journal_title：Journal of cancer research and clinical oncology

authors： Park KS,Kim HK,Lee JH,Choi YB,Park SY,Yang SH,Kim SY,Hong KM

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:Bone marrow adherent cells contain conventional bone marrow stromal cells and mesenchymal stem cells and these cells constitute the hematopoietic microenvironment. Mesenchymal stem cells have the capacity to give rise to multiple mesenchymal lineage cells and even ectodermal lineage cells. In the present study,...

journal_title：Journal of cancer research and clinical oncology

authors： Li Q,Hisha H,Takaki T,Adachi Y,Li M,Song C,Feng W,Okazaki S,Mizokami T,Kato J,Inaba M,Hosaka N,Maki M,Ikehara S

更新日期：2010-06-01 00:00:00

abstract：:159 "poor risk" patients with previously untreated small cell lung cancer were entered into a randomised study of intravenous bolus versus continuous infusion chemotherapy with doxorubicin on weeks 1, 3, 5 and ifosfamide with mesna on weeks 2, 4, 6. Oral etoposide was given on days 1-5, 15-19, and 29-33. There was no ...

journal_title：Journal of cancer research and clinical oncology

authors： Anderson H,Prendiville J,Thatcher N,Radford JA,Swindell R

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:The present study was undertaken to examine the amplification and expression status of Cks1 in breast cancer and its significance. METHODS:The amplification and expression status of Cks1 gene was examined by FISH, real-time PCR and immunohistochemistry, respectively. RNA interference was used to detect the eff...

journal_title：Journal of cancer research and clinical oncology

authors： Wang XC,Tian LL,Tian J,Wu HL,Meng AM

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:Pancreatic cancer is commonly detected at advanced stages when the tumor is no longer amenable to surgical resection. Therefore, finding biomarkers for early stage disease is urgent. Here, we show that high-definition mass spectrometry (HDMS(E)) can be used to identify serum protein alterations associated with ...

journal_title：Journal of cancer research and clinical oncology

authors： Ansari D,Andersson R,Bauden MP,Andersson B,Connolly JB,Welinder C,Sasor A,Marko-Varga G

更新日期：2015-02-01 00:00:00

abstract：:The oxazaphosphorine analog ifosfamide (IFO) has demonstrated an increased therapeutic index in a variety of solid tumors and hematologic malignancies compared with its parent compound cyclophosphamide. A fractionated dose schedule over 5 days as continuous infusion in combination with the uroprotective agent sodium-2...

journal_title：Journal of cancer research and clinical oncology

authors： Loeffler TM,Weber FW,Hausamen TU

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Recent reports have shown an increase in frequency of intra-hepatic cholangiocarcinoma (IHC) with a stable or decreased frequency of extra-hepatic cholangiocarcinoma (EHC). However, data on the demographic patterns associated with this change are limited. We analyzed cases of cholangiocarcinoma (CC) with aim to...

journal_title：Journal of cancer research and clinical oncology

authors： Singal AK,Vauthey JN,Grady JJ,Stroehlein JR

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly remain unknown. This study was aimed to investigate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of p...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang ZM,Wang Y,Huang R,Liu YP,Li X,Hu FL,Zhu L,Wang F,Cui BB,Dong XS,Zhao YS

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:To establish whether women over 65 years of age with newly diagnosed with breast cancer (BC) receive adjuvant chemotherapy less frequently than younger postmenopausal women and whether comorbidity influences this potential undertreatment. MATERIALS AND METHODS:In a single-site, retrospective, comparative study...

journal_title：Journal of cancer research and clinical oncology

authors： Wallwiener CW,Hartkopf AD,Grabe E,Wallwiener M,Taran FA,Fehm T,Brucker SY,Krämer B

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To determine the cytotoxicity of, and radioenhancement by, gemcitabine on a glioma cell line grown as a monolayer and as spheroid cultures. MATERIAL AND METHODS:We used a human glioma cell line, Gli-6, which originated from a biopsy specimen of a patient with a glioblastoma multiforme. Spheroids...

journal_title：Journal of cancer research and clinical oncology

authors： Genç M,Castro Kreder N,Barten-van Rijbroek A,Stalpers LJ,Haveman J

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:The proto-oncogene forkhead box M1 (FOXM1) is associated with poor survival in many cancers. The impact of FOXM1 expression on progression-free survival (PFS) of non-muscle invasive bladder cancer (NMIBC) has not yet been investigated. The differential expression of FOXM1 between the different molecular NMIBC s...

journal_title：Journal of cancer research and clinical oncology

authors： Rinaldetti S,Wirtz R,Worst TS,Hartmann A,Breyer J,Dyrskjot L,Erben P

更新日期：2018-09-01 00:00:00

abstract：PURPOSE AND METHODS:Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome ...

journal_title：Journal of cancer research and clinical oncology

authors： Pehlivan D,Gunduz E,Gunduz M,Nagatsuka H,Beder LB,Cengiz B,Rivera RS,Fukushima K,Palanduz S,Ozturk S,Yamanaka N,Shimizu K

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Aim of the present study was to identify the genetic heterogeneity, prevalence and frequency of germline mutations of BRCA2 gene in Hereditary Breast/Ovarian cancer patients from Kerala, South India. METHODS:We analyzed 102 Breast/Ovarian cancer patients from 96 breast and/ovarian cancer families for BRCA2 gen...

journal_title：Journal of cancer research and clinical oncology

authors： Syamala V,Sreeja L,Syamala VS,Vinodkumar B,Raveendran PB,Sreedharan H,Kuttappan R,Balakrishnan L,Ankathil R

更新日期：2007-11-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), a very important in the process of tumor angiogenesis, was chosen as a target in a study to determine whether manipulation of angiogenesis with antibody against VEGF may interrupt tumor growth and metastasis. Anti-VEGF antibody was obtained from immunized rabbits, purified on...

journal_title：Journal of cancer research and clinical oncology

authors： Wang G,Dong Z,Xu G,Yang Z,Shou C,Wang N,Liu T

更新日期：1998-01-01 00:00:00

abstract：:Increased expression of P glycoprotein is associated with multidrug resistance in many cell lines. P glycoprotein has been detected in different human tumors. To assess the implication of multidrug resistance in the prognosis of Ewing's sarcoma the expression of P glycoprotein was studied immunohistochemically in pre-...

journal_title：Journal of cancer research and clinical oncology

authors： Roessner A,Ueda Y,Bockhorn-Dworniczak B,Blasius S,Peters A,Wuisman P,Ritter J,Paulussen M,Jürgens H,Böcker W

更新日期：1993-01-01 00:00:00

abstract：:Targeted therapy refers to anticancer treatment which specifically targets key molecules of cancer cells and/or neovascular cells, aiming to thus interfere with processes of tumorigenesis, cancer progression and metastasis. The epidermal growth factor receptor (EGFR) was the first receptor to be proposed for targeted ...

journal_title：Journal of cancer research and clinical oncology

authors： Zahorowska B,Crowe PJ,Yang JL

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Investigation of cell migration and proliferation of human glioma cell line spheroids (CLS) and evaluation of morphology, apoptosis, and immunohistochemical expression of MIB-1, p53, and p21 of organotypic muticellular spheroids (OMS) following cisplatin (CDDP) and irradiation (RT). MATERIAL AND METHODS:Sphero...

journal_title：Journal of cancer research and clinical oncology

authors： Fehlauer F,Muench M,Rades D,Stalpers LJ,Leenstra S,van der Valk P,Slotman B,Smid EJ,Sminia P

更新日期：2005-11-01 00:00:00

abstract：:In 1989, 65%-75% of previously untreated adults with ALL or AML may be expected to enter complete remission. Approximately 40% of these completely responding patients, whether they are treated with intensive chemotherapy, intensive chemotherapy followed by autologous bone marrow transplantation, or allogeneic bone mar...

journal_title：Journal of cancer research and clinical oncology

authors： Mayer RJ

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Oral cancer (OC) patients are at high risk to develop recurrent disease or secondary primary cancers with no available biomarkers to detect these events until a visible lesion is readily present and diagnosed by biopsy. Exosomes secreted by cancer cells are involved in tumor growth, invasion and metastasis. We ...

journal_title：Journal of cancer research and clinical oncology

authors： Zlotogorski-Hurvitz A,Dayan D,Chaushu G,Salo T,Vered M

更新日期：2016-01-01 00:00:00

abstract：:Mice with s.c. grafts of gastric carcinoma MKN45 or osteosarcoma 788T were injected i.v. with recombinant tumour necrosis factor alpha (rTNF alpha) and tumour blood flow rates were determined 4 h later as a fraction of the cardiac output g tissue-1. With MKN45, the tumour blood flow rate was significantly reduced from...

journal_title：Journal of cancer research and clinical oncology

authors： Pimm MV,Gribben SJ,Morris TM

更新日期：1991-01-01 00:00:00