Reversal of natural resistance to bouvardin (NSC 259968) in sarcoma 180 cells in vitro and in vivo by verapamil.

abstract：PURPOSE:CC chemokine receptor 1 (CCR1) plays a critical role in the recruitment of leukocytes to the site of inflammation. Tumor invasion and metastasis share many similarities with leukocyte trafficking, which is critically regulated by chemokines and their receptors. In this study, we aimed to assess the role of CCR1...

journal_title：Journal of cancer research and clinical oncology

authors： Wang CL,Sun BS,Tang Y,Zhuang HQ,Cao WZ

更新日期：2009-05-01 00:00:00

abstract：:In the present study, we report that the betel quid ingredient catechu, its extract and pure principle catechin were nonmutagenic in Salmonella typhimurium TA 100, TA 1535, TA 98, and TA 1538 assays with or without metabolic activation. They also exhibited dose-dependent decreases in mutagenicity of benzo(a)pyrene [B(...

journal_title：Journal of cancer research and clinical oncology

authors： Nagabhushan M,Maru GB,Amonkar AJ,Nair UJ,Santhanam U,Ammigan N,D'Souza AV,Bhide SV

更新日期：1988-01-01 00:00:00

abstract：:Cancer development depends on the aberrant activation of signal transduction pathways that control cell growth and survival and play important roles in normal embryonic development. This review will focus on one of the most powerful pathways, the canonical Wnt signal transduction cascade, which has been originally des...

journal_title：Journal of cancer research and clinical oncology

authors： Lustig B,Behrens J

更新日期：2003-04-01 00:00:00

abstract：:The long-term prognosis of surgery for hepatocellular carcinoma (HCC) is not yet satisfactory, the main reason being the high recurrence rate. The authors report the results of a long-term follow-up of 308 patients with HCC who became alpha-fetoprotein-(AFP)-negative after resection between 1975 and 1991. By March 199...

journal_title：Journal of cancer research and clinical oncology

authors： Zhou XD,Tang ZY,Yu YQ,Yang BH,Lu JZ,Lin ZY,Ma ZC,Zhang BH

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:A number of studies have investigated the role of serum lactate dehydrogenase (LDH) level in patients with osteosarcoma but have yielded inconsistent and inconclusive results. Thus, we conducted a meta-analysis to assess its prognostic value more precisely. METHODS:Systematic computerized searches of PubMed...

journal_title：Journal of cancer research and clinical oncology

authors： Chen J,Sun MX,Hua YQ,Cai ZD

更新日期：2014-07-01 00:00:00

abstract：:A previous cohort-study in a cardboard factory demonstrated that high and prolonged occupational exposure to trichloroethene (C2HCl3) is associated with an increased incidence of renal cell cancer. The present hospital-based case/control study investigates occupational exposure in 58 patients with renal cell cancer wi...

journal_title：Journal of cancer research and clinical oncology

authors： Vamvakas S,Brüning T,Thomasson B,Lammert M,Baumüller A,Bolt HM,Dekant W,Birner G,Henschler D,Ulm K

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:Lung cancer has become a crucial problem among individuals living with the human immunodeficiency virus (HIV) and causes high mortality in Western countries. Japan has an increasing number of newly infected HIV patients, and lung cancer is becoming a theme in this population. However, clinical factors of this p...

journal_title：Journal of cancer research and clinical oncology

authors： Okuma Y,Tanuma J,Kamiryo H,Kojima Y,Yotsumoto M,Ajisawa A,Uehira T,Nagai H,Takeda Y,Setoguchi Y,Okada S

更新日期：2015-09-01 00:00:00

abstract：:The DMBA-TPA-mediated two-stage skin carcinogenesis experiment was modified in that pregnant mice were systemically treated once during pregnancy with the carcinogen. Intragastric application times were fetal days 6, 8, and 10-20. A control group of pregnant mice received repeated doses (from days 8-20) of sesame oil,...

journal_title：Journal of cancer research and clinical oncology

authors： Goerttler K,Loehrke H,Schweizer J,Hesse B

更新日期：1980-01-01 00:00:00

abstract：:The concentration of estrogen receptor protein (ER) in 113 primary or metastatic breast cancers was studied. ER was found to be correlated with the age of the patient. The ER values were generally lower in premenopausal patients (5.6 fmol/mg cytosol protein) than in postmenopausal patients (32.8 fmol/mg cytosol protei...

journal_title：Journal of cancer research and clinical oncology

authors： Johansson R,Vanharanta R,Söderholm J

更新日期：1984-01-01 00:00:00

abstract：:Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are markers of collagen absorption and LP is specific for collagen type I in bone. In the present study we evaluated the concentration of HP and LP in urine of patients with osteosarcoma ( n=20; age range 16-49 years) and chondrosarcoma ( n=15; age range 18-70 y...

journal_title：Journal of cancer research and clinical oncology

authors： Açil Y,Springer I,Behrens P,Ullrich KP,Hedderich J,Bruns J

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:In the United States, cancer is the second leading cause of mortality, and millions more battle cancer worldwide. As such, primary prevention of cancer is a major interest globally. Aspirin has been studied as a primary prevention method for multiple diseases, mainly cardiovascular disease and various forms ...

journal_title：Journal of cancer research and clinical oncology

authors： Haykal T,Barbarawi M,Zayed Y,Yelangi A,Dhillon H,Goranta S,Kheiri B,Chahine A,Samji V,Kerbage J,Katato K,Bachuwa G

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To investigate the efficacy and safety of nab-paclitaxel plus S-1 (nab-P/S) versus nab-paclitaxel plus gemcitabine (nab-P/G) as first-line chemotherapy in patients with advanced pancreatic ductal adenocarcinoma (PDAC). METHODS:Treatment-naïve patients with advanced PDAC were equally randomized to receive nab-P...

journal_title：Journal of cancer research and clinical oncology

authors： Zong Y,Yuan J,Peng Z,Lu M,Wang X,Shen L,Zhou J

更新日期：2020-11-15 00:00:00

abstract：PURPOSE:The benefit of adding docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy to chemoradiotherapy (CRT) in head and neck squamous cell carcinoma (HNSCC) remains uncertain. We aimed to investigate whether ICT is well tolerated when given with prophylactic treatment against predicted adverse effects...

journal_title：Journal of cancer research and clinical oncology

authors： Lowe NM,Bernstein JM,Mais K,Garcez K,Lee LW,Sykes A,Thomson DJ,Homer JJ,West CM,Slevin NJ

更新日期：2018-02-01 00:00:00

abstract：:Carboplatin and interferon beta (IFN beta) were tested alone and in combination for their antiproliferative activity on the human melanoma cell line SK-MEL 28 in vitro. Cells were incubated for 4 days in the presence of carboplatin (0.1 mM and 0.1 microM) and interferon beta (5 pM and 5 nM) and cell growth inhibition ...

journal_title：Journal of cancer research and clinical oncology

authors： Hübner B,Eckert K,Garbe C,Maurer HR

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To analyze prognostic factors and long-term outcomes in patients with locally recurrent pelvic cancer (LRPC) treated with a multidisciplinary approach. METHODS AND MATERIALS:From January 1995 to December 2011, 81 patients [rectal (47 %); gynecologic (39 %); retroperitoneal sarcoma (14 %)] underwent extended su...

journal_title：Journal of cancer research and clinical oncology

authors： Sole CV,Calvo FA,de Sierra PA,Herranz R,Gonzalez-Bayon L,García-Sabrido JL

更新日期：2014-07-01 00:00:00

abstract：:Sarcoma 180 tumor tissue from C57 mice was processed in a soft agar clonogenic assay immediately after removal from the animal and after various methods of storage. The sensitivity to the antineoplastic drug cis-platinum was not affected by different storage methods. The highest yield of colony forming cells per 100 m...

journal_title：Journal of cancer research and clinical oncology

authors： Krischke W,Hartmann R,Schneider M,Schönenberger H

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Adenovirus (Ads) is one of the most popular vectors used in gene therapy for the treatment of cancer. However, systemic therapy is limited by circulating antiviral antibodies and poor viral delivery in vivo. In this study, we used cytokine-induced killer (CIK) cells as delivery vehicles of Ads KGHV500 carrying ...

journal_title：Journal of cancer research and clinical oncology

authors： Lin XR,Zhou XL,Feng Q,Pan XY,Song SL,Fang H,Lei J,Yang JL

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-gamma) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expre...

journal_title：Journal of cancer research and clinical oncology

authors： Coppola D,Parikh V,Boulware D,Blanck G

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:The Wnt pathway plays an important role in embryonic development, and defects in this pathway have been implicated in the tumorigenesis. The Dickkopf 3 (DKK3) is a putative Wnt signaling inhibitor that is frequently inactivated in human cancers. However, the expression of DKK3 in ovarian cancer remains unknown....

journal_title：Journal of cancer research and clinical oncology

authors： You A,Fokas E,Wang LF,He H,Kleb B,Niederacher D,Engenhart-Cabillic R,An HX

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:Recently, we identified the microRNA-99 family as unfavorable prognostic factor in patients with pancreatic ductal adenocarcinoma (PDAC). The aim of this study is to evaluate its value as circulating biomarker for PDAC. METHODS:Tissue and corresponding preoperative blood samples of 181 patients with PDAC UICC ...

journal_title：Journal of cancer research and clinical oncology

authors： Stroese AJ,Ullerich H,Koehler G,Raetzel V,Senninger N,Dhayat SA

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine breast tumors and normal breast tissues for the expression of the glycoprotein lacritin. The mRNA and protein expression of lacritin has been reported to be restricted to the lacrimal gland. METHODS:We investigated 37 human primary invasive breast tumors, seven breast c...

journal_title：Journal of cancer research and clinical oncology

authors： Weigelt B,Bosma AJ,van 't Veer LJ

更新日期：2003-12-01 00:00:00

abstract：:Two human melanoma xenografts were compared with respect to their in vivo growth and metastatic potentials as well as glycosaminoglycan patterns. The less differentiated HT 168 tumor showed faster growth at primary sites and a more pronounced capacity for metastasis into the liver. Although chondroitin sulfate was the...

journal_title：Journal of cancer research and clinical oncology

authors： Timár J,Kovalszky I,Paku S,Lapis K,Kopper L

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:The blockade of the renin-angiotensin-aldosterone system (RAAS) by angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) is one of the most common treatments for hypertension, heart failure and renal diseases. However, concerns have been raised about a possible link between RA...

journal_title：Journal of cancer research and clinical oncology

authors： Rachow T,Schiffl H,Lang SM

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:In recurrent ovarian cancer (ROC), there is a high demand on effective therapies with a mild toxicity profile. Treosulfan is an alkylating agent approved as oral (p.o.) and intravenous (i.v.) formulation for the treatment of recurrent ovarian cancer. Data on safety and efficacy for either formulation are rare...

journal_title：Journal of cancer research and clinical oncology

authors： Sehouli J,Tomè O,Dimitrova D,Camara O,Runnebaum IB,Tessen HW,Rautenberg B,Chekerov R,Muallem MZ,Lux MP,Trarbach T,Gitsch G

更新日期：2017-03-01 00:00:00

abstract：:Telomerase, a ribonucleoprotein enzyme, is expected to be a new marker for cancer diagnosis. TRAP (the telomeric-repeat amplification protocol) developed by Kim et al. is a sensitive method to detect telomerase activity. Telomerase activity is detected by TRAP in most malignant cells in vivo and in vitro, but it is no...

journal_title：Journal of cancer research and clinical oncology

authors： Hirose M,Abe-Hashimoto J,Ogura K,Tahara H,Ide T,Yoshimura T

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:The epithelial cell adhesion molecule (Ep-CAM) is a clinically validated target for antibody-based therapy of cancer. The aim of this work was to evaluate the specific cytotoxic activity of a novel fully human Ep-CAM-specific IgG1 antibody, called MT201, against primary ovarian tumor cells and an ovarian tumor ...

journal_title：Journal of cancer research and clinical oncology

authors： Xiang W,Wimberger P,Dreier T,Diebold J,Mayr D,Baeuerle PA,Kimmig R

更新日期：2003-06-01 00:00:00

abstract：:Tissue sections of frozen biopsy specimens obtained from normal and hyperplastic human lymphoid tissues as well as 40 cases of non-Hodgkin's lymphomas were analysed in immunofluorescence tests (using red TRITC and green FITC double-labeling). A panel of antisera including well-characterized conventional reagents to im...

journal_title：Journal of cancer research and clinical oncology

authors： Janossy G,Thomas JA,Pizzolo G

更新日期：1981-01-01 00:00:00

abstract：:A series of 191 female breast carcinomas (with long-term follow-up) were analysed immunohistochemically (with a monoclonal MIB1 antibody) for Ki-67 (a proliferation marker) expression with special reference to well-established prognostic factors and patient survival. Expression of Ki-67 was directly related to the S-p...

journal_title：Journal of cancer research and clinical oncology

authors： Pietiläinen T,Lipponen P,Aaltomaa S,Eskelinen M,Kosma VM,Syrjänen K

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:Renal cell carcinoma (RCC) is the most common malignancy of the urinary system, and it is a serious threat to human health. HOXA transcript at the distal tip (HOTTIP), located at the 5' end of the HOXA locus, is a long non-coding RNA that has been newly discovered in recent years. It has been reported to prom...

journal_title：Journal of cancer research and clinical oncology

authors： Su Y,Lu J,Chen X,Liang C,Luo P,Qin C,Zhang J

更新日期：2019-03-01 00:00:00