当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Quantitative light and electron microscopic changes in thymic reticular epithelial cells during Moloney-virus-induced lymphoma development.

Quantitative light and electron microscopic changes in thymic reticular epithelial cells during Moloney-virus-induced lymphoma development.

Abstract：

:This report describes two types of reticular epithelial cell in the thymic cortex of the BALB/c mouse, an immature and a mature form. During early stages of lymphoma development, i.e., 2-6 weeks postinfection (p.i.) with Moloney leukemia virus (M-MuLV), activation of the epithelial cells is observed. Although the percentage of these cells in the total cell population of the thymic cortex remains constant during that time, the number of mature epithelial cells is significantly increased in infected animals. Subsequently, about 6 weeks p.i., the number of immature epithelial cells starts to increase, whereas the number of mature reticular epithelial cells declines and the appearance of the mature epithelial cells changes drastically. The results of light and electron microscopic studies indicate degeneration of the mature reticular epithelial cells at the onset of lymphoma development at a time when the first deficiencies in the immunologic competence of the reticular epithelial cells are apparent.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Heine UI,Krueger GR,Karpinski A,Munoz E,Krueger MB

doi

10.1007/BF00395387

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

102-11

issue

2

eissn

0171-5216

issn

1432-1335

journal_volume

106

pub_type

杂志文章

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