Different effects of cyclophosphamide in vivo and phosphamide mustard in vitro on two cell clones of chemically induced mammary carcinoma of the rat.

abstract：PURPOSE:Hypersensitivity reactions (HSRs) to chemotherapy is an ongoing issue in cancer treatments. Strategies to induce tolerance and maximize chemotherapy efficacy include desensitization protocols. The precise impact of these protocols, however, in the long-term treatments remains unclear. We aim to compare overall ...

journal_title：Journal of cancer research and clinical oncology

authors： Altwerger G,Florsheim EB,Menderes G,Black J,Schwab C,Gressel GM,Nelson WK,Carusillo N,Passante T,Huang G,Litkouhi B,Azodi M,Silasi DA,Santin A,Schwartz PE,Ratner ES

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To elucidate the effect of tumor oxygenation status on recovery from damage following gamma-ray or accelerated carbon ion irradiation in vivo, including in quiescent (Q) cells. METHODS:SCC VII tumor-bearing mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. They r...

journal_title：Journal of cancer research and clinical oncology

authors： Masunaga S,Hirayama R,Uzawa A,Kashino G,Suzuki M,Kinashi Y,Liu Y,Koike S,Ando K,Ono K

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:No study has evaluated the prognostic impact of the age-adjusted Charlson comorbidity index (AACI) in those with renal cell carcinoma (RCC). This study aimed to evaluate the utility of the AACI for predicting long-term survival in patients with surgically treated non-metastatic clear cell RCC (ccRCC). METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Kang HW,Kim SM,Kim WT,Yun SJ,Lee SC,Kim WJ,Hwang EC,Kang SH,Hong SH,Chung J,Kwon TG,Kim HH,Kwak C,Byun SS,Kim YJ,KORCC (KOrean Renal Cell Carcinoma) Group.

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To evaluate the role of radioembolization and systemic chemotherapy as a combined modality therapy for unresectable colorectal liver metastases. PATIENTS AND METHODS:Prospective database of a major yttrium-90 microsphere radioembolization treatment center in Sydney, Australia, that included 140 patients with u...

journal_title：Journal of cancer research and clinical oncology

authors： Chua TC,Bester L,Saxena A,Morris DL

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of concurrent radiochemotherapy in patients with stage III non-small cell lung cancer (NSCLC), and to examine the effect of hemoglobin levels on survival of those patients. The negative impact of anemia on survival has been noticed for other cancer sites including the head and neck, and...

journal_title：Journal of cancer research and clinical oncology

authors： Pradier O,Lederer K,Hille A,Weiss E,Christiansen H,Schmidberger H,Hess CF

更新日期：2005-04-01 00:00:00

abstract：:Leukaemic and lymphomatous infiltration of the appendix is rare and even rarer is acute appendicitis as the initial manifestation. From our routine biopsy material we collected four cases of haematological malignancies presenting as acute appendicitis or acute abdomen, caused or accompanied by tumoral infiltration of ...

journal_title：Journal of cancer research and clinical oncology

authors： Müller G,Dargent JL,Duwel V,D'Olne D,Vanvuchelen J,Haot J,Hustin J

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Early treatment of pancreatic ductal adenocarcinoma (PDAC) is significantly delayed due to the lack of liquid biopsy markers for early diagnosis at surgically resectable tumor stages. Recent studies suggest that microRNA-205 (miR-205) is involved in PDAC progression by post-transcriptional regulation of epithel...

journal_title：Journal of cancer research and clinical oncology

authors： Michael Traeger M,Rehkaemper J,Ullerich H,Steinestel K,Wardelmann E,Senninger N,Abdallah Dhayat S

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Evidence from multiple clinical trials showed that local consolidative therapy (LCT) improved survival in oligometastatic non-small cell lung cancer (NSCLC) patients. In the present study, we aim to explore the potential role of microwave ablation (MWA) as LCT for epidermal growth factor receptor (EGFR)-muta...

journal_title：Journal of cancer research and clinical oncology

authors： Ni Y,Ye X,Yang X,Huang G,Li W,Wang J,Han X,Wei Z,Meng M

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Human papillomavirus (HPV) type 16 and 18 are the most prevalent genotypes in cervical cancers. The viral oncoproteins E6 and E7 are considered to be tumor-specific targets for immunotherapy. HPV E7 antigen-loaded dendritic cells (DC) were evaluated as cellular tumor vaccine. METHODS:Autologous monocyte-derive...

journal_title：Journal of cancer research and clinical oncology

authors： Nonn M,Schinz M,Zumbach K,Pawlita M,Schneider A,Dürst M,Kaufmann AM

更新日期：2003-09-01 00:00:00

abstract：INTRODUCTION:Kaposi's Sarcoma (KS) is a malignant neoplasm arising from endothelial cells. HHV8-infection represents a key pathogenic determinant for the development of KS. There are no standard criteria to treat KS in immunosuppressed-individuals. Six cases (2.1%) of KS occurred in our Center among 285-recipients who ...

journal_title：Journal of cancer research and clinical oncology

authors： Di Benedetto F,Di Sandro S,De Ruvo N,Berretta M,Masetti M,Montalti R,Ballarin R,Cocchi S,Potenza L,Luppi M,Gerunda GE

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Based on the poor prognosis of drug resistance in pediatric acute lymphoblastic leukemia (ALL) and adverse effects of chemotherapy, this study was aimed to evaluate the effect of several herbal extracts on leukemic cells. METHODS:Two subtypes of T- and B-ALL cell lines, followed by ALL primary cells were treat...

journal_title：Journal of cancer research and clinical oncology

authors： Rahimi Babasheikhali S,Rahgozar S,Mohammadi M

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To examine the associations between modifiable health-related factors, such as smoking, low physical activity and higher body mass index (BMI), and annual health care visits and expenditures among adult cancer survivors in the United States. METHODS:Using data from the 2010-2014 Medical Expenditures Panel Su...

journal_title：Journal of cancer research and clinical oncology

authors： Kaul S,Avila JC,Jupiter D,Rodriguez AM,Kirchhoff AC,Kuo YF

更新日期：2017-12-01 00:00:00

abstract：:The chemotherapeutic action of tegafur (FT) against adenocarcinoma 755 in mice was markedly potentiated by oral administration of L-cysteine and L-cystine without increasing its toxicity. In particular, the combination of FT at 200 mg/kg per day (maximum dose) and 1000 mg/kg per day of L-cystine markedly inhibited tum...

journal_title：Journal of cancer research and clinical oncology

authors： Iigo M,Hoshi A,Kitagawa H

更新日期：1986-01-01 00:00:00

abstract：:The aim of the present studies was to elucidate the effects and optimal modulatory conditions of 5-ethyl-2'-deoxyuridine (EtdUrd) on the antitumour efficacy, pharmacokinetics and catabolism of 5-fluorouracil (5-FU) on Colon-26 and Colon-38 murine tumours. HPLC and GC-MS techniques were used to measure the concentratio...

journal_title：Journal of cancer research and clinical oncology

authors： Kralovánszky J,Katona C,Jeney A,Pandi E,Noordhuis P,Erdélyi-Tóth V,Otvös L,Kovács P,Van der Wilt CL,Peters GJ

更新日期：1999-12-01 00:00:00

abstract：:The uptake of tritiated N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into Ehrlich-Ascites-Tumor cells of mice was studied by means of the siliconoil-filtration technique. At 10 mM concentration no permeation of the metabolite into the tumor cells could be found within 5 min at 1 degrees C, while its congenors cyclop...

journal_title：Journal of cancer research and clinical oncology

authors： Lenssen U,Hohorst HJ

更新日期：1979-02-19 00:00:00

abstract：PURPOSE:Recently, we identified the microRNA-99 family as unfavorable prognostic factor in patients with pancreatic ductal adenocarcinoma (PDAC). The aim of this study is to evaluate its value as circulating biomarker for PDAC. METHODS:Tissue and corresponding preoperative blood samples of 181 patients with PDAC UICC ...

journal_title：Journal of cancer research and clinical oncology

authors： Stroese AJ,Ullerich H,Koehler G,Raetzel V,Senninger N,Dhayat SA

更新日期：2018-12-01 00:00:00

abstract：:Carboplatin and interferon beta (IFN beta) were tested alone and in combination for their antiproliferative activity on the human melanoma cell line SK-MEL 28 in vitro. Cells were incubated for 4 days in the presence of carboplatin (0.1 mM and 0.1 microM) and interferon beta (5 pM and 5 nM) and cell growth inhibition ...

journal_title：Journal of cancer research and clinical oncology

authors： Hübner B,Eckert K,Garbe C,Maurer HR

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:The N-myc downstream regulated gene 1 (NDRG1)/Cap43 is overexpressed in multiple cancer types, including lung cancer. In this study, we investigated the expression of NDRG1/Cap43 in lung cancer tissues and in serum from 90 lung cancer patients and 60 healthy controls. MATERIALS AND METHODS:Ninety patients with...

journal_title：Journal of cancer research and clinical oncology

authors： Wang D,Tian X,Jiang Y

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:Papillary thyroid carcinoma (PTC), the most common malignant tumor of the thyroid, has been criticized as overtreated by some researchers in recent years. Active surveillance (AS) was first proposed at Kuma Hospital in 1993, and popularized in other institutes ever since. We provide a brief review of low-risk P...

journal_title：Journal of cancer research and clinical oncology

authors： Ze Y,Zhang X,Shao F,Zhu L,Shen S,Zhu D,Bi Y

更新日期：2019-11-01 00:00:00

abstract：:Intravenous tumor cell injection and spontaneously metastasising transplantable tumors have been used as models for haematogenous tumor spread. To evaluate the validity of these two experimental approaches for the study of blood coagulability and metastases, the effect of anticoagulants on "secondary" tumor growth was...

journal_title：Journal of cancer research and clinical oncology

authors： Maat B,Hilgard P

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Recent advances in sequencing technologies supported the development of molecularly targeted therapy in cancer patients. Thus, genomic analyses are becoming a routine part in clinical practice and accurate detection of actionable mutations is essential to assist diagnosis and therapy choice. However, this is...

journal_title：Journal of cancer research and clinical oncology

authors： Ofner R,Ritter C,Ugurel S,Cerroni L,Stiller M,Bogenrieder T,Solca F,Schrama D,Becker JC

更新日期：2017-07-01 00:00:00

abstract：:Induction of gene transcription in response to extracellular stimuli constitutes an essential aspect of host defense mechanisms. Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating the mechanism of t...

journal_title：Journal of cancer research and clinical oncology

authors： Taniguchi T,Harada H,Lamphier M

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Proteins involved in the aberrant regulation of signaling pathways and their downstream effectors are promising targets for cancer therapy. Survivin is an anti-apoptotic and cell cycle-promoting protein, which is consistently overexpressed in cancer cells. In normal cells, its expression is tightly controlle...

journal_title：Journal of cancer research and clinical oncology

authors： Weiss A,Brill B,Borghouts C,Delis N,Mack L,Groner B

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:To identify crucial molecular alterations of receptor tyrosine kinases that can be used as potential therapeutic targets for eyelid sebaceous gland carcinoma (SbGC). METHODS:The expression levels of HER2, EGFR, C-MET, and FGFR1 were determined by immunohistochemistry (IHC). The copy numbers of the HER2, EGFR, ...

journal_title：Journal of cancer research and clinical oncology

authors： Lee MJ,Kim N,Choung HK,Choe JY,Khwarg SI,Kim JE

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:The majority of patients with germ cell tumors are cured by multimodality therapy that consists of cisplatin-based chemotherapy and/or surgical resection. Serum tumor markers and conventional radiographs are utilized to stratify patients into treatment categories. Efforts to individualize chemotherapy or minimi...

journal_title：Journal of cancer research and clinical oncology

authors： Amato R,Kim EE,Prow D,Andreopoulos D,Kasi LP

更新日期：2000-03-01 00:00:00

abstract：:A continuous line of human breast carcinoma cells, VHB-1, was established in culture following collagenase treatment of an infiltrating duct cell carcinoma. The cells displayed an epithelial pattern and multiplied rapidly. Maintained in monolayer culture, the VHB-1 cells exhibited a 30-h doubling time and a plating ef...

journal_title：Journal of cancer research and clinical oncology

authors： Vandewalle B,Collyn d'Hooghe M,Savary JB,Vilain MO,Peyrat JP,Deminatti M,Delobelle-Deroide A,Lefebvre J

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Streptozocin (STZ) administration with or without other cytotoxic drugs remains a crucial chemotherapy for patients with advanced pancreatic neuroendocrine neoplasms (Pan-NENs). However, the therapeutic effects of combination treatment with weekly STZ and oral S-1 therapy (STS1) remain unknown. Therefore, th...

journal_title：Journal of cancer research and clinical oncology

authors： Ono H,Kudo A,Akahoshi K,Ogura T,Ogawa K,Ban D,Tanaka S,Tanabe M

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:Kinase insert domain-containing receptor (KDR) is one of the molecular targets used in cancer therapy. We studied the KDR expression characteristics and the relationship with the clinical parameters of the patients with lung cancer, to give the basic evidence and clue for tailoring therapy. METHODS:Reverse tra...

journal_title：Journal of cancer research and clinical oncology

authors： An SJ,Nie Q,Chen ZH,Lin QX,Wang Z,Xie Z,Chen SL,Huang Y,Zhang AY,Yan JF,Wu HS,Lin JY,Li R,Zhang XC,Guo AL,Mok TS,Wu YL

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:Tumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation. METHODS:TNBC patients (n = 179) with complete clinical data and up to 18-year follow-up...

journal_title：Journal of cancer research and clinical oncology

authors： Vihervuori H,Autere TA,Repo H,Kurki S,Kallio L,Lintunen MM,Talvinen K,Kronqvist P

更新日期：2019-12-01 00:00:00