Overexpression of Cks1 is associated with poor survival by inhibiting apoptosis in breast cancer.

abstract：OBJECTIVE:To investigate whether an association exists between a history of fertility treatments and future risk of female malignancies. STUDY DESIGN:A population-based study compared the incidence of long-term female malignancies in a cohort of women with and without a history of fertility treatments including in vit...

journal_title：Journal of cancer research and clinical oncology

authors： Kessous R,Davidson E,Meirovitz M,Sergienko R,Sheiner E

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:G-protein-coupled receptors are known to mediate cell growth via divergent signaling pathways. It has been reported that colon cancer cells express muscarinic acetylcholine receptor (mAChR) although their functional role is largely unknown. The aim of this study is to elucidate possible mechanisms responsible f...

journal_title：Journal of cancer research and clinical oncology

authors： Ukegawa JI,Takeuchi Y,Kusayanagi S,Mitamura K

更新日期：2003-05-01 00:00:00

abstract：:The genetically engineered chimeric cB72.3m4 and cB72.3m12 antibodies recognize the same tumor-associated TAG72 antigen. The high-affinity cB72.3m4 antibody had an approximately 18-fold higher affinity constant for the TAG72 antigen than the low-affinity cB72.3m12 antibody. The relationship between antibody affinity a...

journal_title：Journal of cancer research and clinical oncology

authors： Qi Y,Matte G,Wilkinson A,Jim X

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Her-2/neu and the insulin-like growth factor-1 receptor (IGF-1R) share common postreceptor-signaling pathways, and pre-clinical models have implicated IGF-1R-signaling in resistance to treatment with the anti-Her-2/neu antibody trastuzumab. The present analysis was performed to evaluate the clinical relevance o...

journal_title：Journal of cancer research and clinical oncology

authors： Köstler WJ,Hudelist G,Rabitsch W,Czerwenka K,Müller R,Singer CF,Zielinski CC

更新日期：2006-01-01 00:00:00

abstract：:Modulation of 5-fluorouracil (5-FU) is currently being investigated in advanced colorectal cancer. In an attempt to improve the results obtainable for the association of 5-FU and leucovorin, we decided to add cisplatin to 5-FU and (6S)-leucovorin (S-LV) after disease progression. The hypothesis was that a pharmacologi...

journal_title：Journal of cancer research and clinical oncology

authors： Cassano A,Pozzo C,Corsi DC,Fontana T,Noviello MR,Astone A,Barone C

更新日期：1995-01-01 00:00:00

abstract：:For therapeutic purposes, two chimeric DNA/RNA hammerhead ribozymes were synthesized to cleave AML1/MTG8, the t(8;21)-associated fusion mRNA of acute myeloid leukemia. One ribozyme, A/MRZ-1, recognizes the area adjacent to the fusion point between AML1 and MTG8, and cleaves six bases downstream from this point. The ot...

journal_title：Journal of cancer research and clinical oncology

authors： Kozu T,Sueoka E,Okabe S,Sueoka N,Komori A,Fujiki H

更新日期：1996-01-01 00:00:00

abstract：:The uptake of tritiated N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into Ehrlich-Ascites-Tumor cells of mice was studied by means of the siliconoil-filtration technique. At 10 mM concentration no permeation of the metabolite into the tumor cells could be found within 5 min at 1 degrees C, while its congenors cyclop...

journal_title：Journal of cancer research and clinical oncology

authors： Lenssen U,Hohorst HJ

更新日期：1979-02-19 00:00:00

abstract：:Gastric cancer is a major health issue and a leading cause of death worldwide. The results of standard therapy remain unsatisfactory mainly because of diagnosis at the late stage of disease. Innovative strategies such as neoadjuvant chemotherapy in locally advanced cancer have improved the outcome even in operable cas...

journal_title：Journal of cancer research and clinical oncology

authors： Menges M,Hoehler T

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor that usually occurs in infants. It is commonly associated with Kasabach-Merritt phenomenon which is directly responsible for the significant morbidity and mortality, including hemodynamic instability, local invasion, and compression...

journal_title：Journal of cancer research and clinical oncology

authors： Kai L,Wang Z,Yao W,Dong K,Xiao X

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:Drinking green tea daily is part of Japanese culture, and various studies have revealed that green tea is a cancer preventive. We here review our progress in cancer prevention with green tea on 12 main topics, from basic to clinical level. TOPICS AND METHODS: Biochemical and biological studies of green tea cate...

journal_title：Journal of cancer research and clinical oncology

authors： Fujiki H,Imai K,Nakachi K,Shimizu M,Moriwaki H,Suganuma M

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:Angiosarcoma of the scalp and face is a rare malignant endothelial tumor arising mainly in elderly people. The prognosis is poor. Effective and safe treatments are warranted. METHODS:A 79-year-old woman with an angiosarcoma of the scalp larger than 5 cm in diameter was treated with intravenous liposomal doxoru...

journal_title：Journal of cancer research and clinical oncology

authors： Wollina U,Füller J,Graefe T,Kaatz M,Lopatta E

更新日期：2001-01-01 00:00:00

abstract：:High-dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) has become an important method of treatment for hematological and solid tumors. We examined levels of interleukin(IL)-4, interferon (IFN)gamma, soluble (s) CD30, and sIL-2 receptor (R) before and after autologous PBSCT, and compared finding...

journal_title：Journal of cancer research and clinical oncology

authors： Nagahama M,Nomura S,Katsura K,Ozaki Y,Yoshimura C,Kagawa H,Fukuhara S

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:No study has evaluated the prognostic impact of the age-adjusted Charlson comorbidity index (AACI) in those with renal cell carcinoma (RCC). This study aimed to evaluate the utility of the AACI for predicting long-term survival in patients with surgically treated non-metastatic clear cell RCC (ccRCC). METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Kang HW,Kim SM,Kim WT,Yun SJ,Lee SC,Kim WJ,Hwang EC,Kang SH,Hong SH,Chung J,Kwon TG,Kim HH,Kwak C,Byun SS,Kim YJ,KORCC (KOrean Renal Cell Carcinoma) Group.

更新日期：2020-01-01 00:00:00

abstract：:A short-term organ culture of rat tracheal epithelium was used to detect the ability of 53 chemicals to induce UDS. In this system all direct-acting compounds (ultimate or proximate carcinogens) tested induced UDS. Of 24 compounds requiring metabolism (procarcinogens), nine induced UDS, viz., 4NQO, AF-2, BP, DMN, DEN,...

journal_title：Journal of cancer research and clinical oncology

authors： Ide F,Ishikawa T,Takayama S

更新日期：1981-01-01 00:00:00

abstract：:This study was undertaken in order to compare the usefulness of three indices of tumour proliferation in detecting primary hepatocellular carcinoma (HCC) and in differentiating this neoplasm from liver cirrhosis. In 10 patients with HCC and in 63 with liver cirrhosis serum alpha-fetoprotein (AFP), tissue polypeptide a...

journal_title：Journal of cancer research and clinical oncology

authors： Leandro G,Basso D,Fabris C,Zizzari S,Elba S,Del Favero G,Di Mario F,Meggiato T,Angonese C,Naccarato R

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Lung cancer is the commonest cause of cancer deaths worldwide, and its mortality can be reduced significantly by performing early diagnosis and screening. Since the 1960s, driven by the pressing needs to accurately and effectively interpret the massive volume of chest images generated daily, computer-assisted d...

journal_title：Journal of cancer research and clinical oncology

authors： Liu B,Chi W,Li X,Li P,Liang W,Liu H,Wang W,He J

更新日期：2020-01-01 00:00:00

abstract：:In the supernatant of melanoma cell culture SK mel 25 three indolic compounds - 5-hydroxy-6-methoxyindole, 5-hydroxy-6-methoxyindolyl-2-carboxylic, and 6-hydroxy-5-methoxyindolyl-2-carboxylic acids - have been identified. The supernatants were extracted with ethyl acetate, derivatized, and analyzed by gas chromatograp...

journal_title：Journal of cancer research and clinical oncology

authors： Pavel S,Muskiet FA,de Ley L,The TH,van der Slik W

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to determine which clinicopathological factors influenced the long-term survival after potentially curative resection of colorectal cancer patients with a normal preoperative serum level of carcinoembryonic antigen (CEA). METHODS:A total of 1,732 patients who underwent curative surger...

journal_title：Journal of cancer research and clinical oncology

authors： Huh JW,Kim CH,Lim SW,Kim HR,Kim YJ

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Objective of this work was to extend pharmacokinetic scaling theory of the writer for bolus dosing to include the case of constant-rate i.v. dosing over fixed interval so as to allow projection of adult dose and schedule of typically administered anticancer agents to children. METHODS:The basis for the scaling...

journal_title：Journal of cancer research and clinical oncology

authors： Dawson TH

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:Pheochromocytomas/paragangliomas (PHEOs/PGLs) are rare in children with only a few SDHB mutation-related cases. Previous studies on children were conducted in small cohorts. This large set of pediatric patients provides robust data in the evaluation of clinical outcomes. METHODS:Sixty-four pediatric PHEO/PGL p...

journal_title：Journal of cancer research and clinical oncology

authors： Jochmanova I,Abcede AMT,Guerrero RJS,Malong CLP,Wesley R,Huynh T,Gonzales MK,Wolf KI,Jha A,Knue M,Prodanov T,Nilubol N,Mercado-Asis LB,Stratakis CA,Pacak K

更新日期：2020-04-01 00:00:00

abstract：:Nitrosodiphenylamine was tested for induction of DNA single strand breaks in rat hepatocytes and Chinese hamster V 79 cells with the alkaline filter elution assay. While in rat hepatocytes DNA damage was observed, negative results were obtained in V 79 cells. In view of the metabolic capacity of hepatocytes and the ch...

journal_title：Journal of cancer research and clinical oncology

authors： Appel KE,Görsdorf S,Scheper T,Ruf HH,Rühl CS,Hildebrandt AG

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Insulin-like growth factor 1 (IGF-1) stimulates mitosis and inhibits apoptosis. High circulating IGF-1 levels are linked with an increased risk of colorectal and breast cancer. Recently, IGF-1 single nucleotide polymorphisms (SNPs), especially variant rs2946834, have been associated with poor clinical outcome i...

journal_title：Journal of cancer research and clinical oncology

authors： Muendlein A,Lang AH,Geller-Rhomberg S,Winder T,Gasser K,Drexel H,Decker T,Mueller-Holzner E,Chamson M,Marth C,Hubalek M

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:Metastasizing epithelioid sarcoma (ES) is an extremely aggressive tumor, because conventional chemotherapy and irradiation are largely ineffective. Here, we analyzed the impact of the CD95-mediated drug-induced apoptosis in ES cell lines. METHODS:The effects of paclitaxel (Taxol) and 5-FU were determined by MT...

journal_title：Journal of cancer research and clinical oncology

authors： Heikaus S,Matuszek KS,Suschek CV,Ramp U,Reinecke P,Grinstein E,Haremza J,Gabbert HE,Mahotka C

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:To elucidate the effect of tumor oxygenation status on recovery from damage following gamma-ray or accelerated carbon ion irradiation in vivo, including in quiescent (Q) cells. METHODS:SCC VII tumor-bearing mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. They r...

journal_title：Journal of cancer research and clinical oncology

authors： Masunaga S,Hirayama R,Uzawa A,Kashino G,Suzuki M,Kinashi Y,Liu Y,Koike S,Ando K,Ono K

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:The proto-oncogene forkhead box M1 (FOXM1) is associated with poor survival in many cancers. The impact of FOXM1 expression on progression-free survival (PFS) of non-muscle invasive bladder cancer (NMIBC) has not yet been investigated. The differential expression of FOXM1 between the different molecular NMIBC s...

journal_title：Journal of cancer research and clinical oncology

authors： Rinaldetti S,Wirtz R,Worst TS,Hartmann A,Breyer J,Dyrskjot L,Erben P

更新日期：2018-09-01 00:00:00

abstract：:Although the biological action of phthalates has been widely discussed there is little information on early cellular changes indicative for toxic or carcinogenic effects. To study subtle alterations in the cell morphology, we have by means of image processing evaluated the nuclei of hamster hepatocytes after treatment...

journal_title：Journal of cancer research and clinical oncology

authors： Komitowski D,Schmezer P,Schmitt B,Ehemann V,Muto S

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:The development of brain metastases (BMs) was associated with poor prognosis in melanoma patients. Patients with BMs have a median survival of <6 months. Melanoma is the third most common tumor to metastasize to the brain with a reported incidence of 10-40 %. Our aim was to identify factors predicting develo...

journal_title：Journal of cancer research and clinical oncology

authors： Gumusay O,Coskun U,Akman T,Ekinci AS,Kocar M,Erceleb OB,Yazıcı O,Kaplan MA,Berk V,Cetin B,Taskoylu BY,Yildiz A,Goksel G,Alacacioglu A,Demirci U,Algin E,Uysal M,Oztop I,Oksuzoglu B,Dane F,Gumus M,Buyukberber S

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To identify and characterize novel genetic alterations in hepatocellular carcinoma (HCC). METHODS:DNA was extracted from 29 HCC and corresponding normal tissues and amplified with 59 different 10-base arbitrary primers. A 550 bp DNA fragment amplified using primer Q-9 and which was present in 19 of 29 cases (6...

journal_title：Journal of cancer research and clinical oncology

authors： Saelee P,Wongkham S,Bhudhisawasdi V,Sripa B,Chariyalertsak S,Petmitr S

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:Kinase insert domain-containing receptor (KDR) is one of the molecular targets used in cancer therapy. We studied the KDR expression characteristics and the relationship with the clinical parameters of the patients with lung cancer, to give the basic evidence and clue for tailoring therapy. METHODS:Reverse tra...

journal_title：Journal of cancer research and clinical oncology

authors： An SJ,Nie Q,Chen ZH,Lin QX,Wang Z,Xie Z,Chen SL,Huang Y,Zhang AY,Yan JF,Wu HS,Lin JY,Li R,Zhang XC,Guo AL,Mok TS,Wu YL

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To calculate the accuracy of the Tokuhashi score (TS) in recent patients with vertebral metastasis (VM), candidates or not to surgical treatment, and thus to assess the external validity of TS. METHODS:Retrospective analysis of prospectively collected data from 90 patients (55 men, 35 women) with VM between 20...

journal_title：Journal of cancer research and clinical oncology

authors： Hernandez-Fernandez A,Vélez R,Lersundi-Artamendi A,Pellisé F

更新日期：2012-09-01 00:00:00