High-affinity chimeric anti-(colorectal carcinoma) antibody correlated to enhanced tumor targeting in biodistribution and imaging.

abstract：PURPOSE:Metastasizing epithelioid sarcoma (ES) is an extremely aggressive tumor, because conventional chemotherapy and irradiation are largely ineffective. Here, we analyzed the impact of the CD95-mediated drug-induced apoptosis in ES cell lines. METHODS:The effects of paclitaxel (Taxol) and 5-FU were determined by MT...

journal_title：Journal of cancer research and clinical oncology

authors： Heikaus S,Matuszek KS,Suschek CV,Ramp U,Reinecke P,Grinstein E,Haremza J,Gabbert HE,Mahotka C

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:PIK3CA mutation appears to predict a lack of response to anti-EGFR monoclonal antibody (mAb) treatment in patients with metastatic colorectal cancer (mCRC). However, the predictive value of PIK3CA mutations for survival remains inconclusive. Here, we pooled the data from published studies to estimate the associ...

journal_title：Journal of cancer research and clinical oncology

authors： Wu S,Gan Y,Wang X,Liu J,Li M,Tang Y

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to explore the demographics, multimodality therapeutic outcomes*** and prognostic factors in sinonasal rhabdomyosarcoma (SNRMS). METHODS:We conducted a retrospective analysis of 40 patients who underwent treatment of SNRMS from March 2007 to March 2018. The Kaplan-Meier method ...

journal_title：Journal of cancer research and clinical oncology

authors： Li W,Lu H,Wang D

更新日期：2019-11-01 00:00:00

abstract：:Intravenous tumor cell injection and spontaneously metastasising transplantable tumors have been used as models for haematogenous tumor spread. To evaluate the validity of these two experimental approaches for the study of blood coagulability and metastases, the effect of anticoagulants on "secondary" tumor growth was...

journal_title：Journal of cancer research and clinical oncology

authors： Maat B,Hilgard P

更新日期：1981-01-01 00:00:00

abstract：:Reversal of natural resistance to bouvardin (NSC 259968) has been attained in vitro and in vivo, by the calcium influx blocker verapamil in sarcoma 180 cells insensitive to bouvardin. Verapamil increased the in vitro lethality of the tumor cells following exposure with cells for 1 and 3 h as a result of the cytotoxic ...

journal_title：Journal of cancer research and clinical oncology

authors： Chitnis MP,Menon RS,Basrur VS,Adwankar MK,Satyamoorthy K

更新日期：1985-01-01 00:00:00

abstract：:Three oxygenated propylnitrosomethylamines were administered to female Syrian hamsters at doses similar to those which had induced high incidences of esophageal neoplasms in rats. Nitrosomethyl-2-oxopropylamine (NMOP) given at the rate of 2 mg/animal/week, whether as one application of 2 mg or two applications of 1 mg...

journal_title：Journal of cancer research and clinical oncology

authors： Lijinsky W,Kovatch RM,Knutsen GL

更新日期：1985-01-01 00:00:00

abstract：:The formation of foci with loss of ATPase and emergence of gamma-GTase was studied histochemically in livers of male and female Wistar and Sprague-Dawley rats of 3--4 and 6--7 weeks of age, respectively, after application of diethylnitrosamine. A single dose of 8 mg/kg body weight induced a considerable island formati...

journal_title：Journal of cancer research and clinical oncology

authors： Deml E,Oesterle D,Wolff T,Greim H

更新日期：1981-01-01 00:00:00

abstract：:Trace metals are essential for the growth and several other properties of human lymphocytes. We studied the effects of media with variable concentrations of three metals (Fe2+, Cu2+, Zn2+), a metal chelator (deferoxamine, DFX) and a cell-growth inhibitor (hydroxyurea) on the growth, intracellular metal concentration a...

journal_title：Journal of cancer research and clinical oncology

authors： Oblender M,Carpentieri U

更新日期：1991-01-01 00:00:00

abstract：:In supporting the human-tumor cloning effort of the Southwest Oncology Group, we conducted an independent retrospective study to evaluate the clinical correlations of the soft-agar colony-forming assay developed by Hamburger and Salmon (1977). This study was made with the cooperation of 76 clinicians and 11 hospitals ...

journal_title：Journal of cancer research and clinical oncology

authors： Fan D,Morgan LR,Schneider C,Blank H,Fan S

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Angiosarcoma of the scalp and face is a rare malignant endothelial tumor arising mainly in elderly people. The prognosis is poor. Effective and safe treatments are warranted. METHODS:A 79-year-old woman with an angiosarcoma of the scalp larger than 5 cm in diameter was treated with intravenous liposomal doxoru...

journal_title：Journal of cancer research and clinical oncology

authors： Wollina U,Füller J,Graefe T,Kaatz M,Lopatta E

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To investigate the effects of Akt/ARK5 pathways on the metastatic potential of human breast cancer cells. MATERIALS AND METHODS:The human ARK5 gene was transfected into MDA-MB-231 cells. Effects of ARK5 on MDA-MB-231 cells were investigated in vitro. The tumorigenicity and spontaneously metastatic capability r...

journal_title：Journal of cancer research and clinical oncology

authors： Chang XZ,Yu J,Liu HY,Dong RH,Cao XC

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:Alterations in the cell cycle regulatory p16INK4a/Cyclin D1/pRb pathway play a pivotal role in tumorigenesis. Knowledge of alterations in the tumor suppressor protein pRb and its negative regulator, p16CDKN2/MTS1/INK4a in esophageal squamous cell carcinoma (ESCC) from the Indian subcontinent is meager. To gain ...

journal_title：Journal of cancer research and clinical oncology

authors： Ralhan R,Mathew R,Arora S,Bahl R,Shukla NK,Mathur M

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:Expression of CD44 and its variants has been shown to be relevant to tumor progression in various human malignancies. We evaluated the expression of CD44v6 in the primary lesions of stage I non-small cell lung cancer (NSCLC) and correlated the expression level to its prognosis. METHODS:The expression of CD44v6...

journal_title：Journal of cancer research and clinical oncology

authors： Situ D,Long H,Lin P,Zhu Z,Wang J,Zhang X,Xie Z,Rong T

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:The inhibitor of growth (ING) family consists of ING1, ING2, ING3, ING4 and ING5, which function as the type II tumor suppressors. INGs regulate cell proliferation, senescence, apoptosis, differentiation, angiogenesis, DNA repair, metastasis, and invasion by multiple pathways. In addition, INGs increase cancer ...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang R,Jin J,Shi J,Hou Y

更新日期：2017-02-01 00:00:00

abstract：:Protein extracted from conventional formalin-fixed and paraffin-embedded tissue sections of human gliomas was examined for immunoblot analysis using antibody against the placental form of glutathione S-transferase (GST-pi). Four benign astrocytomas, five anaplastic astrocytomas and four glioblastomas were used in this...

journal_title：Journal of cancer research and clinical oncology

authors： Hara A,Sakai N,Yamada H,Yoshimi N,Tanaka T,Mori H

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To study pre-treatment serum VEGF of patients with invasive cervical cancer and its possible role as prognostic indicator. METHODS:VEGF was measured using ELISA in the largest patient group (n = 167) to date. RESULTS:Serum VEGF was significantly higher in advanced tumor stage (P = 0.01), large tumor size (tum...

journal_title：Journal of cancer research and clinical oncology

authors： Zusterzeel PL,Span PN,Dijksterhuis MG,Thomas CM,Sweep FC,Massuger LF

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:Acute intestinal damage induced by chemotherapeutic agent is often a dose-limiting factor in clinical cancer therapy. The aim of this study was to investigate the effect of chemokine CXCL9 on the intestinal damage after chemotherapy and explore the therapeutic potential of anti-CXCL9 agents. METHODS:In vitro c...

journal_title：Journal of cancer research and clinical oncology

authors： Lu H,Liu H,Wang J,Shen J,Weng S,Han L,Sun T,Qian L,Wu M,Zhu S,Yu Y,Han W,Zhu J,Moldenhauer A

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:The purpose of this study was to characterize changes in the expression of copper-zinc superoxide dismutase (Cu/Zn-SOD) and manganese SOD (Mn-SOD) in oral squamous-cell carcinoma (OSCC). METHODS:Real-time quantitative reverse transcriptase-polymerase chain reaction analysis of Cu/Zn-SOD and Mn-SOD mRNA express...

journal_title：Journal of cancer research and clinical oncology

authors： Yokoe H,Nomura H,Yamano Y,Fushimi K,Sakamoto Y,Ogawara K,Shiiba M,Bukawa H,Uzawa K,Takiguchi Y,Tanzawa H

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:TNF-related apoptosis-inducing ligand (TRAIL) is a potential cancer therapeutic agent that preferentially induces apoptosis in cancer cells. However, breast cancer cells are generally resistant to TRAIL. Bufalin is a major active ingredient of the traditional Chinese medicine ChanSu. The present study aimed to ...

journal_title：Journal of cancer research and clinical oncology

authors： Yan S,Qu X,Xu C,Zhu Z,Zhang L,Xu L,Song N,Teng Y,Liu Y

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:B-cell translocation gene 3 (BTG3) has been identified as a candidate driver gene for various cancers, but its specific role in colorectal cancer (CRC) is poorly understood. We aimed to investigate the relationship between expression of BTG3 and clinicopathological features and prognosis, as well as to explore ...

journal_title：Journal of cancer research and clinical oncology

authors： Lv C,Wang H,Tong Y,Yin H,Wang D,Yan Z,Liang Y,Wu D,Su Q

更新日期：2018-02-01 00:00:00

abstract：:In a population-based case/control study the differential lung cancer risk patterns due to tobacco smoking habits of various histological types have been investigated. The cases were 1432 deaths from lung cancer in the years 1980-1987, of which the histological type was known for 627 individuals. There was 54% squamou...

journal_title：Journal of cancer research and clinical oncology

authors： Jedrychowski W,Becher H,Wahrendorf J,Basa-Cierpialek Z,Gomola K

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To study the interplay of drugs and energy metabolism of tumor cells, metabolic changes induced by chloroacetaldehyde and cytochalasin B were analyzed in colon carcinoma cells LS174T. METHODS:O(2)-consumption and extracellular acidification were recorded using a bioelectronic sensor-chip system, which monitors...

journal_title：Journal of cancer research and clinical oncology

authors： Motrescu ER,Otto AM,Brischwein M,Zahler S,Wolf B

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:The objectives of this work were to investigate whether the serum-free fatty acid (FFA) level is meaningful in cancer patients and its role in cancer diagnosis. METHODS:A total of 2206 patients were divided into a cancer group (n = 1019) and a noncancer group (n = 1187). Age, sex, body mass index (BMI), and se...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang L,Han L,He J,Lv J,Pan R,Lv T

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:Mutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and prognostic effects of TP53 mutations in certain cancers. METHODS:Over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer (IARC) TP...

journal_title：Journal of cancer research and clinical oncology

authors： Li VD,Li KH,Li JT

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Cancer stem cells (CSCs) represent a population with tumour-initiating, self-renewal, and differentiation potential. This study aimed to evaluate the expression patterns and clinical significance of chemokine receptor type 4 (CXCR4) as a novel CSC marker in renal cell carcinoma (RCC). METHODS:The expression of...

journal_title：Journal of cancer research and clinical oncology

authors： Rasti A,Abolhasani M,Zanjani LS,Asgari M,Mehrazma M,Madjd Z

更新日期：2017-01-01 00:00:00

abstract：:To investigate multidrug-resistance gene (MDR1) promoter efficacy and drug inducibility in cells with different multidrug-resistance phenotypes, multidrug-resistant HCT15 and drug-sensitive KM12 human colon carcinoma cell lines were transfected with constructs incorporating the chloramphenicol acetyltransferase (CAT) ...

journal_title：Journal of cancer research and clinical oncology

authors： Stein U,Walther W,Shoemaker RH

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Recent reports have shown an increase in frequency of intra-hepatic cholangiocarcinoma (IHC) with a stable or decreased frequency of extra-hepatic cholangiocarcinoma (EHC). However, data on the demographic patterns associated with this change are limited. We analyzed cases of cholangiocarcinoma (CC) with aim to...

journal_title：Journal of cancer research and clinical oncology

authors： Singal AK,Vauthey JN,Grady JJ,Stroehlein JR

更新日期：2011-07-01 00:00:00

abstract：:In 361 Sprague-Dawley rats autochthonous colorectal carcinomas were induced by intrarectal application of the carcinogen AMMN. Tumor-bearing animals were treated with a synthetic thioether-lysophospholipid (TLP) derivative and in combination chemotherapy with 5-fluorouracil (5-FU) and carmustine (BCNU). There was no d...

journal_title：Journal of cancer research and clinical oncology

authors： Heim ME,Swoboda M,Pahlke W,Edler L,Bicker U

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:To describe the clinical characteristics and outcomes of patients with dual-phenotype hepatocellular carcinoma (DPHCC) and investigate the use of radiomics to establish an image-based signature for preoperative differential diagnosis. METHODS:This study included 50 patients with a postoperative pathological di...

journal_title：Journal of cancer research and clinical oncology

authors： Huang X,Long L,Wei J,Li Y,Xia Y,Zuo P,Chai X

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:To investigate the levels for some specified microRNAs in human's peripheral blood so as to determine whether they can serve as biomarkers for metastatic non-small-cell lung cancer. METHODS:Use a quantitative stem-loop RT-PCR method to examine the serum levels for certain microRNAs including has-miR-125a-5p, h...

journal_title：Journal of cancer research and clinical oncology

authors： Lin Q,Mao W,Shu Y,Lin F,Liu S,Shen H,Gao W,Li S,Shen D

更新日期：2012-01-01 00:00:00