Expression of the Wnt antagonist DKK3 is frequently suppressed in sporadic epithelial ovarian cancer.

abstract：:In addition to spontaneous uterine endometrial adenocarcinomas at a high incidence (35.1%), development of endometrial hyperplasia/adenoma was also frequently detected in rats of the Donryu strain. The total yield of all observed proliferative endometrial lesions was very high (60.6%). The tumors arose commonly in the...

journal_title：Journal of cancer research and clinical oncology

authors： Nagaoka T,Onodera H,Matsushima Y,Todate A,Shibutani M,Ogasawara H,Maekawa A

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-gamma) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expre...

journal_title：Journal of cancer research and clinical oncology

authors： Coppola D,Parikh V,Boulware D,Blanck G

更新日期：2009-09-01 00:00:00

abstract：:Aclacinomycin A (ACM) is a new anthracycline antibiotic with a reduced cardiac toxicity in animal models. A phase II study was performed in a total of 25 patients, 23 of whom are evaluable for response. All suffered from recurrent and advanced tumors. Pretreatment consisted of at least four different chemotherapeutic ...

journal_title：Journal of cancer research and clinical oncology

authors： Schütte J,Niederle N,Seeber S

更新日期：1983-01-01 00:00:00

abstract：:The histologic grade of regression of 50 osteosarcomas after polychemotherapy - according to the protocol study, COSS 80 - was classified on a six-stage regression scale; 56% of all patients responded well to chemotherapy regression grades I, II, and III and no significant difference between BCD- and CPL-treated patie...

journal_title：Journal of cancer research and clinical oncology

authors： Salzer-Kuntschik M,Delling G,Beron G,Sigmund R

更新日期：1983-01-01 00:00:00

abstract：:The dihydropyridine, dexniguldipine hydrochloride (B859-35), has shown therapeutic activity in experimentally induced neuroendocrine hamster lung tumors and demonstrated antiproliferative effects in a mammary cancer cell line via inhibition of Ca2+ calmodulin. Studies in NIH 3T3 fibroblasts have provided evidence that...

journal_title：Journal of cancer research and clinical oncology

authors： Schuller HM,Orloff M,Reznik GK

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:It is estimated that about half of cancer patients use at least one form of complementary and alternative medicines (CAM) in their life but there is a strong reticence of patients in talking about CAM with their oncologist. Primary aim of this study was to inform patients about CAM, focusing on their suppose...

journal_title：Journal of cancer research and clinical oncology

authors： Bozza C,Gerratana L,Basile D,Vitale MG,Bartoletti M,Agostinetto E,Russo S,Follador A,De Carlo E,Pella N,Sottile R,Fasola G,Puglisi F

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Transforming growth factor beta1 (TGF-beta1) and its receptor II (TGF-betaRII) are two key components of TGF-beta signaling and play an important role in carcinogenesis. Several functional polymorphisms were identified in TGFB1 and TGFBR2 and associated with elevated serum or plasma level of TGF-beta1 and enhan...

journal_title：Journal of cancer research and clinical oncology

authors： Jin G,Deng Y,Miao R,Hu Z,Zhou Y,Tan Y,Wang J,Hua Z,Ding W,Wang L,Chen W,Shen J,Wang X,Xu Y,Shen H

更新日期：2008-03-01 00:00:00

abstract：:Butylnitrosourea (BNU) was used to induce thymic lymphomas in BDF1 mice. During and after the 12-week BNU exposure the spontaneous NK cell activity against YAC-1 cells and that arising 4 days after stimulation with Corynebacterium parvum (CP) were measured, as were the mitogen responses of splenic T and B cells. In ad...

journal_title：Journal of cancer research and clinical oncology

authors： Seidel HJ,Stolz W

更新日期：1984-01-01 00:00:00

abstract：:A phase II trial of etoposide (100 mg/m2) on days 4, 5, 6, doxorubicin (Adriamycin, 20 mg/m2) on days 1, 7, and cisplatin (30 mg/m2) on days 2, 8 (EAP) was carried out in order to reduce toxicity associated with a full-dose EAP regimen for advanced and/or metastatic gastric adenocarcinoma. Out of 21 evaluable patients...

journal_title：Journal of cancer research and clinical oncology

authors： Gebbia V,Valenza R,Testa A,Sciume C,Longo A,Cipolla C,Borsellino N,Leo P,Latteri M,Florena M

更新日期：1994-01-01 00:00:00

abstract：:The effect of beta-cyclodextrin-benzaldehyde (CDBA) on experimental pulmonary metastasis in C3H/He mice was examined. In an in vitro assay, the growth of RCT(+) cells was inhibited by 1200 micrograms/ml CDBA using unrenewed media, and by 600 micrograms/ml CDBA in that using daily renewed media. When mice were treated ...

journal_title：Journal of cancer research and clinical oncology

authors： Ochiai H,Niwayama S,Masuyama K

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Multidrug resistance (MDR) has been linked to sphingolipid metabolism and preclinical data ascribe glucosylceramide synthase (GCS) a major role for MDR especially in breast cancer cells but no profound data are available on the expression of this potential therapeutic target in clinical breast cancer specimens....

journal_title：Journal of cancer research and clinical oncology

authors： Ruckhäberle E,Karn T,Hanker L,Gätje R,Metzler D,Holtrich U,Kaufmann M,Rody A

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Triple (ER-, PR-, HER2-) negative breast carcinoma lack targeted therapies, making this group of tumors difficult to treat. By definition, the lack of HER2 expression means a case scoring 0 or 1+ after immunophenotypical analysis and makes the patients avoiding therapeutical chances with anti-HER2 inhibitors. W...

journal_title：Journal of cancer research and clinical oncology

authors： Brunello E,Bogina G,Bria E,Vergine M,Zamboni G,Pedron S,Daniele I,Furlanetto J,Carbognin L,Marconi M,Manfrin E,Ibrahim M,Miller K,Tortora G,Molino A,Jasani B,Beccari S,Bonetti F,Chilosi M,Martignoni G,Brunelli M

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The receptor for the cytokine TWEAK (TweakR) is a cell surface member of the tumor necrosis factor receptor superfamily with diverse biological roles. TNFRSF family members are appealing therapeutic targets in oncology due to their aberrant expression and function in tumor cells. The goal of the current stud...

journal_title：Journal of cancer research and clinical oncology

authors： Chao DT,Su M,Tanlimco S,Sho M,Choi D,Fox M,Ye S,Hsi ED,Durkin L,Yin J,Zhang Y,Kim H,Starling GC,Culp PA

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Pheochromocytomas/paragangliomas (PHEOs/PGLs) are rare in children with only a few SDHB mutation-related cases. Previous studies on children were conducted in small cohorts. This large set of pediatric patients provides robust data in the evaluation of clinical outcomes. METHODS:Sixty-four pediatric PHEO/PGL p...

journal_title：Journal of cancer research and clinical oncology

authors： Jochmanova I,Abcede AMT,Guerrero RJS,Malong CLP,Wesley R,Huynh T,Gonzales MK,Wolf KI,Jha A,Knue M,Prodanov T,Nilubol N,Mercado-Asis LB,Stratakis CA,Pacak K

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:Mutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and prognostic effects of TP53 mutations in certain cancers. METHODS:Over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer (IARC) TP...

journal_title：Journal of cancer research and clinical oncology

authors： Li VD,Li KH,Li JT

更新日期：2019-03-01 00:00:00

abstract：:Antinucleolar antisera were raised in rabbits, goats and sheep to nucleoli isolated from three human tumor cell lines. The antisera were shown to cross-react by immunofluorescence with human tumor cell lines originating from different organs and with frozen sections from a wide variety of human malignant and non-malig...

journal_title：Journal of cancer research and clinical oncology

authors： Greenfield RS,Lamon MO,Olech LJ,Grattan JA

更新日期：1989-01-01 00:00:00

abstract：:This report describes two types of reticular epithelial cell in the thymic cortex of the BALB/c mouse, an immature and a mature form. During early stages of lymphoma development, i.e., 2-6 weeks postinfection (p.i.) with Moloney leukemia virus (M-MuLV), activation of the epithelial cells is observed. Although the perc...

journal_title：Journal of cancer research and clinical oncology

authors： Heine UI,Krueger GR,Karpinski A,Munoz E,Krueger MB

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:This study was to investigate whether the topoisomerase (Top) I inhibitor topotecan and the Top II inhibitor etoposide could modulate the hypoxia-induced HIF-1alpha expression in non-small cell lung cancer (NSCLC) cell lines. METHODS:Hypoxic conditions were maintained in a humidified airtight anaerobic incubat...

journal_title：Journal of cancer research and clinical oncology

authors： Choi YJ,Rho JK,Lee SJ,Jang WS,Lee SS,Kim CH,Lee JC

更新日期：2009-08-01 00:00:00

abstract：:Irritant diterpene ester toxins were isolated from Euphorbia nubica and E. helioscopia, which are contaminants of the green fodder of livestock in Egypt. Fractionations of methanol extracts of aerial parts of both plants were monitored by the irritation unit on the mouse ear. Plant extracts were subjected to multiplic...

journal_title：Journal of cancer research and clinical oncology

authors： Zayed SM,Farghaly M,Soliman SM,Gotta H,Sorg B,Hecker E

更新日期：2001-01-01 00:00:00

abstract：:The DMBA-TPA-mediated two-stage skin carcinogenesis experiment was modified in that pregnant mice were systemically treated once during pregnancy with the carcinogen. Intragastric application times were fetal days 6, 8, and 10-20. A control group of pregnant mice received repeated doses (from days 8-20) of sesame oil,...

journal_title：Journal of cancer research and clinical oncology

authors： Goerttler K,Loehrke H,Schweizer J,Hesse B

更新日期：1980-01-01 00:00:00

abstract：:Leukaemic and lymphomatous infiltration of the appendix is rare and even rarer is acute appendicitis as the initial manifestation. From our routine biopsy material we collected four cases of haematological malignancies presenting as acute appendicitis or acute abdomen, caused or accompanied by tumoral infiltration of ...

journal_title：Journal of cancer research and clinical oncology

authors： Müller G,Dargent JL,Duwel V,D'Olne D,Vanvuchelen J,Haot J,Hustin J

更新日期：1997-01-01 00:00:00

abstract：:Female carriers of mutations in the BRCA1 gene on chromosome 17q have a very high risk of developing breast and/or ovarian cancer during their lifetime. There is, however, little knowledge of to what extent non-genetic risk factors, such as age at menarche, age at first birth, and body mass index, alter the age at ons...

journal_title：Journal of cancer research and clinical oncology

authors： Chang-Claude J,Becher H,Eby N,Bastert G,Wahrendorf J,Hamann U

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:The precise determination of energy metabolites is challenged by the heterogeneity of their distribution, their rapid changes after surgical resection and the architectural complexity of malignancies. Induced metabolic bioluminescence imaging (imBI) allows to determine energy metabolites in tissue sections and ...

journal_title：Journal of cancer research and clinical oncology

authors： Battista MJ,Goetze K,Schmidt M,Cotarelo C,Weyer-Elberich V,Hasenburg A,Mueller-Klieser W,Walenta S

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:Due to PSA screening and increased awareness, prostate cancer (PCa) is identified earlier resulting in smaller diagnostic samples on prostate needle biopsy. Because Gleason grading plays a critical role in treatment planning, we undertook a controlled study to evaluate interobserver variability among German ...

journal_title：Journal of cancer research and clinical oncology

authors： Burchardt M,Engers R,Müller M,Burchardt T,Willers R,Epstein JI,Ackermann R,Gabbert HE,de la Taille A,Rubin MA

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:No study has evaluated the prognostic impact of the age-adjusted Charlson comorbidity index (AACI) in those with renal cell carcinoma (RCC). This study aimed to evaluate the utility of the AACI for predicting long-term survival in patients with surgically treated non-metastatic clear cell RCC (ccRCC). METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Kang HW,Kim SM,Kim WT,Yun SJ,Lee SC,Kim WJ,Hwang EC,Kang SH,Hong SH,Chung J,Kwon TG,Kim HH,Kwak C,Byun SS,Kim YJ,KORCC (KOrean Renal Cell Carcinoma) Group.

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To investigate the efficacy and safety of nab-paclitaxel plus S-1 (nab-P/S) versus nab-paclitaxel plus gemcitabine (nab-P/G) as first-line chemotherapy in patients with advanced pancreatic ductal adenocarcinoma (PDAC). METHODS:Treatment-naïve patients with advanced PDAC were equally randomized to receive nab-P...

journal_title：Journal of cancer research and clinical oncology

authors： Zong Y,Yuan J,Peng Z,Lu M,Wang X,Shen L,Zhou J

更新日期：2020-11-15 00:00:00

abstract：:The isolation of deoxyguanosine-resistant 10T1/2 mouse cell lines following stepwise selection in the presence of increasing concentrations of drug led to the identification of a highly metastatic line, as measured by the ability to form secondary tumors in syngenic mice after intravenous injection. This metastatic de...

journal_title：Journal of cancer research and clinical oncology

authors： Damen JE,Spearman MA,Greenberg AH,Wright JA

更新日期：1991-01-01 00:00:00

abstract：:A series of 202 breast cancer biopsy specimens were analysed immunohistochemically for collagen IV to demonstrate basement membrane (BM) structures and blood vessels within tumour tissue. Integrity of the BM was graded into four categories and the number of vascular channels per square millimetre of tumour tissue were...

journal_title：Journal of cancer research and clinical oncology

authors： Lipponen P,Ji H,Aaltomaa S,Syrjänen K

更新日期：1994-01-01 00:00:00

abstract：:In 1989, 65%-75% of previously untreated adults with ALL or AML may be expected to enter complete remission. Approximately 40% of these completely responding patients, whether they are treated with intensive chemotherapy, intensive chemotherapy followed by autologous bone marrow transplantation, or allogeneic bone mar...

journal_title：Journal of cancer research and clinical oncology

authors： Mayer RJ

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Survivin, an inhibitor of apoptosis protein and a cell cycle regulator, has been detected in the majority of human cancers. Five splice variants (survivin, survivin-2alpha, survivin-2B, survivin-3B, and survivin-DeltaEx3) have been identified; their expressions have been investigated here. METHODS:By means of ...

journal_title：Journal of cancer research and clinical oncology

authors： De Maria S,Pannone G,Bufo P,Santoro A,Serpico R,Metafora S,Rubini C,Pasquali D,Papagerakis SM,Staibano S,De Rosa G,Farina E,Emanuelli M,Santarelli A,Mariggiò MA,Lo Russo L,Lo Muzio L

更新日期：2009-01-01 00:00:00