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Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer.

Abstract：

PURPOSE:Multidrug resistance (MDR) has been linked to sphingolipid metabolism and preclinical data ascribe glucosylceramide synthase (GCS) a major role for MDR especially in breast cancer cells but no profound data are available on the expression of this potential therapeutic target in clinical breast cancer specimens. METHODS:We analyzed microarray data of GCS expression in a large cohort of 1,681 breast tumors. RESULTS:Expression of GCS was associated with a positive estrogen receptor (ER) status, lower histological grading, low Ki67 levels and ErbB2 negativity (P < 0.001 for all). In univariate analysis there was a benefit for disease free survival for patients with tumors displaying low levels of GCS expression but this significance was lost in multivariate Cox regression. CONCLUSIONS:Our results suggest ER positive tumors may be the most promising candidates for a potential therapeutic application of GCS inhibitors.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Ruckhäberle E,Karn T,Hanker L,Gätje R,Metzler D,Holtrich U,Kaufmann M,Rody A

doi

10.1007/s00432-008-0436-9

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

81-90

issue

1

eissn

0171-5216

issn

1432-1335

journal_volume

135

pub_type

杂志文章

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