ARK5 is associated with the invasive and metastatic potential of human breast cancer cells.

abstract：:The effects of three non-myelotoxic cancer drugs on the growth of neuroblastoma cells were investigated in vitro and in vivo: dihydroxyphenylalanine (L-dopa, a drug with selective toxicity for melanoma cells), DL-buthionine sulphoximine (BSO, a drug with radiosensitizing effects), and tamoxifen (a drug used in the tre...

journal_title：Journal of cancer research and clinical oncology

authors： Busse E,Bartsch O,Kornhuber B

更新日期：1991-01-01 00:00:00

abstract：:Febrile neutropenic events (FNE) were studied in 90 patients on chemotherapy protocols for solid tumours, from 1986 to 1990. All patients received intensive chemotherapy with a high dose intensity. There were 51 FNE admissions in 31 patients, with an average event rate of 1.6/patient. The average periods of granulocyt...

journal_title：Journal of cancer research and clinical oncology

authors： Nobbenhuis M,Cleton FJ

更新日期：1992-01-01 00:00:00

abstract：:Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer pa...

journal_title：Journal of cancer research and clinical oncology

authors： Kynast B,Binder L,Marx D,Zoll B,Schmoll HJ,Oellerich M,Schauer A

更新日期：1993-01-01 00:00:00

abstract：:Reversal of natural resistance to bouvardin (NSC 259968) has been attained in vitro and in vivo, by the calcium influx blocker verapamil in sarcoma 180 cells insensitive to bouvardin. Verapamil increased the in vitro lethality of the tumor cells following exposure with cells for 1 and 3 h as a result of the cytotoxic ...

journal_title：Journal of cancer research and clinical oncology

authors： Chitnis MP,Menon RS,Basrur VS,Adwankar MK,Satyamoorthy K

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Several reports describe the importance of the chaperone HSP27 (HSPB1) in cancer progression, and the demand for drugs that modulate HSPB1-activity is increasing rapidly. We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in pancreatic cancer. METH...

journal_title：Journal of cancer research and clinical oncology

authors： Heinrich JC,Tuukkanen A,Schroeder M,Fahrig T,Fahrig R

更新日期：2011-09-01 00:00:00

abstract：:The proliferative activity in 70 cases of soft-tissue tumours was estimated immunohistochemically using the monoclonal antibody PC-10, which recognizes proliferating-cell nuclear antigen (PCNA) in paraffin sections. The PCNA index (i.e. the percentage of positive neoplastic nuclei) and to a lesser degree the PCNA coun...

journal_title：Journal of cancer research and clinical oncology

authors： Korkolopoulou P,Christodoulou P,Papanikolaou A,Tsenga A,Thomas-Tsagli E

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:Tumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation. METHODS:TNBC patients (n = 179) with complete clinical data and up to 18-year follow-up...

journal_title：Journal of cancer research and clinical oncology

authors： Vihervuori H,Autere TA,Repo H,Kurki S,Kallio L,Lintunen MM,Talvinen K,Kronqvist P

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Sec8, a component of the exocyst complex, has been implicated in tethering of secretory vesicles to specific regions on the plasma membrane. To investigate the involvement of Sec8 in oral squamous-cell carcinoma (OSCC), we evaluated the expression status and effect of Sec8 in OSCC cell lines. METHODS:Sec8 mRNA...

journal_title：Journal of cancer research and clinical oncology

authors： Yamamoto A,Kasamatsu A,Ishige S,Koike K,Saito K,Kouzu Y,Koike H,Sakamoto Y,Ogawara K,Shiiba M,Tanzawa H,Uzawa K

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:The purposes of our study were to elucidate the role of BRG1 in the development of human glioma and to determine the effect of BRG1 on glioma cell growth, migration and invasion. METHODS:Using tissue microarray and immunohistochemistry, we evaluated BRG1 staining in 190 glioma tissues, 8 normal brain tissues a...

journal_title：Journal of cancer research and clinical oncology

authors： Bai J,Mei PJ,Liu H,Li C,Li W,Wu YP,Yu ZQ,Zheng JN

更新日期：2012-06-01 00:00:00

abstract：CONTEXT:Parathyroid carcinoma (PC) is a rare endocrine malignancy with no approved systemic therapies for unresectable locally invasive or distant metastatic disease. Understanding the molecular changes in advanced PC can provide better understanding of this disease and potentially help directing targeted therapy. OBJ...

journal_title：Journal of cancer research and clinical oncology

authors： Kutahyalioglu M,Nguyen HT,Kwatampora L,Clarke C,Silva A,Ibrahim E,Waguespack SG,Cabanillas ME,Jimenez C,Hu MI,Sherman SI,Kopetz S,Broaddus R,Dadu R,Wanland K,Williams M,Zafereo M,Perrier N,Busaidy NL

更新日期：2019-08-01 00:00:00

abstract：:Lambda-DNA and plasmid pBR 322-DNA, respectively, were treated in vitro with increasing amounts of 4-S-ethanolsulfido-cyclophosphamide (CPA-P1). Subsequent digestion with restriction endonuclease Pvu II or Mbo II revealed discrete alterations in the cleavage patterns as compared to the controls, indicating subtle chan...

journal_title：Journal of cancer research and clinical oncology

authors： Lindemann H

更新日期：1985-01-01 00:00:00

abstract：:The association of Epstein-Barr virus (EBV) with gastric medullary carcinoma with lymphoid infiltration (GMCL) was investigated. The presence of GMCL exhibited a 2/1 male-to-female ratio and a 1/2 early-to-advanced cancer ratio, predominantly located in the cardia and corpus of the stomach (90%). The presence of EBV D...

journal_title：Journal of cancer research and clinical oncology

authors： Takano Y,Kato Y,Sugano H

更新日期：1994-01-01 00:00:00

abstract：:To investigate multidrug-resistance gene (MDR1) promoter efficacy and drug inducibility in cells with different multidrug-resistance phenotypes, multidrug-resistant HCT15 and drug-sensitive KM12 human colon carcinoma cell lines were transfected with constructs incorporating the chloramphenicol acetyltransferase (CAT) ...

journal_title：Journal of cancer research and clinical oncology

authors： Stein U,Walther W,Shoemaker RH

更新日期：1996-01-01 00:00:00

abstract：:Cancer development depends on the aberrant activation of signal transduction pathways that control cell growth and survival and play important roles in normal embryonic development. This review will focus on one of the most powerful pathways, the canonical Wnt signal transduction cascade, which has been originally des...

journal_title：Journal of cancer research and clinical oncology

authors： Lustig B,Behrens J

更新日期：2003-04-01 00:00:00

abstract：:High-dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) has become an important method of treatment for hematological and solid tumors. We examined levels of interleukin(IL)-4, interferon (IFN)gamma, soluble (s) CD30, and sIL-2 receptor (R) before and after autologous PBSCT, and compared finding...

journal_title：Journal of cancer research and clinical oncology

authors： Nagahama M,Nomura S,Katsura K,Ozaki Y,Yoshimura C,Kagawa H,Fukuhara S

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and survival time of acquired immunodeficiency syndrome-related malignancies among HIV-infected population. METHODS:A clinical database search, chart review and verification with health records were undertaken for all AIDS-defining cancers diagnosed in Zhongnan Hospital Wuhan Unive...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang YX,Gui XE,Zhong YH,Rong YP,Yan YJ

更新日期：2011-04-01 00:00:00

abstract：:This report describes two types of reticular epithelial cell in the thymic cortex of the BALB/c mouse, an immature and a mature form. During early stages of lymphoma development, i.e., 2-6 weeks postinfection (p.i.) with Moloney leukemia virus (M-MuLV), activation of the epithelial cells is observed. Although the perc...

journal_title：Journal of cancer research and clinical oncology

authors： Heine UI,Krueger GR,Karpinski A,Munoz E,Krueger MB

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:We compared laparoscopic approach with the conventional laparotomy approach for the treatment of patients with endometrial carcinoma in developing country. METHODS:Two hundred and seventy-two patients with endometrial carcinoma were enrolled in a prospective randomized trial and treated with laparoscopic or la...

journal_title：Journal of cancer research and clinical oncology

authors： Lu Q,Liu H,Liu C,Wang S,Li S,Guo S,Lu J,Zhang Z

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-gamma) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expre...

journal_title：Journal of cancer research and clinical oncology

authors： Coppola D,Parikh V,Boulware D,Blanck G

更新日期：2009-09-01 00:00:00

abstract：:Aclacinomycin A (ACM) is a new anthracycline antibiotic with a reduced cardiac toxicity in animal models. A phase II study was performed in a total of 25 patients, 23 of whom are evaluable for response. All suffered from recurrent and advanced tumors. Pretreatment consisted of at least four different chemotherapeutic ...

journal_title：Journal of cancer research and clinical oncology

authors： Schütte J,Niederle N,Seeber S

更新日期：1983-01-01 00:00:00

abstract：:The Harvey ras locus was examined for restriction fragment polymorphism and loss of allelic heterozygosity in 62 oral cancer patients. Southern blot analysis on BamHI digests of the tumour tissue DNA, revealed 23 patients with H-ras-1 heterozygosity. The probes used to study the polymorphism were the BamHI 6.6-kb frag...

journal_title：Journal of cancer research and clinical oncology

authors： Saranath D,Bhoite LT,Mehta AR,Sanghavi V,Deo MG

更新日期：1991-01-01 00:00:00

abstract：AIM:To examine the expressions of focal adhesion kinase (FAK) and its clinical significance in hepatocellular carcinoma (HCC). METHODS:We determined the expression levels of FAK on both steady-state mRNA and protein levels in 50 HCC samples by quantitative real-time PCR and immunohistochemistry, respectively. The corr...

journal_title：Journal of cancer research and clinical oncology

authors： Yuan Z,Zheng Q,Fan J,Ai KX,Chen J,Huang XY

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:CC chemokine receptor 1 (CCR1) plays a critical role in the recruitment of leukocytes to the site of inflammation. Tumor invasion and metastasis share many similarities with leukocyte trafficking, which is critically regulated by chemokines and their receptors. In this study, we aimed to assess the role of CCR1...

journal_title：Journal of cancer research and clinical oncology

authors： Wang CL,Sun BS,Tang Y,Zhuang HQ,Cao WZ

更新日期：2009-05-01 00:00:00

abstract：:DNA repair is an important process. It is as essential for the cell as is transcription and replication. There is evidence that deficient DNA repair processes lead to human disease including cancer, and recent progress in the field of DNA repair is likely to expand our knowledge about these relationships considerably....

journal_title：Journal of cancer research and clinical oncology

authors： Bohr VA

更新日期：1990-01-01 00:00:00

abstract：:The authors of this "Letter to the Editors" express their major concern about selective and biased reporting in this paper. ...

journal_title：Journal of cancer research and clinical oncology

authors： Boehle A,Kahmann F,Henkel TO,Zimmermann J,Machtens S

更新日期：2021-01-28 00:00:00

abstract：PURPOSE:Tumor grade is one of the more controversial factors with limited prognostic information in squamous cell carcinomas (SCC) of the uterine cervix. METHODS:Histologic slides of 233 surgically treated cervical SCC (FIGO IB1) were re-examined regarding the prognostic impact of the WHO-based grading system, using t...

journal_title：Journal of cancer research and clinical oncology

authors： Horn LC,Höhn AK,Hentschel B,Fischer U,Bilek K,Brambs CE

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Explore patient-reported outcomes (PROs), including health-related quality of life (HRQoL), satisfaction with therapy, impact of the therapy on work and daily life, and concerns related to the therapy and identify variables associated with PROs in persons with chronic myeloid leukemia (CML) receiving tyrosine k...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang Q,Wang HB,Yu L,Gale RP

更新日期：2017-06-01 00:00:00

abstract：:Protein extracted from conventional formalin-fixed and paraffin-embedded tissue sections of human gliomas was examined for immunoblot analysis using antibody against the placental form of glutathione S-transferase (GST-pi). Four benign astrocytomas, five anaplastic astrocytomas and four glioblastomas were used in this...

journal_title：Journal of cancer research and clinical oncology

authors： Hara A,Sakai N,Yamada H,Yoshimi N,Tanaka T,Mori H

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Nasal type extranodal natural killer/T-cell lymphoma (ENKTL) can be associated with hemophagocytic lymphohistiocytosis (NK/T-LAHLH), which is a rare and fatal disease with no effective therapy. We evaluated whether etoposide + dexamethasone-based chemotherapy regimens might be useful for treating NK/T-LAHLH. M...

journal_title：Journal of cancer research and clinical oncology

authors： Wei L,Yang L,Cong J,Ye J,Li X,Yao N,Yang J,Ding J,Wang J

更新日期：2020-10-06 00:00:00

abstract：:Three thousand Yoshida sarcoma cells were inoculated into the wall of the descending colon of each of 120 male Sprague-Dawley rats. On day 8 after the tumor implantation, the animals were at random divided into four groups of 30 rats each. The effect of cyclophosphamide (70 mg/kg), BCNU (25 mg/kg), and methyl-CCNU (45...

journal_title：Journal of cancer research and clinical oncology

authors： Bhide S,Habs M,Reinbold H,Schmähl D

更新日期：1979-05-14 00:00:00