DNA adducts by N-nitroso compounds.

abstract：PURPOSE:In stomach adenocarcinoma, the role of the hormonal receptor, estrogen receptor (ER), has been controversial. Recently, a new estrogen receptor, called estrogen receptor beta (ER beta), was found to be expressed in various tissues including normal gastrointestinal tract. In this paper, the expression of ER beta...

journal_title：Journal of cancer research and clinical oncology

authors： Matsuyama S,Ohkura Y,Eguchi H,Kobayashi Y,Akagi K,Uchida K,Nakachi K,Gustafsson JA,Hayashi S

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:To establish more effective diagnostic procedures to identify the characteristic features of abdominopelvic tuberculosis (APTB) mimicking advanced ovarian cancer. METHODS:A retrospective review of 20 cases of APTB mimicking advanced ovarian cancer was undertaken. RESULTS:The mean age of the patients was 28....

journal_title：Journal of cancer research and clinical oncology

authors： Xi X,Shuang L,Dan W,Ting H,Han MY,Ying C,Quan M,Sun C,Chen Z,Cui F,Ming C,Zhou JF,Xuan WS,Lu YP,Ma D

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:In recurrent ovarian cancer (ROC), there is a high demand on effective therapies with a mild toxicity profile. Treosulfan is an alkylating agent approved as oral (p.o.) and intravenous (i.v.) formulation for the treatment of recurrent ovarian cancer. Data on safety and efficacy for either formulation are rare...

journal_title：Journal of cancer research and clinical oncology

authors： Sehouli J,Tomè O,Dimitrova D,Camara O,Runnebaum IB,Tessen HW,Rautenberg B,Chekerov R,Muallem MZ,Lux MP,Trarbach T,Gitsch G

更新日期：2017-03-01 00:00:00

abstract：:Laboratory and clinical data suggest some interactions between cytotoxic agents and tamoxifen. The mechanisms of these interactions differ in estrogen-receptor-negative cell lines. The ability of tamoxifen to modify the effects of epirubicin on the cell-cycle phases of estrogen-receptor-negative Ehrlich's carcinoma as...

journal_title：Journal of cancer research and clinical oncology

authors： Aydiner A,Ridvanogullari M,Anil D,Topuz E,Nurten R,Disci R

更新日期：1997-01-01 00:00:00

abstract：:Ftorafur (FT), a 2-tetrahydrofuryl derivative of 5-fluorouracil (5-FU) was introduced into cancer chemotherapy with the hope to obtain a therapeutic effect comparable to 5-FU with a smaller dose and less side effects. A comparison of the effect of FT and 5-FU on the proliferation of L 1210 ascites tumor cells in the p...

journal_title：Journal of cancer research and clinical oncology

authors： Schultze B,Jellinghaus W,Weis G,Müller V,Maurer W

更新日期：1981-01-01 00:00:00

abstract：:Metastatic interstitial cell tumor of the testis is one of the rarest human neoplasms. This is the nineteenth case to be reported. While most of these tumors are combined with hormonal dysfunction, the present tumor, apart from its uncommon hormonal profile, is remarkable because of its capacity of producing and secre...

journal_title：Journal of cancer research and clinical oncology

authors： Higi M,Niederle N,Scheulen ME,Richter HJ

更新日期：1979-07-27 00:00:00

abstract：:This paper confirms previous results that hyperglycemia (5 g/l) lasting 250 min, when combined with local hyperthermia (43 degrees C) for the last 100 min, strongly inhibits microcirculation in Yoshida sarcomas and DS-carcinosarcomas. This inhibition occurs independently of heparinization of the animals (700 IU/200 G ...

journal_title：Journal of cancer research and clinical oncology

authors： von Ardenne M,Reitnauer PG

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is gaining worldwide attention recently, emerging as a major public health threat. However, the association between the development of AKI and subsequent malignancy has not been studied before. METHODS:We conducted a population study based on the Taiwan National Health Insurance da...

journal_title：Journal of cancer research and clinical oncology

authors： Chao CT,Wang CY,Lai CF,Huang TM,Chen YY,Kao TW,Chu TS,Chang CH,Wu VC,Ko WJ,Chen L,Wu KD,National Taiwan University Study Group on Acute Renal Failure.

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:Metastases are a common event in breast cancer. The expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) is essential for therapy and prognosis, and their conversion during disease progression potentially affects the treatment regimen. The aim was...

journal_title：Journal of cancer research and clinical oncology

authors： Nauroth A,Kalder M,Rössler M,Wichmann G,Dietz A,Wiegand S

更新日期：2017-09-01 00:00:00

abstract：:To verify whether a mild, but prolonged liver injury by chemicals needing bioactivation causes both hepatic cirrhosis and the appearance of hepatocyte nodules and tumors (providing the liver has been exposed previously to initiating stimuli), diethylnitrosamine-initiated and uninitiated rats were administered thioacet...

journal_title：Journal of cancer research and clinical oncology

authors： Gervasi PG,Longo V,Marzano M,Saviozzi M,Malvaldi G

更新日期：1989-01-01 00:00:00

abstract：:General principles for anticancer drug development include traditional drug-screening methods in biological test systems. Today, testing of a drug in a panel of selected human tumor xenografts in mice is assumed to have the best predictive value for clinical efficacy. Chemical modification of well-known antitumor drug...

journal_title：Journal of cancer research and clinical oncology

authors： Unger C

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Only few immunohistochemical markers besides c-kit exist for gastrointestinal stromal tumors (GISTs). Thy-1, a cell-surface glycoprotein, is a marker for several types of stem cells and particularly for neuronal precursor cells. The aim of this study was to determine Thy-1 expression in GISTs. MATERIALS AND ME...

journal_title：Journal of cancer research and clinical oncology

authors： Oikonomou D,Hassan K,Kaifi JT,Fiegel HC,Schurr PG,Reichelt U,Aridome K,Yekebas EF,Mann O,Kluth D,Strate T,Izbicki JR

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:The objectives of this work were to investigate whether the serum-free fatty acid (FFA) level is meaningful in cancer patients and its role in cancer diagnosis. METHODS:A total of 2206 patients were divided into a cancer group (n = 1019) and a noncancer group (n = 1187). Age, sex, body mass index (BMI), and se...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang L,Han L,He J,Lv J,Pan R,Lv T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The CD-TK double suicide gene has become an effective therapy for bladder cancer. A novel molecular-targeted ultrasound (US) method has been developed to precisely guide nanobubbles loaded with this gene to regions within bladder tumor cells and is widely used due to its efficiency in delivering drugs to the...

journal_title：Journal of cancer research and clinical oncology

authors： Hu C,Jiang D,Wu M,Wang J,Zhang R

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:To determine the incidence of hepatocellular carcinoma in cirrhosis and to examine the influence of age and sex, and the contribution of etiological factors. METHODS:967 patients with liver cirrhosis and free of hepatocellular carcinoma were enrolled in this longitudinal, retrospective and observational study....

journal_title：Journal of cancer research and clinical oncology

authors： del Olmo JA,Serra MA,Rodríguez F,Escudero A,Gilabert S,Rodrigo JM

更新日期：1998-01-01 00:00:00

abstract：:The occurrence of malignancies during pregnancy has increased over the last decades. They complicate approximately 1 per 1000 pregnancies. The most common malignancies associated with pregnancy include malignant melanoma, malignant lymphomas and leukemia, and cancer of the cervix, breast, ovary, colon and thyroid. Sin...

journal_title：Journal of cancer research and clinical oncology

authors： Oduncu FS,Kimmig R,Hepp H,Emmerich B

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:Angiosarcoma of the scalp and face is a rare malignant endothelial tumor arising mainly in elderly people. The prognosis is poor. Effective and safe treatments are warranted. METHODS:A 79-year-old woman with an angiosarcoma of the scalp larger than 5 cm in diameter was treated with intravenous liposomal doxoru...

journal_title：Journal of cancer research and clinical oncology

authors： Wollina U,Füller J,Graefe T,Kaatz M,Lopatta E

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:TNF-related apoptosis-inducing ligand (TRAIL) is a potential cancer therapeutic agent that preferentially induces apoptosis in cancer cells. However, breast cancer cells are generally resistant to TRAIL. Bufalin is a major active ingredient of the traditional Chinese medicine ChanSu. The present study aimed to ...

journal_title：Journal of cancer research and clinical oncology

authors： Yan S,Qu X,Xu C,Zhu Z,Zhang L,Xu L,Song N,Teng Y,Liu Y

更新日期：2012-08-01 00:00:00

abstract：:Coumarin (1,2-benzopyrone) is a natural substance that has shown antitumor activity in vivo. The major human metabolite of coumarin, 7-hydroxycoumarin (7-HC), is the active form of the drug. While the exact mechanism(s) of action of coumarin is unknown, it has been shown previously that this drug possesses immunomodul...

journal_title：Journal of cancer research and clinical oncology

authors： Marshall ME,Kervin K,Benefield C,Umerani A,Albainy-Jenei S,Zhao Q,Khazaeli MB

更新日期：1994-01-01 00:00:00

abstract：:This special report discusses problems relevant to histological diagnosis of cancer after chemo- and/or radiotherapy. One of the issues relates to pitfalls, i.e. over-, under- or misdiagnosis or oversight, stemming from a lack of concern or awareness of therapeutic effects on tumors or normal tissues. Another set of q...

journal_title：Journal of cancer research and clinical oncology

authors： Ishikawa Y,Kato Y,Kitagawa T

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Molecules which are exclusively or preferentially expressed by malignant cells are potential targets for immunotherapeutic approaches to the treatment of cancer. METHODS:We therefore tested serum samples of 95 patients with aggressive B-cell lymphomas for antibodies against lymphoma-associated molecules using ...

journal_title：Journal of cancer research and clinical oncology

authors： Zwick C,Held G,Hammermeister V,Alahmad A,Kubuschok B,Bittenbring J,Ahlgrimm M,Neumann F,Preuss KD,Pfreundschuh M

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Treatment for malignant ascites in advanced ovarian cancer (OC) patients remains controversial. The objective of this study was to investigate the efficacy of combined continuous circulatory hyperthermic intraperitoneal chemotherapy (HIPEC) preceded or followed by cytoreductive surgery (CRS) f...

journal_title：Journal of cancer research and clinical oncology

authors： Ba M,Long H,Zhang X,Tang Y,Wu Y,Yu F,Wang S,Cui S

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:To investigate the impact of different KRAS mutations on treatment with the tyrosine kinase inhibitor sunitinib in SW48 colorectal cancer cell line variants. MATERIALS AND METHODS:Isogenic SW48 KRAS wt, G12A, G12C, G12D, G12R, G12S, G12 V, and G13D cells were evaluated for ERK phosphorylation with and without ...

journal_title：Journal of cancer research and clinical oncology

authors： Modest DP,Camaj P,Heinemann V,Schwarz B,Jung A,Laubender RP,Gamba S,Haertl C,Stintzing S,Primo S,Bruns CJ

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Expression of CD44 and its variants has been shown to be relevant to tumor progression in various human malignancies. We evaluated the expression of CD44v6 in the primary lesions of stage I non-small cell lung cancer (NSCLC) and correlated the expression level to its prognosis. METHODS:The expression of CD44v6...

journal_title：Journal of cancer research and clinical oncology

authors： Situ D,Long H,Lin P,Zhu Z,Wang J,Zhang X,Xie Z,Rong T

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:The appearance of the cervical mucosa is regulated by different factors including retinoic acid. Hormone-dependent alteration of the cervix uteri mucosa is accompanied by a decrease or increase of cytoplasmatic retinoic-acid-binding protein (CRABP). To elucidate whether this hormone-dependent alteration of CRAB...

journal_title：Journal of cancer research and clinical oncology

authors： Volz-Köster S,Volz J,Kiefer A,Biesalski HK

更新日期：2000-01-01 00:00:00

abstract：:The role of DNA adducts in the initiation of cancer is scrutinized in this presentation. Work on the activation of oncogenes, particularly on ras, has provided new evidence to link DNA adducts and tumour formation. Polycyclic hydrocarbons and nitroso compounds can cause activation of ras oncogenes through a defined po...

journal_title：Journal of cancer research and clinical oncology

authors： Hemminki K,Försti A,Mustonen R,Savela K

更新日期：1986-01-01 00:00:00

abstract：:To study whether fluorescent lighting at work might increase carcinogenesis, hairless mice were exposed to a bank of six 36 W standard fluorescent lamps (neutral-white) every workday for 8 h at an illuminance level of 1,000 lx. For comparison, other mice were exposed to UVB radiation or to simulated solar radiation. I...

journal_title：Journal of cancer research and clinical oncology

authors： Wiskemann A,Sturm E,Klehr NW

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Elevated expression of the beta-thymosin isotypes T beta(4), T beta(10), and T(15) appears to be involved in the manifestation of a malignant phenotype of human tumor cells, including those of mammary carcinomas. This has evoked an interest in these peptides as diagnostic/prognostic tumor markers. If increased ...

journal_title：Journal of cancer research and clinical oncology

authors： Otto AM,Müller CS,Huff T,Hannappel E

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:The high comorbidity in patients with head and neck cancer (HNC) is mainly caused by the high incidence of tobacco and alcohol abuse and has direct impact on overall survival. We investigated whether HNC and its comorbidity also influence routine laboratory values and whether these values have influence on over...

journal_title：Journal of cancer research and clinical oncology

authors： Peter F,Wittekindt C,Finkensieper M,Kiehntopf M,Guntinas-Lichius O

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Multiple gastrointestinal stromal tumors (GISTs) rarely occur in patients with neurofibromatosis type 1 (NF-1). In contrast to sporadic GISTs characterized by frequent allelic losses of 1p, 14q and 22q and mutations of KIT or PDGFRA gene with the activation of the downstream RAS-MAPK pathway, the molecular path...

journal_title：Journal of cancer research and clinical oncology

authors： Yamamoto H,Tobo T,Nakamori M,Imamura M,Kojima A,Oda Y,Nakamura N,Takahira T,Yao T,Tsuneyoshi M

更新日期：2009-06-01 00:00:00