当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Induction of tumors of the forestomach in rats by oral application of N-methyl-N'-nitro-nitrosoguanidine.

Induction of tumors of the forestomach in rats by oral application of N-methyl-N'-nitro-nitrosoguanidine.

Abstract：

:After 12 oral applications of 80 mg/kg MNNG as a suspension in 30% aqueous ethanol at weekly intervals, 98 Sprague-Dawley rats died with multiple tumors of the forestomach after a medium latency period of 226 days. Histological examination showed generalized papillomatosis developing into keratinizing squamous cell carcinomas with infiltrative growth in 88/98 (89%) animals. Tumorigenic lesions in the glandular stomach ware only observed in 3/98 rats. In two of these animals, mucosal adenocarcinomas were found and in the third a leiomyosarcoma. In about 30% of the animals treated with MNNG, degenerative liver changes were found, especially single cell and focal necroses, cystic alterations, and bile-duct proliferations.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Eichler G,Habs M,Schmähl D

doi

10.1007/BF00406933

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

194-6

issue

2

eissn

0171-5216

issn

1432-1335

journal_volume

105

pub_type

杂志文章

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