Lysophosphatidylcholine suppresses apoptotic cell death by inducing cyclooxygenase-2 expression via a Raf-1 dependent mechanism in human cholangiocytes.

abstract：PURPOSE:Although important for apoptosis, the signaling pathway involving MOAP-1(Modulator of Apoptosis 1), RASSF1A (RAS association domain family 1A), and Bax (Bcl-2 associated X protein) is likely to be dysfunctional in many types of human cancers due to mechanisms associated with gene mutation and DNA hyper-methylat...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YH,Pang SW,Revai Lechtich E,Shah K,Simon SE,Ponnusamy S,Narayanan R,Poh CL,Tan KO

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:This study aimed to determine the dose effect of smoking on the mutational frequency and spectrum of epidermal growth factor receptor (EGFR) gene in Korean non-small cell lung cancer (NSCLC). METHODS:Detailed smoking histories were obtained from 324 consecutively enrolled Korean NSCLC patients. Mutational stat...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YJ,Shim HS,Kang YA,Hong SJ,Kim HK,Kim H,Kim SK,Choi SH,Kim JH,Cho BC

更新日期：2010-12-01 00:00:00

abstract：:General principles for anticancer drug development include traditional drug-screening methods in biological test systems. Today, testing of a drug in a panel of selected human tumor xenografts in mice is assumed to have the best predictive value for clinical efficacy. Chemical modification of well-known antitumor drug...

journal_title：Journal of cancer research and clinical oncology

authors： Unger C

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Patterns of locoregional rectal cancer recurrences following total mesorectal excision (TME) were analyzed to define the irradiation volume, especially the lateral pelvic lymph node (LPLN). MATERIALS AND METHODS:Of 1243 patients who underwent TME without pelvic radiotherapy between 2005 and 2012, the data of 8...

journal_title：Journal of cancer research and clinical oncology

authors： Choi SH,Chang JS,Yoon HI,Jang DS,Kim NK,Lim JS,Min BS,Huh H,Shin SJ,Ahn JB,Koom WS

更新日期：2018-06-01 00:00:00

abstract：:Hybridoma clones were produced by fusion of splenocytes from glioma-immunized hosts and the X63-Ag8.653 mouse myeloma line and Y3-Ag.1.2.3. rat myeloma line. Oncornavirus particles were found in all clones descending from the mouse myeloma line. No virus particles could be found in either the spleens of immunized Balb...

journal_title：Journal of cancer research and clinical oncology

authors： Stavrou D,Bilzer T,Tsangaris T,Dürr E,Steinecke M,Anzil AP

更新日期：1983-01-01 00:00:00

abstract：:As currently recognized, the essential aspects of ovarian carcinoma surgery are: (1) the search for occult metastases in tumors located in the lower pelvis, (2) the maximum tumor removal ("tumor-reductive surgery") in advanced ovarian carcinoma and (3) the exploratory laparotomy to confirm a complete clinical remissio...

journal_title：Journal of cancer research and clinical oncology

authors： Almendral AC

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Oxidative stress is considered a risk factor for prostate cancer development and is associated with the production of reactive oxygen species (ROS). The base excision repair gene MYH protects against ROS-mediated damage to DNA. Inherited MYH mutations predispose to colorectal adenomas and cancer. A compromised ...

journal_title：Journal of cancer research and clinical oncology

authors： Shin EJ,Chappell E,Pethe V,Hersey K,van der Kwast T,Fleshner N,Bapat B

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To understand how nanomechanical stiffness affects metastatic potential, we studied the relationship between cell migration, a characteristic of metastasis, and cell stiffness using atomic force microscopy (AFM), which can measure stiffness (elasticity) of individual living cells. METHODS:Migration and cell st...

journal_title：Journal of cancer research and clinical oncology

authors： Watanabe T,Kuramochi H,Takahashi A,Imai K,Katsuta N,Nakayama T,Fujiki H,Suganuma M

更新日期：2012-05-01 00:00:00

abstract：:A series of 202 breast cancer biopsy specimens were analysed immunohistochemically for collagen IV to demonstrate basement membrane (BM) structures and blood vessels within tumour tissue. Integrity of the BM was graded into four categories and the number of vascular channels per square millimetre of tumour tissue were...

journal_title：Journal of cancer research and clinical oncology

authors： Lipponen P,Ji H,Aaltomaa S,Syrjänen K

更新日期：1994-01-01 00:00:00

abstract：:The epoxide hydratase inhibitor, 1,1,1-trichloro-2,3-propene oxide (TCPO) in combination with benzo[a]pyrene (B[a]P) was injected s.c. in ddN mice. The formation of fibrosarcoma by B[a]P was slightly accelerated at low dose of TCPO, and remarkably inhibited at high dose of TCPO. The correlation of carcinogenesis with ...

journal_title：Journal of cancer research and clinical oncology

authors： Kodama M,Ioki Y,Nagata C

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:Based on the poor prognosis of drug resistance in pediatric acute lymphoblastic leukemia (ALL) and adverse effects of chemotherapy, this study was aimed to evaluate the effect of several herbal extracts on leukemic cells. METHODS:Two subtypes of T- and B-ALL cell lines, followed by ALL primary cells were treat...

journal_title：Journal of cancer research and clinical oncology

authors： Rahimi Babasheikhali S,Rahgozar S,Mohammadi M

更新日期：2019-08-01 00:00:00

abstract：:Rat 13672 mammary carcinoma tumors were grown subcutaneously in the hind legs of female Fischer 344 rats to a volume of about 1 cm3. Tumor oxygenation was measured using an Eppendorf PO2 histograph. Tumor oxygen measurements were made under four conditions: (a) normal air breathing, (b) carbogen breathing, (c) after i...

journal_title：Journal of cancer research and clinical oncology

authors： Teicher BA,Sotomayor EA,Dupuis NP,Kusumoto T,Menon K

更新日期：1994-01-01 00:00:00

abstract：:Although the biological action of phthalates has been widely discussed there is little information on early cellular changes indicative for toxic or carcinogenic effects. To study subtle alterations in the cell morphology, we have by means of image processing evaluated the nuclei of hamster hepatocytes after treatment...

journal_title：Journal of cancer research and clinical oncology

authors： Komitowski D,Schmezer P,Schmitt B,Ehemann V,Muto S

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Approximately 5% of patients with cutaneous squamous cell carcinoma (CSCC) may develop recurrent or metastatic disease. The management of such cases is challenging and requires multi-disciplinary care. Immunotherapy using PD-1 inhibition was approved to treat unresectable or metastatic CSCC in 2018. Given limit...

journal_title：Journal of cancer research and clinical oncology

authors： In GK,Vaidya P,Filkins A,Hermel DJ,King KG,Ragab O,Tseng WW,Swanson M,Kokot N,Lang JE,Menendez L,DeClerck B,Kim G,Hu JC,Terando A,Jadvar H,Ricker C,Miller KA,Peng DH,Wysong A

更新日期：2020-11-18 00:00:00

abstract：PURPOSE:Triple (ER-, PR-, HER2-) negative breast carcinoma lack targeted therapies, making this group of tumors difficult to treat. By definition, the lack of HER2 expression means a case scoring 0 or 1+ after immunophenotypical analysis and makes the patients avoiding therapeutical chances with anti-HER2 inhibitors. W...

journal_title：Journal of cancer research and clinical oncology

authors： Brunello E,Bogina G,Bria E,Vergine M,Zamboni G,Pedron S,Daniele I,Furlanetto J,Carbognin L,Marconi M,Manfrin E,Ibrahim M,Miller K,Tortora G,Molino A,Jasani B,Beccari S,Bonetti F,Chilosi M,Martignoni G,Brunelli M

更新日期：2013-09-01 00:00:00

abstract：:The antigen complex A60 of Mycobacterium bovis bacillus Calmette-Guérin protected mice against experimental tuberculous infection, and prevented cancer development after challenge with EMT 6 cells. Although humoral and cellular immune reactions elicited by A60 in vivo remained unaffected in cases of tumor rejection, t...

journal_title：Journal of cancer research and clinical oncology

authors： Maes H,Cocito C

更新日期：1996-01-01 00:00:00

abstract：:Cell proliferation kinetics of the urinary bladder urothelium have been analyzed in a total of 218 female Wistar rats after partial cystectomy. After one-third resection of the bladder DNA synthesis started 15 h postoperatively in the bladder stump and reached its maximum at 25 h with a mean 3H-TdR index of 10.1%. In ...

journal_title：Journal of cancer research and clinical oncology

authors： Kunze E,Albrecht H,Wöltjen HH,Schauer A

更新日期：1979-10-01 00:00:00

abstract：PURPOSE:The majority of patients with germ cell tumors are cured by multimodality therapy that consists of cisplatin-based chemotherapy and/or surgical resection. Serum tumor markers and conventional radiographs are utilized to stratify patients into treatment categories. Efforts to individualize chemotherapy or minimi...

journal_title：Journal of cancer research and clinical oncology

authors： Amato R,Kim EE,Prow D,Andreopoulos D,Kasi LP

更新日期：2000-03-01 00:00:00

abstract：:Primary CNS lymphomas (PCNSL), until recently representing about 1% of all brain tumors, show dramatically increased incidence both in high-risk groups (immunocompromised, AIDS) and in the general population. They are extranodal diffuse non-Hodgkin's lymphomas, the morphology and classification of which are identical ...

journal_title：Journal of cancer research and clinical oncology

authors： Jellinger KA,Paulus W

更新日期：1992-01-01 00:00:00

abstract：:In the supernatant of melanoma cell culture SK mel 25 three indolic compounds - 5-hydroxy-6-methoxyindole, 5-hydroxy-6-methoxyindolyl-2-carboxylic, and 6-hydroxy-5-methoxyindolyl-2-carboxylic acids - have been identified. The supernatants were extracted with ethyl acetate, derivatized, and analyzed by gas chromatograp...

journal_title：Journal of cancer research and clinical oncology

authors： Pavel S,Muskiet FA,de Ley L,The TH,van der Slik W

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to identify novel genes following genomic DNA copy number changes using a genome-wide array-based comparative genomic hybridization (array-CGH) analysis in uterine leiomyosarcoma (ULMS). METHODS:Genomic DNA copy number changes were analyzed in 15 cases of ULMS from St Mary's Hospita...

journal_title：Journal of cancer research and clinical oncology

authors： Raish M,Khurshid M,Ansari MA,Chaturvedi PK,Bae SM,Kim JH,Park EK,Park DC,Ahn WS

更新日期：2012-07-01 00:00:00

abstract：:A total of 45 cases of bone tumors and tumor-like lesions were studied in order to determine the expression of an HLA-DR antigen by the monoclonal antibody 910-D-7, and its possible correlation with histology, using the indirect immunoperoxidase method on frozen sections. The pattern of antigen expression was nearly c...

journal_title：Journal of cancer research and clinical oncology

authors： Petzsch M,Vassallo J,Roessner A,Zwadlo G,Sorg C,Vollmer E,Grundmann E

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To explore the appropriate method of mediastinal lymph node dissection for selected clinical stage IA (cIA) non-small cell lung cancer (NSCLC). METHODS:From 1998 through 2002, the curative-intent surgery was performed to 105 patients with cIA NSCLC who had been postoperatively identified as pathologic-stage T1...

journal_title：Journal of cancer research and clinical oncology

authors： Ma K,Chang D,He B,Gong M,Tian F,Hu X,Ji Z,Wang T

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To investigate the expression of sex steroid receptors in gastric cancer and to correlate their tumor expression profile with the clinicopathological parameters and overall survival of the patients. METHODS:Immunohistochemical methodology was employed in formalin-fixed paraffin-embedded sections from 86 patien...

journal_title：Journal of cancer research and clinical oncology

authors： Kominea A,Konstantinopoulos PA,Kapranos N,Vandoros G,Gkermpesi M,Andricopoulos P,Artelaris S,Savva S,Varakis I,Sotiropoulou-Bonikou G,Papavassiliou AG

更新日期：2004-05-01 00:00:00

abstract：:The role of DNA adducts in the initiation of cancer is scrutinized in this presentation. Work on the activation of oncogenes, particularly on ras, has provided new evidence to link DNA adducts and tumour formation. Polycyclic hydrocarbons and nitroso compounds can cause activation of ras oncogenes through a defined po...

journal_title：Journal of cancer research and clinical oncology

authors： Hemminki K,Försti A,Mustonen R,Savela K

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To analyse hepcidin serum and urine levels during radiotherapy for prostate cancer. METHODS:In 18 patients undergoing radiotherapy for prostate cancer, blood, plasma, and urine samples were taken before and during radiotherapy. Complete blood cell count, pro-hepcidin-, ferritin-, transferrin-, IL-1beta-, IL-6-...

journal_title：Journal of cancer research and clinical oncology

authors： Christiansen H,Saile B,Hermann RM,Rave-Fränk M,Hille A,Schmidberger H,Hess CF,Ramadori G

更新日期：2007-05-01 00:00:00

abstract：:159 "poor risk" patients with previously untreated small cell lung cancer were entered into a randomised study of intravenous bolus versus continuous infusion chemotherapy with doxorubicin on weeks 1, 3, 5 and ifosfamide with mesna on weeks 2, 4, 6. Oral etoposide was given on days 1-5, 15-19, and 29-33. There was no ...

journal_title：Journal of cancer research and clinical oncology

authors： Anderson H,Prendiville J,Thatcher N,Radford JA,Swindell R

更新日期：1991-01-01 00:00:00

abstract：:An in vitro double-labeling technique for determination of kinetic growth parameters was tested; 13 renal sarcomas of rats were incubated after excision under standardized conditions with 14C- and 3H-thymidine successively. Another ten tumors were evaluated after in vivo double injection of 14C and 3H-thymidine into s...

journal_title：Journal of cancer research and clinical oncology

authors： Lang W,Kienzle S,Georgii A

更新日期：1983-01-01 00:00:00

abstract：:Trace metals are essential for the growth and several other properties of human lymphocytes. We studied the effects of media with variable concentrations of three metals (Fe2+, Cu2+, Zn2+), a metal chelator (deferoxamine, DFX) and a cell-growth inhibitor (hydroxyurea) on the growth, intracellular metal concentration a...

journal_title：Journal of cancer research and clinical oncology

authors： Oblender M,Carpentieri U

更新日期：1991-01-01 00:00:00

abstract：:Modulation of 5-fluorouracil (5-FU) is currently being investigated in advanced colorectal cancer. In an attempt to improve the results obtainable for the association of 5-FU and leucovorin, we decided to add cisplatin to 5-FU and (6S)-leucovorin (S-LV) after disease progression. The hypothesis was that a pharmacologi...

journal_title：Journal of cancer research and clinical oncology

authors： Cassano A,Pozzo C,Corsi DC,Fontana T,Noviello MR,Astone A,Barone C

更新日期：1995-01-01 00:00:00