Synergistic interactions between interferon beta and carboplatin on SK-MEL 28 human melanoma cell growth inhibition in vitro.

abstract：:The uptake of tritiated N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into Ehrlich-Ascites-Tumor cells of mice was studied by means of the siliconoil-filtration technique. At 10 mM concentration no permeation of the metabolite into the tumor cells could be found within 5 min at 1 degrees C, while its congenors cyclop...

journal_title：Journal of cancer research and clinical oncology

authors： Lenssen U,Hohorst HJ

更新日期：1979-02-19 00:00:00

abstract：PURPOSE:The precise determination of energy metabolites is challenged by the heterogeneity of their distribution, their rapid changes after surgical resection and the architectural complexity of malignancies. Induced metabolic bioluminescence imaging (imBI) allows to determine energy metabolites in tissue sections and ...

journal_title：Journal of cancer research and clinical oncology

authors： Battista MJ,Goetze K,Schmidt M,Cotarelo C,Weyer-Elberich V,Hasenburg A,Mueller-Klieser W,Walenta S

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Brain metastasis as the first symptom of lung cancer is a unique clinical entity. We conducted a retrospective study to investigate the clinical characteristics and survival of patients with lung cancer whose first symptom was brain metastases in an Asian population. METHODS:A retrospective study of 186 such...

journal_title：Journal of cancer research and clinical oncology

authors： Jin J,Zhou X,Liang X,Huang R,Chu Z,Jiang J,Zhan Q

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Two hundred and fourteen patients with benign giant cell tumor of bone (GCTB), treated from 1980 to 2007 at the Department of Orthopedics of the University of Muenster (Germany), were analyzed in a retrospective study. PATIENTS AND METHODS:The mean age was 33.3 years with a female-to-male ratio of 1.2 : 1. ...

journal_title：Journal of cancer research and clinical oncology

authors： Balke M,Schremper L,Gebert C,Ahrens H,Streitbuerger A,Koehler G,Hardes J,Gosheger G

更新日期：2008-09-01 00:00:00

abstract：:Carboplatin therapy has a more favorable toxicity profile than cisplatin and, given in appropriate doses, is equivalent in efficacy to cisplatin for suboptimal ovarian cancer. However myelosuppression frequently curtails therapy with carboplatin. Diethyldithiocarbamate (DDTC) is a thiol compound and heavy-metal-chelat...

journal_title：Journal of cancer research and clinical oncology

authors： Francis P,Markman M,Hakes T,Reichman B,Rubin S,Jones W,Lewis JL Jr,Curtin J,Barakat R,Phillips M

更新日期：1993-01-01 00:00:00

abstract：:The XP cell strain XP29MA, its malignant counterpart XP29MAmal and a normal human fibroblast strain were tested for colony-forming ability after treatment with HECNU in the presence of m6G, m6Gua, and he7G. In XP29MAmal, inhibition of post-HECNU colony-forming ability was 35% when 0.25 mM of either m6G or m6Gua were p...

journal_title：Journal of cancer research and clinical oncology

authors： Thielmann HW,Edler L,Müller N,Eisenbrand G

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Allogeneic haematopoietic stem cell transplantation (HSCT) is a proven treatment for patients with haematological malignancies. In this retrospective analysis, the impact of donor matching on outcome of unrelated HSCT was analysed in patients transplanted at the University of Leipzig. METHODS:From 2000 to 2009...

journal_title：Journal of cancer research and clinical oncology

authors： Rockstroh A,Al-Ali HK,Lange T,Pönisch W,Krahl R,Cross M,Behre G,Niederwieser D,Pfrepper C

更新日期：2015-12-01 00:00:00

abstract：:To verify whether a mild, but prolonged liver injury by chemicals needing bioactivation causes both hepatic cirrhosis and the appearance of hepatocyte nodules and tumors (providing the liver has been exposed previously to initiating stimuli), diethylnitrosamine-initiated and uninitiated rats were administered thioacet...

journal_title：Journal of cancer research and clinical oncology

authors： Gervasi PG,Longo V,Marzano M,Saviozzi M,Malvaldi G

更新日期：1989-01-01 00:00:00

abstract：:Human ovarian cancer cells from ten patients were cultured in the agar double layer assay as described by Hamburger and Salmon and in a methylcellulose monolayer system. The assays were compared under the same experimental conditions. The rate of positives (defined as greater than 30 colonies/dish) was 75% in the meth...

journal_title：Journal of cancer research and clinical oncology

authors： Runge HM,Neumann HA,Bücke W,Pfleiderer A

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Uterine neoplasms comprise a broad spectrum of lesions, some of which may pose a diagnostic challenge even to experienced pathologists. Recently, genome-wide DNA methylation-based classification of central nervous system tumors has been shown to increase diagnostic precision in clinical practice when combined w...

journal_title：Journal of cancer research and clinical oncology

authors： Kommoss FKF,Stichel D,Schrimpf D,Kriegsmann M,Tessier-Cloutier B,Talhouk A,McAlpine JN,Chang KTE,Sturm D,Pfister SM,Romero-Pérez L,Kirchner T,Grünewald TGP,Buslei R,Sinn HP,Mechtersheimer G,Schirmacher P,Schmidt D,Leh

更新日期：2020-01-01 00:00:00

abstract：:A prospective, randomized, double-blind placebo-controlled trial was designed to evaluate the impact of granulocyte/macrophage-colony-stimulating factor (GM-CSF) on the efficacy of sequential high-dose cytosine arabinoside/mitoxantrone chemotherapy (S-HAM) in adult patients with high-risk myelodysplastic syndromes (MD...

journal_title：Journal of cancer research and clinical oncology

authors： Verbeek W,Wörmann B,Koch P,Aul C,Hinrichs HF,Balleisen L,Rowe JM,Bennett J,Haase D,Fonatsch C,Heinecke A,Büchner T,Hiddemann W

更新日期：1999-01-01 00:00:00

abstract：:Butylnitrosourea (BNU) was used to induce thymic lymphomas in BDF1 mice. During and after the 12-week BNU exposure the spontaneous NK cell activity against YAC-1 cells and that arising 4 days after stimulation with Corynebacterium parvum (CP) were measured, as were the mitogen responses of splenic T and B cells. In ad...

journal_title：Journal of cancer research and clinical oncology

authors： Seidel HJ,Stolz W

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:To investigate the pattern and level of cyclooxygenase-2 (COX-2) expression in a series of high grade primary and recurrent glioblastoma multiforme (GBM) and correlation with time to recurrence and patients' survival following therapy. The relationship between COX-2 and epidermal growth factor receptor (EGFR) i...

journal_title：Journal of cancer research and clinical oncology

authors： Sminia P,Stoter TR,van der Valk P,Elkhuizen PH,Tadema TM,Kuipers GK,Vandertop WP,Lafleur MV,Slotman BJ

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To study pre-treatment serum VEGF of patients with invasive cervical cancer and its possible role as prognostic indicator. METHODS:VEGF was measured using ELISA in the largest patient group (n = 167) to date. RESULTS:Serum VEGF was significantly higher in advanced tumor stage (P = 0.01), large tumor size (tum...

journal_title：Journal of cancer research and clinical oncology

authors： Zusterzeel PL,Span PN,Dijksterhuis MG,Thomas CM,Sweep FC,Massuger LF

更新日期：2009-02-01 00:00:00

abstract：AIM:To study the role of beta-catenin gene mutation and expression in hepatocellular carcinogenesis. METHOD:Thirty-four hepatocellular carcinoma (HCC) specimens and adjacent para-cancerous tissues, and four normal liver tissues were analyzed. Subcellular distribution of beta-catenin was examined by immunohistochemistr...

journal_title：Journal of cancer research and clinical oncology

authors： Cui J,Zhou X,Liu Y,Tang Z

更新日期：2001-09-01 00:00:00

abstract：:Reversal of natural resistance to bouvardin (NSC 259968) has been attained in vitro and in vivo, by the calcium influx blocker verapamil in sarcoma 180 cells insensitive to bouvardin. Verapamil increased the in vitro lethality of the tumor cells following exposure with cells for 1 and 3 h as a result of the cytotoxic ...

journal_title：Journal of cancer research and clinical oncology

authors： Chitnis MP,Menon RS,Basrur VS,Adwankar MK,Satyamoorthy K

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the prognostic significance of the absolute natural killer (NK) cell counts in peripheral blood in patients with chronic lymphocytic leukemia (CLL). METHODS:A total of 273 previously untreated patients with CLL from April 2004 and October 2015 were enrolled into this re...

journal_title：Journal of cancer research and clinical oncology

authors： Wang WT,Zhu HY,Wu YJ,Xia Y,Wu JZ,Wu W,Liang JH,Wang L,Fan L,Li JY,Xu W

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Cholangiocarcinoma is defined as a chronic liver disease with altered estrogen metabolism and could result in estrogen retention. Estrogenic response was known as a promoting factor in progression of some cancer. In this study, we determined the significant increase of estrogen level in cholangiocarcinoma patie...

journal_title：Journal of cancer research and clinical oncology

authors： Hunsawong T,Singsuksawat E,In-chon N,Chawengrattanachot W,Thuwajit C,Sripa B,Paupairoj A,Chau-in S,Thuwajit P

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:Multidrug resistance (MDR) has been linked to sphingolipid metabolism and preclinical data ascribe glucosylceramide synthase (GCS) a major role for MDR especially in breast cancer cells but no profound data are available on the expression of this potential therapeutic target in clinical breast cancer specimens....

journal_title：Journal of cancer research and clinical oncology

authors： Ruckhäberle E,Karn T,Hanker L,Gätje R,Metzler D,Holtrich U,Kaufmann M,Rody A

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Recent reports have shown an increase in frequency of intra-hepatic cholangiocarcinoma (IHC) with a stable or decreased frequency of extra-hepatic cholangiocarcinoma (EHC). However, data on the demographic patterns associated with this change are limited. We analyzed cases of cholangiocarcinoma (CC) with aim to...

journal_title：Journal of cancer research and clinical oncology

authors： Singal AK,Vauthey JN,Grady JJ,Stroehlein JR

更新日期：2011-07-01 00:00:00

abstract：:The complex problem of drug resistance is discussed with respect to host toxicity, to tumor characteristics (kinetic resistance, heterogeneity of cell subpopulations, hypoxia, mutation and gene amplification), and to the medication itself (pharmacokinetic and pharmacodynamic resistance: cell membrane, intracellular me...

journal_title：Journal of cancer research and clinical oncology

authors： Cazin JL,Gosselin P,Cappelaere P,Robert J,Demaille A

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:In stomach adenocarcinoma, the role of the hormonal receptor, estrogen receptor (ER), has been controversial. Recently, a new estrogen receptor, called estrogen receptor beta (ER beta), was found to be expressed in various tissues including normal gastrointestinal tract. In this paper, the expression of ER beta...

journal_title：Journal of cancer research and clinical oncology

authors： Matsuyama S,Ohkura Y,Eguchi H,Kobayashi Y,Akagi K,Uchida K,Nakachi K,Gustafsson JA,Hayashi S

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:Many biochemical processes are closely related to ion exchange, adsorption, and catalysis. Zeolites reversibly bind small molecules such as oxygen or nitric oxide; they possess size and shape selectivity, the possibility of metalloenzyme mimicry, and immunomodulatory activity. These properties make them interes...

journal_title：Journal of cancer research and clinical oncology

authors： Pavelic K,Katic M,Sverko V,Marotti T,Bosnjak B,Balog T,Stojkovic R,Radacic M,Colic M,Poljak-Blazi M

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:The objectives of this work were to investigate whether the serum-free fatty acid (FFA) level is meaningful in cancer patients and its role in cancer diagnosis. METHODS:A total of 2206 patients were divided into a cancer group (n = 1019) and a noncancer group (n = 1187). Age, sex, body mass index (BMI), and se...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang L,Han L,He J,Lv J,Pan R,Lv T

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:The high incidence of biliary tract carcinoma in patients with anomalous pancreaticobiliary ductal junction (APBDJ) implicates that a compositional alteration in bile may contribute to the genesis of this cancer. Lysophosphatidylcholine (LPC) is generated in the bile of these patients. Given the role of cycloox...

journal_title：Journal of cancer research and clinical oncology

authors： Gwak GY,Yoon JH,Lee SH,Lee SM,Lee HS,Gores GJ

更新日期：2006-12-01 00:00:00

abstract：:Three oxygenated propylnitrosomethylamines were administered to female Syrian hamsters at doses similar to those which had induced high incidences of esophageal neoplasms in rats. Nitrosomethyl-2-oxopropylamine (NMOP) given at the rate of 2 mg/animal/week, whether as one application of 2 mg or two applications of 1 mg...

journal_title：Journal of cancer research and clinical oncology

authors： Lijinsky W,Kovatch RM,Knutsen GL

更新日期：1985-01-01 00:00:00

abstract：:A cohort of 5,477 male Japanese physicians was studied to examine the relationship between smoking habits and mortalities from cancer, coronary heart disease (CHD) and stroke over 12.7 years. The logistic regression analysis based on proportional hazard models was used for statistical assessment. The risks of both lun...

journal_title：Journal of cancer research and clinical oncology

authors： Kono S,Ikeda M,Tokudome S,Nishizumi M,Kuratsune M

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:The development of brain metastases (BMs) was associated with poor prognosis in melanoma patients. Patients with BMs have a median survival of <6 months. Melanoma is the third most common tumor to metastasize to the brain with a reported incidence of 10-40 %. Our aim was to identify factors predicting develo...

journal_title：Journal of cancer research and clinical oncology

authors： Gumusay O,Coskun U,Akman T,Ekinci AS,Kocar M,Erceleb OB,Yazıcı O,Kaplan MA,Berk V,Cetin B,Taskoylu BY,Yildiz A,Goksel G,Alacacioglu A,Demirci U,Algin E,Uysal M,Oztop I,Oksuzoglu B,Dane F,Gumus M,Buyukberber S

更新日期：2014-01-01 00:00:00

abstract：:Modulation of 5-fluorouracil (5-FU) is currently being investigated in advanced colorectal cancer. In an attempt to improve the results obtainable for the association of 5-FU and leucovorin, we decided to add cisplatin to 5-FU and (6S)-leucovorin (S-LV) after disease progression. The hypothesis was that a pharmacologi...

journal_title：Journal of cancer research and clinical oncology

authors： Cassano A,Pozzo C,Corsi DC,Fontana T,Noviello MR,Astone A,Barone C

更新日期：1995-01-01 00:00:00

abstract：:A transplantable non-immunogenic murine carcinoma of spontaneous origin, WHT Carcinoma N-C (Hewitt), was used to assess the effectiveness of melphalan (Ml) and/or methotrexate (Mx) for treatment of occult metastatic disease following surgical excision of primary tumors. Early surgical excision alone cured 66% of mice;...

journal_title：Journal of cancer research and clinical oncology

authors： Zebro T,Wright EA

更新日期：1980-01-01 00:00:00