当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Determination of growth kinetics in a renal sarcoma of the rat by double labeling with 14C- and 3H-thymidine.

Determination of growth kinetics in a renal sarcoma of the rat by double labeling with 14C- and 3H-thymidine.

Abstract：

:An in vitro double-labeling technique for determination of kinetic growth parameters was tested; 13 renal sarcomas of rats were incubated after excision under standardized conditions with 14C- and 3H-thymidine successively. Another ten tumors were evaluated after in vivo double injection of 14C and 3H-thymidine into sarcoma-bearing animals. In both groups histoautoradiography was performed using a simple stripping-film method. Results including labeling indices, mitotic indices, length of DNA-synthesis phase and cell-production rate obtained by both methods were in excellent agreement. All values fitted those determined in earlier experiments using a continuous labeling and a fraction-labeled-mitoses method in vivo. Theoretical considerations on the calculation of kinetic parameters by double labeling have been added. The experimental results found in this study represent a base for evaluation of biopsies from human tumors.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Lang W,Kienzle S,Georgii A

doi

10.1007/BF00391832

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

55-61

issue

1

eissn

0171-5216

issn

1432-1335

journal_volume

105

pub_type

杂志文章

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