Overexpressed CA12 has prognostic value in pancreatic cancer and promotes tumor cell apoptosis via NF-κB signaling.

abstract：:P-glycoprotein (P-gp), a cell membrane protein, has been found in multidrug-resistant cancer cells. A total of 104 smears from patients with breast-cancer-associated pleural effusions and ovarian-cancer-related peritoneal effusions were studied for P-gp with the antibody C-219 and the avidin-biotin-immunoperoxidase me...

journal_title：Journal of cancer research and clinical oncology

authors： Athanassiadou P,Athanassiades P,Petrakakou E,Zerva C,Mavrikakis M

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Previous studies showed poorer survival in T4 disease with residual lesion. To evaluate the efficacy and toxicity of a boost dose for T4 nasopharyngeal carcinoma (NPC), patients with a residual primary lesion after intensity-modulated radiotherapy (IMRT). METHODS:398 T4 NPC patients with residual primary le...

journal_title：Journal of cancer research and clinical oncology

authors： Fei Z,Xu T,Qiu X,Li M,Chen T,Li L,Huang C,Chen C

更新日期：2021-01-03 00:00:00

abstract：:Cell proliferation kinetics of the urinary bladder urothelium have been analyzed in a total of 218 female Wistar rats after partial cystectomy. After one-third resection of the bladder DNA synthesis started 15 h postoperatively in the bladder stump and reached its maximum at 25 h with a mean 3H-TdR index of 10.1%. In ...

journal_title：Journal of cancer research and clinical oncology

authors： Kunze E,Albrecht H,Wöltjen HH,Schauer A

更新日期：1979-10-01 00:00:00

abstract：OBJECTIVE:Renal cell carcinoma (RCC) is the most common malignancy of the urinary system, and it is a serious threat to human health. HOXA transcript at the distal tip (HOTTIP), located at the 5' end of the HOXA locus, is a long non-coding RNA that has been newly discovered in recent years. It has been reported to prom...

journal_title：Journal of cancer research and clinical oncology

authors： Su Y,Lu J,Chen X,Liang C,Luo P,Qin C,Zhang J

更新日期：2019-03-01 00:00:00

abstract：:To evaluate the epidermal growth factor receptor (EGFR) protein expression, gene mutations and amplification as predictors of clinical outcome in patients with non-small-cell lung cancer (NSCLC) receiving gefitinib, we have performed fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). We investig...

journal_title：Journal of cancer research and clinical oncology

authors： Sasaki H,Endo K,Okuda K,Kawano O,Kitahara N,Tanaka H,Matsumura A,Iuchi K,Takada M,Kawahara M,Kawaguchi T,Yukiue H,Yokoyama T,Yano M,Fujii Y

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:Acute intestinal damage induced by chemotherapeutic agent is often a dose-limiting factor in clinical cancer therapy. The aim of this study was to investigate the effect of chemokine CXCL9 on the intestinal damage after chemotherapy and explore the therapeutic potential of anti-CXCL9 agents. METHODS:In vitro c...

journal_title：Journal of cancer research and clinical oncology

authors： Lu H,Liu H,Wang J,Shen J,Weng S,Han L,Sun T,Qian L,Wu M,Zhu S,Yu Y,Han W,Zhu J,Moldenhauer A

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in gastric cancer patients. METHODS:A systematic literature search was conducted to identify eligible studies in PubMed and Embase. The pooled hazard ratios (HRs) or odds ratios (ORs) with their correspond...

journal_title：Journal of cancer research and clinical oncology

authors： Wei K,Jiang L,Wei Y,Wang Y,Qian X,Dai Q,Guan Q

更新日期：2015-04-01 00:00:00

abstract：:The genetically engineered chimeric cB72.3m4 and cB72.3m12 antibodies recognize the same tumor-associated TAG72 antigen. The high-affinity cB72.3m4 antibody had an approximately 18-fold higher affinity constant for the TAG72 antigen than the low-affinity cB72.3m12 antibody. The relationship between antibody affinity a...

journal_title：Journal of cancer research and clinical oncology

authors： Qi Y,Matte G,Wilkinson A,Jim X

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:E- and P-selectins, expressed on vascular endothelium, and their sialyl-Lewis(x )(sLe(x))- and/or sialyl-Lewis(a) (sLe(a))-containing ligands have a crucial role in extravasation and metastasis of circulating cells. We wanted to analyse the role of selectins and their ligands in head and neck tumours. METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Renkonen J,Mäkitie A,Paavonen T,Renkonen R

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:Angiosarcoma of the scalp and face is a rare malignant endothelial tumor arising mainly in elderly people. The prognosis is poor. Effective and safe treatments are warranted. METHODS:A 79-year-old woman with an angiosarcoma of the scalp larger than 5 cm in diameter was treated with intravenous liposomal doxoru...

journal_title：Journal of cancer research and clinical oncology

authors： Wollina U,Füller J,Graefe T,Kaatz M,Lopatta E

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:The t(11;18)(q21;q21) chromosome translocation is frequent in gastric MALT lymphoma, but the t(11;18)(q21;q21) chromosome translocation is very rare in other sites of MALT lymphomas. We investigated the possibility that MALT lymphoma occurred in the right buccal mucosa of a 66-year-old Japanese woman who had th...

journal_title：Journal of cancer research and clinical oncology

authors： Tanaka T,Iino M

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To establish a hepatocellular carcinoma (HCC) cell line from lung metastatic lesions of human HCC in nude mice so as to provide a suitable model for the study of lung-metastasis-related molecular mechanisms. METHODS:HCC clone cells MHCC97-H were inoculated into BALB/c nude mice, and the pulmonary metastatic le...

journal_title：Journal of cancer research and clinical oncology

authors： Li Y,Tang Y,Ye L,Liu B,Liu K,Chen J,Xue Q

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly remain unknown. This study was aimed to investigate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of p...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang ZM,Wang Y,Huang R,Liu YP,Li X,Hu FL,Zhu L,Wang F,Cui BB,Dong XS,Zhao YS

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:To explore the value of Prostate Imaging Reporting and Data System Version 2 (PI-RADS v2) for predicting prostate biopsy results in patients with prostate specific antigen (PSA) levels of 4-10 ng/ml. METHODS:We retrospectively reviewed multi-parameter magnetic resonance images from 528 patients with PSA levels...

journal_title：Journal of cancer research and clinical oncology

authors： Xu N,Wu YP,Chen DN,Ke ZB,Cai H,Wei Y,Zheng QS,Huang JB,Li XD,Xue XY

更新日期：2018-05-01 00:00:00

abstract：:Lambda-DNA and plasmid pBR 322-DNA, respectively, were treated in vitro with increasing amounts of 4-S-ethanolsulfido-cyclophosphamide (CPA-P1). Subsequent digestion with restriction endonuclease Pvu II or Mbo II revealed discrete alterations in the cleavage patterns as compared to the controls, indicating subtle chan...

journal_title：Journal of cancer research and clinical oncology

authors： Lindemann H

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Significant prolongation of overall survival (OS) has been reached in metastatic colorectal cancer (mCRC) treatment within the last 5-10 years. Our study was conducted in order to evaluate and compare OS of different standard of care treatment options in a university-based outpatient clinic. METHODS:One hundre...

journal_title：Journal of cancer research and clinical oncology

authors： Moehler M,Thomaidis T,Zeifri C,Barhoom T,Marquardt J,Ploch P,Schattenberg J,Maderer A,Schimanski CC,Weinmann A,Woerns MA,Kranich AL,Warnecke JM,Galle PR

更新日期：2015-03-01 00:00:00

abstract：:The nuclear DNA content (DNA ploidy) level was determined in a series of 83 human brain metastases, for which 35 complete clinical follow-ups were available. The DNA ploidy level determination was carried out by means of DNA histogram types. The results show that certain brain metastases were diploid, while others exh...

journal_title：Journal of cancer research and clinical oncology

authors： Kiss R,Rorive S,Camby I,Pasteels JL,Brotchi J,Salmon I

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndromes (MDS) are mainly a disease of the elderly. Commonly, MDS patients are treated in an outpatient setting making hematological/oncological private practices (PP) an important backbone in the management of MDS patients. METHODS:To gain more insights into the characteristics of patients...

journal_title：Journal of cancer research and clinical oncology

authors： Nolte F,Schumann C,Klein S,Reinwald M,Hofmann WK

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:Sec8, a component of the exocyst complex, has been implicated in tethering of secretory vesicles to specific regions on the plasma membrane. To investigate the involvement of Sec8 in oral squamous-cell carcinoma (OSCC), we evaluated the expression status and effect of Sec8 in OSCC cell lines. METHODS:Sec8 mRNA...

journal_title：Journal of cancer research and clinical oncology

authors： Yamamoto A,Kasamatsu A,Ishige S,Koike K,Saito K,Kouzu Y,Koike H,Sakamoto Y,Ogawara K,Shiiba M,Tanzawa H,Uzawa K

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:We sought to characterize the clinical features and management of patients diagnosed as Kaposiform hemangioendothelioma (KHE) without cutaneous involvement. METHODS:The electronic patient chats at six Triple A hospitals in China were searched to find all patient diagnoses with KHE without cutaneous involvement...

journal_title：Journal of cancer research and clinical oncology

authors： Ji Y,Chen S,Li L,Yang K,Xia C,Li L,Yang G,Kong F,Lu G,Liu X

更新日期：2018-12-01 00:00:00

abstract：:The concentration of estrogen receptor protein (ER) in 113 primary or metastatic breast cancers was studied. ER was found to be correlated with the age of the patient. The ER values were generally lower in premenopausal patients (5.6 fmol/mg cytosol protein) than in postmenopausal patients (32.8 fmol/mg cytosol protei...

journal_title：Journal of cancer research and clinical oncology

authors： Johansson R,Vanharanta R,Söderholm J

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the frequency of second primary non-breast cancer after breast cancer diagnosis and treatment, and its correlation with clinicopathological features. METHODS:Data from 21,527 patients with primary breast cancer were collected retrospectively in a single cancer centre; 4.1% o...

journal_title：Journal of cancer research and clinical oncology

authors： Corso G,Veronesi P,Santomauro GI,Maisonneuve P,Morigi C,Peruzzotti G,Intra M,Sacchini V,Galimberti V

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Maintaining telomeres by recruiting telomerase-to-chromosome ends is essential for cancer cell survival. Inhibiting telomerase recruitment to telomeres represents a novel strategy for telomere-based lung cancer therapy. However, approaches for interrupting telomerase recruitment for cancer therapy still need to...

journal_title：Journal of cancer research and clinical oncology

authors： Zhu J,Liu W,Chen C,Zhang H,Yue D,Li C,Zhang L,Gao L,Huo Y,Liu C,Giaccone G,Zhang B,Wang C

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Alterations in the cell cycle regulatory p16INK4a/Cyclin D1/pRb pathway play a pivotal role in tumorigenesis. Knowledge of alterations in the tumor suppressor protein pRb and its negative regulator, p16CDKN2/MTS1/INK4a in esophageal squamous cell carcinoma (ESCC) from the Indian subcontinent is meager. To gain ...

journal_title：Journal of cancer research and clinical oncology

authors： Ralhan R,Mathew R,Arora S,Bahl R,Shukla NK,Mathur M

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:Tumor angiogenesis is an important factor for the continuous growth of human malignancies and can be used to predict the prognosis for patients. In the current study, we examined the expression of EGF-like domain 7 (EGFL7), an endothelial cell-derived secreted factor, in malignant gliomas and explored its clini...

journal_title：Journal of cancer research and clinical oncology

authors： Huang CH,Li XJ,Zhou YZ,Luo Y,Li C,Yuan XR

更新日期：2010-11-01 00:00:00

abstract：:Preoperative cytologic examinations were performed on bronchial material from 92 patients with postsurgical (pathologic) stage I (American Joint Committee) adenocarcinoma of the lung. All patients were followed up for at least 5 years or until death; thus, cases of adenocarcinoma metastatic to the lungs were virtually...

journal_title：Journal of cancer research and clinical oncology

authors： Bjornsson J,Goellner JR,Williams DE,Scheiber MV

更新日期：1986-01-01 00:00:00

abstract：:A novel butyric acid derivative, pivaloyloxymethyl butyrate, AN-9, was previously shown to be a potent differentiating agent. AN-9 exerts a significant anticancer activity in vitro and in vivo. In all the activities examined, AN-9 was more potent than butyric acid. Here we show that AN-9 and butyric acid induce cell d...

journal_title：Journal of cancer research and clinical oncology

authors： Zimra Y,Wasserman L,Maron L,Shaklai M,Nudelman A,Rephaeli A

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:This study aimed to establish new criteria for limited resection of non-small cell lung cancer (NSCLC) based on computed tomography findings and maximum standardized uptake value (SUVmax). METHODS:Between December 2007 and December 2015, 611 patients underwent lung cancer surgery; of these, 70 with cT1aN0M0 wh...

journal_title：Journal of cancer research and clinical oncology

authors： Aragaki M,Hida Y,Kato T,Fujiwara-Kuroda A,Kaga K,Wakasa S

更新日期：2020-11-05 00:00:00

abstract：PURPOSE:The aim of our study was to identify factors which influence survival in patients with disseminated seminoma in the good prognostic group according to IGCCCG, as well as to evaluate the impact of treatment intensification in patients with negative prognostic factors. METHODS:We analyzed the database of the pat...

journal_title：Journal of cancer research and clinical oncology

authors： Fedyanin M,Tryakin A,Bulanov A,Vybarava A,Tjulandina A,Chekini D,Sekhina O,Figurin K,Garin A,Tjulandin S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Bone morphogenetic proteins (BMPs) are multifunctional regulators of various cell functions. The BMP-signalling network plays a pivotal role during embryogenesis and tumorigenesis. BMPs, e.g. BMP-2 exert their biological function in a time and concentration-dependent manner but also modulated by the context of ...

journal_title：Journal of cancer research and clinical oncology

authors： Steinert S,Kroll TC,Taubert I,Pusch L,Hortschansky P,Höffken K,Wölfl S,Clement JH

更新日期：2008-11-01 00:00:00