当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Studies on natural killer cell activity and the influence of Corynebacterium parvum on murine T-cell leukemogenesis induced by butylnitrosourea.

Studies on natural killer cell activity and the influence of Corynebacterium parvum on murine T-cell leukemogenesis induced by butylnitrosourea.

Abstract：

:Butylnitrosourea (BNU) was used to induce thymic lymphomas in BDF1 mice. During and after the 12-week BNU exposure the spontaneous NK cell activity against YAC-1 cells and that arising 4 days after stimulation with Corynebacterium parvum (CP) were measured, as were the mitogen responses of splenic T and B cells. In addition to BNU, groups of mice received multiple injections of the interferon inducer CP during or after the BNU exposure period. The results show a slight impairment of the NK cell activity by BNU and also after the injections of CP depending heavily on the treatment protocol. After the multiple injections of CP, either into BNU-treated mice or into controls, no further stimulation by CP was possible. The mitogen responses, reduced after BNU, were further reduced after the additional treatment. Both effects can be explained by the known induction of suppressor cells by CP. Although these treatments had pronounced effects on the parameters tested in vitro there was no significant influence on the development of thymic lymphomas in vivo.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Seidel HJ,Stolz W

doi

10.1007/BF01032607

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

199-205

issue

3

eissn

0171-5216

issn

1432-1335

journal_volume

107

pub_type

杂志文章

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