Long non-coding RNA HOTTIP affects renal cell carcinoma progression by regulating autophagy via the PI3K/Akt/Atg13 signaling pathway.

abstract：PURPOSE:The purposes of our study were to elucidate the role of BRG1 in the development of human glioma and to determine the effect of BRG1 on glioma cell growth, migration and invasion. METHODS:Using tissue microarray and immunohistochemistry, we evaluated BRG1 staining in 190 glioma tissues, 8 normal brain tissues a...

journal_title：Journal of cancer research and clinical oncology

authors： Bai J,Mei PJ,Liu H,Li C,Li W,Wu YP,Yu ZQ,Zheng JN

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:Long interspersed nuclear element 1 (LINE-1 or L1) is a dominant non-long terminal repeat (non-LTR) retrotransposon in the human genome that has been implicated in the overexpression of MET. Both the canonical MET and L1-MET transcripts are considered to play a role in hepatocellular carcinoma (HCC) development...

journal_title：Journal of cancer research and clinical oncology

authors： Rashed WM,Kandeil MA,Mahmoud MO,Maher D,Ezzat S,Abdel-Rahman MH

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The development of brain metastases (BMs) was associated with poor prognosis in melanoma patients. Patients with BMs have a median survival of <6 months. Melanoma is the third most common tumor to metastasize to the brain with a reported incidence of 10-40 %. Our aim was to identify factors predicting develo...

journal_title：Journal of cancer research and clinical oncology

authors： Gumusay O,Coskun U,Akman T,Ekinci AS,Kocar M,Erceleb OB,Yazıcı O,Kaplan MA,Berk V,Cetin B,Taskoylu BY,Yildiz A,Goksel G,Alacacioglu A,Demirci U,Algin E,Uysal M,Oztop I,Oksuzoglu B,Dane F,Gumus M,Buyukberber S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Treatment for malignant ascites in advanced ovarian cancer (OC) patients remains controversial. The objective of this study was to investigate the efficacy of combined continuous circulatory hyperthermic intraperitoneal chemotherapy (HIPEC) preceded or followed by cytoreductive surgery (CRS) f...

journal_title：Journal of cancer research and clinical oncology

authors： Ba M,Long H,Zhang X,Tang Y,Wu Y,Yu F,Wang S,Cui S

更新日期：2014-09-01 00:00:00

abstract：:An in vitro double-labeling technique for determination of kinetic growth parameters was tested; 13 renal sarcomas of rats were incubated after excision under standardized conditions with 14C- and 3H-thymidine successively. Another ten tumors were evaluated after in vivo double injection of 14C and 3H-thymidine into s...

journal_title：Journal of cancer research and clinical oncology

authors： Lang W,Kienzle S,Georgii A

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:The t(11;18)(q21;q21) chromosome translocation is frequent in gastric MALT lymphoma, but the t(11;18)(q21;q21) chromosome translocation is very rare in other sites of MALT lymphomas. We investigated the possibility that MALT lymphoma occurred in the right buccal mucosa of a 66-year-old Japanese woman who had th...

journal_title：Journal of cancer research and clinical oncology

authors： Tanaka T,Iino M

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:The aim of this paper is to provide an overview of the most investigated optical diagnostic techniques: optical coherence tomography, fluorescence spectrometry, reflectance spectrometry, Raman spectroscopy, and confocal microscopy. METHODS:A search of three databases was conducted using specific keywords and e...

journal_title：Journal of cancer research and clinical oncology

authors： Calin MA,Parasca SV,Savastru R,Calin MR,Dontu S

更新日期：2013-07-01 00:00:00

abstract：:Synergy of folinic acid and FU has been shown in several experimental systems. In the present study we examined the kinetics of concurrent administration of folinic acid on the kinetics of FU in an in vivo model. Folinic acid significantly increased the amount of FU bound to the TS complex. In the sequential combinati...

journal_title：Journal of cancer research and clinical oncology

authors： Herrmann R,Reuter J,Port R,Osswald H

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether an association exists between a history of fertility treatments and future risk of female malignancies. STUDY DESIGN:A population-based study compared the incidence of long-term female malignancies in a cohort of women with and without a history of fertility treatments including in vit...

journal_title：Journal of cancer research and clinical oncology

authors： Kessous R,Davidson E,Meirovitz M,Sergienko R,Sheiner E

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Genomic stability is maintained by error-free DNA replication, repair, and recombination. To determine if repair genes contribute to genomic instability, we used a newly established cell line RCC-AJR (from clear-cell renal cell carcinoma) to examine hMSH2 (a mismatch-repair gene) and the gene encoding DNA beta ...

journal_title：Journal of cancer research and clinical oncology

authors： Chen HC,Bhattacharyya N,Wang L,Recupero AJ,Klein EA,Harter ML,Banerjee S

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:In the United States, cancer is the second leading cause of mortality, and millions more battle cancer worldwide. As such, primary prevention of cancer is a major interest globally. Aspirin has been studied as a primary prevention method for multiple diseases, mainly cardiovascular disease and various forms ...

journal_title：Journal of cancer research and clinical oncology

authors： Haykal T,Barbarawi M,Zayed Y,Yelangi A,Dhillon H,Goranta S,Kheiri B,Chahine A,Samji V,Kerbage J,Katato K,Bachuwa G

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:A growing body of evidence has shown the possible relevance of survivin -31G>C (rs9904341) promoter polymorphism to the genetic susceptibility of cancer. Because of the lack of available conclusive data, we performed a meta-analysis of all relevant available studies to derive a more precise estimation of the re...

journal_title：Journal of cancer research and clinical oncology

authors： Qin Q,Zhang C,Zhu H,Yang X,Xu L,Liu J,Lu J,Zhan L,Cheng H,Sun X

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:The inhibitor of growth (ING) family consists of ING1, ING2, ING3, ING4 and ING5, which function as the type II tumor suppressors. INGs regulate cell proliferation, senescence, apoptosis, differentiation, angiogenesis, DNA repair, metastasis, and invasion by multiple pathways. In addition, INGs increase cancer ...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang R,Jin J,Shi J,Hou Y

更新日期：2017-02-01 00:00:00

abstract：:The purpose of this study was to examine the structure/activity relationships of a series of substituted benzamides as poly(ADP-ribose) polymerase inhibitors. The experimental approach has involved the use of in vitro and in vivo assays in order to gather information either on the intrinsic activity of the benzamides ...

journal_title：Journal of cancer research and clinical oncology

authors： Sestili P,Spadoni G,Balsamini C,Scovassi I,Cattabeni F,Duranti E,Cantoni O,Higgins D,Thomson C

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To investigate the expression of sex steroid receptors in gastric cancer and to correlate their tumor expression profile with the clinicopathological parameters and overall survival of the patients. METHODS:Immunohistochemical methodology was employed in formalin-fixed paraffin-embedded sections from 86 patien...

journal_title：Journal of cancer research and clinical oncology

authors： Kominea A,Konstantinopoulos PA,Kapranos N,Vandoros G,Gkermpesi M,Andricopoulos P,Artelaris S,Savva S,Varakis I,Sotiropoulou-Bonikou G,Papavassiliou AG

更新日期：2004-05-01 00:00:00

abstract：:Sarcoma 180 tumor tissue from C57 mice was processed in a soft agar clonogenic assay immediately after removal from the animal and after various methods of storage. The sensitivity to the antineoplastic drug cis-platinum was not affected by different storage methods. The highest yield of colony forming cells per 100 m...

journal_title：Journal of cancer research and clinical oncology

authors： Krischke W,Hartmann R,Schneider M,Schönenberger H

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors' biology and explore t...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang F,Cai Z,Lv H,Li W,Liang M,Wei X,Zhou F

更新日期：2019-01-01 00:00:00

abstract：:In a population-based case/control study the differential lung cancer risk patterns due to tobacco smoking habits of various histological types have been investigated. The cases were 1432 deaths from lung cancer in the years 1980-1987, of which the histological type was known for 627 individuals. There was 54% squamou...

journal_title：Journal of cancer research and clinical oncology

authors： Jedrychowski W,Becher H,Wahrendorf J,Basa-Cierpialek Z,Gomola K

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To identify crucial molecular alterations of receptor tyrosine kinases that can be used as potential therapeutic targets for eyelid sebaceous gland carcinoma (SbGC). METHODS:The expression levels of HER2, EGFR, C-MET, and FGFR1 were determined by immunohistochemistry (IHC). The copy numbers of the HER2, EGFR, ...

journal_title：Journal of cancer research and clinical oncology

authors： Lee MJ,Kim N,Choung HK,Choe JY,Khwarg SI,Kim JE

更新日期：2016-01-01 00:00:00

abstract：:A new experimental method to test the effect of drugs on tumor-induced osteolysis using a bladder tumor in mice has been designed. The method consisted of inoculating MBT-2 tumor cells s.c. over the calvaria in mice, resulting in a local tumor causing fragmentation of the bone. This was accompanied by adjacent osteopl...

journal_title：Journal of cancer research and clinical oncology

authors： Nemoto R,Uchida K,Tsutsumi M,Koiso K,Satou S,Satou T

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:The activity of dihydropyrimidine dehydrogenase (DPD) - the rate-limiting enzyme in fluorouracil (5-FU) catabolism - has been reported to vary according to the time of day. On the basis of this data, so-called chronomodulated chemotherapy regimens with variable-rate infusions of 5-FU have been investigated in t...

journal_title：Journal of cancer research and clinical oncology

authors： Raida M,Kliche KO,Schwabe W,Häusler P,Clement JH,Behnke D,Höffken K

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:As the molecular mechanisms of Cytarabine,one of the most important drugs used in the leukaemia’s treatment, are only partially understood and the role of autophagy on leukaemia development and treatment is only recently being investigated, in this study, by using Chloroquine (CQ) and 3-methyladenine (3MA) a...

journal_title：Journal of cancer research and clinical oncology

authors： Palmeira dos Santos C,Pereira GJ,Barbosa CM,Jurkiewicz A,Smaili SS,Bincoletto C

更新日期：2014-06-01 00:00:00

abstract：:In order to evaluate the preventive efficacy, safety and usefulness of mesna (Sodium 2-mercaptoethane sulfonate) against ifosfamide-induced urinary disorders, a placebo-controlled double-blind comparative study was performed. Ifosfamide was administered by intravenous drip infusion at a daily dose of 2 g/m2 for 5 cons...

journal_title：Journal of cancer research and clinical oncology

authors： Fukuoka M,Negoro S,Masuda N,Furuse K,Kawahara M,Kodama N,Ikegami H,Nakamura S,Nishio H,Ohnoshi T

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Although important for apoptosis, the signaling pathway involving MOAP-1(Modulator of Apoptosis 1), RASSF1A (RAS association domain family 1A), and Bax (Bcl-2 associated X protein) is likely to be dysfunctional in many types of human cancers due to mechanisms associated with gene mutation and DNA hyper-methylat...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YH,Pang SW,Revai Lechtich E,Shah K,Simon SE,Ponnusamy S,Narayanan R,Poh CL,Tan KO

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of a novel low dose chemotherapy as a remission induction regimen for elderly de novo AML patients ineligible for intensive chemotherapy. METHOD:Fifty consecutive patients, aged 60 to 85, with untreated de novo AML were enrolled. Patients with poor PS or defined non-hematolo...

journal_title：Journal of cancer research and clinical oncology

authors： Tsurumi H,Kanemura N,Hara T,Kasahara S,Yamada T,Sawada M,Oyama M,Moriwaki H

更新日期：2007-08-01 00:00:00

abstract：:High-dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) has become an important method of treatment for hematological and solid tumors. We examined levels of interleukin(IL)-4, interferon (IFN)gamma, soluble (s) CD30, and sIL-2 receptor (R) before and after autologous PBSCT, and compared finding...

journal_title：Journal of cancer research and clinical oncology

authors： Nagahama M,Nomura S,Katsura K,Ozaki Y,Yoshimura C,Kagawa H,Fukuhara S

更新日期：2000-02-01 00:00:00

abstract：:Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer pa...

journal_title：Journal of cancer research and clinical oncology

authors： Kynast B,Binder L,Marx D,Zoll B,Schmoll HJ,Oellerich M,Schauer A

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Cluster of differentiation (CD) 44 is a cell surface receptor that correlates with the development of drug resistance in epithelial ovarian cancer (EOC). Here, we prospectively investigated the clinical impact of CD44 expression on the development of chemoresistance, and on disease-free and overall survival in ...

journal_title：Journal of cancer research and clinical oncology

authors： Elzarkaa AA,Sabaa BE,Abdelkhalik D,Mansour H,Melis M,Shaalan W,Farouk M,Malik E,Soliman AA

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:Achievement of deep molecular response with a tyrosine kinase inhibitor in patients with chronic myeloid leukemia (CML) is required to attempt discontinuation of therapy in these patients. The current subanalysis from the Evaluating Nilotinib Efficacy and Safety in Clinical Trials as First-Line Treatment (ENEST...

journal_title：Journal of cancer research and clinical oncology

authors： Giles FJ,Rea D,Rosti G,Cross NCP,Steegmann JL,Griskevicius L,le Coutre P,Coriu D,Petrov L,Ossenkoppele GJ,Mahon FX,Saussele S,Hellmann A,Koskenvesa P,Brümmendorf TH,Gastl G,Castagnetti F,Vincenzi B,Haenig J,Hochhaus

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:E- and P-selectins, expressed on vascular endothelium, and their sialyl-Lewis(x )(sLe(x))- and/or sialyl-Lewis(a) (sLe(a))-containing ligands have a crucial role in extravasation and metastasis of circulating cells. We wanted to analyse the role of selectins and their ligands in head and neck tumours. METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Renkonen J,Mäkitie A,Paavonen T,Renkonen R

更新日期：1999-10-01 00:00:00