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Increasing rates of DNA single-strand breaks in lymphocytes of clinical personnel handling cytostatic drugs.

Abstract：

:A total of 27 persons, working in cancer stations with exposure to cytostatics, and 40 healthy control persons were examined for DNA single-strand breaks in peripheral lymphocytes. Non-smoking personnel from cancer stations were found to have an increased rate of DNA single-strand breaks compared to the non-smoking control subjects. In the case of smokers an increased rate of DNA single-strand breaks could be recorded for those working in cancer stations as well as with the controls. DNA single-strand breaks indicate reversible damage to DNA. As DNA repair is not perfect in every case, an increased number of DNA single-strand breaks leads to irreversible DNA damage.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Reitz M,Afghanyar S,Gutjahr P

doi

10.1007/BF01624437

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

237-42

issue

4

eissn

0171-5216

issn

1432-1335

journal_volume

119

pub_type

杂志文章

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