A cluster of specified microRNAs in peripheral blood as biomarkers for metastatic non-small-cell lung cancer by stem-loop RT-PCR.

Abstract:

PURPOSE:To investigate the levels for some specified microRNAs in human's peripheral blood so as to determine whether they can serve as biomarkers for metastatic non-small-cell lung cancer. METHODS:Use a quantitative stem-loop RT-PCR method to examine the serum levels for certain microRNAs including has-miR-125a-5p, has-miR-126, has-miR-183, has-miR-200, has-miR-221, and has-miR-222 from the patients with Stage IV, Stage I/II non-small-cell lung cancer and the controls. RESULTS:There was statistical difference in the serum levels for hsa-miR-126, hsa-miR-183, and hsa-miR-222 between the controls and the Stage IV patients, but not for has-miR-125a-5p, has-miR-200 and has-miR-221. It also showed statistical difference for hsa-miR-126 and hsa-miR-183 between the Stage I/II patients and Stage IV patients, but not between the controls and Stage I/II patients. CONCLUSION:Hsa-miR-126 and hsa-miR-183 may serve as potential serum biomarkers for metastatic non-small-cell lung cancer.

authors

Lin Q,Mao W,Shu Y,Lin F,Liu S,Shen H,Gao W,Li S,Shen D

doi

10.1007/s00432-011-1068-z

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

85-93

issue

1

eissn

0171-5216

issn

1432-1335

journal_volume

138

pub_type

杂志文章
  • Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). V. Skin irriitant and tumor-promoting diterpene ester toxins of the tigliane and ingenane type in the herbs Euphorbia nubi

    abstract::Irritant diterpene ester toxins were isolated from Euphorbia nubica and E. helioscopia, which are contaminants of the green fodder of livestock in Egypt. Fractionations of methanol extracts of aerial parts of both plants were monitored by the irritation unit on the mouse ear. Plant extracts were subjected to multiplic...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s004320000214

    authors: Zayed SM,Farghaly M,Soliman SM,Gotta H,Sorg B,Hecker E

    更新日期:2001-01-01 00:00:00

  • Comparative metabolism and carcinogenicity of ring-halogenated 3,3-dimethyl-1-phenyltriazenes.

    abstract::The objective of this study was to compare urinary metabolism of parent 3,3-dimethyl-1-phenyltriazene with that of its ring-substituted 1-(4-chlorophenyl)-3,3-dimethyltriazene and 1-(2,4,6-trichlorophenyl)-3,3-dimethyltriazene congeners, in an attempt to evaluate the molecular requirements for systemic carcinogenic ac...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF00390976

    authors: Kolar GF,Habs M

    更新日期:1984-01-01 00:00:00

  • Catechin as an antimutagen: its mode of action.

    abstract::In the present study, we report that the betel quid ingredient catechu, its extract and pure principle catechin were nonmutagenic in Salmonella typhimurium TA 100, TA 1535, TA 98, and TA 1538 assays with or without metabolic activation. They also exhibited dose-dependent decreases in mutagenicity of benzo(a)pyrene [B(...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF00417833

    authors: Nagabhushan M,Maru GB,Amonkar AJ,Nair UJ,Santhanam U,Ammigan N,D'Souza AV,Bhide SV

    更新日期:1988-01-01 00:00:00

  • Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers.

    abstract:PURPOSE:Recent studies indicated undisputed contribution of connective tissue growth factor (CTGF) in the development of many cancers, including non-small cell lung cancer (NSCLC). However, the functional role and regulation of CTGF expression during tumorigenesis remain elusive. Our goal was to determine CTGF transcri...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-016-2195-3

    authors: Drzewiecka H,Gałęcki B,Jarmołowska-Jurczyszyn D,Kluk A,Dyszkiewicz W,Jagodziński PP

    更新日期:2016-09-01 00:00:00

  • Spontaneous high-titered IgG antibody responses against BCL-2 in patients with aggressive lymphomas.

    abstract:PURPOSE:Molecules which are exclusively or preferentially expressed by malignant cells are potential targets for immunotherapeutic approaches to the treatment of cancer. METHODS:We therefore tested serum samples of 95 patients with aggressive B-cell lymphomas for antibodies against lymphoma-associated molecules using ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-009-0561-0

    authors: Zwick C,Held G,Hammermeister V,Alahmad A,Kubuschok B,Bittenbring J,Ahlgrimm M,Neumann F,Preuss KD,Pfreundschuh M

    更新日期:2009-09-01 00:00:00

  • Ultrasound-mediated nanobubble destruction (UMND) facilitates the delivery of VEGFR2-targeted CD-TK-loaded cationic nanobubbles in the treatment of bladder cancer.

    abstract:BACKGROUND:The CD-TK double suicide gene has become an effective therapy for bladder cancer. A novel molecular-targeted ultrasound (US) method has been developed to precisely guide nanobubbles loaded with this gene to regions within bladder tumor cells and is widely used due to its efficiency in delivering drugs to the...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-020-03160-7

    authors: Hu C,Jiang D,Wu M,Wang J,Zhang R

    更新日期:2020-06-01 00:00:00

  • A high serum-free fatty acid level is associated with cancer.

    abstract:PURPOSE:The objectives of this work were to investigate whether the serum-free fatty acid (FFA) level is meaningful in cancer patients and its role in cancer diagnosis. METHODS:A total of 2206 patients were divided into a cancer group (n = 1019) and a noncancer group (n = 1187). Age, sex, body mass index (BMI), and se...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-019-03095-8

    authors: Zhang L,Han L,He J,Lv J,Pan R,Lv T

    更新日期:2020-03-01 00:00:00

  • Alterations in cyclin D1 expression in esophageal squamous cell carcinoma in the Indian population.

    abstract:PURPOSE:The p16/cyclin D1/pRb pathway plays a critical role in tumourigenesis. We recently reported alterations in expression of tumour suppressor gene products, p16 and pRb in esophageal cancer. Knowledge of alterations in cyclin D1, a vital component of this pathway in esophageal carcinomas from the Indian subcontine...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s004320000185

    authors: Mathew R,Arora S,Khanna R,Shukla NK,Mathur M,Ralhan R

    更新日期:2001-04-01 00:00:00

  • Ginger extract has anti-leukemia and anti-drug resistant effects on malignant cells.

    abstract:PURPOSE:Based on the poor prognosis of drug resistance in pediatric acute lymphoblastic leukemia (ALL) and adverse effects of chemotherapy, this study was aimed to evaluate the effect of several herbal extracts on leukemic cells. METHODS:Two subtypes of T- and B-ALL cell lines, followed by ALL primary cells were treat...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-019-02949-5

    authors: Rahimi Babasheikhali S,Rahgozar S,Mohammadi M

    更新日期:2019-08-01 00:00:00

  • Different pattern of expression of cellular oncogenes in human non-small-cell lung cancer cell lines.

    abstract::Altered and deregulated cellular oncogenes were found in many human solid tumors. Except for a few types of tumors that consistently exhibited specific altered proto-oncogenes, the majority of tumors are associated with a number of transcriptionally activated cellular oncogenes. In the heterologous group of non-small-...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF01612637

    authors: Kiefer PE,Wegmann B,Bacher M,Erbil C,Heidtmann H,Havemann K

    更新日期:1990-01-01 00:00:00

  • Characterization of steroid hormone sensitivity in human breast cancers maintained ex vivo under organotypical culture conditions.

    abstract:PURPOSE:The methodology we propose combines the immunohistochemical determination of the oestrogen and progesterone receptors (ER and PgR) with the characterization of the oestradiol- and progesterone-induced influence on cell proliferation in breast cancers in order to characterize their steroid hormone sensitivity at...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s004320050340

    authors: Darro F,Schwarz G Jr,Pétein M,Schwarz S,Chaboteaux C,Nogaret JM,Decaestecker C,Salmon I,Kiss R

    更新日期:2000-05-01 00:00:00

  • Phase II study of 5-fluoruracil leucovorin and azidothymidine in patients with metastatic colorectal cancer.

    abstract::The primary objective of this study was to determine the response rate of patients with metastatic colorectal cancer to combined therapy with 5-fluorouracil (5-FU), leucovorin, and intravenous azidothymidine (AZT), a thymidine nucleoside analog. By itself, AZT has limited antineoplastic efficacy. However, experimental...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01213552

    authors: Clark J,Sikov W,Cummings F,Browne M,Akerley W,Wanebo H,Weitberg A,Kennedy T,Cole B,Bigley J,Beitz J,Darnowski J

    更新日期:1996-01-01 00:00:00

  • Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers.

    abstract::Female carriers of mutations in the BRCA1 gene on chromosome 17q have a very high risk of developing breast and/or ovarian cancer during their lifetime. There is, however, little knowledge of to what extent non-genetic risk factors, such as age at menarche, age at first birth, and body mass index, alter the age at ons...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF01208638

    authors: Chang-Claude J,Becher H,Eby N,Bastert G,Wahrendorf J,Hamann U

    更新日期:1997-01-01 00:00:00

  • Expression of metalloproteinase genes in human prostate cancer.

    abstract::Twenty-five surgical specimens of malignant human prostate, 3 lymph nodes with metastatic prostate carcinoma, 11 normal human prostates, as well as 3 human prostate cell lines (DU-145, PC3 and LNCaP) were examined for the expression of the human matrix metalloproteinase-7 gene (MMP-7) from the human collagenase family...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF01613138

    authors: Pajouh MS,Nagle RB,Breathnach R,Finch JS,Brawer MK,Bowden GT

    更新日期:1991-01-01 00:00:00

  • Presence and absence of virus particles in hybridomas secreting monoclonal antibodies against gliomas.

    abstract::Hybridoma clones were produced by fusion of splenocytes from glioma-immunized hosts and the X63-Ag8.653 mouse myeloma line and Y3-Ag.1.2.3. rat myeloma line. Oncornavirus particles were found in all clones descending from the mouse myeloma line. No virus particles could be found in either the spleens of immunized Balb...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF00399903

    authors: Stavrou D,Bilzer T,Tsangaris T,Dürr E,Steinecke M,Anzil AP

    更新日期:1983-01-01 00:00:00

  • Enhanced ABL-inhibitor-induced MAPK-activation in T315I-BCR-ABL-expressing cells: a potential mechanism of altered leukemogenicity.

    abstract:BACKGROUND:Targeted treatment of chronic myelogenous leukemia using imatinib has dramatically improved patient outcome. However, residual disease can be detected in the majority of patients treated with imatinib. Compensatory activation of MAP kinases (MAPK1/2) in response to BCR-ABL-inhibitors has been reported as a p...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-011-1086-x

    authors: Härtel N,Klag T,Hanfstein B,Mueller MC,Schenk T,Erben P,Hochhaus A,La Rosée P

    更新日期:2012-02-01 00:00:00

  • Identification of prognostic markers of high grade prostate cancer through an integrated bioinformatics approach.

    abstract:PURPOSE:Prostate cancer is one of the leading causes of cancer death for male. In the present study, we applied an integrated bioinformatics approach to provide a novel perspective and identified some hub genes of prostate cancer. METHOD:Microarray data of fifty-nine prostate cancer were downloaded from Gene Expressio...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-017-2497-0

    authors: Huang H,Zhang Q,Ye C,Lv JM,Liu X,Chen L,Wu H,Yin L,Cui XG,Xu DF,Liu WH

    更新日期:2017-12-01 00:00:00

  • Malignant fibrous histiocytoma of the renal capsule.

    abstract::We report about an extremely rare case of malignant fibrous histiocytoma (MFH) of the renal capsule. The tumor is composed of fibroblast-like cells arranged in a storiform pattern and histiocyte-like cells with multinucleated giant cells, both showing no iron reaction. Characteristic of the histiocytic quality of the ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF00410689

    authors: Gabbert H,Wagner R,Becht E

    更新日期:1981-01-01 00:00:00

  • Surgically treated oropharyngeal cancer: risk factors and tumor characteristics.

    abstract:PURPOSE:To assess risk factors of patients with oropharyngeal squamous cell carcinoma in the Munich area of Southern Germany in relation to human papillomavirus (HPV) association of the tumors. To demonstrate differences in tumor characteristics and their impact on adjuvant treatment. METHODS:Between November 2010 and...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-014-1631-5

    authors: Baumeister P,Reiter M,Welz C,Becker S,Betz C,Harréus U

    更新日期:2014-06-01 00:00:00

  • Radioembolization and systemic chemotherapy improves response and survival for unresectable colorectal liver metastases.

    abstract:PURPOSE:To evaluate the role of radioembolization and systemic chemotherapy as a combined modality therapy for unresectable colorectal liver metastases. PATIENTS AND METHODS:Prospective database of a major yttrium-90 microsphere radioembolization treatment center in Sydney, Australia, that included 140 patients with u...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-010-0948-y

    authors: Chua TC,Bester L,Saxena A,Morris DL

    更新日期:2011-05-01 00:00:00

  • Risk of lung cancer and renin-angiotensin blockade: a concise review.

    abstract:PURPOSE:The blockade of the renin-angiotensin-aldosterone system (RAAS) by angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) is one of the most common treatments for hypertension, heart failure and renal diseases. However, concerns have been raised about a possible link between RA...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s00432-020-03445-x

    authors: Rachow T,Schiffl H,Lang SM

    更新日期:2021-01-01 00:00:00

  • Phase II trial of aclacinomycin A in acute leukemia and various solid tumors.

    abstract::Aclacinomycin A (ACM) is a new anthracycline antibiotic with a reduced cardiac toxicity in animal models. A phase II study was performed in a total of 25 patients, 23 of whom are evaluable for response. All suffered from recurrent and advanced tumors. Pretreatment consisted of at least four different chemotherapeutic ...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF00406927

    authors: Schütte J,Niederle N,Seeber S

    更新日期:1983-01-01 00:00:00

  • Tissue connections in a transplantable virus-producing sebaceous adenoma of the mouse. II. A freeze-fracture study in conjunction with filipin.

    abstract::The distribution, size, and configuration of intercellular junctions in the sebaceous tumor of mice were examined using the freeze-fracture technique. Three types of junctions were observed: desmosomes, gap, and tight junctions. Tight junctions in general consisted of short linear unbranched fibrils, and macular or co...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF00411341

    authors: Robenek H,Schöpper C,Fasske E,Fetting R,Themann H

    更新日期:1982-01-01 00:00:00

  • Prognostic value of immunohistochemistry for p53 in primary soft-tissue sarcomas: a multivariate analysis of five antibodies.

    abstract::Most changes of tumor suppressor p53 and its pathway involve a protein with prolonged half-life that permits immunohistochemical detection. The goal of this study was to compare the prognostic relevance of five different p53 antibodies in primary soft-tissue sarcomas (STS) with known p53 mutation status, using a multi...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF01192205

    authors: Würl P,Taubert H,Meye A,Berger D,Lautenschläger C,Holzhausen HJ,Schmidt H,Kalthoff H,Rath FW,Dralle H

    更新日期:1997-01-01 00:00:00

  • Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines.

    abstract:OBJECTIVES:The present study was designed to investigate the possible protective effects of berberine against cyclophosphamide (CP)-induced hepatotoxicity in rats. METHODS:The experimental rats were treated with berberine orally at a dose of 50 mg/kg for 11 consecutive days after the administration of a single intrape...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-014-1665-8

    authors: Germoush MO,Mahmoud AM

    更新日期:2014-07-01 00:00:00

  • Hyaluronic acid-modified polyamidoamine dendrimer G5-entrapped gold nanoparticles delivering METase gene inhibits gastric tumor growth via targeting CD44+ gastric cancer cells.

    abstract:BACKGROUND:Gastric cancer (GC) is the second most common leading cause of cancer-related death. Cancer stem cell (CSC) with the mark of CD44 played an important role in GC. rMETase was wildly exploited as chemotherapeutic option for GC. Polymers synthetic nanoparticle drug delivery systems have been commonly used for c...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-018-2678-5

    authors: Li YF,Zhang HT,Xin L

    更新日期:2018-08-01 00:00:00

  • Differential enhancement of collagen crosslink excretion in cases of osteosarcoma and chondrosarcoma.

    abstract::Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are markers of collagen absorption and LP is specific for collagen type I in bone. In the present study we evaluated the concentration of HP and LP in urine of patients with osteosarcoma ( n=20; age range 16-49 years) and chondrosarcoma ( n=15; age range 18-70 y...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-003-0470-6

    authors: Açil Y,Springer I,Behrens P,Ullrich KP,Hedderich J,Bruns J

    更新日期:2003-10-01 00:00:00

  • Epigenetic silencing of ADAMTS5 is associated with increased invasiveness and poor survival in patients with colorectal cancer.

    abstract:PURPOSE:A disintegrin and metalloprotease with motif 5(ADAMTS5) has been involved in colorectal cancer (CRC) with hypermethylation in the promoter. However, its role in CRC remains unclear. The aim of this study was to explore the clinical significance and biological effect of ADAMTS5 on colorectal carcinogenesis. Thro...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-017-2545-9

    authors: Li J,Liao Y,Huang J,Sun Y,Chen H,Chen C,Li S,Yang Z

    更新日期:2018-02-01 00:00:00

  • Lack of correlation between deoxyribonucleotide pool sizes, spontaneous mutation rates and malignant potential in Chinese hamster ovary cells.

    abstract::To examine the relationship between altered spontaneous mutation rates and malignant characteristics of cells, two hydroxyurea-resistant Chinese hamster ovary cell lines, with alterations in ribonucleotide reductase, were examined for their rates of spontaneous mutation to 6-thioguanine and ouabain resistance, tumor g...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/BF00393331

    authors: Tagger AY,Damen JE,Greenberg AH,Wright JA

    更新日期:1989-01-01 00:00:00

  • High KIT and PDGFRA are associated with shorter patients survival in gastroenteropancreatic neuroendocrine tumors, but mutations are a rare event.

    abstract:PURPOSE:(1) To test whether in genomewide expression profiling differentially expressed genes were also distinct on the protein level including KIT and PDGFRA (2) to correlate the expression with clinicopathological parameters (3) to identify activating mutations that might be eligible for tyrosine kinase inhibitor the...

    journal_title:Journal of cancer research and clinical oncology

    pub_type: 杂志文章

    doi:10.1007/s00432-011-1107-9

    authors: Knösel T,Chen Y,Altendorf-Hofmann A,Danielczok C,Freesmeyer M,Settmacher U,Wurst C,Schulz S,Yang LL,Petersen I

    更新日期:2012-03-01 00:00:00