当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Incidence and risk factors for morbidity and mortality in elderly head and neck cancer patients undergoing major oncological surgery.

Incidence and risk factors for morbidity and mortality in elderly head and neck cancer patients undergoing major oncological surgery.

Abstract：

PURPOSE:Cancer incidence in the elderly population has been continuously rising, and their treatment is an increasing concern among oncologists. This study aimed to evaluate the incidence and risk factors for morbidity and mortality after major oncological surgery in elderly patients with head and neck squamous cell carcinoma (HNSCC). METHODS:The 196 HNSCC patients aged 55 and older who underwent major curative surgery. Patients were categorized into three groups: far-old (≥75 years; n = 41); old (65-74 years; n = 72); or middle-aged (55-64 years; n = 83). The rates of early and late postoperative complications, hospital stays, and mortality were compared among groups. Univariate and multivariate analyses were performed to identify the factors associated with early postoperative complications. RESULTS:No study patients had mortality during surgery or within 3-month postoperation. Karnofsky performance status, frail functional status, comorbidity, and index cancer and noncancer mortality were the poorest in the far-old group. The far-old group demonstrated significantly higher rates of early overall complications, readmission within 1 month, and recurrence rates (P < 0.05 each). Multivariate analysis showed that age, postoperative hemoglobin, and C-reactive protein are independent predictors of early postoperative complications (P < 0.05 each). CONCLUSIONS:In elderly patients, chronological age affects the increased risk of early postoperative morbidity and later mortality following major HNSCC surgery. In combination with these risk factors, older patients who are diagnosed with HNSCC should be carefully monitored in order to determine the potential occurrence of postsurgical complications.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Yoo SH,Roh JL,Choi SH,Nam SY,Kim SY

doi

10.1007/s00432-016-2141-4

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

1343-51

issue

eissn

0171-5216

issn

1432-1335

pii

10.1007/s00432-016-2141-4

journal_volume

142

pub_type

杂志文章

在线工具

Incidence and risk factors for morbidity and mortality in elderly head and neck cancer patients undergoing major oncological surgery.