Discontinuation and non-adherence to endocrine therapy in breast cancer patients: is lack of communication the decisive factor?

abstract：PURPOSE:To associate the global gene expression of B7/CD28 family transcripts with pathologic features of colon cancer, we determined the B7/CD28 family transcripts in peripheral blood mononuclear cells (PBMCs) from normal subjects and patients with adenomatous polyps and colon cancer, and correlated the results with p...

journal_title：Journal of cancer research and clinical oncology

authors： Lee H,Kim JH,Yang SY,Kong J,Oh M,Jeong DH,Chung JI,Bae KB,Shin JY,Hong KH,Choi I

更新日期：2010-09-01 00:00:00

abstract：:1,1,2-Triphenylbut-1-enes substituted with 3- or 4-acetoxy (OAc) groups on one, two, or three phenyl rings were tested for their estrogen receptor affinities, their estrogenic and antiestrogenic properties in the immature mouse, and their effect on the growth of the hormone-dependent MXT mammary tumor of the mouse. Th...

journal_title：Journal of cancer research and clinical oncology

authors： Schneider MR

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:This study aimed to establish new criteria for limited resection of non-small cell lung cancer (NSCLC) based on computed tomography findings and maximum standardized uptake value (SUVmax). METHODS:Between December 2007 and December 2015, 611 patients underwent lung cancer surgery; of these, 70 with cT1aN0M0 wh...

journal_title：Journal of cancer research and clinical oncology

authors： Aragaki M,Hida Y,Kato T,Fujiwara-Kuroda A,Kaga K,Wakasa S

更新日期：2020-11-05 00:00:00

abstract：PURPOSE:Signalling through the insulin-like growth factor 1 receptor (IGF-1R) is implicated in carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. The purpose of this study was to investigate the prognostic role of IGF-1R expression in surgically resected non-small-cell lung cancer (NSCLC), and re...

journal_title：Journal of cancer research and clinical oncology

authors： Agulló-Ortuño MT,Díaz-García CV,Agudo-López A,Pérez C,Cortijo A,Paz-Ares L,López-Ríos F,Pozo F,de Castro J,Cortés-Funes H,López Martín JA

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To investigate the effect of a monoclonal antibody (CH12), targeted against epidermal growth factor receptor type III variant (EGFRvIII), on human ovarian cancer cells when administered in combination with cisplatin chemotherapy. METHODS:Western blot and reverse transcription polymerase chain reaction (RT-PCR)...

journal_title：Journal of cancer research and clinical oncology

authors： Li N,Chu Y,Yao L,Ying X,Jiang H,Zhou M,Xu C

更新日期：2011-10-01 00:00:00

abstract：:Twenty-five surgical specimens of malignant human prostate, 3 lymph nodes with metastatic prostate carcinoma, 11 normal human prostates, as well as 3 human prostate cell lines (DU-145, PC3 and LNCaP) were examined for the expression of the human matrix metalloproteinase-7 gene (MMP-7) from the human collagenase family...

journal_title：Journal of cancer research and clinical oncology

authors： Pajouh MS,Nagle RB,Breathnach R,Finch JS,Brawer MK,Bowden GT

更新日期：1991-01-01 00:00:00

abstract：:In view of the great variation in the size of epithelial cell nuclei in benign changes in the mammary gland, the cytologist is often faced with diagnostic difficulties. Clear differences in the size of the nuclei in aspiration biopsies from the mammary glands of pregnant women and those from the mammary glands of post...

journal_title：Journal of cancer research and clinical oncology

authors： Schöndorf H,Naujoks H

更新日期：1985-01-01 00:00:00

abstract：:Several investigators have discussed the possible combination of tamoxifen and interferon (IFN) in the treatment of breast cancer patients. The rationale in combining these drugs is that IFN induces the expression of estrogen receptors and therefore increases the sensitivity of breast cancer cells toward the growth-in...

journal_title：Journal of cancer research and clinical oncology

authors： Porzsolt F,Otto AM,Trauschel B,Buck C,Wawer AW,Schönenberger H

更新日期：1989-01-01 00:00:00

abstract：:The expression of mRNAs for epidermal growth factor (EGF), transforming growth factor alpha(TGF alpha), EGFR, platelet-derived growth factor (PDGF) A and B chain, PDGF receptor (PDGFR), transforming growth factor beta (TGF beta), erbB-2 and estrogen receptor (ER) genes was first examined in 6 human esophageal carcinom...

journal_title：Journal of cancer research and clinical oncology

authors： Yoshida K,Kuniyasu H,Yasui W,Kitadai Y,Toge T,Tahara E

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Riproximin, a type II ribosome-inactivating protein (RIP), has shown significant cytotoxic effects in diverse types of cancer cells. To better understand its therapeutic potential, elaborated investigations on the mechanistic aspects of riproximin deem crucial. In this study, we focused on riproximin-mediate...

journal_title：Journal of cancer research and clinical oncology

authors： Pervaiz A,Zepp M,Adwan H,Berger MR

更新日期：2016-01-01 00:00:00

abstract：:Although the biological action of phthalates has been widely discussed there is little information on early cellular changes indicative for toxic or carcinogenic effects. To study subtle alterations in the cell morphology, we have by means of image processing evaluated the nuclei of hamster hepatocytes after treatment...

journal_title：Journal of cancer research and clinical oncology

authors： Komitowski D,Schmezer P,Schmitt B,Ehemann V,Muto S

更新日期：1986-01-01 00:00:00

abstract：:Metastatic interstitial cell tumor of the testis is one of the rarest human neoplasms. This is the nineteenth case to be reported. While most of these tumors are combined with hormonal dysfunction, the present tumor, apart from its uncommon hormonal profile, is remarkable because of its capacity of producing and secre...

journal_title：Journal of cancer research and clinical oncology

authors： Higi M,Niederle N,Scheulen ME,Richter HJ

更新日期：1979-07-27 00:00:00

abstract：:A transplantable non-immunogenic murine carcinoma of spontaneous origin, WHT Carcinoma N-C (Hewitt), was used to assess the effectiveness of melphalan (Ml) and/or methotrexate (Mx) for treatment of occult metastatic disease following surgical excision of primary tumors. Early surgical excision alone cured 66% of mice;...

journal_title：Journal of cancer research and clinical oncology

authors： Zebro T,Wright EA

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:Results from in vitro chemosensitivity testing recommend treosulfan/gemcitabine chemotherapy for the treatment of stage IV uveal melanoma. METHODS:Twenty patients received treosulfan 3,500 mg/m2 followed by gemcitabine 1,000 mg/m2 on day 1 and day 8 repeated on day 29. In cases of prior chemotherapy only 75% o...

journal_title：Journal of cancer research and clinical oncology

authors： Terheyden P,Bröcker EB,Becker JC

更新日期：2004-07-01 00:00:00

abstract：:Induction of gene transcription in response to extracellular stimuli constitutes an essential aspect of host defense mechanisms. Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating the mechanism of t...

journal_title：Journal of cancer research and clinical oncology

authors： Taniguchi T,Harada H,Lamphier M

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To investigate the interaction between Wnt/β-catenin and estrogen signaling pathways in endometrial cancer (EC). METHODS:119 women were involved in this study, including 65 women with histologically confirmed EC and 54 healthy women as a control group. Serum protein levels of Dkk1 were measured using ELISA. Pr...

journal_title：Journal of cancer research and clinical oncology

authors： Kasoha M,Dernektsi C,Seibold A,Bohle RM,Takacs Z,Ioan-Iulian I,Solomayer EF,Juhasz-Böss I

更新日期：2020-02-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) exerts pleiotropic effects on mammalian cells via stimulation of its receptor (IGF-IR), a receptor tyrosine kinase. In vivo, IGF-I acts both as a local tissue growth factor and as a circulating hormone. In oncological research, IGF-I has received increased attention as the activate...

journal_title：Journal of cancer research and clinical oncology

authors： Grothey A,Voigt W,Schöber C,Müller T,Dempke W,Schmoll HJ

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:In the phase 3 BFORE trial (NCT02130557), treatment with bosutinib resulted in a significantly higher major molecular response rate at 12 months versus imatinib in the modified intent-to-treat (mITT) population of patients with newly diagnosed chronic phase chronic myeloid leukemia (CP CML). Assessment of pa...

journal_title：Journal of cancer research and clinical oncology

authors： Cortes JE,Gambacorti-Passerini C,Deininger MW,Mauro MJ,Chuah C,Kim DW,Milojkovic D,le Coutre P,Garcia-Gutierrez V,Crescenzo R,Mamolo C,Reisman A,Hochhaus A,Brümmendorf TH,BFORE Study Investigators.

更新日期：2019-06-01 00:00:00

abstract：:Leukaemic and lymphomatous infiltration of the appendix is rare and even rarer is acute appendicitis as the initial manifestation. From our routine biopsy material we collected four cases of haematological malignancies presenting as acute appendicitis or acute abdomen, caused or accompanied by tumoral infiltration of ...

journal_title：Journal of cancer research and clinical oncology

authors： Müller G,Dargent JL,Duwel V,D'Olne D,Vanvuchelen J,Haot J,Hustin J

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:In the United States, cancer is the second leading cause of mortality, and millions more battle cancer worldwide. As such, primary prevention of cancer is a major interest globally. Aspirin has been studied as a primary prevention method for multiple diseases, mainly cardiovascular disease and various forms ...

journal_title：Journal of cancer research and clinical oncology

authors： Haykal T,Barbarawi M,Zayed Y,Yelangi A,Dhillon H,Goranta S,Kheiri B,Chahine A,Samji V,Kerbage J,Katato K,Bachuwa G

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Piperlongumine (PL) has been shown to selectively induce apoptotic cell death in cancer cells via reactive oxygen species (ROS) accumulation. In this study, we characterized a molecular mechanism for PL-induced cell death. METHODS:Cell viability and cell death were assessed by MTT assay and Annexin V-FITC/PI s...

journal_title：Journal of cancer research and clinical oncology

authors： Jin HO,Lee YH,Park JA,Lee HN,Kim JH,Kim JY,Kim B,Hong SE,Kim HA,Kim EK,Noh WC,Kim JI,Chang YH,Hong SI,Hong YJ,Park IC,Lee JK

更新日期：2014-12-01 00:00:00

abstract：:Cachexia and a decreased immune function are negative prognostic factors for cancer patients. While the decreased immunity results in a greater susceptibility to bacterial infection, the response of the host to the resulting infection is not clear. The experiments reported here were designed to evaluate the toxicity o...

journal_title：Journal of cancer research and clinical oncology

authors： Grossie VB Jr,Mailman D

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:To elucidate the effect of tumor oxygenation status on recovery from damage following gamma-ray or accelerated carbon ion irradiation in vivo, including in quiescent (Q) cells. METHODS:SCC VII tumor-bearing mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. They r...

journal_title：Journal of cancer research and clinical oncology

authors： Masunaga S,Hirayama R,Uzawa A,Kashino G,Suzuki M,Kinashi Y,Liu Y,Koike S,Ando K,Ono K

更新日期：2009-08-01 00:00:00

abstract：:The uptake of tritiated N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into Ehrlich-Ascites-Tumor cells of mice was studied by means of the siliconoil-filtration technique. At 10 mM concentration no permeation of the metabolite into the tumor cells could be found within 5 min at 1 degrees C, while its congenors cyclop...

journal_title：Journal of cancer research and clinical oncology

authors： Lenssen U,Hohorst HJ

更新日期：1979-02-19 00:00:00

abstract：PURPOSE:Many biochemical processes are closely related to ion exchange, adsorption, and catalysis. Zeolites reversibly bind small molecules such as oxygen or nitric oxide; they possess size and shape selectivity, the possibility of metalloenzyme mimicry, and immunomodulatory activity. These properties make them interes...

journal_title：Journal of cancer research and clinical oncology

authors： Pavelic K,Katic M,Sverko V,Marotti T,Bosnjak B,Balog T,Stojkovic R,Radacic M,Colic M,Poljak-Blazi M

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:The detection of disseminated tumor cells in the bone marrow (DTC-BM) of breast cancer patients is an independent prognostic factor. In recent years, the focus of research was on finding methods for the detection of circulating tumor cells (CTC) in peripheral blood (PB). In this study, we investigated the prese...

journal_title：Journal of cancer research and clinical oncology

authors： Schindlbeck C,Andergassen U,Hofmann S,Jückstock J,Jeschke U,Sommer H,Friese K,Janni W,Rack B

更新日期：2013-06-01 00:00:00

abstract：:The purpose of this study was to examine the structure/activity relationships of a series of substituted benzamides as poly(ADP-ribose) polymerase inhibitors. The experimental approach has involved the use of in vitro and in vivo assays in order to gather information either on the intrinsic activity of the benzamides ...

journal_title：Journal of cancer research and clinical oncology

authors： Sestili P,Spadoni G,Balsamini C,Scovassi I,Cattabeni F,Duranti E,Cantoni O,Higgins D,Thomson C

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and has been shown to induce extrinsic pathway of apoptosis in many types of cancer cells. AT-101, an (-)-enantiomer of gossypol, is a potent anticancer agent that is shown to be an inhibitor of Bcl-2/Bcl-XL. In t...

journal_title：Journal of cancer research and clinical oncology

authors： Kisim A,Atmaca H,Cakar B,Karabulut B,Sezgin C,Uzunoglu S,Uslu R,Karaca B

更新日期：2012-07-01 00:00:00

abstract：:Antibody-toxin conjugates, termed immunotoxins, are currently being evaluated as potential new anticancer agents. The monoclonal antibodies that recognize antigens on the surface of tumor cells should deliver the toxins or the catalytic subunits of toxins to cancer cells. The catalytically active parts of the immunoto...

journal_title：Journal of cancer research and clinical oncology

authors： Pirker R

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Multiple gastrointestinal stromal tumors (GISTs) rarely occur in patients with neurofibromatosis type 1 (NF-1). In contrast to sporadic GISTs characterized by frequent allelic losses of 1p, 14q and 22q and mutations of KIT or PDGFRA gene with the activation of the downstream RAS-MAPK pathway, the molecular path...

journal_title：Journal of cancer research and clinical oncology

authors： Yamamoto H,Tobo T,Nakamori M,Imamura M,Kojima A,Oda Y,Nakamura N,Takahira T,Yao T,Tsuneyoshi M

更新日期：2009-06-01 00:00:00