[Permeability of N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into tumor cells (author's transl)].

abstract：PURPOSE:Normalization of the tumor vasculature and microenvironment by several angiogenesis inhibitors has been reported. Given that recombinant human endostatin (rh-endostatin) is also an endogenous angiogenesis inhibitor, a comprehensive evaluation of the effects of rh-endostatin on tumor vasculature and microenviron...

journal_title：Journal of cancer research and clinical oncology

authors： Huang G,Chen L

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Individuals affected by rheumatoid arthritis (RA) occasionally develop lymphoproliferative disorders (RA-LPD). To study the molecular changes underscoring the RA-LPD, mutations of p53 and Bak gene were analyzed in RA-LPD with (MTX-LPD) or without methotrexate treatment for RA (non-MTX-LPD). METHODS:Histology a...

journal_title：Journal of cancer research and clinical oncology

authors： Xu JX,Hoshida Y,Hongyo T,Sasaki T,Miyazato H,Tomita Y,Aozasa K

更新日期：2007-02-01 00:00:00

abstract：:Point mutations occurring at codon 201 of the gene coding for the alpha subunit of the stimulatory G protein impair intrinsic GTPase activity and lead to a constitutive activation of adenylate cyclase. We have examined thyroid follicular and papillary carcinomas and follicular adenomas and found samples that bear this...

journal_title：Journal of cancer research and clinical oncology

authors： Gorelov VN,Dumon K,Barteneva NS,Palm D,Röher HD,Goretzki PE

更新日期：1995-01-01 00:00:00

abstract：:This report describes two types of reticular epithelial cell in the thymic cortex of the BALB/c mouse, an immature and a mature form. During early stages of lymphoma development, i.e., 2-6 weeks postinfection (p.i.) with Moloney leukemia virus (M-MuLV), activation of the epithelial cells is observed. Although the perc...

journal_title：Journal of cancer research and clinical oncology

authors： Heine UI,Krueger GR,Karpinski A,Munoz E,Krueger MB

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and adolescents. However, few biomarkers of diagnostic significance have been established. In recent years, high-throughput transcriptomic and metabolomic approaches make it possible for studying the levels of thousands of bioma...

journal_title：Journal of cancer research and clinical oncology

authors： Chen K,Zhu C,Cai M,Fu D,Cheng B,Cai Z,Li G,Liu J

更新日期：2014-10-01 00:00:00

abstract：:Radiation chimeras with trisomy 19 hematopoietic cells were constructed to test the sensitivity of the trisomic hematopoietic system to infection with Rauscher leukemia virus: Hematopoietic cells from livers of trisomic fetuses were rescued by transplantation into lethally irradiated adult mice. These Ts 19 radiation ...

journal_title：Journal of cancer research and clinical oncology

authors： Herbst EW,Gropp A,Pluznik DH

更新日期：1985-01-01 00:00:00

abstract：:The chemotherapeutic action of tegafur (FT) against adenocarcinoma 755 in mice was markedly potentiated by oral administration of L-cysteine and L-cystine without increasing its toxicity. In particular, the combination of FT at 200 mg/kg per day (maximum dose) and 1000 mg/kg per day of L-cystine markedly inhibited tum...

journal_title：Journal of cancer research and clinical oncology

authors： Iigo M,Hoshi A,Kitagawa H

更新日期：1986-01-01 00:00:00

abstract：:Resistance to cytotoxic chemotherapy is a major problem in the management of patients with metastatic breast cancer. Various data suggest P-glycoprotein-associated multidrug resistance (MDR) to be a relevant resistance mechanism in this tumor. The purpose of this study was to evaluate feasibility and activity of combi...

journal_title：Journal of cancer research and clinical oncology

authors： Thürlimann B,Kröger N,Greiner J,Mross K,Schüller J,Schernhammer E,Schumacher K,Gastl G,Hartlapp J,Kupper H

更新日期：1995-01-01 00:00:00

abstract：:High-dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) has become an important method of treatment for hematological and solid tumors. We examined levels of interleukin(IL)-4, interferon (IFN)gamma, soluble (s) CD30, and sIL-2 receptor (R) before and after autologous PBSCT, and compared finding...

journal_title：Journal of cancer research and clinical oncology

authors： Nagahama M,Nomura S,Katsura K,Ozaki Y,Yoshimura C,Kagawa H,Fukuhara S

更新日期：2000-02-01 00:00:00

abstract：:Peptide growth factors involved in the regulation of haematopoiesis (HPGF), for example granulocyte-colony-stimulating factor (G-CSF) and granulocyte/macrophage-colony-stimulating factor (GM-CSF), are of clinical importance in the treatment of testicular germ cell tumour (GCT) patients with modern chemotherapy regimen...

journal_title：Journal of cancer research and clinical oncology

authors： Dunn TA,Schmoll HJ,Rie C,Hartmann K,Casper J

更新日期：1998-01-01 00:00:00

abstract：:Seventy-three evaluable patients with advanced measurable solid tumors were given cisdichlorodiammineplatinum (II) (DDP) at a dose of 20 mg/M2 IV for 1-5 days every 3 weeks, and 19 patients who failed on this low dose DDP protocol received a single high dose of 100 mg/M2 IV once every 3 weeks. Forty-six patients had r...

journal_title：Journal of cancer research and clinical oncology

authors： Schilcher RB,Wessels M,Niederle N,Seeber S,Schmidt CG

更新日期：1984-01-01 00:00:00

abstract：:Human breast carcinomas were evaluated for estrogen and progesterone receptors by immunohistochemistry using monoclonal anti-receptor antibodies (n = 267) and by cytosol steroid-binding assays (n = 212). The estrogen and progesterone receptor contents of the tumors correlated with histological features of differentiat...

journal_title：Journal of cancer research and clinical oncology

authors： Helle M,Helin M,Isola J,Helin H

更新日期：1989-01-01 00:00:00

abstract：:The carcinogenicity of long-term feeding of masheri extract to animals in a vitamin-A-sufficient (SLO+) and deficient (SLO-) state was studied in Sprague Dawley rats by feeding daily dose of 3 mg extract over a period of 21 months. The phase I activating enzymes, the glutathione (GSH)/glutathione S-transferase (GST) d...

journal_title：Journal of cancer research and clinical oncology

authors： Ammigan N,Nair UJ,Lalitha VS,Bhide SV

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. METHODS:We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of th...

journal_title：Journal of cancer research and clinical oncology

authors： Rottmann M,Burges A,Mahner S,Anthuber C,Beck T,Grab D,Schnelzer A,Kiechle M,Mayr D,Pölcher M,Schubert-Fritschle G,Engel J

更新日期：2017-09-01 00:00:00

abstract：:Twenty-five surgical specimens of malignant human prostate, 3 lymph nodes with metastatic prostate carcinoma, 11 normal human prostates, as well as 3 human prostate cell lines (DU-145, PC3 and LNCaP) were examined for the expression of the human matrix metalloproteinase-7 gene (MMP-7) from the human collagenase family...

journal_title：Journal of cancer research and clinical oncology

authors： Pajouh MS,Nagle RB,Breathnach R,Finch JS,Brawer MK,Bowden GT

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Approximately 5% of patients with cutaneous squamous cell carcinoma (CSCC) may develop recurrent or metastatic disease. The management of such cases is challenging and requires multi-disciplinary care. Immunotherapy using PD-1 inhibition was approved to treat unresectable or metastatic CSCC in 2018. Given limit...

journal_title：Journal of cancer research and clinical oncology

authors： In GK,Vaidya P,Filkins A,Hermel DJ,King KG,Ragab O,Tseng WW,Swanson M,Kokot N,Lang JE,Menendez L,DeClerck B,Kim G,Hu JC,Terando A,Jadvar H,Ricker C,Miller KA,Peng DH,Wysong A

更新日期：2020-11-18 00:00:00

abstract：PURPOSE:The growth pattern of peripheral squamous cell carcinoma (SCC) of the lung is divided into two types: alveolar space-filling (ASF) growth and alveolar space-destructive (ASD) growth. The aim of this study was to investigate the clinicopathological differences between cancer cells displaying ASF and ASD growth. ...

journal_title：Journal of cancer research and clinical oncology

authors： Omori T,Aokage K,Nakamura H,Katsumata S,Miyoshi T,Sugano M,Kojima M,Fujii S,Kuwata T,Ochiai A,Ikeda N,Tsuboi M,Ishii G

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Imatinib is a small molecule inhibiting the tyrosine kinases bcr-abl, c-kit, PDGFR-alpha and PDGFR-beta. Investigations were performed to screen ovarian cancer cell lines and tumor samples for target receptor expression. Effects of Imatinib on cell proliferation and apoptosis induction were measured with and wi...

journal_title：Journal of cancer research and clinical oncology

authors： Mundhenke C,Weigel MT,Sturner KH,Roesel F,Meinhold-Heerlein I,Bauerschlag DO,Schem C,Hilpert F,Jonat W,Maass N

更新日期：2008-12-01 00:00:00

abstract：:The inducibility of cytotoxic T lymphocytes (CTL) that react with carcinoembryonic antigen (CEA) was tested in cancer patients with elevated (more than 5 ng/ml) serum CEA levels when antigen presentation was carried out with paraformaldehyde-fixed adhesive peripheral blood mononuclear cells (PBMC) from the patient tha...

journal_title：Journal of cancer research and clinical oncology

authors： Kim CH,Todoroki T,Matsumura M,Ohno T

更新日期：2000-07-01 00:00:00

abstract：:Human ovarian cancer cells from ten patients were cultured in the agar double layer assay as described by Hamburger and Salmon and in a methylcellulose monolayer system. The assays were compared under the same experimental conditions. The rate of positives (defined as greater than 30 colonies/dish) was 75% in the meth...

journal_title：Journal of cancer research and clinical oncology

authors： Runge HM,Neumann HA,Bücke W,Pfleiderer A

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:With the increasing interest in treatment decision-making based on risk prediction models, it is essential for clinicians to understand the steps in developing and interpreting such models. METHODS:A retrospective registry of 20 Dutch hospitals with data on patients treated for castration-resistant prostate ca...

journal_title：Journal of cancer research and clinical oncology

authors： Veen KM,de Angst IB,Mokhles MM,Westgeest HM,Kuppen M,Groot CAU,Gerritsen WR,Kil PJM,Takkenberg JJM

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Despite of the introduction of novel treatment modalities for multiple myeloma, high-dose chemotherapy with hematopoietic stem-cell rescue is still considered the standard of care for eligible patients <65 years of age. As we have previously reported, stem-cell grafts regularly contain quantities of plasma c...

journal_title：Journal of cancer research and clinical oncology

authors： Kopp HG,Yildirim S,Weisel KC,Kanz L,Vogel W

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine breast tumors and normal breast tissues for the expression of the glycoprotein lacritin. The mRNA and protein expression of lacritin has been reported to be restricted to the lacrimal gland. METHODS:We investigated 37 human primary invasive breast tumors, seven breast c...

journal_title：Journal of cancer research and clinical oncology

authors： Weigelt B,Bosma AJ,van 't Veer LJ

更新日期：2003-12-01 00:00:00

abstract：:A prospective, randomized, double-blind placebo-controlled trial was designed to evaluate the impact of granulocyte/macrophage-colony-stimulating factor (GM-CSF) on the efficacy of sequential high-dose cytosine arabinoside/mitoxantrone chemotherapy (S-HAM) in adult patients with high-risk myelodysplastic syndromes (MD...

journal_title：Journal of cancer research and clinical oncology

authors： Verbeek W,Wörmann B,Koch P,Aul C,Hinrichs HF,Balleisen L,Rowe JM,Bennett J,Haase D,Fonatsch C,Heinecke A,Büchner T,Hiddemann W

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Allogeneic haematopoietic stem cell transplantation (HSCT) is a proven treatment for patients with haematological malignancies. In this retrospective analysis, the impact of donor matching on outcome of unrelated HSCT was analysed in patients transplanted at the University of Leipzig. METHODS:From 2000 to 2009...

journal_title：Journal of cancer research and clinical oncology

authors： Rockstroh A,Al-Ali HK,Lange T,Pönisch W,Krahl R,Cross M,Behre G,Niederwieser D,Pfrepper C

更新日期：2015-12-01 00:00:00

abstract：:The chemosensitizing potency of dexniguldipine hydrochloride (B8509-035) on epidoxorubicin was assessed in a multidrug-resistant (MDR) tumour model, the intrinsic MDR rat colon carcinoma CC531. In vitro in the sulphorhodamine B cell-viability assay the cytotoxicity of epidoxorubicin was increased approximately 15-fold...

journal_title：Journal of cancer research and clinical oncology

authors： Van de Vrie W,Schellens JH,Loss WJ,Kolker HJ,Verwey J,Stoter G,Durante NM,Eggermont AM

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To investigate the effects of Akt/ARK5 pathways on the metastatic potential of human breast cancer cells. MATERIALS AND METHODS:The human ARK5 gene was transfected into MDA-MB-231 cells. Effects of ARK5 on MDA-MB-231 cells were investigated in vitro. The tumorigenicity and spontaneously metastatic capability r...

journal_title：Journal of cancer research and clinical oncology

authors： Chang XZ,Yu J,Liu HY,Dong RH,Cao XC

更新日期：2012-02-01 00:00:00

abstract：:A novel butyric acid derivative, pivaloyloxymethyl butyrate, AN-9, was previously shown to be a potent differentiating agent. AN-9 exerts a significant anticancer activity in vitro and in vivo. In all the activities examined, AN-9 was more potent than butyric acid. Here we show that AN-9 and butyric acid induce cell d...

journal_title：Journal of cancer research and clinical oncology

authors： Zimra Y,Wasserman L,Maron L,Shaklai M,Nudelman A,Rephaeli A

更新日期：1997-01-01 00:00:00

abstract：:In view of the great variation in the size of epithelial cell nuclei in benign changes in the mammary gland, the cytologist is often faced with diagnostic difficulties. Clear differences in the size of the nuclei in aspiration biopsies from the mammary glands of pregnant women and those from the mammary glands of post...

journal_title：Journal of cancer research and clinical oncology

authors： Schöndorf H,Naujoks H

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The feasibility of radioimmunotherapy (RAIT) combined with 5-fluorouracil (5-FU) was examined in colon cancer xenografts. The mode of interaction of the two treatments was also investigated. METHODS:Mice bearing human colon cancer were treated with a combination of 4.63 MBq (L-RAIT) or 9.25 MBq (H-RAIT) (131)I...

journal_title：Journal of cancer research and clinical oncology

authors： Kinuya S,Yokoyama K,Tega H,Hiramatsu T,Konishi S,Watanabe N,Shuke N,Aburano T,Takayama T,Michigishi T,Tonami N

更新日期：1999-11-01 00:00:00