当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > The risk of female malignancies after fertility treatments: a cohort study with 25-year follow-up.

The risk of female malignancies after fertility treatments: a cohort study with 25-year follow-up.

Abstract：

OBJECTIVE:To investigate whether an association exists between a history of fertility treatments and future risk of female malignancies. STUDY DESIGN:A population-based study compared the incidence of long-term female malignancies in a cohort of women with and without a history of fertility treatments including in vitro fertilization (IVF) and ovulation induction (OI). Deliveries occurred between the years 1988-2013, with a mean follow-up duration of 12 years. Excluded from the study were women with known genetic predisposition for malignancies or known malignancies prior to the index pregnancy. Female malignancies were divided into specific types including ovarian, uterine, breast and cervix. Kaplan-Meier survival curve was used to estimate cumulative incidence of malignancies. Cox proportional hazard models were used to estimate the adjusted hazard ratios (HRs) for female malignancy. RESULTS:During the study period, 106,031 women met the inclusion criteria; 4.1 % (n = 4363) occurred in patients following fertility treatments. During the follow-up period, patients with a history of IVF treatments had a significantly increased risk of being diagnosed with ovarian and uterine cancer as compared to patients after OI and patients with no history of fertility treatments. Cox proportional hazard models were constructed for ovarian and uterine cancer separately, controlling for confounders such as maternal age and obesity. A history of IVF treatment remained independently associated with ovarian and uterine cancer (adjusted HR 3.9; 95 % CI 1.2-12.6; P = 0.022 and adjusted HR 4.6; 95 % CI 1.4-14.9; P = 0.011; respectively). CONCLUSION:IVF treatments pose a significant risk of subsequent long-term ovarian and uterine cancer.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Kessous R,Davidson E,Meirovitz M,Sergienko R,Sheiner E

doi

10.1007/s00432-015-2035-x

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

287-93

issue

1

eissn

0171-5216

issn

1432-1335

pii

10.1007/s00432-015-2035-x

journal_volume

142

pub_type

杂志文章

相关文献

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY文献大全
  • MET canonical transcript expression is a predictive biomarker for chemo-sensitivity to MET-inhibitors in hepatocellular carcinoma cell lines.

    abstract：PURPOSE:Long interspersed nuclear element 1 (LINE-1 or L1) is a dominant non-long terminal repeat (non-LTR) retrotransposon in the human genome that has been implicated in the overexpression of MET. Both the canonical MET and L1-MET transcripts are considered to play a role in hepatocellular carcinoma (HCC) development...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-020-03395-4

    authors： Rashed WM,Kandeil MA,Mahmoud MO,Maher D,Ezzat S,Abdel-Rahman MH

    更新日期：2021-01-01 00:00:00

  • The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma.

    abstract：PURPOSE:Dysregulation of microRNA (miRNA) metabolism has been observed in a variety of human cancers, but the expression patterns of the enzymes responsible for generating miRNAs remain largely unexplored. In this study, we investigated the expression profiles of the two most important enzymes of the miRNA machinery, D...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-011-1058-1

    authors： Guo X,Liao Q,Chen P,Li X,Xiong W,Ma J,Li X,Luo Z,Tang H,Deng M,Zheng Y,Wang R,Zhang W,Li G

    更新日期：2012-01-01 00:00:00

  • Alkylphosphocholine-induced production of nitric oxide and tumor necrosis factor alpha by U 937 cells.

    abstract：:The human histiocytic cell line U 937, which expresses a number of monocyte markers and properties, was investigated with regard to its ability to be activated for NO and tumor necrosis factor (TNF) release after treatment with alkylphosphocholines (APC) and APC liposomes. Using APC multilamellar vesicles (MLV) a clea...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01225687

    authors： Eue I,Zeisig R,Arndt D

    更新日期：1995-01-01 00:00:00

  • Lack of correlation between deoxyribonucleotide pool sizes, spontaneous mutation rates and malignant potential in Chinese hamster ovary cells.

    abstract：:To examine the relationship between altered spontaneous mutation rates and malignant characteristics of cells, two hydroxyurea-resistant Chinese hamster ovary cell lines, with alterations in ribonucleotide reductase, were examined for their rates of spontaneous mutation to 6-thioguanine and ouabain resistance, tumor g...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00393331

    authors： Tagger AY,Damen JE,Greenberg AH,Wright JA

    更新日期：1989-01-01 00:00:00

  • Butyric acid and pivaloyloxymethyl butyrate, AN-9, a novel butyric acid derivative, induce apoptosis in HL-60 cells.

    abstract：:A novel butyric acid derivative, pivaloyloxymethyl butyrate, AN-9, was previously shown to be a potent differentiating agent. AN-9 exerts a significant anticancer activity in vitro and in vivo. In all the activities examined, AN-9 was more potent than butyric acid. Here we show that AN-9 and butyric acid induce cell d...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01214667

    authors： Zimra Y,Wasserman L,Maron L,Shaklai M,Nudelman A,Rephaeli A

    更新日期：1997-01-01 00:00:00

  • Mechanisms of tumor metastasis: cell biological aspects and clinical implications.

    abstract：:The clinical course--and hence the prognosis--of patients suffering from malignant tumors are essentially determined by the capability of tumor cells to metastasize. During the past decade knowledge about genetic aberrations, as well as molecular and cell biological mechanisms which are involved in the regulation of t...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s004320000148

    authors： Engers R,Gabbert HE

    更新日期：2000-12-01 00:00:00

  • Integrative metabolome and transcriptome profiling reveals discordant glycolysis process between osteosarcoma and normal osteoblastic cells.

    abstract：BACKGROUND:Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and adolescents. However, few biomarkers of diagnostic significance have been established. In recent years, high-throughput transcriptomic and metabolomic approaches make it possible for studying the levels of thousands of bioma...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1719-y

    authors： Chen K,Zhu C,Cai M,Fu D,Cheng B,Cai Z,Li G,Liu J

    更新日期：2014-10-01 00:00:00

  • Acetoxy substituted 1,1,2-triphenylbut-1-enes: estrogenic, antiestrogenic and mammary tumor inhibiting activity.

    abstract：:1,1,2-Triphenylbut-1-enes substituted with 3- or 4-acetoxy (OAc) groups on one, two, or three phenyl rings were tested for their estrogen receptor affinities, their estrogenic and antiestrogenic properties in the immature mouse, and their effect on the growth of the hormone-dependent MXT mammary tumor of the mouse. Th...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00404393

    authors： Schneider MR

    更新日期：1986-01-01 00:00:00

  • Determination of the cellular retinoic-acid-binding protein in dysplastic epithelia of the cervix uteri, differentiated into apo and holo forms.

    abstract：PURPOSE:The appearance of the cervical mucosa is regulated by different factors including retinoic acid. Hormone-dependent alteration of the cervix uteri mucosa is accompanied by a decrease or increase of cytoplasmatic retinoic-acid-binding protein (CRABP). To elucidate whether this hormone-dependent alteration of CRAB...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320050008

    authors： Volz-Köster S,Volz J,Kiefer A,Biesalski HK

    更新日期：2000-01-01 00:00:00

  • IL-6 signaling contributes to radioresistance of prostate cancer through key DNA repair-associated molecules ATM, ATR, and BRCA 1/2.

    abstract：PURPOSE:To study an association between IL-6 signaling and resistance to radiotherapy of prostate cancer (PCa) and explore the molecular mechanisms involved. METHODS:IL-6 expressing C4-2 and CWR22Rv1 (C4-2IL-6/CWRIL-6) and vector control (C4-2vec/CWRvec) cell lines were developed. Radiation-sensitivities of these cell...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-019-02917-z

    authors： Chen X,Chen F,Ren Y,Weng G,Xu L,Xue X,Keng PC,Lee SO,Chen Y

    更新日期：2019-06-01 00:00:00

  • KRAS allel-specific activity of sunitinib in an isogenic disease model of colorectal cancer.

    abstract：PURPOSE:To investigate the impact of different KRAS mutations on treatment with the tyrosine kinase inhibitor sunitinib in SW48 colorectal cancer cell line variants. MATERIALS AND METHODS:Isogenic SW48 KRAS wt, G12A, G12C, G12D, G12R, G12S, G12 V, and G13D cells were evaluated for ERK phosphorylation with and without ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-013-1401-9

    authors： Modest DP,Camaj P,Heinemann V,Schwarz B,Jung A,Laubender RP,Gamba S,Haertl C,Stintzing S,Primo S,Bruns CJ

    更新日期：2013-06-01 00:00:00

  • Effects of von Hippel-Lindau gene mutation and methylation status on expression of transmembrane carbonic anhydrases in renal cell carcinoma.

    abstract：PURPOSE:Our primary goal was to determine whether increased expression of the transmembrane carbonic anhydrase (CA) isozymes in renal cell carcinoma (RCC) is regulated by the von Hippel-Lindau (VHL) gene. METHODS:We studied mRNA expression of all three transmembrane CAs - CA IX, XII, and XIV - in 17 RCC cell lines, tr...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-002-0374-x

    authors： Ashida S,Nishimori I,Tanimura M,Onishi S,Shuin T

    更新日期：2002-10-01 00:00:00

  • Determination of a fragment of the c-erbB-2 translational product p185 in serum of breast cancer patients.

    abstract：:Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer pa...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01212719

    authors： Kynast B,Binder L,Marx D,Zoll B,Schmoll HJ,Oellerich M,Schauer A

    更新日期：1993-01-01 00:00:00

  • Protein deep sequencing applied to biobank samples from patients with pancreatic cancer.

    abstract：PURPOSE:Pancreatic cancer is commonly detected at advanced stages when the tumor is no longer amenable to surgical resection. Therefore, finding biomarkers for early stage disease is urgent. Here, we show that high-definition mass spectrometry (HDMS(E)) can be used to identify serum protein alterations associated with ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1817-x

    authors： Ansari D,Andersson R,Bauden MP,Andersson B,Connolly JB,Welinder C,Sasor A,Marko-Varga G

    更新日期：2015-02-01 00:00:00

  • Influence of the Ward colon tumor on the host response to endotoxin.

    abstract：:Cachexia and a decreased immune function are negative prognostic factors for cancer patients. While the decreased immunity results in a greater susceptibility to bacterial infection, the response of the host to the resulting infection is not clear. The experiments reported here were designed to evaluate the toxicity o...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01240314

    authors： Grossie VB Jr,Mailman D

    更新日期：1997-01-01 00:00:00

  • TFAP2E hypermethylation was associated with survival advantage in patients with colorectal cancer.

    abstract：PURPOSE:Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly remain unknown. This study was aimed to investigate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of p...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1766-4

    authors： Zhang ZM,Wang Y,Huang R,Liu YP,Li X,Hu FL,Zhu L,Wang F,Cui BB,Dong XS,Zhao YS

    更新日期：2014-12-01 00:00:00

  • Morphological grades of regression in osteosarcoma after polychemotherapy - study COSS 80.

    abstract：:The histologic grade of regression of 50 osteosarcomas after polychemotherapy - according to the protocol study, COSS 80 - was classified on a six-stage regression scale; 56% of all patients responded well to chemotherapy regression grades I, II, and III and no significant difference between BCD- and CPL-treated patie...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00625047

    authors： Salzer-Kuntschik M,Delling G,Beron G,Sigmund R

    更新日期：1983-01-01 00:00:00

  • Locoregional administration of 5-fluoro-2'-deoxyuridine (FdUrd) in Novikoff hepatoma in the rat: effects of dose and infusion time on tumor growth and on FdUrd metabolite levels in tumor tissue as determined by 19F-NMR spectroscopy.

    abstract：:The influence of infusion time and dose on the anticancer efficacy of 5-fluoro-2'-deoxyuridine (FdUrd) was investigated using a locoregional therapy model: Novikoff hepatoma transplanted i.m. into the thigh of Wistar rats and FdUrd infusion via a catheter implanted in the femoral artery. In experiment A the FdUrd dose...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01630711

    authors： Naser-Hijazi B,Berger MR,Schmähl D,Schlag P,Hull WE

    更新日期：1991-01-01 00:00:00

  • Angiosarcoma of the scalp: treatment with liposomal doxorubicin and radiotherapy.

    abstract：PURPOSE:Angiosarcoma of the scalp and face is a rare malignant endothelial tumor arising mainly in elderly people. The prognosis is poor. Effective and safe treatments are warranted. METHODS:A 79-year-old woman with an angiosarcoma of the scalp larger than 5 cm in diameter was treated with intravenous liposomal doxoru...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320000221

    authors： Wollina U,Füller J,Graefe T,Kaatz M,Lopatta E

    更新日期：2001-01-01 00:00:00

  • PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines.

    abstract：PURPOSE:PARP inhibitors (PARPi) are used in a wide range of human solid tumours but a limited evidence is reported in rhabdomyosarcoma (RMS), the most frequent childhood soft-tissue sarcoma. The cellular and molecular effects of Olaparib, a specific PARP1/2 inhibitor, and AZD2461, a newly synthesized PARP1/2/3 inhibito...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-018-2774-6

    authors： Camero S,Ceccarelli S,De Felice F,Marampon F,Mannarino O,Camicia L,Vescarelli E,Pontecorvi P,Pizer B,Shukla R,Schiavetti A,Mollace MG,Pizzuti A,Tombolini V,Marchese C,Megiorni F,Dominici C

    更新日期：2019-01-01 00:00:00

  • Evidence that a "treatment-free interval of less than 6 months" does not equate with clinically defined platinum resistance in ovarian cancer or primary peritoneal carcinoma.

    abstract：:The standard definition of platinum-resistant ovarian cancer or primary peritoneal carcinoma commonly includes patients whose disease initially responded to a platinum-based combination regimen, but recurred less than 6 months after the completion of primary therapy. Recent experience with several patients with these ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320050177

    authors： Markman M,Kennedy A,Webster K,Kulp B,Peterson G,Belinson J

    更新日期：1998-01-01 00:00:00

  • Surgery of malignant ovarian tumors.

    abstract：:As currently recognized, the essential aspects of ovarian carcinoma surgery are: (1) the search for occult metastases in tumors located in the lower pelvis, (2) the maximum tumor removal ("tumor-reductive surgery") in advanced ovarian carcinoma and (3) the exploratory laparotomy to confirm a complete clinical remissio...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00399377

    authors： Almendral AC

    更新日期：1984-01-01 00:00:00

  • Relevance of cellular and serum carbonic anhydrase IX in primary breast cancer.

    abstract：BACKGROUND:Carbonic anhydrase IX (CAIX) is involved in pH homeostasis, growth and survival of tumor cells. Besides the membranous form of CAIX, a soluble form is detectable in serum (s-CAIX). Overexpression of CAIX in tumors offers the opportunity for therapeutic strategies such as CAIX targeting antibodies. The aim of...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-013-1378-4

    authors： Schütze D,Milde-Langosch K,Witzel I,Rody A,Karn T,Schmidt M,Choschzick M,Jänicke F,Müller V

    更新日期：2013-05-01 00:00:00

  • Activity of type IV collagenases (MMP-2 and MMP-9) in primary pulmonary carcinomas: a quantitative analysis.

    abstract：PURPOSE:Matrix metalloproteinases MMP-2 and MMP-9 are implicated in invasion and metastasis of malignant tumors. We investigated the expression and activation of MMP-2 and MMP-9 in lung cancer compared with normal lung parenchyma, and looked for a potential marker of malignancy. METHODS:Thirty-six pulmonary carcinomas...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-001-0320-3

    authors： Hrabec E,Strek M,Nowak D,Greger J,Suwalski M,Hrabec Z

    更新日期：2002-04-01 00:00:00

  • Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers.

    abstract：PURPOSE:Recent studies indicated undisputed contribution of connective tissue growth factor (CTGF) in the development of many cancers, including non-small cell lung cancer (NSCLC). However, the functional role and regulation of CTGF expression during tumorigenesis remain elusive. Our goal was to determine CTGF transcri...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-016-2195-3

    authors： Drzewiecka H,Gałęcki B,Jarmołowska-Jurczyszyn D,Kluk A,Dyszkiewicz W,Jagodziński PP

    更新日期：2016-09-01 00:00:00

  • Dept. of Microbiology, School of Medicine, East Carolina University, Greenville, NC.

    abstract：:The responsiveness of spleen cells from C57BL/6J mice to various immunogenic stimuli was examined during the progressive growth of a poorly immunogenic fibrosarcoma T241. A strong correlation was observed between the progressive tumor growth and the depression of response to Concanavalin A, lipopolysaccharide, sheep r...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00410112

    authors： Gautam SC,Gautam S,Deodhar SD

    更新日期：1981-01-01 00:00:00

  • The chemokine CXCL9 exacerbates chemotherapy-induced acute intestinal damage through inhibition of mucosal restitution.

    abstract：PURPOSE:Acute intestinal damage induced by chemotherapeutic agent is often a dose-limiting factor in clinical cancer therapy. The aim of this study was to investigate the effect of chemokine CXCL9 on the intestinal damage after chemotherapy and explore the therapeutic potential of anti-CXCL9 agents. METHODS:In vitro c...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1869-y

    authors： Lu H,Liu H,Wang J,Shen J,Weng S,Han L,Sun T,Qian L,Wu M,Zhu S,Yu Y,Han W,Zhu J,Moldenhauer A

    更新日期：2015-06-01 00:00:00

  • Cooperative evaluation of human tumor chemosensitivity in the soft-agar assay and its clinical correlations.

    abstract：:In supporting the human-tumor cloning effort of the Southwest Oncology Group, we conducted an independent retrospective study to evaluate the clinical correlations of the soft-agar colony-forming assay developed by Hamburger and Salmon (1977). This study was made with the cooperation of 76 clinicians and 11 hospitals ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF01884250

    authors： Fan D,Morgan LR,Schneider C,Blank H,Fan S

    更新日期：1985-01-01 00:00:00

  • Cancer of the ovary, fallopian tube, and peritoneum: a population-based comparison of the prognostic factors and outcomes.

    abstract：PURPOSE:The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. METHODS:We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of th...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-017-2422-6

    authors： Rottmann M,Burges A,Mahner S,Anthuber C,Beck T,Grab D,Schnelzer A,Kiechle M,Mayr D,Pölcher M,Schubert-Fritschle G,Engel J

    更新日期：2017-09-01 00:00:00

  • Immunohistochemical and biochemical characterization of antisera raised to human tumor nucleoli.

    abstract：:Antinucleolar antisera were raised in rabbits, goats and sheep to nucleoli isolated from three human tumor cell lines. The antisera were shown to cross-react by immunofluorescence with human tumor cell lines originating from different organs and with frozen sections from a wide variety of human malignant and non-malig...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00400962

    authors： Greenfield RS,Lamon MO,Olech LJ,Grattan JA

    更新日期：1989-01-01 00:00:00