Relevance of cellular and serum carbonic anhydrase IX in primary breast cancer.

abstract：PURPOSE:To describe the clinical characteristics and outcomes of patients with dual-phenotype hepatocellular carcinoma (DPHCC) and investigate the use of radiomics to establish an image-based signature for preoperative differential diagnosis. METHODS:This study included 50 patients with a postoperative pathological di...

journal_title：Journal of cancer research and clinical oncology

authors： Huang X,Long L,Wei J,Li Y,Xia Y,Zuo P,Chai X

更新日期：2019-12-01 00:00:00

abstract：:The DMBA-TPA-mediated two-stage skin carcinogenesis experiment was modified in that pregnant mice were systemically treated once during pregnancy with the carcinogen. Intragastric application times were fetal days 6, 8, and 10-20. A control group of pregnant mice received repeated doses (from days 8-20) of sesame oil,...

journal_title：Journal of cancer research and clinical oncology

authors： Goerttler K,Loehrke H,Schweizer J,Hesse B

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndromes (MDS) are mainly a disease of the elderly. Commonly, MDS patients are treated in an outpatient setting making hematological/oncological private practices (PP) an important backbone in the management of MDS patients. METHODS:To gain more insights into the characteristics of patients...

journal_title：Journal of cancer research and clinical oncology

authors： Nolte F,Schumann C,Klein S,Reinwald M,Hofmann WK

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:TNF-related apoptosis-inducing ligand (TRAIL) is a potential cancer therapeutic agent that preferentially induces apoptosis in cancer cells. However, breast cancer cells are generally resistant to TRAIL. Bufalin is a major active ingredient of the traditional Chinese medicine ChanSu. The present study aimed to ...

journal_title：Journal of cancer research and clinical oncology

authors： Yan S,Qu X,Xu C,Zhu Z,Zhang L,Xu L,Song N,Teng Y,Liu Y

更新日期：2012-08-01 00:00:00

abstract：:A transplantable non-immunogenic murine carcinoma of spontaneous origin, WHT Carcinoma N-C (Hewitt), was used to assess the effectiveness of melphalan (Ml) and/or methotrexate (Mx) for treatment of occult metastatic disease following surgical excision of primary tumors. Early surgical excision alone cured 66% of mice;...

journal_title：Journal of cancer research and clinical oncology

authors： Zebro T,Wright EA

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:Individuals affected by rheumatoid arthritis (RA) occasionally develop lymphoproliferative disorders (RA-LPD). To study the molecular changes underscoring the RA-LPD, mutations of p53 and Bak gene were analyzed in RA-LPD with (MTX-LPD) or without methotrexate treatment for RA (non-MTX-LPD). METHODS:Histology a...

journal_title：Journal of cancer research and clinical oncology

authors： Xu JX,Hoshida Y,Hongyo T,Sasaki T,Miyazato H,Tomita Y,Aozasa K

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:Natural killer (NK) cells can kill transformed cells and represent anti-tumor activities for improving the immunotherapy of cancer. In previous works, we established human interleukin-15 (hIL-15) gene-modified NKL cells (NKL-IL15) and demonstrated their efficiency against human hepatocarcinoma cells (HCCs) in v...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang W,Zhang C,Tian Z,Zhang J

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Lysine-specific demethylase 1 (LSD1) was highly expressed in several malignancies and had been implicated in pathological processes of cancer cells. However, the role of LSD1 in colorectal cancer (CRC) carcinogenesis, prognosis and treatment remains uncharacterized. METHODS:In this study, we examined LSD1 expr...

journal_title：Journal of cancer research and clinical oncology

authors： Hsu HC,Liu YS,Tseng KC,Yang TS,Yeh CY,You JF,Hung HY,Chen SJ,Chen HC

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Insulin-like growth factor 1 (IGF-1) stimulates mitosis and inhibits apoptosis. High circulating IGF-1 levels are linked with an increased risk of colorectal and breast cancer. Recently, IGF-1 single nucleotide polymorphisms (SNPs), especially variant rs2946834, have been associated with poor clinical outcome i...

journal_title：Journal of cancer research and clinical oncology

authors： Muendlein A,Lang AH,Geller-Rhomberg S,Winder T,Gasser K,Drexel H,Decker T,Mueller-Holzner E,Chamson M,Marth C,Hubalek M

更新日期：2013-03-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy. About 75% are sporadic (sMTC) while the remaining 25% are hereditary (hMTC). The treatment of choice for both sMTC and hMTC is surgery. An adequate initial operation provides the best chance of cure. Hence, the diagnosis of MTC should be made preoperative...

journal_title：Journal of cancer research and clinical oncology

authors： Gimm O,Sutter T,Dralle H

更新日期：2001-01-01 00:00:00

abstract：:Solitary fibrous tumors (SFT) of extremities, especially the thighs are very rare. Despite SFTs are generally benign, well-circumscribed soft tissue tumors new cases should be presented and followed up carefully to monitor their biological behavior. In general for tumor classification a biopsy is state of the art. His...

journal_title：Journal of cancer research and clinical oncology

authors： Anders JO,Aurich M,Lang T,Wagner A

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Serrated adenomas (SAs), which include a wide spectrum of lesions, can be broadly divided into two subtypes: type I, closely mimicking hyperplastic polyps (HPs), and type II, unequivocal adenomatous tumor. Our preliminary findings showed clinicopathologic differences between them. The present study was conducte...

journal_title：Journal of cancer research and clinical oncology

authors： Mitomi H,Sada M,Kobayashi K,Igarashi M,Mori A,Kanazawa H,Nishiyama Y,Ihara A,Otani Y

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:The aim of our study was to identify factors which influence survival in patients with disseminated seminoma in the good prognostic group according to IGCCCG, as well as to evaluate the impact of treatment intensification in patients with negative prognostic factors. METHODS:We analyzed the database of the pat...

journal_title：Journal of cancer research and clinical oncology

authors： Fedyanin M,Tryakin A,Bulanov A,Vybarava A,Tjulandina A,Chekini D,Sekhina O,Figurin K,Garin A,Tjulandin S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:The high incidence of biliary tract carcinoma in patients with anomalous pancreaticobiliary ductal junction (APBDJ) implicates that a compositional alteration in bile may contribute to the genesis of this cancer. Lysophosphatidylcholine (LPC) is generated in the bile of these patients. Given the role of cycloox...

journal_title：Journal of cancer research and clinical oncology

authors： Gwak GY,Yoon JH,Lee SH,Lee SM,Lee HS,Gores GJ

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:This retrospective study evaluated the diagnostic value of integrated whole-body (18)F-fluorodeoxyglucose positron-emission tomography and computed tomography ((18)F-FDG-PET/CT) in early detection of second primary malignancies in cancer patients. MATERIALS AND METHODS:From June 2007 to October 2008, 677 cance...

journal_title：Journal of cancer research and clinical oncology

authors： Xu H,Zhang M,Zhai G,Li B

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To explore lymph node-related risk factors and investigate the benefit of different adjuvant therapy strategies in hypopharyngeal squamous-cell carcinoma (HPSCC) patients with nodal metastasis (N +). METHODS:We conducted a retrospective review covering 266 HPSCC patients with nodal metastasis. Kaplan-Meier cur...

journal_title：Journal of cancer research and clinical oncology

authors： Lin H,Wang T,Heng Y,Zhu X,Zhou L,Zhang M,Shi Y,Cao P,Tao L

更新日期：2020-07-29 00:00:00

abstract：:Mice with s.c. grafts of gastric carcinoma MKN45 or osteosarcoma 788T were injected i.v. with recombinant tumour necrosis factor alpha (rTNF alpha) and tumour blood flow rates were determined 4 h later as a fraction of the cardiac output g tissue-1. With MKN45, the tumour blood flow rate was significantly reduced from...

journal_title：Journal of cancer research and clinical oncology

authors： Pimm MV,Gribben SJ,Morris TM

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Two hundred and fourteen patients with benign giant cell tumor of bone (GCTB), treated from 1980 to 2007 at the Department of Orthopedics of the University of Muenster (Germany), were analyzed in a retrospective study. PATIENTS AND METHODS:The mean age was 33.3 years with a female-to-male ratio of 1.2 : 1. ...

journal_title：Journal of cancer research and clinical oncology

authors： Balke M,Schremper L,Gebert C,Ahrens H,Streitbuerger A,Koehler G,Hardes J,Gosheger G

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Brain metastasis as the first symptom of lung cancer is a unique clinical entity. We conducted a retrospective study to investigate the clinical characteristics and survival of patients with lung cancer whose first symptom was brain metastases in an Asian population. METHODS:A retrospective study of 186 such...

journal_title：Journal of cancer research and clinical oncology

authors： Jin J,Zhou X,Liang X,Huang R,Chu Z,Jiang J,Zhan Q

更新日期：2013-03-01 00:00:00

abstract：:Expression of the glutathione S-transferase (GST) subclasses alpha, mu and pi was investigated immunohistochemically in 20 normal or hyperplastic mesothelium and in 57 malignant mesothelioma cases. These results were correlated with survival and also with P-170 glycoprotein expression. Nearly all the non-neoplastic me...

journal_title：Journal of cancer research and clinical oncology

authors： Segers K,Kumar-Singh S,Weyler J,Bogers J,Ramael M,Van Meerbeeck J,Van Marck E

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Long noncoding RNAs (LncRNAs) have been demonstrated as playing important roles in diverse biological processes including tumorigenesis. However, the clinical significance and biological function of LncRNA nuclear-enriched abundant transcript 1 (NEAT1) in gastric cancer are still unknown. The aim of this stu...

journal_title：Journal of cancer research and clinical oncology

authors： Fu JW,Kong Y,Sun X

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:The majority of patients with germ cell tumors are cured by multimodality therapy that consists of cisplatin-based chemotherapy and/or surgical resection. Serum tumor markers and conventional radiographs are utilized to stratify patients into treatment categories. Efforts to individualize chemotherapy or minimi...

journal_title：Journal of cancer research and clinical oncology

authors： Amato R,Kim EE,Prow D,Andreopoulos D,Kasi LP

更新日期：2000-03-01 00:00:00

abstract：:Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract...

journal_title：Journal of cancer research and clinical oncology

authors： Green U,Althoff J

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:The monoterpene perillyl alcohol (POH) a Ras inhibitor with potential capacity to arrest gliomagenesis is being used in a phase I/II clinical trial in adults with recurrent malignant glioma. The present study aimed to investigate the efficacy of intranasal administration of monoterpene POH upon survival rate of...

journal_title：Journal of cancer research and clinical oncology

authors： da Fonseca CO,Simão M,Lins IR,Caetano RO,Futuro D,Quirico-Santos T

更新日期：2011-02-01 00:00:00

abstract：:Preoperative cytologic examinations were performed on bronchial material from 92 patients with postsurgical (pathologic) stage I (American Joint Committee) adenocarcinoma of the lung. All patients were followed up for at least 5 years or until death; thus, cases of adenocarcinoma metastatic to the lungs were virtually...

journal_title：Journal of cancer research and clinical oncology

authors： Bjornsson J,Goellner JR,Williams DE,Scheiber MV

更新日期：1986-01-01 00:00:00

abstract：:A brain metastasis of bronchial squamous cell carcinoma in a patient was cultivated. The cells with epithelium-like characteristics were selected from the primary culture, and were subcultured to establish a cell line. The cultured cells were identified to be neoplastic by means of heterologous transplantation to nude...

journal_title：Journal of cancer research and clinical oncology

authors： Takaki T

更新日期：1980-01-01 00:00:00

abstract：:We describe a slide assay that allows the demonstration of antigens localized in the nucleus from isolated white blood cells as well as from single tumor cells derived from malignant effusions. With the antibodies Ki-67 and anti-p-145 an increased rate of nuclear and nucleolar staining resulted in cells from highly ma...

journal_title：Journal of cancer research and clinical oncology

authors： Hirsch FW,Deibert P,Busch H,Löhr GW,Bross KJ

更新日期：1991-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were treated for 7 weeks with 120 mg/l N-nitrosomorpholine in their drinking water. At the end of the treatment period there were large numbers of enzyme-altered foci in the liver. During the following 10 weeks, the number of foci decreased significantly. This decrease in the number of enzyme-...

journal_title：Journal of cancer research and clinical oncology

authors： Enzmann H,Bannasch P

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:In 2013, 2009, and 2006, the Arbeitsgemeinschaft Gynäkologische Onkologie evaluated the therapeutic approaches and the adherence to their guidelines for endometrial carcinoma (EC) in Germany. Here, we present the results concerning the surgical procedures. METHODS:A questionnaire was developed and sent to 682 ...

journal_title：Journal of cancer research and clinical oncology

authors： Battista MJ,Schmidt M,Rieks N,Steetskamp J,Sicking I,Lebrecht A,Koelbl H,Mallmann P,Hoffmann G,Steiner E

更新日期：2014-12-01 00:00:00