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Immunostimulatory effect of natural clinoptilolite as a possible mechanism of its antimetastatic ability.

Abstract：

PURPOSE:Many biochemical processes are closely related to ion exchange, adsorption, and catalysis. Zeolites reversibly bind small molecules such as oxygen or nitric oxide; they possess size and shape selectivity, the possibility of metalloenzyme mimicry, and immunomodulatory activity. These properties make them interesting for pharmaceutical industry and medicine. METHODS:The experiments were performed on mice. Different biochemical and molecular methods were used. RESULTS:Micronized zeolite (MZ) administered by gastric intubation to mice injected with melanoma cells significantly reduced the number of melanoma metastases. In mice fed MZ for 28 days, concentration of lipid-bound sialic acid (LSA) in serum increased, but lipid peroxidation in liver decreased. The lymphocytes from lymph nodes of these mice provoked a significantly higher alogeneic graft-versus-host (GVH) reaction than cells of control mice. After i.p. application of MZ, the number of peritoneal macrophages, as well as their production of superoxide anion, increased. However, NO generation was totally abolished. At the same time, translocation of p65 (NFkappaB subunit) to the nucleus of splenic cells was observed. CONCLUSION:Here we report antimetastatic and immunostimulatory effect of MZ and we propose a possible mechanism of its action.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Pavelic K,Katic M,Sverko V,Marotti T,Bosnjak B,Balog T,Stojkovic R,Radacic M,Colic M,Poljak-Blazi M

doi

10.1007/s00432-001-0301-6

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

37-44

issue

1

eissn

0171-5216

issn

1432-1335

journal_volume

128

pub_type

杂志文章

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