Comparative metabolism and carcinogenicity of ring-halogenated 3,3-dimethyl-1-phenyltriazenes.

abstract：PURPOSE:Significant prolongation of overall survival (OS) has been reached in metastatic colorectal cancer (mCRC) treatment within the last 5-10 years. Our study was conducted in order to evaluate and compare OS of different standard of care treatment options in a university-based outpatient clinic. METHODS:One hundre...

journal_title：Journal of cancer research and clinical oncology

authors： Moehler M,Thomaidis T,Zeifri C,Barhoom T,Marquardt J,Ploch P,Schattenberg J,Maderer A,Schimanski CC,Weinmann A,Woerns MA,Kranich AL,Warnecke JM,Galle PR

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Recently, we identified the microRNA-99 family as unfavorable prognostic factor in patients with pancreatic ductal adenocarcinoma (PDAC). The aim of this study is to evaluate its value as circulating biomarker for PDAC. METHODS:Tissue and corresponding preoperative blood samples of 181 patients with PDAC UICC ...

journal_title：Journal of cancer research and clinical oncology

authors： Stroese AJ,Ullerich H,Koehler G,Raetzel V,Senninger N,Dhayat SA

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:The TNM classification is used to assess cancers of the oral cavity, and advancements in imaging techniques have revealed clear variations in tumor volume at presentation. This study therefore aimed to clarify whether preoperative imaging, with exact measurements of the tumor, could affect post-surgery survival...

journal_title：Journal of cancer research and clinical oncology

authors： Mücke T,Mitchell DA,Ritschl LM,Tannapfel A,Wolff KD,Kesting MR,Loeffelbein DJ,Kanatas A

更新日期：2015-06-01 00:00:00

abstract：:A previous cohort-study in a cardboard factory demonstrated that high and prolonged occupational exposure to trichloroethene (C2HCl3) is associated with an increased incidence of renal cell cancer. The present hospital-based case/control study investigates occupational exposure in 58 patients with renal cell cancer wi...

journal_title：Journal of cancer research and clinical oncology

authors： Vamvakas S,Brüning T,Thomasson B,Lammert M,Baumüller A,Bolt HM,Dekant W,Birner G,Henschler D,Ulm K

更新日期：1998-01-01 00:00:00

abstract：:The relation between the intracellular glutathione (GSH) concentration and hydrogen-peroxide(H2O2)-induced cytotoxicity was investigated. The intracellular GSH concentration in human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines was one or two orders of magnitude higher than that in a human myelogenous leuke...

journal_title：Journal of cancer research and clinical oncology

authors： Iida M,Sunaga S,Hirota N,Kuribayashi N,Sakagami H,Takeda M,Matsumoto K

更新日期：1997-01-01 00:00:00

abstract：:The study shows inhibition of the antitumor effect of cyclophosphamide (CPA) on mammary carcinomas growing in mice prior-immunized by intragastric inoculations of the tumor. Immunization with tumor cells through this route produces under certain conditions factors able to modulate the antigenic determinants on tumor c...

journal_title：Journal of cancer research and clinical oncology

authors： Laursen ML

更新日期：1980-01-01 00:00:00

abstract：:The responsiveness of spleen cells from C57BL/6J mice to various immunogenic stimuli was examined during the progressive growth of a poorly immunogenic fibrosarcoma T241. A strong correlation was observed between the progressive tumor growth and the depression of response to Concanavalin A, lipopolysaccharide, sheep r...

journal_title：Journal of cancer research and clinical oncology

authors： Gautam SC,Gautam S,Deodhar SD

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:The purposes of our study were to elucidate the role of BRG1 in the development of human glioma and to determine the effect of BRG1 on glioma cell growth, migration and invasion. METHODS:Using tissue microarray and immunohistochemistry, we evaluated BRG1 staining in 190 glioma tissues, 8 normal brain tissues a...

journal_title：Journal of cancer research and clinical oncology

authors： Bai J,Mei PJ,Liu H,Li C,Li W,Wu YP,Yu ZQ,Zheng JN

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:To identify and characterize novel genetic alterations in hepatocellular carcinoma (HCC). METHODS:DNA was extracted from 29 HCC and corresponding normal tissues and amplified with 59 different 10-base arbitrary primers. A 550 bp DNA fragment amplified using primer Q-9 and which was present in 19 of 29 cases (6...

journal_title：Journal of cancer research and clinical oncology

authors： Saelee P,Wongkham S,Bhudhisawasdi V,Sripa B,Chariyalertsak S,Petmitr S

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:Objective of this work was to extend pharmacokinetic scaling theory of the writer for bolus dosing to include the case of constant-rate i.v. dosing over fixed interval so as to allow projection of adult dose and schedule of typically administered anticancer agents to children. METHODS:The basis for the scaling...

journal_title：Journal of cancer research and clinical oncology

authors： Dawson TH

更新日期：2013-12-01 00:00:00

abstract：:Elevated glutamate concentrations are commonly observed in tumor patients, and glutamate was recently found to competitively inhibit the membrane transport of cystine. We therefore investigated the possibility that elevated plasma glutamate levels may damage the immune system. The experiments in this report demonstrat...

journal_title：Journal of cancer research and clinical oncology

authors： Dröge W,Eck HP,Betzler M,Schlag P,Drings P,Ebert W

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Metastatic renal cell carcinoma (mRCC) sometimes presents with an indolent course without any significant symptoms. Here, the potential impact of active surveillance (AS) on clinical outcomes in asymptomatic or minimally symptomatic mRCC patients was retrospectively evaluated. METHODS:mRCC patients who were fo...

journal_title：Journal of cancer research and clinical oncology

authors： Park I,Lee JL,Ahn JH,Lee DH,Lee KH,Jeong IG,Song C,Hong B,Hong JH,Ahn H

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The clinical behaviour and outcome of young patients with gastroesophageal tumours (GET) is surmised to differ from older patients, yet data on the comparison of these two patient subgroups is scarce. This study focuses on the investigation of the clinical characteristics and survival outcome of younger-age ...

journal_title：Journal of cancer research and clinical oncology

authors： Puhr HC,Karner A,Taghizadeh H,Jomrich G,Schoppmann SF,Preusser M,Ilhan-Mutlu A

更新日期：2020-12-01 00:00:00

abstract：:The effect of growth phase on enzymatic activities of the de novo and salvage pathways for purine and pyrimidine nucleotide synthesis was studied in a hepatocyte-derived cell line from the rat. The cells were in lag phase after plating for 36 h; log phase started at 48 h and persisted up to 120 h of culture. Then the ...

journal_title：Journal of cancer research and clinical oncology

authors： Mayer D,Natsumeda Y,Ikegami T,Faderan M,Lui M,Emrani J,Reardon M,Oláh E,Weber G

更新日期：1990-01-01 00:00:00

abstract：:Peptide growth factors involved in the regulation of haematopoiesis (HPGF), for example granulocyte-colony-stimulating factor (G-CSF) and granulocyte/macrophage-colony-stimulating factor (GM-CSF), are of clinical importance in the treatment of testicular germ cell tumour (GCT) patients with modern chemotherapy regimen...

journal_title：Journal of cancer research and clinical oncology

authors： Dunn TA,Schmoll HJ,Rie C,Hartmann K,Casper J

更新日期：1998-01-01 00:00:00

abstract：:The effects of four barbiturates with or without liver-tumor-promoting activity were examined on survival and deoxyribonucleic acid (DNA) synthesis of suckling and adult rat hepatocytes in serum-free primary culture: Of the four barbiturates, two promoters, phenobarbital and barbital, enhanced DNA synthesis of sucklin...

journal_title：Journal of cancer research and clinical oncology

authors： Miyazaki M,Bai L,Tsuboi S,Namba M

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Since 1997, several monoclonal antibodies (mAbs) targeting the same receptor or its ligand have been approved for use in oncology. However, no studies have summarized head-to-head trials of these mAbs. METHODS:Systematic search of the biomedical literature and ClinicalTrials.gov for randomized studies compa...

journal_title：Journal of cancer research and clinical oncology

authors： Luo J,Nishikawa G,Prasad V

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndromes (MDS) are mainly a disease of the elderly. Commonly, MDS patients are treated in an outpatient setting making hematological/oncological private practices (PP) an important backbone in the management of MDS patients. METHODS:To gain more insights into the characteristics of patients...

journal_title：Journal of cancer research and clinical oncology

authors： Nolte F,Schumann C,Klein S,Reinwald M,Hofmann WK

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:Putative tumor suppressor genes LATS1 and LATS2 are implicated in the regulation of the cell cycle at the G2/M and G1/S phase, respectively. This study investigated possible correlations of intra-tumoral LATS1 and LATS2 mRNA levels with response to epirubicin plus cyclophosphamide (EC) or docetaxel (DOC) treatm...

journal_title：Journal of cancer research and clinical oncology

authors： Takahashi Y,Miyoshi Y,Morimoto K,Taguchi T,Tamaki Y,Noguchi S

更新日期：2007-08-01 00:00:00

abstract：:The Harvey ras locus was examined for restriction fragment polymorphism and loss of allelic heterozygosity in 62 oral cancer patients. Southern blot analysis on BamHI digests of the tumour tissue DNA, revealed 23 patients with H-ras-1 heterozygosity. The probes used to study the polymorphism were the BamHI 6.6-kb frag...

journal_title：Journal of cancer research and clinical oncology

authors： Saranath D,Bhoite LT,Mehta AR,Sanghavi V,Deo MG

更新日期：1991-01-01 00:00:00

abstract：:Female carriers of mutations in the BRCA1 gene on chromosome 17q have a very high risk of developing breast and/or ovarian cancer during their lifetime. There is, however, little knowledge of to what extent non-genetic risk factors, such as age at menarche, age at first birth, and body mass index, alter the age at ons...

journal_title：Journal of cancer research and clinical oncology

authors： Chang-Claude J,Becher H,Eby N,Bastert G,Wahrendorf J,Hamann U

更新日期：1997-01-01 00:00:00

abstract：:A series of 202 breast cancer biopsy specimens were analysed immunohistochemically for collagen IV to demonstrate basement membrane (BM) structures and blood vessels within tumour tissue. Integrity of the BM was graded into four categories and the number of vascular channels per square millimetre of tumour tissue were...

journal_title：Journal of cancer research and clinical oncology

authors： Lipponen P,Ji H,Aaltomaa S,Syrjänen K

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:Recent studies indicated undisputed contribution of connective tissue growth factor (CTGF) in the development of many cancers, including non-small cell lung cancer (NSCLC). However, the functional role and regulation of CTGF expression during tumorigenesis remain elusive. Our goal was to determine CTGF transcri...

journal_title：Journal of cancer research and clinical oncology

authors： Drzewiecka H,Gałęcki B,Jarmołowska-Jurczyszyn D,Kluk A,Dyszkiewicz W,Jagodziński PP

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To discover new molecular targets for cancer therapy and diagnosis, we surveyed signal transducers and activators of transcription 3 (Stat3)-regulated genes, because constitutive activation of Stat3 is associated with a wide variety of human malignancies. METHODS:We investigated the Stat3-regulated genes in 29...

journal_title：Journal of cancer research and clinical oncology

authors： Tomida M,Ohtake H,Yokota T,Kobayashi Y,Kurosumi M

更新日期：2008-05-01 00:00:00

abstract：INTRODUCTION:Protein profiles of endoscopically collected pancreatic juice from normal, chronic pancreatitis patients and pancreatic cancer patients were compared to identify diagnostic biomarkers of pancreatic cancer. METHODS:Secretin was injected intravenously and pancreatic juice was collected via selective cannula...

journal_title：Journal of cancer research and clinical oncology

authors： Park JY,Kim SA,Chung JW,Bang S,Park SW,Paik YK,Song SY

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:We aimed to clarify the prognostic impact of the anatomic extent of hepatic resection (Hr) related to the tumor hepatic involvement (H) on patients' survival in the treatment of hepatocellular carcinoma (HCC). METHOD:The 305 patients with HCC who had undergone hepatectomy were analyzed retrospectively. The pat...

journal_title：Journal of cancer research and clinical oncology

authors： Ochiai T,Sonoyama T,Kikuchi S,Okayama T,Konishi H,Kitagawa M,Tagi T,Ueda Y,Otsuji E

更新日期：2007-08-01 00:00:00

abstract：:Nitrosodiphenylamine was tested for induction of DNA single strand breaks in rat hepatocytes and Chinese hamster V 79 cells with the alkaline filter elution assay. While in rat hepatocytes DNA damage was observed, negative results were obtained in V 79 cells. In view of the metabolic capacity of hepatocytes and the ch...

journal_title：Journal of cancer research and clinical oncology

authors： Appel KE,Görsdorf S,Scheper T,Ruf HH,Rühl CS,Hildebrandt AG

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:In the phase 3 BFORE trial (NCT02130557), treatment with bosutinib resulted in a significantly higher major molecular response rate at 12 months versus imatinib in the modified intent-to-treat (mITT) population of patients with newly diagnosed chronic phase chronic myeloid leukemia (CP CML). Assessment of pa...

journal_title：Journal of cancer research and clinical oncology

authors： Cortes JE,Gambacorti-Passerini C,Deininger MW,Mauro MJ,Chuah C,Kim DW,Milojkovic D,le Coutre P,Garcia-Gutierrez V,Crescenzo R,Mamolo C,Reisman A,Hochhaus A,Brümmendorf TH,BFORE Study Investigators.

更新日期：2019-06-01 00:00:00

abstract：:General principles for anticancer drug development include traditional drug-screening methods in biological test systems. Today, testing of a drug in a panel of selected human tumor xenografts in mice is assumed to have the best predictive value for clinical efficacy. Chemical modification of well-known antitumor drug...

journal_title：Journal of cancer research and clinical oncology

authors： Unger C

更新日期：1996-01-01 00:00:00