Antioxidant enzyme activities and lipid peroxides in the plasma of patients with benign prostatic hyperplasia or prostate cancer are not predictive.

abstract：BACKGROUND:Several reports describe the importance of the chaperone HSP27 (HSPB1) in cancer progression, and the demand for drugs that modulate HSPB1-activity is increasing rapidly. We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in pancreatic cancer. METH...

journal_title：Journal of cancer research and clinical oncology

authors： Heinrich JC,Tuukkanen A,Schroeder M,Fahrig T,Fahrig R

更新日期：2011-09-01 00:00:00

abstract：:Second-line intraperitoneal (i.p.) therapy has been demonstrated to result in surgically defined complete responses (S-CR) in 25%-40% of patients with small-volume residual ovarian cancer (microscopic disease or largest tumor mass less than 1 cm in diameter). To evaluate the influence of the surgical finding of diffus...

journal_title：Journal of cancer research and clinical oncology

authors： Markman M,Reichman B,Hakes T,Barakat R,Curtin J,Rubin S,Jones W,Lewis JL Jr,Almadrones L,Hoskins W

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Serum low molecular weight protein biomarkers might be important in relation to portal vein tumor thrombi (PVTT) in hepatocellular carcinoma (HCC). This study aimed to screen and to detect these biomarkers. METHODS:We selected sera of 3 groups from 12 healthy volunteers, 12 HCC patients without PVTT and 12 HCC...

journal_title：Journal of cancer research and clinical oncology

authors： Qiu JG,Fan J,Liu YK,Zhou J,Dai Z,Huang C,Tang ZY

更新日期：2008-03-01 00:00:00

abstract：:The aim of this study was to produce large liver tumors reliably, and to diagnose the tumors during development. Therefore, New Zealand white rabbits were treated with N-nitrosodiethylamine orally three times per week by gavage and were examined by clinical-chemical assay at regular intervals during the average treatm...

journal_title：Journal of cancer research and clinical oncology

authors： Reznik GK,Padberg G

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Within hypoxic tumor regions anaerobic dissimilation of glucose is the sole source of energy generation. It yields only 5% of the ATP that is normally gained by means of oxidative glucose catabolism. The increased need for glucose may aggravate cancer cachexia. We investigated the impact of recombinant human...

journal_title：Journal of cancer research and clinical oncology

authors： van Halteren HK,Bongaerts GP,Verhagen CA,Kamm YJ,Willems JL,Grutters GJ,Koopman JP,Wagener DJ

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:Due to PSA screening and increased awareness, prostate cancer (PCa) is identified earlier resulting in smaller diagnostic samples on prostate needle biopsy. Because Gleason grading plays a critical role in treatment planning, we undertook a controlled study to evaluate interobserver variability among German ...

journal_title：Journal of cancer research and clinical oncology

authors： Burchardt M,Engers R,Müller M,Burchardt T,Willers R,Epstein JI,Ackermann R,Gabbert HE,de la Taille A,Rubin MA

更新日期：2008-10-01 00:00:00

abstract：:The nuclear DNA content (DNA ploidy) level was determined in a series of 83 human brain metastases, for which 35 complete clinical follow-ups were available. The DNA ploidy level determination was carried out by means of DNA histogram types. The results show that certain brain metastases were diploid, while others exh...

journal_title：Journal of cancer research and clinical oncology

authors： Kiss R,Rorive S,Camby I,Pasteels JL,Brotchi J,Salmon I

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To investigate antitumour efficacy of the combination of the antiangiogenic agent TNP-470 combined with chemoimmunotherapy in different tumour models in mice MATERIALS:B6D2F1 mice and BALB/c mice were inoculated in the footpad of the right hind limb with B16F10 melanoma cells or colon adenocarcinoma cells C-26...

journal_title：Journal of cancer research and clinical oncology

authors： Dabrowska-Iwanicka A,Olszewska D,Jalili A,Makowski M,Grzela T,Marczak M,Hoser G,Giermasz A,Golab J,Jakóbisiak M

更新日期：2002-08-01 00:00:00

abstract：:The levels of total human serum RNAase activity (HSRA) from 24 patients with ovarian cancer have been followed up for a period of over 5 months. The determinations of HSRA were carried out according to our assay system described earlier. Two representative patterns of the HSRA are presented, one from a patient with an...

journal_title：Journal of cancer research and clinical oncology

authors： Schleich HG,Wiest W

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:Aim of the present study was to identify the genetic heterogeneity, prevalence and frequency of germline mutations of BRCA2 gene in Hereditary Breast/Ovarian cancer patients from Kerala, South India. METHODS:We analyzed 102 Breast/Ovarian cancer patients from 96 breast and/ovarian cancer families for BRCA2 gen...

journal_title：Journal of cancer research and clinical oncology

authors： Syamala V,Sreeja L,Syamala VS,Vinodkumar B,Raveendran PB,Sreedharan H,Kuttappan R,Balakrishnan L,Ankathil R

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. METHODS:We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of th...

journal_title：Journal of cancer research and clinical oncology

authors： Rottmann M,Burges A,Mahner S,Anthuber C,Beck T,Grab D,Schnelzer A,Kiechle M,Mayr D,Pölcher M,Schubert-Fritschle G,Engel J

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Abnormal expression of miRNAs is intimately related to a variety of human cancers. The purpose of this study is to confirm the expression of miR-181a and elucidate its physiological function and mechanism in pediatric acute myeloid leukemia (AML). METHODS:Pediatric AML patients and healthy controls were enroll...

journal_title：Journal of cancer research and clinical oncology

authors： Liu X,Liao W,Peng H,Luo X,Luo Z,Jiang H,Xu L

更新日期：2016-01-01 00:00:00

abstract：:To date, all risk assessment studies on benzene have been based almost exclusively on epidemiological data. We have attempted a more integrated and quantitative evaluation of carcinogenic risk for humans, trying to utilize, in addition to the epidemiological data, all data available, specifically data on metabolism, g...

journal_title：Journal of cancer research and clinical oncology

authors： Grilli S,Lutz WK,Parodi S

更新日期：1987-01-01 00:00:00

abstract：:Coumarin (1,2-benzopyrone) is a natural substance that has shown antitumor activity in vivo. The major human metabolite of coumarin, 7-hydroxycoumarin (7-HC), is the active form of the drug. While the exact mechanism(s) of action of coumarin is unknown, it has been shown previously that this drug possesses immunomodul...

journal_title：Journal of cancer research and clinical oncology

authors： Marshall ME,Kervin K,Benefield C,Umerani A,Albainy-Jenei S,Zhao Q,Khazaeli MB

更新日期：1994-01-01 00:00:00

abstract：:Mice with s.c. grafts of gastric carcinoma MKN45 or osteosarcoma 788T were injected i.v. with recombinant tumour necrosis factor alpha (rTNF alpha) and tumour blood flow rates were determined 4 h later as a fraction of the cardiac output g tissue-1. With MKN45, the tumour blood flow rate was significantly reduced from...

journal_title：Journal of cancer research and clinical oncology

authors： Pimm MV,Gribben SJ,Morris TM

更新日期：1991-01-01 00:00:00

abstract：:The effect of beta-cyclodextrin-benzaldehyde (CDBA) on experimental pulmonary metastasis in C3H/He mice was examined. In an in vitro assay, the growth of RCT(+) cells was inhibited by 1200 micrograms/ml CDBA using unrenewed media, and by 600 micrograms/ml CDBA in that using daily renewed media. When mice were treated ...

journal_title：Journal of cancer research and clinical oncology

authors： Ochiai H,Niwayama S,Masuyama K

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Targeted treatment of chronic myelogenous leukemia using imatinib has dramatically improved patient outcome. However, residual disease can be detected in the majority of patients treated with imatinib. Compensatory activation of MAP kinases (MAPK1/2) in response to BCR-ABL-inhibitors has been reported as a p...

journal_title：Journal of cancer research and clinical oncology

authors： Härtel N,Klag T,Hanfstein B,Mueller MC,Schenk T,Erben P,Hochhaus A,La Rosée P

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:Elevated expression of the beta-thymosin isotypes T beta(4), T beta(10), and T(15) appears to be involved in the manifestation of a malignant phenotype of human tumor cells, including those of mammary carcinomas. This has evoked an interest in these peptides as diagnostic/prognostic tumor markers. If increased ...

journal_title：Journal of cancer research and clinical oncology

authors： Otto AM,Müller CS,Huff T,Hannappel E

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:The epithelial cell adhesion molecule (Ep-CAM) is a clinically validated target for antibody-based therapy of cancer. The aim of this work was to evaluate the specific cytotoxic activity of a novel fully human Ep-CAM-specific IgG1 antibody, called MT201, against primary ovarian tumor cells and an ovarian tumor ...

journal_title：Journal of cancer research and clinical oncology

authors： Xiang W,Wimberger P,Dreier T,Diebold J,Mayr D,Baeuerle PA,Kimmig R

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Estrogen receptor β (ERβ) is the predominant ER in the colorectal epithelium, whose expression is greatly reduced in colorectal cancer compared with normal colon tissue. Recent in vitro studies suggested that ERβ may suppress tumor growth. No research was reported whether ERβ can be used as therapeutic agent...

journal_title：Journal of cancer research and clinical oncology

authors： Tu Z,Ma Y,Tian J,Li H,Akers W,Achilefu S,Gu Y

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:Signalling through the insulin-like growth factor 1 receptor (IGF-1R) is implicated in carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. The purpose of this study was to investigate the prognostic role of IGF-1R expression in surgically resected non-small-cell lung cancer (NSCLC), and re...

journal_title：Journal of cancer research and clinical oncology

authors： Agulló-Ortuño MT,Díaz-García CV,Agudo-López A,Pérez C,Cortijo A,Paz-Ares L,López-Ríos F,Pozo F,de Castro J,Cortés-Funes H,López Martín JA

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Colorectal cancer (CRC) is one of the major health problems worldwide and is often diagnosed at late stage. There is growing body of evidence in early detection of this disease with novel screening modalities to reduce compliance and increase specificity of available methods. The aim of current review is to giv...

journal_title：Journal of cancer research and clinical oncology

authors： Vatandoost N,Ghanbari J,Mojaver M,Avan A,Ghayour-Mobarhan M,Nedaeinia R,Salehi R

更新日期：2016-02-01 00:00:00

abstract：:Female carriers of mutations in the BRCA1 gene on chromosome 17q have a very high risk of developing breast and/or ovarian cancer during their lifetime. There is, however, little knowledge of to what extent non-genetic risk factors, such as age at menarche, age at first birth, and body mass index, alter the age at ons...

journal_title：Journal of cancer research and clinical oncology

authors： Chang-Claude J,Becher H,Eby N,Bastert G,Wahrendorf J,Hamann U

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Cancer incidence in the elderly population has been continuously rising, and their treatment is an increasing concern among oncologists. This study aimed to evaluate the incidence and risk factors for morbidity and mortality after major oncological surgery in elderly patients with head and neck squamous cell ca...

journal_title：Journal of cancer research and clinical oncology

authors： Yoo SH,Roh JL,Choi SH,Nam SY,Kim SY

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:The feasibility of radioimmunotherapy (RAIT) combined with 5-fluorouracil (5-FU) was examined in colon cancer xenografts. The mode of interaction of the two treatments was also investigated. METHODS:Mice bearing human colon cancer were treated with a combination of 4.63 MBq (L-RAIT) or 9.25 MBq (H-RAIT) (131)I...

journal_title：Journal of cancer research and clinical oncology

authors： Kinuya S,Yokoyama K,Tega H,Hiramatsu T,Konishi S,Watanabe N,Shuke N,Aburano T,Takayama T,Michigishi T,Tonami N

更新日期：1999-11-01 00:00:00

abstract：:Elevated glutamate concentrations are commonly observed in tumor patients, and glutamate was recently found to competitively inhibit the membrane transport of cystine. We therefore investigated the possibility that elevated plasma glutamate levels may damage the immune system. The experiments in this report demonstrat...

journal_title：Journal of cancer research and clinical oncology

authors： Dröge W,Eck HP,Betzler M,Schlag P,Drings P,Ebert W

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Normalization of the tumor vasculature and microenvironment by several angiogenesis inhibitors has been reported. Given that recombinant human endostatin (rh-endostatin) is also an endogenous angiogenesis inhibitor, a comprehensive evaluation of the effects of rh-endostatin on tumor vasculature and microenviron...

journal_title：Journal of cancer research and clinical oncology

authors： Huang G,Chen L

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:CC chemokine receptor 1 (CCR1) plays a critical role in the recruitment of leukocytes to the site of inflammation. Tumor invasion and metastasis share many similarities with leukocyte trafficking, which is critically regulated by chemokines and their receptors. In this study, we aimed to assess the role of CCR1...

journal_title：Journal of cancer research and clinical oncology

authors： Wang CL,Sun BS,Tang Y,Zhuang HQ,Cao WZ

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Angiosarcoma of the scalp and face is a rare malignant endothelial tumor arising mainly in elderly people. The prognosis is poor. Effective and safe treatments are warranted. METHODS:A 79-year-old woman with an angiosarcoma of the scalp larger than 5 cm in diameter was treated with intravenous liposomal doxoru...

journal_title：Journal of cancer research and clinical oncology

authors： Wollina U,Füller J,Graefe T,Kaatz M,Lopatta E

更新日期：2001-01-01 00:00:00

abstract：:The precise place of local estrogen production in mammary cancer is still controversial. In this investigation localization of aromatase (the key enzyme of estrogen biosynthesis) was studied in breast cancer tissue by immunohistochemical method using polyclonal rabbit antibodies. The cytoplasmic staining was found in ...

journal_title：Journal of cancer research and clinical oncology

authors： Berstein LM,Larionov AA,Kyshtoobaeva ASh,Pozharisski KM,Semiglazov VF,Ivanova OA

更新日期：1996-01-01 00:00:00