Combination of interferons and cytostatic drugs for treatment of advanced colorectal cancer.

abstract：PURPOSE:In stomach adenocarcinoma, the role of the hormonal receptor, estrogen receptor (ER), has been controversial. Recently, a new estrogen receptor, called estrogen receptor beta (ER beta), was found to be expressed in various tissues including normal gastrointestinal tract. In this paper, the expression of ER beta...

journal_title：Journal of cancer research and clinical oncology

authors： Matsuyama S,Ohkura Y,Eguchi H,Kobayashi Y,Akagi K,Uchida K,Nakachi K,Gustafsson JA,Hayashi S

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVES:Evidence from multiple clinical trials showed that local consolidative therapy (LCT) improved survival in oligometastatic non-small cell lung cancer (NSCLC) patients. In the present study, we aim to explore the potential role of microwave ablation (MWA) as LCT for epidermal growth factor receptor (EGFR)-muta...

journal_title：Journal of cancer research and clinical oncology

authors： Ni Y,Ye X,Yang X,Huang G,Li W,Wang J,Han X,Wei Z,Meng M

更新日期：2020-01-01 00:00:00

abstract：:We report about an extremely rare case of malignant fibrous histiocytoma (MFH) of the renal capsule. The tumor is composed of fibroblast-like cells arranged in a storiform pattern and histiocyte-like cells with multinucleated giant cells, both showing no iron reaction. Characteristic of the histiocytic quality of the ...

journal_title：Journal of cancer research and clinical oncology

authors： Gabbert H,Wagner R,Becht E

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors' biology and explore t...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang F,Cai Z,Lv H,Li W,Liang M,Wei X,Zhou F

更新日期：2019-01-01 00:00:00

abstract：:Sequential studies were made on the histopathologic changes in the glandular stomach of rats induced by a weak carcinogen. N-propyl-N'-nitro-N-nitrosoguanidine (PNNG). Fiftyfour rats were given 100 micrograms/ml of PNNG in their drinking water for 44 weeks, and then normal tap water until the end of the experiment. Ra...

journal_title：Journal of cancer research and clinical oncology

authors： Matsukura N,Itabashi M,Kawachi T,Hirota T,Sugimura T

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:The study aim was to compare the disease control in two groups of patients affected by liver metastases from CRC treated with microwave ablation (MWA) or stereotactic body radiation therapy (SBRT). METHODS:We extracted data of patients treated between 2009 and 2016. Inclusion criteria were: (1) maximum diamete...

journal_title：Journal of cancer research and clinical oncology

authors： Franzese C,Comito T,Clerici E,Di Brina L,Tomatis S,Navarria P,Reggiori G,Viganò L,Poretti D,Pedicini V,Torzilli G,Solbiati L,Scorsetti M

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:The high incidence of biliary tract carcinoma in patients with anomalous pancreaticobiliary ductal junction (APBDJ) implicates that a compositional alteration in bile may contribute to the genesis of this cancer. Lysophosphatidylcholine (LPC) is generated in the bile of these patients. Given the role of cycloox...

journal_title：Journal of cancer research and clinical oncology

authors： Gwak GY,Yoon JH,Lee SH,Lee SM,Lee HS,Gores GJ

更新日期：2006-12-01 00:00:00

abstract：:Female rats aged 3 months and 15 months each received a single i.v. administration of N-nitrosomethylurea (NMU) at one of three doses: 10, 20, and 50 mg/kg. The rats exposed to NMU at the age of 3 months developed neoplasms of all sites examined, including mammary carcinomas and tumors of the kidney, ovaries and colon...

journal_title：Journal of cancer research and clinical oncology

authors： Anisimov VN

更新日期：1988-01-01 00:00:00

abstract：:The subsets and functions of lymphocytes were investigated in patients with nasopharyngeal carcinoma (NPC). The patients were divided into two groups comprising tumor-bearing patients and those in remission. There was no difference in the proportion of T cells among tumor-bearing, remission and healthy control groups....

journal_title：Journal of cancer research and clinical oncology

authors： Tsukuda M,Sawaki S,Yanoma S

更新日期：1993-01-01 00:00:00

abstract：:Expression of the glutathione S-transferase (GST) subclasses alpha, mu and pi was investigated immunohistochemically in 20 normal or hyperplastic mesothelium and in 57 malignant mesothelioma cases. These results were correlated with survival and also with P-170 glycoprotein expression. Nearly all the non-neoplastic me...

journal_title：Journal of cancer research and clinical oncology

authors： Segers K,Kumar-Singh S,Weyler J,Bogers J,Ramael M,Van Meerbeeck J,Van Marck E

更新日期：1996-01-01 00:00:00

abstract：:Bromelain, a pineapple-derived plant product, added to C57Bl/6 mice laboratory chow decreased lung metastasis of Lewis lung cancer cells implanted s.c. This antimetastatic potential was demonstrated by both the active and inactive bromelain with or without proteolytic, anticoagulant properties. ...

journal_title：Journal of cancer research and clinical oncology

authors： Batkin S,Taussig SJ,Szekerezes J

更新日期：1988-01-01 00:00:00

abstract：:Female carriers of mutations in the BRCA1 gene on chromosome 17q have a very high risk of developing breast and/or ovarian cancer during their lifetime. There is, however, little knowledge of to what extent non-genetic risk factors, such as age at menarche, age at first birth, and body mass index, alter the age at ons...

journal_title：Journal of cancer research and clinical oncology

authors： Chang-Claude J,Becher H,Eby N,Bastert G,Wahrendorf J,Hamann U

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Survivin, an inhibitor of apoptosis protein and a cell cycle regulator, has been detected in the majority of human cancers. Five splice variants (survivin, survivin-2alpha, survivin-2B, survivin-3B, and survivin-DeltaEx3) have been identified; their expressions have been investigated here. METHODS:By means of ...

journal_title：Journal of cancer research and clinical oncology

authors： De Maria S,Pannone G,Bufo P,Santoro A,Serpico R,Metafora S,Rubini C,Pasquali D,Papagerakis SM,Staibano S,De Rosa G,Farina E,Emanuelli M,Santarelli A,Mariggiò MA,Lo Russo L,Lo Muzio L

更新日期：2009-01-01 00:00:00

abstract：AIMS:With three consecutive tetratricopeptide repeat (TPR) motifs at its C-terminus essential for neuronal migration, and a p23 domain at its N-terminus, DYX1C1 was the first gene proposed to have a role in developmental dyslexia. In this study, we attempted to identify the potential interaction of DYX1C1 and heat shoc...

journal_title：Journal of cancer research and clinical oncology

authors： Chen Y,Zhao M,Wang S,Chen J,Wang Y,Cao Q,Zhou W,Liu J,Xu Z,Tong G,Li J

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVES:Solitary plasmacytoma (SP) is characterized by a single mass of clonal plasma cells. Definitive RT can result in long-term local control of the SP. Due to the small number of patients and narrow range of doses, phase III randomized trials are lacking. The aim of this study is to further support the potential...

journal_title：Journal of cancer research and clinical oncology

authors： Alghisi A,Borghetti P,Maddalo M,Roccaro AM,Tucci A,Mazzola R,Magrini SM,Lo Casto A,Bonù ML,Tomasini D,Pasinetti N,Peretto G,Bertagna F,Tomasi C,Buglione M,Triggiani L

更新日期：2020-11-17 00:00:00

abstract：:Metastatic interstitial cell tumor of the testis is one of the rarest human neoplasms. This is the nineteenth case to be reported. While most of these tumors are combined with hormonal dysfunction, the present tumor, apart from its uncommon hormonal profile, is remarkable because of its capacity of producing and secre...

journal_title：Journal of cancer research and clinical oncology

authors： Higi M,Niederle N,Scheulen ME,Richter HJ

更新日期：1979-07-27 00:00:00

abstract：PURPOSE:Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen. SLCO4A1 is highly expressed in several cancers and a gender bias has been observed in colorectal cancer ...

journal_title：Journal of cancer research and clinical oncology

authors： Ban MJ,Ji SH,Lee CK,Bae SB,Kim HJ,Ahn TS,Lee MS,Baek MJ,Jeong D

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Long interspersed nuclear element 1 (LINE-1 or L1) is a dominant non-long terminal repeat (non-LTR) retrotransposon in the human genome that has been implicated in the overexpression of MET. Both the canonical MET and L1-MET transcripts are considered to play a role in hepatocellular carcinoma (HCC) development...

journal_title：Journal of cancer research and clinical oncology

authors： Rashed WM,Kandeil MA,Mahmoud MO,Maher D,Ezzat S,Abdel-Rahman MH

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Cancer is a serious public health problem worldwide, and difficulty in early diagnosis has been the chief obstacle to improve the prognosis of patients. Recently, microRNAs (miRNAs) were widely studied to be potential biomarkers for cancer detection. miR-16 is a prevalent but sophisticated one. In the curren...

journal_title：Journal of cancer research and clinical oncology

authors： Huang Z,Chen W,Du Y,Guo Q,Mao Y,Zhou X,Hua D

更新日期：2019-03-01 00:00:00

abstract：INTRODUCTION:Non-adherence to anti-hormonal therapy is a major problem in gynecologic oncology. Reasons reported are side effects and lack of support. The aim of our study was an analysis of influence of experiences of patients with endocrine therapy and communication and information on this topic and their influence o...

journal_title：Journal of cancer research and clinical oncology

authors： Wuensch P,Hahne A,Haidinger R,Meißler K,Tenter B,Stoll C,Senf B,Huebner J

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:PTEN is an essential tumour suppressor gene which encodes a phosphatase protein that antagonises the PI3K/Akt/mTOR antiapoptotic pathway. Impairment of this tumour suppressor pathway potentially becomes a causal factor for development of malignancies. This review aims to assess current understanding of mechanis...

journal_title：Journal of cancer research and clinical oncology

authors： Lim HJ,Crowe P,Yang JL

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:T cell transcription factors are nuclear effectors of the Wnt signaling transduction pathway and play crucial roles in embryonic and malignant development. Our previous study showed increased expression level of Tcf mRNA in liver cancer. In the present paper, antisense Tcf RNA was used to explore the possible t...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang Y,Zhou XD,Liu YK,Huang XW,Zhao Y,Xue Q,Sun RX,Chen J,Wu X

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To describe the clinical characteristics and outcomes of patients with dual-phenotype hepatocellular carcinoma (DPHCC) and investigate the use of radiomics to establish an image-based signature for preoperative differential diagnosis. METHODS:This study included 50 patients with a postoperative pathological di...

journal_title：Journal of cancer research and clinical oncology

authors： Huang X,Long L,Wei J,Li Y,Xia Y,Zuo P,Chai X

更新日期：2019-12-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) exerts pleiotropic effects on mammalian cells via stimulation of its receptor (IGF-IR), a receptor tyrosine kinase. In vivo, IGF-I acts both as a local tissue growth factor and as a circulating hormone. In oncological research, IGF-I has received increased attention as the activate...

journal_title：Journal of cancer research and clinical oncology

authors： Grothey A,Voigt W,Schöber C,Müller T,Dempke W,Schmoll HJ

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Estrogen receptor β (ERβ) is the predominant ER in the colorectal epithelium, whose expression is greatly reduced in colorectal cancer compared with normal colon tissue. Recent in vitro studies suggested that ERβ may suppress tumor growth. No research was reported whether ERβ can be used as therapeutic agent...

journal_title：Journal of cancer research and clinical oncology

authors： Tu Z,Ma Y,Tian J,Li H,Akers W,Achilefu S,Gu Y

更新日期：2012-07-01 00:00:00

abstract：:Passively administered and actively induced antibodies have been associated with the eradication of circulating tumor cells and micrometastases in mice and humans. We have identified a series of cell surface carbohydrate and peptide antigens on melanomas, sarcomas, and cancer of the breast, prostate. ovary, and lung t...

journal_title：Journal of cancer research and clinical oncology

authors： Musselli C,Livingston PO,Ragupathi G

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:The optimal interval between neoadjuvant chemoradiotherapy (CRT) and surgery has yet to be established. Additionally, it is unknown whether patients with different pathologic stages or chemoradiation responses should undergo different intervals between CRT and surgery. Therefore, the purpose of this study wa...

journal_title：Journal of cancer research and clinical oncology

authors： You KY,Huang R,Zhang LN,Ding PR,Xiao WW,Qiu B,Chang H,Zeng ZF,Pan ZZ,Gao YH

更新日期：2015-04-01 00:00:00

abstract：:Metabolic activation steps involved in carcinogenesis by several aromatic amines, their N-acetylated derivatives, and dialkylnitrosamines are reviewed. N-Hydroxylation is the first activation step in the carcinogenesis by 2-acetylaminofluorene (AAF), other aromatic amides and amines. The cytochrome P-450 enzyme system...

journal_title：Journal of cancer research and clinical oncology

authors： Lotlikar PD

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Recent studies indicated undisputed contribution of connective tissue growth factor (CTGF) in the development of many cancers, including non-small cell lung cancer (NSCLC). However, the functional role and regulation of CTGF expression during tumorigenesis remain elusive. Our goal was to determine CTGF transcri...

journal_title：Journal of cancer research and clinical oncology

authors： Drzewiecka H,Gałęcki B,Jarmołowska-Jurczyszyn D,Kluk A,Dyszkiewicz W,Jagodziński PP

更新日期：2016-09-01 00:00:00

abstract：:Aclacinomycin A (ACM) is a new anthracycline antibiotic with a reduced cardiac toxicity in animal models. A phase II study was performed in a total of 25 patients, 23 of whom are evaluable for response. All suffered from recurrent and advanced tumors. Pretreatment consisted of at least four different chemotherapeutic ...

journal_title：Journal of cancer research and clinical oncology

authors： Schütte J,Niederle N,Seeber S

更新日期：1983-01-01 00:00:00