Malignant tumors after chronic exposure to vinyl chloride.

abstract：PURPOSE:To investigate the genomic alterations in larynx carcinomas (LaCa) tissues and its prognostics values in predicting survival. METHODS:To analyse the aberrations in the genome of LaCa patients, we used array comparative genomic hybridization in 19 human laryngeal tumour samples. DNA samples were also subjected ...

journal_title：Journal of cancer research and clinical oncology

authors： Peralta R,Baudis M,Vazquez G,Juárez S,Ortiz R,Decanini H,Hernandez D,Gallegos F,Valdivia A,Piña P,Salcedo M

更新日期：2010-06-01 00:00:00

abstract：:The effects of three non-myelotoxic cancer drugs on the growth of neuroblastoma cells were investigated in vitro and in vivo: dihydroxyphenylalanine (L-dopa, a drug with selective toxicity for melanoma cells), DL-buthionine sulphoximine (BSO, a drug with radiosensitizing effects), and tamoxifen (a drug used in the tre...

journal_title：Journal of cancer research and clinical oncology

authors： Busse E,Bartsch O,Kornhuber B

更新日期：1991-01-01 00:00:00

abstract：:Reversal of natural resistance to bouvardin (NSC 259968) has been attained in vitro and in vivo, by the calcium influx blocker verapamil in sarcoma 180 cells insensitive to bouvardin. Verapamil increased the in vitro lethality of the tumor cells following exposure with cells for 1 and 3 h as a result of the cytotoxic ...

journal_title：Journal of cancer research and clinical oncology

authors： Chitnis MP,Menon RS,Basrur VS,Adwankar MK,Satyamoorthy K

更新日期：1985-01-01 00:00:00

abstract：:After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carcinomas in female rats (SIV 50). This change of the organ-specific carcinogenic effect is not observed in exper...

journal_title：Journal of cancer research and clinical oncology

authors： Schweinsberg F,Kouros M,Manncke K

更新日期：1979-10-01 00:00:00

abstract：:To date, all risk assessment studies on benzene have been based almost exclusively on epidemiological data. We have attempted a more integrated and quantitative evaluation of carcinogenic risk for humans, trying to utilize, in addition to the epidemiological data, all data available, specifically data on metabolism, g...

journal_title：Journal of cancer research and clinical oncology

authors： Grilli S,Lutz WK,Parodi S

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:The TNM classification is used to assess cancers of the oral cavity, and advancements in imaging techniques have revealed clear variations in tumor volume at presentation. This study therefore aimed to clarify whether preoperative imaging, with exact measurements of the tumor, could affect post-surgery survival...

journal_title：Journal of cancer research and clinical oncology

authors： Mücke T,Mitchell DA,Ritschl LM,Tannapfel A,Wolff KD,Kesting MR,Loeffelbein DJ,Kanatas A

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To study the surgical outcomes of patients with a second primary lung cancer after the extrapulmonary malignancy. MATERIALS AND METHODS:Patients who underwent surgical resection for lung cancers between January 2005 and December 2014 were reviewed. Clinical data, imaging characteristics of tumors, surgical a...

journal_title：Journal of cancer research and clinical oncology

authors： Ko KH,Huang HK,Chen YI,Chang H,Tsai WC,Huang TW

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Since continuous relapse rates are characteristic for advanced low-grade non-Hodgkin's lymphomas (NHL), their treatment remains a problem. Previous phase II studies showed that bendamustine induced high remission rates in pre-treated low-grade NHL. To further examine its efficacy and side effects, bendamustine ...

journal_title：Journal of cancer research and clinical oncology

authors： Bremer K

更新日期：2002-11-01 00:00:00

abstract：:Human ovarian cancer cells from ten patients were cultured in the agar double layer assay as described by Hamburger and Salmon and in a methylcellulose monolayer system. The assays were compared under the same experimental conditions. The rate of positives (defined as greater than 30 colonies/dish) was 75% in the meth...

journal_title：Journal of cancer research and clinical oncology

authors： Runge HM,Neumann HA,Bücke W,Pfleiderer A

更新日期：1985-01-01 00:00:00

abstract：:The antitumor and anti-metastatic effects of a potent angiogenesis inhibitor, O-(chloroacetyl-carbamoyl)fumagillol (TNP-470), was investigated in a highly metastatic model of human hepatocellular carcinoma-LCI-D20. Small pieces of LCI-D20 tumor tissue were implanted subcutaneously into the right axillary region of 24 ...

journal_title：Journal of cancer research and clinical oncology

authors： Xia JL,Yang BH,Tang ZY,Sun FX,Xue Q,Gao DM

更新日期：1997-01-01 00:00:00

abstract：AIM:In men with adverse pathology after radical prostatectomy, the most appropriate timing to administer radiotherapy (RT) remains a topic of debate. We analyzed in terms of efficacy, prognostic factors and toxicity the two therapeutic strategies: immediate postoperative radiotherapy (PORT) and salvage radiotherapy (SA...

journal_title：Journal of cancer research and clinical oncology

authors： Detti B,Scoccianti S,Cassani S,Cipressi S,Villari D,Lapini A,Saieva C,Cai T,Pertici M,Giacomelli I,Livi L,Ceroti M,Nicita G,Carini M,Biti G

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Serum thyrotropin (TSH) is a well-established growth factor for thyroid nodules and suppression of TSH concentrations by administering exogenous thyroxine may interfere with the growth of established nodules as well as the formation of new thyroid nodules. The aim of this study was to investigate whether serum ...

journal_title：Journal of cancer research and clinical oncology

authors： Polyzos SA,Kita M,Efstathiadou Z,Poulakos P,Slavakis A,Sofianou D,Flaris N,Leontsini M,Kourtis A,Avramidis A

更新日期：2008-09-01 00:00:00

abstract：:In 361 Sprague-Dawley rats autochthonous colorectal carcinomas were induced by intrarectal application of the carcinogen AMMN. Tumor-bearing animals were treated with a synthetic thioether-lysophospholipid (TLP) derivative and in combination chemotherapy with 5-fluorouracil (5-FU) and carmustine (BCNU). There was no d...

journal_title：Journal of cancer research and clinical oncology

authors： Heim ME,Swoboda M,Pahlke W,Edler L,Bicker U

更新日期：1984-01-01 00:00:00

abstract：:Antinucleolar antisera were raised in rabbits, goats and sheep to nucleoli isolated from three human tumor cell lines. The antisera were shown to cross-react by immunofluorescence with human tumor cell lines originating from different organs and with frozen sections from a wide variety of human malignant and non-malig...

journal_title：Journal of cancer research and clinical oncology

authors： Greenfield RS,Lamon MO,Olech LJ,Grattan JA

更新日期：1989-01-01 00:00:00

abstract：:The carcinogenicity of long-term feeding of masheri extract to animals in a vitamin-A-sufficient (SLO+) and deficient (SLO-) state was studied in Sprague Dawley rats by feeding daily dose of 3 mg extract over a period of 21 months. The phase I activating enzymes, the glutathione (GSH)/glutathione S-transferase (GST) d...

journal_title：Journal of cancer research and clinical oncology

authors： Ammigan N,Nair UJ,Lalitha VS,Bhide SV

更新日期：1991-01-01 00:00:00

abstract：:Female wistar rats were fed on an Mg-deficient diet. After 8 to 10 weeks, the thymus glands were strongly degenerated and the number of lymphocytes was reduced, especially in the cortex. Thymus degeneration was associated with a decreased rate of DNA, RNA, and protein biosynthesis and necrosis and phagocytosis of lymp...

journal_title：Journal of cancer research and clinical oncology

authors： Averdunk R,Bippus PH,Günther T,Merker HJ

更新日期：1982-01-01 00:00:00

abstract：:After cure of rat leukemia L 5222 in 79 BD IX rats by single doses of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (Hydroxyethyl-CNU) a total of 9 rats (11%) developed secondary malignomas. ...

journal_title：Journal of cancer research and clinical oncology

authors： Zeller WJ,Schmähl D

更新日期：1979-09-01 00:00:00

abstract：PURPOSE:Natural killer (NK) cells can kill transformed cells and represent anti-tumor activities for improving the immunotherapy of cancer. In previous works, we established human interleukin-15 (hIL-15) gene-modified NKL cells (NKL-IL15) and demonstrated their efficiency against human hepatocarcinoma cells (HCCs) in v...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang W,Zhang C,Tian Z,Zhang J

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Members of paraneoplastic Ma (PNMA) family have been identified as onconeuronal antigens, which aberrant expressions in cancer cells of patients with paraneoplastic disorder (PND) are closely linked to manifestation of auto-immunity, neuro-degeneration, and cancer. The purpose of present study was to determine ...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YH,Pang SW,Poh CL,Tan KO

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:Multiple gastrointestinal stromal tumors (GISTs) rarely occur in patients with neurofibromatosis type 1 (NF-1). In contrast to sporadic GISTs characterized by frequent allelic losses of 1p, 14q and 22q and mutations of KIT or PDGFRA gene with the activation of the downstream RAS-MAPK pathway, the molecular path...

journal_title：Journal of cancer research and clinical oncology

authors： Yamamoto H,Tobo T,Nakamori M,Imamura M,Kojima A,Oda Y,Nakamura N,Takahira T,Yao T,Tsuneyoshi M

更新日期：2009-06-01 00:00:00

abstract：:The effect of a single blood transfusion on the formation and outgrowth of experimental lung metastases was assessed in two tumor models in rats. The transfusions were given either 1 week before (day -7) or 1 week after (day +7) tumor cell inoculation. The first approach was performed to investigate the effect of tran...

journal_title：Journal of cancer research and clinical oncology

authors： Marquet RL,de Bruin RW,Dallinga RJ,Singh SK,Jeekel J

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To study pre-treatment serum VEGF of patients with invasive cervical cancer and its possible role as prognostic indicator. METHODS:VEGF was measured using ELISA in the largest patient group (n = 167) to date. RESULTS:Serum VEGF was significantly higher in advanced tumor stage (P = 0.01), large tumor size (tum...

journal_title：Journal of cancer research and clinical oncology

authors： Zusterzeel PL,Span PN,Dijksterhuis MG,Thomas CM,Sweep FC,Massuger LF

更新日期：2009-02-01 00:00:00

abstract：:Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are markers of collagen absorption and LP is specific for collagen type I in bone. In the present study we evaluated the concentration of HP and LP in urine of patients with osteosarcoma ( n=20; age range 16-49 years) and chondrosarcoma ( n=15; age range 18-70 y...

journal_title：Journal of cancer research and clinical oncology

authors： Açil Y,Springer I,Behrens P,Ullrich KP,Hedderich J,Bruns J

更新日期：2003-10-01 00:00:00

abstract：:Lambda-DNA and plasmid pBR 322-DNA, respectively, were treated in vitro with increasing amounts of 4-S-ethanolsulfido-cyclophosphamide (CPA-P1). Subsequent digestion with restriction endonuclease Pvu II or Mbo II revealed discrete alterations in the cleavage patterns as compared to the controls, indicating subtle chan...

journal_title：Journal of cancer research and clinical oncology

authors： Lindemann H

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Two large, randomized, placebo-controlled trials (IRESSA NSCLC Trial Assessing Combination Therapy; INTACT 1 and 2) in non-small-cell lung cancer (NSCLC) failed to show survival benefit for gefitinib (IRESSA) in combination with first-line platinum-based chemotherapy. Epidermal growth factor receptor (EGFR) sta...

journal_title：Journal of cancer research and clinical oncology

authors： Giaccone G,Iacona RB,Fandi A,Janas M,Ochs JS,Herbst RS,Johnson DH

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To determine the potential involvement of ANXA1 in oral squamous-cell carcinoma (OSCC), we evaluated the ANXA1 protein expression in oral premalignant lesions (OPLs) and OSCCs and correlated the results with clinicopathologic variables. METHODS:Matched normal and tumour specimens of 44 primary OSCCs and 28 OPL...

journal_title：Journal of cancer research and clinical oncology

authors： Nomura H,Uzawa K,Yamano Y,Fushimi K,Nakashima D,Kouzu Y,Kasamatsu A,Ogawara K,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:The growth pattern of peripheral squamous cell carcinoma (SCC) of the lung is divided into two types: alveolar space-filling (ASF) growth and alveolar space-destructive (ASD) growth. The aim of this study was to investigate the clinicopathological differences between cancer cells displaying ASF and ASD growth. ...

journal_title：Journal of cancer research and clinical oncology

authors： Omori T,Aokage K,Nakamura H,Katsumata S,Miyoshi T,Sugano M,Kojima M,Fujii S,Kuwata T,Ochiai A,Ikeda N,Tsuboi M,Ishii G

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To investigate the interaction between Wnt/β-catenin and estrogen signaling pathways in endometrial cancer (EC). METHODS:119 women were involved in this study, including 65 women with histologically confirmed EC and 54 healthy women as a control group. Serum protein levels of Dkk1 were measured using ELISA. Pr...

journal_title：Journal of cancer research and clinical oncology

authors： Kasoha M,Dernektsi C,Seibold A,Bohle RM,Takacs Z,Ioan-Iulian I,Solomayer EF,Juhasz-Böss I

更新日期：2020-02-01 00:00:00

abstract：:In order to evaluate a possible significance of the expression of proliferating cell nuclear antigen (PCNA) as clinically useful prognostic parameter, we retrospectively investigated a series of 40 glioblastomas by means of immunohistochemistry and compared the results to patient survival. All glioblastomas included i...

journal_title：Journal of cancer research and clinical oncology

authors： Figge C,Reifenberger G,Vogeley KT,Messing M,Roosen N,Wechsler W

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is gaining worldwide attention recently, emerging as a major public health threat. However, the association between the development of AKI and subsequent malignancy has not been studied before. METHODS:We conducted a population study based on the Taiwan National Health Insurance da...

journal_title：Journal of cancer research and clinical oncology

authors： Chao CT,Wang CY,Lai CF,Huang TM,Chen YY,Kao TW,Chu TS,Chang CH,Wu VC,Ko WJ,Chen L,Wu KD,National Taiwan University Study Group on Acute Renal Failure.

更新日期：2014-04-01 00:00:00