当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Vincristine induction of mutant and wild-type human multidrug-resistance promoters is cell-type-specific and dose-dependent.

Vincristine induction of mutant and wild-type human multidrug-resistance promoters is cell-type-specific and dose-dependent.

Abstract：

:To investigate multidrug-resistance gene (MDR1) promoter efficacy and drug inducibility in cells with different multidrug-resistance phenotypes, multidrug-resistant HCT15 and drug-sensitive KM12 human colon carcinoma cell lines were transfected with constructs incorporating the chloramphenicol acetyltransferase (CAT) reporter gene, driven by wild-type and point-mutated MDR1 promoter regions. The basal CAT expression level in HCT15 cells was markedly elevated compared to KM12 cells. CAT induction by vincristine was dose-dependent over a broad concentration range (40-500 ng/ml) in both lines. The induction levels were related to the cells' MDR phenotype, with the multidrug-resistant HCT15 cells showing the greater effect. In both cell types, basal and drug-induced CAT expression were significantly enhanced by the point-mutated promoter regions. The findings support the possible exploitation of the MDR1 promoter for construction of drug-inducible and MDR-cell-targeted expression vectors for use in gene therapy.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Stein U,Walther W,Shoemaker RH

doi

10.1007/BF01261403

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

275-82

issue

5

eissn

0171-5216

issn

1432-1335

journal_volume

122

pub_type

杂志文章

相关文献

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY文献大全
  • Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia.

    abstract：PURPOSE:The molecular mechanisms underlying the development of intestinal metaplasia (IM) of the human stomach have yet to be clarified in detail. Besides ectopic expression of intestinal transcription factors, Cdx1 and Cdx2, little information is available regarding other regulatory factors. Hence, we here analyzed So...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-003-0519-6

    authors： Tsukamoto T,Inada K,Tanaka H,Mizoshita T,Mihara M,Ushijima T,Yamamura Y,Nakamura S,Tatematsu M

    更新日期：2004-03-01 00:00:00

  • Attitudes of members of the German Society for Palliative Medicine toward complementary and alternative medicine for cancer patients.

    abstract：BACKGROUND:A high proportion of cancer patients use complementary and alternative medicine (CAM). In oncology, risks of CAM are side effects and interactions. OBJECTIVE:Our aim was to conduct a survey on professionals in palliative care regarding attitudes toward CAM. DESIGN AND SUBJECTS:An internet-based survey with...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1656-9

    authors： Conrad AC,Muenstedt K,Micke O,Prott FJ,Muecke R,Huebner J

    更新日期：2014-07-01 00:00:00

  • High K-ras mutation rates in goblet-cell-type adenocarcinomas of the lungs.

    abstract：:Adenocarcinomas of the lungs show a variable histology. We have subclassified such lesions into five cell types: hobnail, columnar, polygonal, mixed and goblet cell types, and investigated their relationships with K-ras mutations. Codons 12, 13 and 61 of the K-ras gene in 120 surgically resected pulmonary adenocarcino...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01197773

    authors： Tsuchiya E,Furuta R,Wada N,Nakagawa K,Ishikawa Y,Kawabuchi B,Nakamura Y,Sugano H

    更新日期：1995-01-01 00:00:00

  • Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas.

    abstract：PURPOSE AND METHODS:Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-008-0423-1

    authors： Pehlivan D,Gunduz E,Gunduz M,Nagatsuka H,Beder LB,Cengiz B,Rivera RS,Fukushima K,Palanduz S,Ozturk S,Yamanaka N,Shimizu K

    更新日期：2008-12-01 00:00:00

  • Comparison of circulating tumor cells (CTC) in peripheral blood and disseminated tumor cells in the bone marrow (DTC-BM) of breast cancer patients.

    abstract：PURPOSE:The detection of disseminated tumor cells in the bone marrow (DTC-BM) of breast cancer patients is an independent prognostic factor. In recent years, the focus of research was on finding methods for the detection of circulating tumor cells (CTC) in peripheral blood (PB). In this study, we investigated the prese...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-013-1418-0

    authors： Schindlbeck C,Andergassen U,Hofmann S,Jückstock J,Jeschke U,Sommer H,Friese K,Janni W,Rack B

    更新日期：2013-06-01 00:00:00

  • Dept. of Microbiology, School of Medicine, East Carolina University, Greenville, NC.

    abstract：:The responsiveness of spleen cells from C57BL/6J mice to various immunogenic stimuli was examined during the progressive growth of a poorly immunogenic fibrosarcoma T241. A strong correlation was observed between the progressive tumor growth and the depression of response to Concanavalin A, lipopolysaccharide, sheep r...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00410112

    authors： Gautam SC,Gautam S,Deodhar SD

    更新日期：1981-01-01 00:00:00

  • Tumor host relations. II. Influence of tumor extent and tumor site on plasma cortisol of patients with malignant diseases.

    abstract：:The increase of plasma cortisol in patients with tumors of five different sites compared with a control group of patients with benign surgical diseases amounted to: +39% (breast), +34% (stomach), +86% (intestine), +60% (skin) and +194% (gall bladder). The first detectable increase of cortisol occurred in patients with...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00964585

    authors： Schaur RJ,Semmelrock HJ,Schauenstein E,Kronberger L

    更新日期：1979-04-12 00:00:00

  • Use and perception of complementary and alternative medicine among cancer patients: the CAMEO-PRO study : Complementary and alternative medicine in oncology.

    abstract：BACKGROUND:It is estimated that about half of cancer patients use at least one form of complementary and alternative medicines (CAM) in their life but there is a strong reticence of patients in talking about CAM with their oncologist. Primary aim of this study was to inform patients about CAM, focusing on their suppose...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-018-2709-2

    authors： Bozza C,Gerratana L,Basile D,Vitale MG,Bartoletti M,Agostinetto E,Russo S,Follador A,De Carlo E,Pella N,Sottile R,Fasola G,Puglisi F

    更新日期：2018-10-01 00:00:00

  • Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb.

    abstract：BACKGROUND:The receptor for the cytokine TWEAK (TweakR) is a cell surface member of the tumor necrosis factor receptor superfamily with diverse biological roles. TNFRSF family members are appealing therapeutic targets in oncology due to their aberrant expression and function in tumor cells. The goal of the current stud...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-012-1332-x

    authors： Chao DT,Su M,Tanlimco S,Sho M,Choi D,Fox M,Ye S,Hsi ED,Durkin L,Yin J,Zhang Y,Kim H,Starling GC,Culp PA

    更新日期：2013-02-01 00:00:00

  • In vitro analysis of cancer prevention by a mycobacterial antigen complex and of cancer-promoted inhibition of immune reactions.

    abstract：:The antigen complex A60 of Mycobacterium bovis bacillus Calmette-Guérin protected mice against experimental tuberculous infection, and prevented cancer development after challenge with EMT 6 cells. Although humoral and cellular immune reactions elicited by A60 in vivo remained unaffected in cases of tumor rejection, t...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01209120

    authors： Maes H,Cocito C

    更新日期：1996-01-01 00:00:00

  • Enhancement of antitumor activity of the oxazaphosphorine cytostatic SUM-IAP by N-methylformamide.

    abstract：PURPOSE:SUM-IAP has been developed with the aim to optimize therapeutic response and minimize toxic reactions of oxazaphosphorine cytostatics. In therapy tests in mice, the primary tumor was successfully eradicated, but animals died due to formation of lethal metastases. We supposed that high activities of SUM-IAP deto...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-016-2132-5

    authors： Voelcker G

    更新日期：2016-06-01 00:00:00

  • Genome-wide detection of allelic genetic variation to predict biochemical recurrence after radical prostatectomy among prostate cancer patients using an exome SNP chip.

    abstract：PURPOSES:Genetic variations among prostate cancer patients who underwent radical prostatectomies were evaluated to predict biochemical recurrence, and used to develop a clinical-genetic model that combines data on clinicopathological factors of prostate cancer and individual genetic variations. MATERIALS AND METHODS:W...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-015-1947-9

    authors： Oh JJ,Park S,Lee SE,Hong SK,Lee S,Lee HM,Lee JK,Ho JN,Yoon S,Byun SS

    更新日期：2015-08-01 00:00:00

  • Peripheral blood gene expression of B7 and CD28 family members associated with tumor progression and microscopic lymphovascular invasion in colon cancer patients.

    abstract：PURPOSE:To associate the global gene expression of B7/CD28 family transcripts with pathologic features of colon cancer, we determined the B7/CD28 family transcripts in peripheral blood mononuclear cells (PBMCs) from normal subjects and patients with adenomatous polyps and colon cancer, and correlated the results with p...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-010-0800-4

    authors： Lee H,Kim JH,Yang SY,Kong J,Oh M,Jeong DH,Chung JI,Bae KB,Shin JY,Hong KH,Choi I

    更新日期：2010-09-01 00:00:00

  • Age-, sex-, and strain-dependent differences in the induction of enzyme-altered islands in rat liver by diethylnitrosamine.

    abstract：:The formation of foci with loss of ATPase and emergence of gamma-GTase was studied histochemically in livers of male and female Wistar and Sprague-Dawley rats of 3--4 and 6--7 weeks of age, respectively, after application of diethylnitrosamine. A single dose of 8 mg/kg body weight induced a considerable island formati...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00403362

    authors： Deml E,Oesterle D,Wolff T,Greim H

    更新日期：1981-01-01 00:00:00

  • Active surveillance of low-risk papillary thyroid carcinoma: a promising strategy requiring additional evidence.

    abstract：PURPOSE:Papillary thyroid carcinoma (PTC), the most common malignant tumor of the thyroid, has been criticized as overtreated by some researchers in recent years. Active surveillance (AS) was first proposed at Kuma Hospital in 1993, and popularized in other institutes ever since. We provide a brief review of low-risk P...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s00432-019-03021-y

    authors： Ze Y,Zhang X,Shao F,Zhu L,Shen S,Zhu D,Bi Y

    更新日期：2019-11-01 00:00:00

  • Antioxidant enzyme activities and lipid peroxides in the plasma of patients with benign prostatic hyperplasia or prostate cancer are not predictive.

    abstract：:In this study, lipid peroxide and total sulfhydryl contents and activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were investigated in the plasma of patients with benign prostatic hyperplasia (BPH) and prostate cancer. No significant change was found in lipid peroxidation or an...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320050293

    authors： Doğru-Abbasoğlu S,Aykaç-Toker G,Koçak T,Unlüer E,Uysal M

    更新日期：1999-07-01 00:00:00

  • High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's-lymphomas.

    abstract：PURPOSE:Since continuous relapse rates are characteristic for advanced low-grade non-Hodgkin's lymphomas (NHL), their treatment remains a problem. Previous phase II studies showed that bendamustine induced high remission rates in pre-treated low-grade NHL. To further examine its efficacy and side effects, bendamustine ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00432-002-0378-6

    authors： Bremer K

    更新日期：2002-11-01 00:00:00

  • Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer.

    abstract：PURPOSE:Multidrug resistance (MDR) has been linked to sphingolipid metabolism and preclinical data ascribe glucosylceramide synthase (GCS) a major role for MDR especially in breast cancer cells but no profound data are available on the expression of this potential therapeutic target in clinical breast cancer specimens....

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-008-0436-9

    authors： Ruckhäberle E,Karn T,Hanker L,Gätje R,Metzler D,Holtrich U,Kaufmann M,Rody A

    更新日期：2009-01-01 00:00:00

  • Alpha-fetoprotein, tissue polypeptide antigen and ferritin in diagnosing primary hepatocellular carcinoma in patients with liver cirrhosis.

    abstract：:This study was undertaken in order to compare the usefulness of three indices of tumour proliferation in detecting primary hepatocellular carcinoma (HCC) and in differentiating this neoplasm from liver cirrhosis. In 10 patients with HCC and in 63 with liver cirrhosis serum alpha-fetoprotein (AFP), tissue polypeptide a...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00391702

    authors： Leandro G,Basso D,Fabris C,Zizzari S,Elba S,Del Favero G,Di Mario F,Meggiato T,Angonese C,Naccarato R

    更新日期：1989-01-01 00:00:00

  • Patterns of breast cancer relapse in accordance to biological subtype.

    abstract：PURPOSE:To evaluate the pattern of recurrence of breast cancer according to its biological subtype in a large cohort of patients treated with therapy representative of current practice. PATIENTS AND METHODS:Patients treated between 2000 and 2016 with known biological subtype were eligible. Data were prospectively coll...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-018-2644-2

    authors： Ignatov A,Eggemann H,Burger E,Ignatov T

    更新日期：2018-07-01 00:00:00

  • Polyploidization of G2M phase cells separated from aerobically and anaerobically grown Ehrlich ascites tumor cells.

    abstract：:G2-enriched fractions of Ehrlich ascites tumor cells (up to 80%-85% G2 cells) separated from anaerobically and aerobically cultured asynchronous populations by centrifugal elutriation revealed the same growth characteristics after recultivation under standard conditions: a significant proportion of cells with increase...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00396389

    authors： Kroll C,Schneider F

    更新日期：1987-01-01 00:00:00

  • The clinical significance of 18F-FDG-PET/CT in early detection of second primary malignancy in cancer patients.

    abstract：PURPOSE:This retrospective study evaluated the diagnostic value of integrated whole-body (18)F-fluorodeoxyglucose positron-emission tomography and computed tomography ((18)F-FDG-PET/CT) in early detection of second primary malignancies in cancer patients. MATERIALS AND METHODS:From June 2007 to October 2008, 677 cance...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-010-0759-1

    authors： Xu H,Zhang M,Zhai G,Li B

    更新日期：2010-08-01 00:00:00

  • Risk of lung cancer and renin-angiotensin blockade: a concise review.

    abstract：PURPOSE:The blockade of the renin-angiotensin-aldosterone system (RAAS) by angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) is one of the most common treatments for hypertension, heart failure and renal diseases. However, concerns have been raised about a possible link between RA...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s00432-020-03445-x

    authors： Rachow T,Schiffl H,Lang SM

    更新日期：2021-01-01 00:00:00

  • Combination of interferons and cytostatic drugs for treatment of advanced colorectal cancer.

    abstract：:Three phase I/II trials were performed in patients with metastatic colorectal cancer using immunochemotherapy--a combination of recombinant interferon beta and gamma with low doses of cytostatic drugs. The third regimen, consisting of a cytostatic component containing 5-fluorouracil plus carboplatin plus mitomycin C b...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF01613230

    authors： Klein HO,Golbach G,Voigt P,Coerper C,Bernhardt C

    更新日期：1991-01-01 00:00:00

  • ARK5 is associated with the invasive and metastatic potential of human breast cancer cells.

    abstract：PURPOSE:To investigate the effects of Akt/ARK5 pathways on the metastatic potential of human breast cancer cells. MATERIALS AND METHODS:The human ARK5 gene was transfected into MDA-MB-231 cells. Effects of ARK5 on MDA-MB-231 cells were investigated in vitro. The tumorigenicity and spontaneously metastatic capability r...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-011-1102-1

    authors： Chang XZ,Yu J,Liu HY,Dong RH,Cao XC

    更新日期：2012-02-01 00:00:00

  • Transformation potential of bone marrow stromal cells into undifferentiated high-grade pleomorphic sarcoma.

    abstract：PURPOSE:Bone marrow adherent cells contain conventional bone marrow stromal cells and mesenchymal stem cells and these cells constitute the hematopoietic microenvironment. Mesenchymal stem cells have the capacity to give rise to multiple mesenchymal lineage cells and even ectodermal lineage cells. In the present study,...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-009-0723-0

    authors： Li Q,Hisha H,Takaki T,Adachi Y,Li M,Song C,Feng W,Okazaki S,Mizokami T,Kato J,Inaba M,Hosaka N,Maki M,Ikehara S

    更新日期：2010-06-01 00:00:00

  • Surgically treated oropharyngeal cancer: risk factors and tumor characteristics.

    abstract：PURPOSE:To assess risk factors of patients with oropharyngeal squamous cell carcinoma in the Munich area of Southern Germany in relation to human papillomavirus (HPV) association of the tumors. To demonstrate differences in tumor characteristics and their impact on adjuvant treatment. METHODS:Between November 2010 and...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1631-5

    authors： Baumeister P,Reiter M,Welz C,Becker S,Betz C,Harréus U

    更新日期：2014-06-01 00:00:00

  • Association of a common genetic variant of the IGF-1 gene with event-free survival in patients with HER2-positive breast cancer.

    abstract：PURPOSE:Insulin-like growth factor 1 (IGF-1) stimulates mitosis and inhibits apoptosis. High circulating IGF-1 levels are linked with an increased risk of colorectal and breast cancer. Recently, IGF-1 single nucleotide polymorphisms (SNPs), especially variant rs2946834, have been associated with poor clinical outcome i...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-012-1355-3

    authors： Muendlein A,Lang AH,Geller-Rhomberg S,Winder T,Gasser K,Drexel H,Decker T,Mueller-Holzner E,Chamson M,Marth C,Hubalek M

    更新日期：2013-03-01 00:00:00

  • Minor role of lipid peroxidation in acute bleomycin toxicity in rats.

    abstract：:Bleomycin was injected i.p. in rats, and the amount of expired ethane which indicates lipid peroxidation was followed up for 78 h. Compared to controls neither 1 x 30 mg/kg and 2 x 30 mg/kg nor 1 x 70 mg/kg bleomycin led to increased ethane expiration, although body weight loss indicated toxicity. That pulmonary toxic...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00409644

    authors： Muliawan H,Burkhardt A,Scheulen ME,Kappus H

    更新日期：1982-01-01 00:00:00

  • Microwave ablation as local consolidative therapy for patients with extracranial oligometastatic EGFR-mutant non-small cell lung cancer without progression after first-line EGFR-TKIs treatment.

    abstract：OBJECTIVES:Evidence from multiple clinical trials showed that local consolidative therapy (LCT) improved survival in oligometastatic non-small cell lung cancer (NSCLC) patients. In the present study, we aim to explore the potential role of microwave ablation (MWA) as LCT for epidermal growth factor receptor (EGFR)-muta...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-019-03043-6

    authors： Ni Y,Ye X,Yang X,Huang G,Li W,Wang J,Han X,Wei Z,Meng M

    更新日期：2020-01-01 00:00:00