Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.

abstract：:A brain metastasis of bronchial squamous cell carcinoma in a patient was cultivated. The cells with epithelium-like characteristics were selected from the primary culture, and were subcultured to establish a cell line. The cultured cells were identified to be neoplastic by means of heterologous transplantation to nude...

journal_title：Journal of cancer research and clinical oncology

authors： Takaki T

更新日期：1980-01-01 00:00:00

abstract：:Methods have been developed in an in vitro system (1) of assessing the number of disseminated tumor cells in peripheral blood and (2) of enriching tumor cells from peripheral blood samples for further characterization. Cells from three human carcinoma lines (E 14, ChaGo, and LEDWiDr) were mixed with leukocytes from no...

journal_title：Journal of cancer research and clinical oncology

authors： Schwartz R,Walk A,Toomes H,Schirrmacher V

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Molecular metastases are precursors of postoperative recurrence, detected by molecular-biological tools. Chemokines and their receptors contribute to dissemination and local immune recognition. A strong expression of the chemokine receptor CCR5 is associated with non-metastatic colorectal cancer and increase...

journal_title：Journal of cancer research and clinical oncology

authors： Schimanski CC,Moehler M,Gockel I,Zimmermann T,Lang H,Galle PR,Berger MR

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:Molecular mechanisms of response to hypomethylating agents in patients with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) still remain largely unknown. Therefore, the effects of 5-Azacytidine (Aza) on clonal architecture and DNA methylation were investigated in this study. METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Gawlitza AL,Speith J,Rinke J,Sajzew R,Müller EK,Schäfer V,Hochhaus A,Ernst T

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:Melanoma antigen gene A3 (MAGE-A3) is aberrantly expressed in a number of cancer types. Because of its high specificity, MAGE-A3 has shown to be a promising candidate for cancer immunotherapy. Dendritic cells (DCs) have emerged as the natural agents for antigen delivery. DCs transduced with antigen may increase...

journal_title：Journal of cancer research and clinical oncology

authors： Lin L,Wei J,Chen Y,Huang A,Li KK,Zhang W

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:In 2013, 2009, and 2006, the Arbeitsgemeinschaft Gynäkologische Onkologie evaluated the therapeutic approaches and the adherence to their guidelines for endometrial carcinoma (EC) in Germany. Here, we present the results concerning the surgical procedures. METHODS:A questionnaire was developed and sent to 682 ...

journal_title：Journal of cancer research and clinical oncology

authors： Battista MJ,Schmidt M,Rieks N,Steetskamp J,Sicking I,Lebrecht A,Koelbl H,Mallmann P,Hoffmann G,Steiner E

更新日期：2014-12-01 00:00:00

abstract：:The expression of mRNAs for epidermal growth factor (EGF), transforming growth factor alpha(TGF alpha), EGFR, platelet-derived growth factor (PDGF) A and B chain, PDGF receptor (PDGFR), transforming growth factor beta (TGF beta), erbB-2 and estrogen receptor (ER) genes was first examined in 6 human esophageal carcinom...

journal_title：Journal of cancer research and clinical oncology

authors： Yoshida K,Kuniyasu H,Yasui W,Kitadai Y,Toge T,Tahara E

更新日期：1993-01-01 00:00:00

abstract：:General principles for anticancer drug development include traditional drug-screening methods in biological test systems. Today, testing of a drug in a panel of selected human tumor xenografts in mice is assumed to have the best predictive value for clinical efficacy. Chemical modification of well-known antitumor drug...

journal_title：Journal of cancer research and clinical oncology

authors： Unger C

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Alzheimer disease (AD) and cancer are seemingly two opposite ends of one spectrum. Studies have suggested that patients with AD showed a reduced risk of cancer and vice versa. However, available evidences are not conclusive. So we conducted a meta-analysis using published literatures to systematically examine c...

journal_title：Journal of cancer research and clinical oncology

authors： Shi HB,Tang B,Liu YW,Wang XF,Chen GJ

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Insulin-like growth factor 1 (IGF-1) stimulates mitosis and inhibits apoptosis. High circulating IGF-1 levels are linked with an increased risk of colorectal and breast cancer. Recently, IGF-1 single nucleotide polymorphisms (SNPs), especially variant rs2946834, have been associated with poor clinical outcome i...

journal_title：Journal of cancer research and clinical oncology

authors： Muendlein A,Lang AH,Geller-Rhomberg S,Winder T,Gasser K,Drexel H,Decker T,Mueller-Holzner E,Chamson M,Marth C,Hubalek M

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Treatment for malignant ascites in advanced ovarian cancer (OC) patients remains controversial. The objective of this study was to investigate the efficacy of combined continuous circulatory hyperthermic intraperitoneal chemotherapy (HIPEC) preceded or followed by cytoreductive surgery (CRS) f...

journal_title：Journal of cancer research and clinical oncology

authors： Ba M,Long H,Zhang X,Tang Y,Wu Y,Yu F,Wang S,Cui S

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:The ENEST1st sub-analysis presents data based on Philadelphia chromosome (Ph) status, i.e., Ph+ and Ph-/BCR-ABL1 + chronic myeloid leukemia. METHODS:Patients received nilotinib 300 mg twice daily, up to 24 months. RESULTS:At screening, 983 patients were identified as Ph+ and 30 patients as Ph-/BCR-ABL + based...

journal_title：Journal of cancer research and clinical oncology

authors： Hochhaus A,Mahon FX,le Coutre P,Petrov L,Janssen JJWM,Cross NCP,Rea D,Castagnetti F,Hellmann A,Rosti G,Gattermann N,Coronel MLP,Gutierrez MAE,Garcia-Gutierrez V,Vincenzi B,Dezzani L,Giles FJ

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the prognostic significance of the absolute natural killer (NK) cell counts in peripheral blood in patients with chronic lymphocytic leukemia (CLL). METHODS:A total of 273 previously untreated patients with CLL from April 2004 and October 2015 were enrolled into this re...

journal_title：Journal of cancer research and clinical oncology

authors： Wang WT,Zhu HY,Wu YJ,Xia Y,Wu JZ,Wu W,Liang JH,Wang L,Fan L,Li JY,Xu W

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Kaposi's sarcoma (KS) is a proliferative process of suspected viral aetiology associated with immune deficiency. In transplanted patients, lesions regress on discontinuation of immunosuppressive therapy. The purpose of this work was to analyse the expression of the p53 oncosuppressor gene product, a proliferati...

journal_title：Journal of cancer research and clinical oncology

authors： Flamini G,Magalini S,Curigliano G,Nanni G,Boninsegna A,Agnes S,Faticato D,Castagneto M,Cittadini A

更新日期：1997-01-01 00:00:00

abstract：:Correlations between exposure to vinyl chloride and the development of malignant tumors in the liver have been know since 1974 and have been confirmed by many an experimental investigation. Based on the evaluation of mortality statistics from nine different countries an increased incidence of malignant tumors of the l...

journal_title：Journal of cancer research and clinical oncology

authors： Emmerich KH,Norpoth K

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor that usually occurs in infants. It is commonly associated with Kasabach-Merritt phenomenon which is directly responsible for the significant morbidity and mortality, including hemodynamic instability, local invasion, and compression...

journal_title：Journal of cancer research and clinical oncology

authors： Kai L,Wang Z,Yao W,Dong K,Xiao X

更新日期：2014-03-01 00:00:00

abstract：:This article summarizes the various current uses of cytokines, and bone marrow and peripheral blood stem cell transplantation for cancer treatment. Interferons, interleukin-2 and hematopoietic growth factors are extensively used for the treatment of hematopoietic as well as nonhematopoietic malignancies, either as the...

journal_title：Journal of cancer research and clinical oncology

authors： Takaku F

更新日期：1995-01-01 00:00:00

abstract：:Passively administered and actively induced antibodies have been associated with the eradication of circulating tumor cells and micrometastases in mice and humans. We have identified a series of cell surface carbohydrate and peptide antigens on melanomas, sarcomas, and cancer of the breast, prostate. ovary, and lung t...

journal_title：Journal of cancer research and clinical oncology

authors： Musselli C,Livingston PO,Ragupathi G

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:Mutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and prognostic effects of TP53 mutations in certain cancers. METHODS:Over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer (IARC) TP...

journal_title：Journal of cancer research and clinical oncology

authors： Li VD,Li KH,Li JT

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndromes (MDS) are mainly a disease of the elderly. Commonly, MDS patients are treated in an outpatient setting making hematological/oncological private practices (PP) an important backbone in the management of MDS patients. METHODS:To gain more insights into the characteristics of patients...

journal_title：Journal of cancer research and clinical oncology

authors： Nolte F,Schumann C,Klein S,Reinwald M,Hofmann WK

更新日期：2012-06-01 00:00:00

abstract：:Among several nucleosides, adenosine is the only one to induce typical apoptotic cell death in human promyelocytic leukemia HL-60 cells. Intracellularly transported adenosine seemed to be required for the induction of apoptosis, since dipyridamole, which inhibits the transport of adenosine, strongly suppressed apoptos...

journal_title：Journal of cancer research and clinical oncology

authors： Kim KT,Yeo EJ,Choi H,Park SC

更新日期：1998-01-01 00:00:00

abstract：:The aim of this study was to correlate chemotherapy-induced nausea and vomiting (CINV) with commonly occurring single nucleotide polymorphisms (SNP) in the 5-hydroxytryptamine receptor 3 genes (HTR3). Women with breast cancer without previous chemotherapy were eligible for this prospective study. All patients received...

journal_title：Journal of cancer research and clinical oncology

authors： Fasching PA,Kollmannsberger B,Strissel PL,Niesler B,Engel J,Kreis H,Lux MP,Weihbrecht S,Lausen B,Bani MR,Beckmann MW,Strick R

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:To establish more effective diagnostic procedures to identify the characteristic features of abdominopelvic tuberculosis (APTB) mimicking advanced ovarian cancer. METHODS:A retrospective review of 20 cases of APTB mimicking advanced ovarian cancer was undertaken. RESULTS:The mean age of the patients was 28....

journal_title：Journal of cancer research and clinical oncology

authors： Xi X,Shuang L,Dan W,Ting H,Han MY,Ying C,Quan M,Sun C,Chen Z,Cui F,Ming C,Zhou JF,Xuan WS,Lu YP,Ma D

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Our goal was to prospectively evaluate self-reported quality-of-life (QoL) during second-line therapy in 51 consecutive patients with cytokine-refractory kidney cancer treated with sorafenib or sunitinib. METHODS:QoL was assessed by the EORTC QoL questionnaire QLQ-C30 at baseline and at weeks 4, 6, 10, 12 and ...

journal_title：Journal of cancer research and clinical oncology

authors： Herrmann E,Gerss J,Bierer S,Köpke T,Bolenz C,Hertle L,Wülfing C

更新日期：2009-01-01 00:00:00

abstract：:Metabolic activation steps involved in carcinogenesis by several aromatic amines, their N-acetylated derivatives, and dialkylnitrosamines are reviewed. N-Hydroxylation is the first activation step in the carcinogenesis by 2-acetylaminofluorene (AAF), other aromatic amides and amines. The cytochrome P-450 enzyme system...

journal_title：Journal of cancer research and clinical oncology

authors： Lotlikar PD

更新日期：1981-01-01 00:00:00

abstract：:Rat 13672 mammary carcinoma tumors were grown subcutaneously in the hind legs of female Fischer 344 rats to a volume of about 1 cm3. Tumor oxygenation was measured using an Eppendorf PO2 histograph. Tumor oxygen measurements were made under four conditions: (a) normal air breathing, (b) carbogen breathing, (c) after i...

journal_title：Journal of cancer research and clinical oncology

authors： Teicher BA,Sotomayor EA,Dupuis NP,Kusumoto T,Menon K

更新日期：1994-01-01 00:00:00

abstract：:The regulatory influence of medroxyprogesterone acetate (MPA) on estrogen and androgen receptors of the human breast cancer cell lines MCF-7 and EFM-19 was explored in conjunction with the growth-promoting properties of these steroids. In the absence of steroidal stimulation, up to 1 microM MPA had no effect on the pr...

journal_title：Journal of cancer research and clinical oncology

authors： Hackenberg R,Hofmann J,Wolff G,Hölzel F,Schulz KD

更新日期：1990-01-01 00:00:00

abstract：:Chemically induced (autochthonous) tumors in the rodent are thought to be the best models at hand to obtain results transferable to the clinical situation. Four different autochthonous tumor models: 1,2-dimethylhydrazine, N-methylnitrosourea (MNU), N-methyl-N-nitro-nitrosoguanidine (MNNG), and N-nitroso-acetoxymethyl-...

journal_title：Journal of cancer research and clinical oncology

authors： Amberger H

更新日期：1986-01-01 00:00:00

abstract：:Sarcoma 180 tumor tissue from C57 mice was processed in a soft agar clonogenic assay immediately after removal from the animal and after various methods of storage. The sensitivity to the antineoplastic drug cis-platinum was not affected by different storage methods. The highest yield of colony forming cells per 100 m...

journal_title：Journal of cancer research and clinical oncology

authors： Krischke W,Hartmann R,Schneider M,Schönenberger H

更新日期：1988-01-01 00:00:00

abstract：:We describe a slide assay that allows the demonstration of antigens localized in the nucleus from isolated white blood cells as well as from single tumor cells derived from malignant effusions. With the antibodies Ki-67 and anti-p-145 an increased rate of nuclear and nucleolar staining resulted in cells from highly ma...

journal_title：Journal of cancer research and clinical oncology

authors： Hirsch FW,Deibert P,Busch H,Löhr GW,Bross KJ

更新日期：1991-01-01 00:00:00