Effects of tumour necrosis factor alpha on bone marrow aspirates of patients with acute myelogenous leukemia determined by flow-cytometric cell-cycle analysis.

abstract：:Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy. About 75% are sporadic (sMTC) while the remaining 25% are hereditary (hMTC). The treatment of choice for both sMTC and hMTC is surgery. An adequate initial operation provides the best chance of cure. Hence, the diagnosis of MTC should be made preoperative...

journal_title：Journal of cancer research and clinical oncology

authors： Gimm O,Sutter T,Dralle H

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:MicroRNAs (miRs) have been frequently reported dysregulating in tumors and playing a crucial role in tumor development and progression. However, the expression of miR-155 and its role in gastric cancer (GC) are still obscure. METHODS:qRT-PCR was applied to detect miR-155 expression in 60 matched GC samples and...

journal_title：Journal of cancer research and clinical oncology

authors： Ma Z,Ma Y,Xia Q,Li Y,Li R,Chang W,Chen J,Leng Z,Tao K

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:Elevated expression of the beta-thymosin isotypes T beta(4), T beta(10), and T(15) appears to be involved in the manifestation of a malignant phenotype of human tumor cells, including those of mammary carcinomas. This has evoked an interest in these peptides as diagnostic/prognostic tumor markers. If increased ...

journal_title：Journal of cancer research and clinical oncology

authors： Otto AM,Müller CS,Huff T,Hannappel E

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:PTEN is an essential tumour suppressor gene which encodes a phosphatase protein that antagonises the PI3K/Akt/mTOR antiapoptotic pathway. Impairment of this tumour suppressor pathway potentially becomes a causal factor for development of malignancies. This review aims to assess current understanding of mechanis...

journal_title：Journal of cancer research and clinical oncology

authors： Lim HJ,Crowe P,Yang JL

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:In stomach adenocarcinoma, the role of the hormonal receptor, estrogen receptor (ER), has been controversial. Recently, a new estrogen receptor, called estrogen receptor beta (ER beta), was found to be expressed in various tissues including normal gastrointestinal tract. In this paper, the expression of ER beta...

journal_title：Journal of cancer research and clinical oncology

authors： Matsuyama S,Ohkura Y,Eguchi H,Kobayashi Y,Akagi K,Uchida K,Nakachi K,Gustafsson JA,Hayashi S

更新日期：2002-06-01 00:00:00

abstract：:Bleomycin was injected i.p. in rats, and the amount of expired ethane which indicates lipid peroxidation was followed up for 78 h. Compared to controls neither 1 x 30 mg/kg and 2 x 30 mg/kg nor 1 x 70 mg/kg bleomycin led to increased ethane expiration, although body weight loss indicated toxicity. That pulmonary toxic...

journal_title：Journal of cancer research and clinical oncology

authors： Muliawan H,Burkhardt A,Scheulen ME,Kappus H

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:T cell transcription factors are nuclear effectors of the Wnt signaling transduction pathway and play crucial roles in embryonic and malignant development. Our previous study showed increased expression level of Tcf mRNA in liver cancer. In the present paper, antisense Tcf RNA was used to explore the possible t...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang Y,Zhou XD,Liu YK,Huang XW,Zhao Y,Xue Q,Sun RX,Chen J,Wu X

更新日期：2004-11-01 00:00:00

abstract：:Breast cancer tissue was examined for overexpression of HER-2/neu and p53 oncogene proteins. Samples from 105 breast cancer patients were investigated by Western-blot analysis and their relationship to other established markers and clinical outcome was examined. In 21.0% of the cases HER-2/neu was overexpressed, and i...

journal_title：Journal of cancer research and clinical oncology

authors： Wiltschke C,Kindas-Muegge I,Steininger A,Reiner A,Reiner G,Preis PN

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the impact of cyclin D1 overexpression (considered separately or jointly with previously assessed p53 and pRb statuses) on survival in a group of 111 surgically treated non-small cell lung cancer patients (NSCLC). METHODS:Cyclin D1 accumulation was assessed immunohistochemic...

journal_title：Journal of cancer research and clinical oncology

authors： Dworakowska D,Jassem E,Jassem J,Boltze C,Wiedorn KH,Dworakowski R,Skokowski J,Jaśkiewicz K,Czestochowska E

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Previous studies showed poorer survival in T4 disease with residual lesion. To evaluate the efficacy and toxicity of a boost dose for T4 nasopharyngeal carcinoma (NPC), patients with a residual primary lesion after intensity-modulated radiotherapy (IMRT). METHODS:398 T4 NPC patients with residual primary le...

journal_title：Journal of cancer research and clinical oncology

authors： Fei Z,Xu T,Qiu X,Li M,Chen T,Li L,Huang C,Chen C

更新日期：2021-01-03 00:00:00

abstract：:An in vitro double-labeling technique for determination of kinetic growth parameters was tested; 13 renal sarcomas of rats were incubated after excision under standardized conditions with 14C- and 3H-thymidine successively. Another ten tumors were evaluated after in vivo double injection of 14C and 3H-thymidine into s...

journal_title：Journal of cancer research and clinical oncology

authors： Lang W,Kienzle S,Georgii A

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:RhoA and RhoC are closely related, small GTPases that are clearly involved in breast cancer tumorigenesis. Nonetheless, their specific roles in the control of estrogen receptor alpha (ERα) activities have not been elucidated. METHODS:We used siRNA sequences to specifically down-regulate RhoA and RhoC expressio...

journal_title：Journal of cancer research and clinical oncology

authors： Malissein E,Meunier E,Lajoie-Mazenc I,Médale-Giamarchi C,Dalenc F,Doisneau-Sixou SF

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:We studied the antitumor activity of 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one (Phx), which was synthesized by the reactions of 2-amino-5-methylphenol with bovine hemoglobin, on human B cell lymphoblastoid cell lines, P3HR-1 and Raji derived from African Burkitt's lymphoma, and the human T...

journal_title：Journal of cancer research and clinical oncology

authors： Koshibu-Koizumi J,Akazawa M,Iwamoto T,Takasaki M,Mizuno F,Kobayashi R,Abe A,Tomoda A,Hamatake M,Ishida R

更新日期：2002-07-01 00:00:00

abstract：:Carboplatin therapy has a more favorable toxicity profile than cisplatin and, given in appropriate doses, is equivalent in efficacy to cisplatin for suboptimal ovarian cancer. However myelosuppression frequently curtails therapy with carboplatin. Diethyldithiocarbamate (DDTC) is a thiol compound and heavy-metal-chelat...

journal_title：Journal of cancer research and clinical oncology

authors： Francis P,Markman M,Hakes T,Reichman B,Rubin S,Jones W,Lewis JL Jr,Curtin J,Barakat R,Phillips M

更新日期：1993-01-01 00:00:00

abstract：:Coumarin (1,2-benzopyrone) is a natural substance that has shown antitumor activity in vivo. The major human metabolite of coumarin, 7-hydroxycoumarin (7-HC), is the active form of the drug. While the exact mechanism(s) of action of coumarin is unknown, it has been shown previously that this drug possesses immunomodul...

journal_title：Journal of cancer research and clinical oncology

authors： Marshall ME,Kervin K,Benefield C,Umerani A,Albainy-Jenei S,Zhao Q,Khazaeli MB

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:Cholangiocarcinoma is defined as a chronic liver disease with altered estrogen metabolism and could result in estrogen retention. Estrogenic response was known as a promoting factor in progression of some cancer. In this study, we determined the significant increase of estrogen level in cholangiocarcinoma patie...

journal_title：Journal of cancer research and clinical oncology

authors： Hunsawong T,Singsuksawat E,In-chon N,Chawengrattanachot W,Thuwajit C,Sripa B,Paupairoj A,Chau-in S,Thuwajit P

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:To investigate the genomic alterations in larynx carcinomas (LaCa) tissues and its prognostics values in predicting survival. METHODS:To analyse the aberrations in the genome of LaCa patients, we used array comparative genomic hybridization in 19 human laryngeal tumour samples. DNA samples were also subjected ...

journal_title：Journal of cancer research and clinical oncology

authors： Peralta R,Baudis M,Vazquez G,Juárez S,Ortiz R,Decanini H,Hernandez D,Gallegos F,Valdivia A,Piña P,Salcedo M

更新日期：2010-06-01 00:00:00

abstract：:The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300,000 IU daily for 12 months) or standard follow-up, and are now evaluable after a median observation ...

journal_title：Journal of cancer research and clinical oncology

authors： Infante M,Pastorino U,Chiesa G,Bera E,Pisani P,Valente M,Ravasi G

更新日期：1991-01-01 00:00:00

abstract：:Trace metals are essential for the growth and several other properties of human lymphocytes. We studied the effects of media with variable concentrations of three metals (Fe2+, Cu2+, Zn2+), a metal chelator (deferoxamine, DFX) and a cell-growth inhibitor (hydroxyurea) on the growth, intracellular metal concentration a...

journal_title：Journal of cancer research and clinical oncology

authors： Oblender M,Carpentieri U

更新日期：1991-01-01 00:00:00

abstract：:A continuous line of human breast carcinoma cells, VHB-1, was established in culture following collagenase treatment of an infiltrating duct cell carcinoma. The cells displayed an epithelial pattern and multiplied rapidly. Maintained in monolayer culture, the VHB-1 cells exhibited a 30-h doubling time and a plating ef...

journal_title：Journal of cancer research and clinical oncology

authors： Vandewalle B,Collyn d'Hooghe M,Savary JB,Vilain MO,Peyrat JP,Deminatti M,Delobelle-Deroide A,Lefebvre J

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:The proto-oncogene forkhead box M1 (FOXM1) is associated with poor survival in many cancers. The impact of FOXM1 expression on progression-free survival (PFS) of non-muscle invasive bladder cancer (NMIBC) has not yet been investigated. The differential expression of FOXM1 between the different molecular NMIBC s...

journal_title：Journal of cancer research and clinical oncology

authors： Rinaldetti S,Wirtz R,Worst TS,Hartmann A,Breyer J,Dyrskjot L,Erben P

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:We have demonstrated that overexpression of osteopontin (OPN) could contribute to metastasis in hepatocellular carcinoma (HCC), and that OPN-positive cancer cells are often localized in the periphery of cancer nodules adjacent to stromal cells. This study was to identify the difference of intratumor genomic abe...

journal_title：Journal of cancer research and clinical oncology

authors： Wu JC,Sun BS,Ren N,Ye QH,Qin LX

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:The clinical assessment of the myocardial damage caused by anthracyclin (ANT)-therapy is difficult. Therefore a study was performed to evaluate non-invasive markers of anthracyclin-induced cardiac effects, with emphasis on course-to-course variation. METHODS:Eligible for study participation were patients,...

journal_title：Journal of cancer research and clinical oncology

authors： Broeyer FJ,Osanto S,Ritsema van Eck HJ,van Steijn AQ,Ballieux BE,Schoemaker RC,Cohen AF,Burggraaf J

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To evaluate through retrospective analysis the efficacy and toxicity of combination chemotherapy with etoposide, vincristine, doxorubin and dexamethasone (EVAD) as second-line therapy in patients with advanced AIDS-related Kaposi's sarcoma (AIDS-KS) after failure of first-line chemotherapy. METHODS:Eighty-ei...

journal_title：Journal of cancer research and clinical oncology

authors： Zhong DT,Shi CM,Chen Q,Huang JZ,Liang JG,Lin D

更新日期：2012-03-01 00:00:00

abstract：:The precise place of local estrogen production in mammary cancer is still controversial. In this investigation localization of aromatase (the key enzyme of estrogen biosynthesis) was studied in breast cancer tissue by immunohistochemical method using polyclonal rabbit antibodies. The cytoplasmic staining was found in ...

journal_title：Journal of cancer research and clinical oncology

authors： Berstein LM,Larionov AA,Kyshtoobaeva ASh,Pozharisski KM,Semiglazov VF,Ivanova OA

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Bone morphogenetic proteins (BMPs) are multifunctional regulators of various cell functions. The BMP-signalling network plays a pivotal role during embryogenesis and tumorigenesis. BMPs, e.g. BMP-2 exert their biological function in a time and concentration-dependent manner but also modulated by the context of ...

journal_title：Journal of cancer research and clinical oncology

authors： Steinert S,Kroll TC,Taubert I,Pusch L,Hortschansky P,Höffken K,Wölfl S,Clement JH

更新日期：2008-11-01 00:00:00

abstract：PURPOSE:To investigate antitumour efficacy of the combination of the antiangiogenic agent TNP-470 combined with chemoimmunotherapy in different tumour models in mice MATERIALS:B6D2F1 mice and BALB/c mice were inoculated in the footpad of the right hind limb with B16F10 melanoma cells or colon adenocarcinoma cells C-26...

journal_title：Journal of cancer research and clinical oncology

authors： Dabrowska-Iwanicka A,Olszewska D,Jalili A,Makowski M,Grzela T,Marczak M,Hoser G,Giermasz A,Golab J,Jakóbisiak M

更新日期：2002-08-01 00:00:00

abstract：:Two cell clones of a methylnitrosourea-induced rat mammary carcinoma, a hyperdiploid (44 chromosomes, clone A) and a hypertetraploid clone (88 chromosomes, clone B) were cultured and transplanted subcutaneously into three groups of eight rats. Group 1 was treated with 62.6 mg cyclophosphamide/kg, group 2 with 41.8 mg/...

journal_title：Journal of cancer research and clinical oncology

authors： Angres G,Scherf HR

更新日期：1989-01-01 00:00:00

abstract：:Irritant diterpene ester toxins were isolated from Euphorbia nubica and E. helioscopia, which are contaminants of the green fodder of livestock in Egypt. Fractionations of methanol extracts of aerial parts of both plants were monitored by the irritation unit on the mouse ear. Plant extracts were subjected to multiplic...

journal_title：Journal of cancer research and clinical oncology

authors： Zayed SM,Farghaly M,Soliman SM,Gotta H,Sorg B,Hecker E

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:Endometrial adenocarcinoma, due to a frequent activation of PI3 K/AKT has been proposed as a candidate neoplasm for the treatment with mTOR inhibitors. Yet, data on the expression of mTOR cascade components in endometrial cancer are lacking. METHODS:To provide a basis for futher studies with mTOR inhibitors, w...

journal_title：Journal of cancer research and clinical oncology

authors： Darb-Esfahani S,Faggad A,Noske A,Weichert W,Buckendahl AC,Müller B,Budczies J,Röske A,Dietel M,Denkert C

更新日期：2009-07-01 00:00:00